Search Results - "WORTH, L"

SDM-a server for predicting effects of mutations on protein stability and malfunction by Worth, Catherine L., Preissner, Robert, Blundell, Tom L.

“…The sheer volume of non-synonymous single nucleotide polymorphisms that have been generated in recent years from projects such as the Human Genome Project, the…”
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Attributable Length of Stay, Mortality Risk, and Costs of Bacterial Health Care-Associated Infections in Australia: A Retrospective Case-cohort Study by Lee, X J, Stewardson, A J, Worth, L J, Graves, N, Wozniak, T M

“…Unbiased estimates of the health and economic impacts of health care-associated infections (HAIs) are scarce and focus largely on patients with bloodstream…”
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Structural and functional constraints in the evolution of protein families by Blundell, Tom L, Gong, Sungsam, Worth, Catherine L

“…Key Points The process of protein evolution is balanced between Darwinian selection for functionally advantageous mutations and neutral evolution, in which…”
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FDG PET/CT imaging in detecting and guiding management of invasive fungal infections: a retrospective comparison to conventional CT imaging by Douglas, A. P., Thursky, K. A., Worth, L. J., Drummond, E., Hogg, A., Hicks, R. J., Slavin, M. A.

“…Purpose Invasive fungal infections (IFIs) are common in immunocompromised patients. While early diagnosis can reduce otherwise high morbidity and mortality,…”
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Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work by Kleinau, Gunnar, Worth, Catherine L, Kreuchwig, Annika, Biebermann, Heike, Marcinkowski, Patrick, Scheerer, Patrick, Krause, Gerd

“…The thyroid-stimulating hormone receptor (TSHR) is a member of the glycoprotein hormone receptors, a sub-group of class A G-protein-coupled receptors (GPCRs)…”
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“Hands off hand hygiene training”: Implementation of a COVID safe auditor training program by Gillespie, E., Faul, C., Worth, L.J.

“…Optimal hand hygiene practices reduce the risk of healthcare-associated infections, especially in high-risk settings of immunocompromised patients. In 2020,…”
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The relationship between diabetes and surgical site infection following coronary artery bypass graft surgery in current-era models of care by Cheuk, N., Worth, L.J., Tatoulis, J., Skillington, P., Kyi, M., Fourlanos, S.

“…Although diabetes is a recognized risk factor for postoperative infections, the seminal Portland Diabetic Project studies in cardiac surgery demonstrated…”
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Establishing essential metrics for antifungal stewardship in hospitals: the results of an international Delphi survey by Khanina, A, Urbancic, K F, Haeusler, G M, Kong, D C M, Douglas, A P, Tio, S Y, Worth, L J, Slavin, M A, Thursky, K A

“…Guidance on assessment of the quantity and appropriateness of antifungal prescribing is required to assist hospitals to interpret data effectively and…”
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Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models by Worth, Catherine L, Kleinau, Gunnar, Krause, Gerd

“…Up until recently the only available experimental (high resolution) structure of a G-protein-coupled receptor (GPCR) was that of bovine rhodopsin. In the past…”
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Development and piloting of a prevention assessment and response tool for healthcare-associated Staphylococcus aureus bloodstream infection (the SAB-PART Study) using a Delphi method by Karanfilovska, D., Cheng, A.C., Spelman, D., Worth, L.J.

“…Healthcare-associated Staphylococcus aureus bloodstream infection (HA-SAB) causes preventable harm in hospitalized patients. Currently, there is no…”
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Cells of the adult human heart by Litviňuková, Monika, Talavera-López, Carlos, Maatz, Henrike, Reichart, Daniel, Worth, Catherine L., Lindberg, Eric L., Kanda, Masatoshi, Polanski, Krzysztof, Heinig, Matthias, Lee, Michael, Nadelmann, Emily R., Roberts, Kenny, Tuck, Liz, Fasouli, Eirini S., DeLaughter, Daniel M., McDonough, Barbara, Wakimoto, Hiroko, Gorham, Joshua M., Samari, Sara, Mahbubani, Krishnaa T., Saeb-Parsy, Kourosh, Patone, Giannino, Boyle, Joseph J., Zhang, Hongbo, Zhang, Hao, Viveiros, Anissa, Oudit, Gavin Y., Bayraktar, Omer Ali, Seidman, J. G., Seidman, Christine E., Noseda, Michela, Hubner, Norbert, Teichmann, Sarah A.

“…Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper…”
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Fludarabine with pharmacokinetically guided IV busulfan is superior to fixed-dose delivery in pretransplant conditioning of AML/MDS patients by Andersson, B S, Thall, P F, Valdez, B C, Milton, D R, Al-Atrash, G, Chen, J, Gulbis, A, Chu, D, Martinez, C, Parmar, S, Popat, U, Nieto, Y, Kebriaei, P, Alousi, A, de Lima, M, Rondon, G, Meng, Q H, Myers, A, Kawedia, J, Worth, L L, Fernandez-Vina, M, Madden, T, Shpall, E J, Jones, R B, Champlin, R E

“…We hypothesized that IV busulfan (Bu) dosing could be safely intensified through pharmacokinetic (PK-) dose guidance to minimize the inter-patient variability…”
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SuperSweet--a resource on natural and artificial sweetening agents by Ahmed, Jessica, Preissner, Saskia, Dunkel, Mathias, Worth, Catherine L, Eckert, Andreas, Preissner, Robert

“…A vast number of sweet tasting molecules are known, encompassing small compounds, carbohydrates, D-amino acids and large proteins. Carbohydrates play a…”
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Asthma- and IgE-associated polymorphisms affect expression of T H 17 genes by Worth, L, Michel, S, Gaertner, V D, Kabesch, M, Schieck, M

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Single-cell and spatially resolved interactomics of tooth-associated keratinocytes in periodontitis by Easter, Quinn T., Fernandes Matuck, Bruno, Beldorati Stark, Germán, Worth, Catherine L., Predeus, Alexander V., Fremin, Brayon, Huynh, Khoa, Ranganathan, Vaishnavi, Ren, Zhi, Pereira, Diana, Rupp, Brittany T., Weaver, Theresa, Miller, Kathryn, Perez, Paola, Hasuike, Akira, Chen, Zhaoxu, Bush, Mandy, Qu, Xufeng, Lee, Janice, Randell, Scott H., Wallet, Shannon M., Sequeira, Inês, Koo, Hyun, Tyc, Katarzyna M., Liu, Jinze, Ko, Kang I., Teichmann, Sarah A., Byrd, Kevin M.

“…Periodontitis affects billions of people worldwide. To address relationships of periodontal niche cell types and microbes in periodontitis, we generated an…”
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Asthma‐ and IgE‐associated polymorphisms affect expression of TH17 genes by Worth, L., Michel, S., Gaertner, V. D., Kabesch, M., Schieck, M.

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A bundle of care to reduce colorectal surgical infections: an Australian experience by Bull, A, Wilson, J, Worth, L.J, Stuart, R.L, Gillespie, E, Waxman, B, Shearer, W, Richards, M

“…Summary Use of ‘bundles of care’ to improve patient outcomes is becoming more widespread; however, their use is more common internationally than in Australia…”
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‘Closing the gap’: Evaluating the success of non-mandatory strategies for influenza vaccination of Victorian healthcare workers by Bennett, N., Crouch, S., Hoskins, A., Malloy, M.J., Walker, K., Worth, L.J.

“…While annual influenza vaccination of healthcare workers (HCWs) is recommended, uptake is often suboptimal. We sought to evaluate influenza vaccination uptake…”
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Performance of a hospital-acquired complication algorithm using administrative data for detection of central line-associated bloodstream infections: experience at an Australian healthcare facility by Herson, M., Curtis, S.J., Land, G., Stewardson, A.J., Worth, L.J.

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Consensus guidelines for optimising antifungal drug delivery and monitoring to avoid toxicity and improve outcomes in patients with haematological malignancy, 2014 by Chau, M. M., Kong, D. C. M., van Hal, S. J., Urbancic, K., Trubiano, J. A., Cassumbhoy, M., Wilkes, J., Cooper, C. M., Roberts, J. A., Marriott, D. J. E., Worth, L. J.

“…Antifungal agents may be associated with significant toxicity or drug interactions leading to sub‐therapeutic antifungal drug concentrations and poorer…”
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