Search Results - "WORTHLEY, Daniel L"

Cancer-associated fibroblasts—heroes or villains? by Gieniec, Krystyna A., Butler, Lisa M., Worthley, Daniel L., Woods, Susan L.

“…Cancer-associated fibroblasts (CAFs) were originally presumed to represent a homogeneous population uniformly driving tumorigenesis, united by their morphology…”
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Krt19+/Lgr5− Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine by Asfaha, Samuel, Hayakawa, Yoku, Muley, Ashlesha, Stokes, Sarah, Graham, Trevor A., Ericksen, Russell E., Westphalen, Christoph B., von Burstin, Johannes, Mastracci, Teresa L., Worthley, Daniel L., Guha, Chandhan, Quante, Michael, Rustgi, Anil K., Wang, Timothy C.

“…Epithelium of the colon and intestine are renewed every 3 days. In the intestine there are at least two principal stem cell pools. The first contains rapid…”
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Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling by Hayakawa, Yoku, Sakitani, Kosuke, Konishi, Mitsuru, Asfaha, Samuel, Niikura, Ryota, Tomita, Hiroyuki, Renz, Bernhard W., Tailor, Yagnesh, Macchini, Marina, Middelhoff, Moritz, Jiang, Zhengyu, Tanaka, Takayuki, Dubeykovskaya, Zinaida A., Kim, Woosook, Chen, Xiaowei, Urbanska, Aleksandra M., Nagar, Karan, Westphalen, Christoph B., Quante, Michael, Lin, Chyuan-Sheng, Gershon, Michael D., Hara, Akira, Zhao, Chun-Mei, Chen, Duan, Worthley, Daniel L., Koike, Kazuhiko, Wang, Timothy C.

“…Within the gastrointestinal stem cell niche, nerves help to regulate both normal and neoplastic stem cell dynamics. Here, we reveal the mechanisms underlying…”
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Quiescent Bone Lining Cells Are a Major Source of Osteoblasts During Adulthood by Matic, Igor, Matthews, Brya G., Wang, Xi, Dyment, Nathaniel A., Worthley, Daniel L., Rowe, David W., Grcevic, Danka, Kalajzic, Ivo

“…The in vivo origin of bone‐producing osteoblasts is not fully defined. Skeletal stem cells, a population of mesenchymal stem cells resident in the bone marrow…”
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Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential by Worthley, Daniel L., Churchill, Michael, Compton, Jocelyn T., Tailor, Yagnesh, Rao, Meenakshi, Si, Yiling, Levin, Daniel, Schwartz, Matthew G., Uygur, Aysu, Hayakawa, Yoku, Gross, Stefanie, Renz, Bernhard W., Setlik, Wanda, Martinez, Ashley N., Chen, Xiaowei, Nizami, Saqib, Lee, Heon Goo, Kang, H. Paco, Caldwell, Jon-Michael, Asfaha, Samuel, Westphalen, C. Benedikt, Graham, Trevor, Jin, Guangchun, Nagar, Karan, Wang, Hongshan, Kheirbek, Mazen A., Kolhe, Alka, Carpenter, Jared, Glaire, Mark, Nair, Abhinav, Renders, Simon, Manieri, Nicholas, Muthupalani, Sureshkumar, Fox, James G., Reichert, Maximilian, Giraud, Andrew S., Schwabe, Robert F., Pradere, Jean-Phillipe, Walton, Katherine, Prakash, Ajay, Gumucio, Deborah, Rustgi, Anil K., Stappenbeck, Thaddeus S., Friedman, Richard A., Gershon, Michael D., Sims, Peter, Grikscheit, Tracy, Lee, Francis Y., Karsenty, Gerard, Mukherjee, Siddhartha, Wang, Timothy C.

“…The stem cells that maintain and repair the postnatal skeleton remain undefined. One model suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise…”
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Medium-throughput Drug Screening of Patient-derived Organoids from Colorectal Peritoneal Metastases to Direct Personalized Therapy by Narasimhan, Vignesh, Wright, Josephine A, Churchill, Michael, Wang, Tongtong, Rosati, Rachele, Lannagan, Tamsin R M, Vrbanac, Laura, Richardson, Anne B, Kobayashi, Hiroki, Price, Timothy, Tye, Gayle X Y, Marker, Julie, Hewett, Peter J, Flood, Michael P, Pereira, Shalini, Whitney, G Adam, Michael, Michael, Tie, Jeanne, Mukherjee, Siddhartha, Grandori, Carla, Heriot, Alexander G, Worthley, Daniel L, Ramsay, Robert G, Woods, Susan L

“…Patients with colorectal cancer with peritoneal metastases (CRPMs) have limited treatment options and the lowest colorectal cancer survival rates. We aimed to…”
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Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche by Hayakawa, Yoku, Ariyama, Hiroshi, Stancikova, Jitka, Sakitani, Kosuke, Asfaha, Samuel, Renz, Bernhard W., Dubeykovskaya, Zinaida A., Shibata, Wataru, Wang, Hongshan, Westphalen, Christoph B., Chen, Xiaowei, Takemoto, Yoshihiro, Kim, Woosook, Khurana, Shradha S., Tailor, Yagnesh, Nagar, Karan, Tomita, Hiroyuki, Hara, Akira, Sepulveda, Antonia R., Setlik, Wanda, Gershon, Michael D., Saha, Subhrajit, Ding, Lei, Shen, Zeli, Fox, James G., Friedman, Richard A., Konieczny, Stephen F., Worthley, Daniel L., Korinek, Vladimir, Wang, Timothy C.

“…The regulation and stem cell origin of normal and neoplastic gastric glands are uncertain. Here, we show that Mist1 expression marks quiescent stem cells in…”
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Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction by Hara, Akitoshi, Kobayashi, Hiroki, Asai, Naoya, Saito, Shigeyoshi, Higuchi, Takahiro, Kato, Katsuhiro, Okumura, Takahiro, Bando, Yasuko K, Takefuji, Mikito, Mizutani, Yasuyuki, Miyai, Yuki, Saito, Shoji, Maruyama, Shoichi, Maeda, Keiko, Ouchi, Noriyuki, Nagasaka, Arata, Miyata, Takaki, Mii, Shinji, Kioka, Noriyuki, Worthley, Daniel L, Murohara, Toyoaki, Takahashi, Masahide, Enomoto, Atsushi

“…RATIONALE:Myofibroblasts have roles in tissue repair following damage associated with ischemia, aging, and inflammation and also promote fibrosis and tissue…”
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Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis by Lannagan, Tamsin R M, Lee, Young K, Wang, Tongtong, Roper, Jatin, Bettington, Mark L, Fennell, Lochlan, Vrbanac, Laura, Jonavicius, Lisa, Somashekar, Roshini, Gieniec, Krystyna, Yang, Miao, Ng, Jia Q, Suzuki, Nobumi, Ichinose, Mari, Wright, Josephine A, Kobayashi, Hiroki, Putoczki, Tracey L, Hayakawa, Yoku, Leedham, Simon J, Abud, Helen E, Yilmaz, Ömer H, Marker, Julie, Klebe, Sonja, Wirapati, Pratyaksha, Mukherjee, Siddhartha, Tejpar, Sabine, Leggett, Barbara A, Whitehall, Vicki L J, Worthley, Daniel L, Woods, Susan L

“…Serrated colorectal cancer (CRC) accounts for approximately 25% of cases and includes tumours that are among the most treatment resistant and with worst…”
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Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer by Dubeykovskaya, Zina, Si, Yiling, Chen, Xiaowei, Worthley, Daniel L., Renz, Bernhard W., Urbanska, Aleksandra M., Hayakawa, Yoku, Xu, Ting, Westphalen, C. Benedikt, Dubeykovskiy, Alexander, Chen, Duan, Friedman, Richard A., Asfaha, Samuel, Nagar, Karan, Tailor, Yagnesh, Muthupalani, Sureshkumar, Fox, James G., Kitajewski, Jan, Wang, Timothy C.

“…CD11b + Gr-1 + myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An…”
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Improving Australian National Bowel Cancer Screening Program outcomes through increased participation and cost-effective investment by Worthington, Joachim, Lew, Jie-Bin, Feletto, Eleonora, Holden, Carol A, Worthley, Daniel L, Miller, Caroline, Canfell, Karen

“…The Australian National Bowel Cancer Screening Program (NBCSP) provides biennial immunochemical faecal occult blood test (iFOBT) screening for people aged…”
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Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis by Ng, Jia Q., Jafarov, Toghrul H., Little, Christopher B., Wang, Tongtong, Ali, Abdullah M., Ma, Yan, Radford, Georgette A., Vrbanac, Laura, Ichinose, Mari, Whittle, Samuel, Hunter, David J., Lannagan, Tamsin R. M., Suzuki, Nobumi, Goyne, Jarrad M., Kobayashi, Hiroki, Wang, Timothy C., Haynes, David R., Menicanin, Danijela, Gronthos, Stan, Worthley, Daniel L., Woods, Susan L., Mukherjee, Siddhartha

“…Osteoarthritis (OA) is characterised by an irreversible degeneration of articular cartilage. Here we show that the BMP-antagonist Gremlin 1 ( Grem1 ) marks a…”
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Stem cell‐directed therapies for osteoarthritis: The promise and the practice by Ng, Jia, Little, Christopher B., Woods, Susan, Whittle, Samuel, Lee, Francis Y., Gronthos, Stan, Mukherjee, Siddhartha, Hunter, David J., Worthley, Daniel L.

“…Osteoarthritis (OA) is a disease of an entire synovial joint characterized by clinical symptoms and distortion of joint tissues, including cartilage, muscles,…”
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The G-protein coupled receptor 56, expressed in colonic stem and cancer cells, binds progastrin to promote proliferation and carcinogenesis by Jin, Guangchun, Sakitani, Kosuke, Wang, Hongshan, Jin, Ying, Dubeykovskiy, Alexander, Worthley, Daniel L, Tailor, Yagnesh, Wang, Timothy C

“…Overexpression of human progastrin increases colonic mucosal proliferation and colorectal cancer progression in mice. The G-protein coupled receptor 56 (GPR56)…”
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Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors by Shibata, Wataru, Ariyama, Hiroshi, Westphalen, Christoph Benedikt, Worthley, Daniel L, Muthupalani, Sureshkumar, Asfaha, Samuel, Dubeykovskaya, Zinaida, Quante, Michael, Fox, James G, Wang, Timothy C

“…Stromal cell-derived factor-1 (SDF-1/CXCL12), the main ligand for CXCR4, is overexpressed in human cancer. This study addressed the precise contribution of…”
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Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasia by Bond, Catherine E., Liu, Cheng, Kawamata, Futoshi, McKeone, Diane M., Fernando, Winnie, Jamieson, Saara, Pearson, Sally-Ann, Kane, Alexandra, Woods, Susan L., Lannagan, Tamsin R. M., Somashekar, Roshini, Lee, Young, Dumenil, Troy, Hartel, Gunter, Spring, Kevin J., Borowsky, Jennifer, Fennell, Lochlan, Bettington, Mark, Lee, Jason, Worthley, Daniel L., Leggett, Barbara A., Whitehall, Vicki L. J.

“…Colorectal cancer is a major cause of cancer death and approximately 20% arises within serrated polyps, which are under-recognized and poorly understood. Human…”
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Stromal DLK1 promotes proliferation and inhibits differentiation of the intestinal epithelium during development by Ichinose, Mari, Suzuki, Nobumi, Wang, Tongtong, Wright, Josephine A, Lannagan, Tamsin R M, Vrbanac, Laura, Kobayashi, Hiroki, Gieniec, Krystyna A, Ng, Jia Q, Hayakawa, Yoku, García-Gallastegui, Patricia, Monsalve, Eva M, Bauer, Steven R, Laborda, Jorge, García-Ramírez, J J, Ibarretxe, Gaskon, Worthley, Daniel L, Woods, Susan L

“…The stem/progenitor cells of the developing intestine are biologically distinct from their adult counterparts. Here, we examine the microenvironmental cues…”
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Delineating proinflammatory microenvironmental signals by ex vivo modeling of the immature intestinal stroma by Ichinose, Mari, Suzuki, Nobumi, Wang, Tongtong, Wright, Josephine A., Lannagan, Tamsin R. M., Vrbanac, Laura, Kobayashi, Hiroki, Gieniec, Krystyna, Ng, Jia Q., Ihara, Souzaburo, Mavrangelos, Chris, Hayakawa, Yoku, Hughes, Patrick, Worthley, Daniel L., Woods, Susan L.

“…The intestinal stroma provides an important microenvironment for immune cell activation. The perturbation of this tightly regulated process can lead to…”
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Oncogenic PIK3CA mutations in colorectal cancers and polyps by Whitehall, Vicki L.J., Rickman, Celestine, Bond, Catherine E., Ramsnes, Ingunn, Greco, Sonia A., Umapathy, Aarti, McKeone, Diane, Faleiro, Rebecca J., Buttenshaw, Ron L., Worthley, Daniel L., Nayler, Sam, Zhao, Zhen Zhen, Montgomery, Grant W., Mallitt, Kylie-Ann, Jass, Jeremy R., Matsubara, Nagahide, Notohara, Kenji, Ishii, Tatsuhiro, Leggett, Barbara A.

“…Oncogenic PIK3CA mutations contribute to colorectal tumorigenesis by activating AKT signaling to decrease apoptosis and increase tumor invasion. A synergistic…”
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CXCR4-expressing Mist1 + progenitors in the gastric antrum contribute to gastric cancer development by Sakitani, Kosuke, Hayakawa, Yoku, Deng, Huan, Ariyama, Hiroshi, Kinoshita, Hiroto, Konishi, Mitsuru, Ono, Satoshi, Suzuki, Nobumi, Ihara, Sozaburo, Niu, Zhengchuan, Kim, Woosook, Tanaka, Takayuki, Liu, Haibo, Chen, Xiaowei, Tailor, Yagnesh, Fox, James G, Konieczny, Stephen F, Onodera, Hiroshi, Sepulveda, Antonia R, Asfaha, Samuel, Hirata, Yoshihiro, Worthley, Daniel L, Koike, Kazuhiko, Wang, Timothy C

“…was recently shown to identify a discrete population of stem cells within the isthmus of the oxyntic gland within the gastric corpus. Chief cells at the base…”
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