Search Results - "WORSAAE, ANNE"

Discovery of neutralizing SARS-CoV-2 antibodies enriched in a unique antigen specific B cell cluster by Lende, Stine Sofie Frank, Barnkob, Nanna Møller, Hansen, Randi Westh, Bansia, Harsh, Vestergaard, Mike, Rothemejer, Frederik Holm, Worsaae, Anne, Brown, Deijona, Pedersen, Maria Lange, Rahimic, Anna Halling Folkmar, Juhl, Anna Karina, Gjetting, Torben, Østergaard, Lars, Georges, Amédée Des, Vuillard, Laurent-Michel, Schleimann, Mariane Høgsbjerg, Koefoed, Klaus, Tolstrup, Martin

“…Despite development of effective SARS-CoV-2 vaccines, a sub-group of vaccine non-responders depends on therapeutic antibodies or small-molecule drugs in cases…”
Get full text

Interleukin-20 as a Target in Psoriasis Treatment by STENDERUP, KARIN, ROSADA, CECILIA, WORSAAE, ANNE, CLAUSEN, JES THORN, NORMAN DAM, TOMAS

“…:  Interleukin‐20 (IL‐20) is a new member of the IL‐10 cytokine family discovered by a structural algorithm. IL‐20 transgenic mice displayed skin abnormalities…”
Get full text

The Existence of Multiple Conformers of Interleukin-21 Directs Engineering of a Superpotent Analogue by Bondensgaard, Kent, Breinholt, Jens, Madsen, Dennis, Omkvist, Diana Højmark, Kang, Lishan, Worsaae, Anne, Becker, Peter, Schiødt, Christine Bruun, Hjorth, Siv A.

“…The high resolution three-dimensional structure of human interleukin (hIL)-21 has been resolved by heteronuclear NMR spectroscopy. Overall, the hIL-21…”
Get full text

Discovery of neutralizing SARS-CoV-2 antibodies enriched in a unique antigen specific B cell cluster by Stine Sofie Frank Lende, Nanna Møller Barnkob, Randi Westh Hansen, Harsh Bansia, Mike Vestergaard, Frederik Holm Rothemejer, Anne Worsaae, Deijona Brown, Maria Lange Pedersen, Anna Halling Folkmar Rahimic, Anna Karina Juhl, Torben Gjetting, Lars Østergaard, Amédée Des Georges, Laurent-Michel Vuillard, Mariane Høgsbjerg Schleimann, Klaus Koefoed, Martin Tolstrup

“…Despite development of effective SARS-CoV-2 vaccines, a sub-group of vaccine non-responders depends on therapeutic antibodies or small-molecule drugs in cases…”
Get full text

New 3-Alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-Dioxide Derivatives Activate ATP-Sensitive Potassium Channels of Pancreatic Beta Cells by Nielsen, Flemming E, Ebdrup, Søren, Jensen, Anette Frost, Ynddal, Lars, Bodvarsdottir, Thora B, Stidsen, Carsten, Worsaae, Anne, Boonen, Harrie C. M, Arkhammar, Per O. G, Fremming, Tinna, Wahl, Philip, Kornø, Hanne T, Hansen, J. Bondo

“…Compound 1a (NN414) is a potent opener of Kir6.2/SUR1 K ATP channels. Compound 1a inhibits insulin release in vitro and in vivo and preserves beta cell…”
Get full text

2-(4-Methoxyphenoxy)-5-nitro- N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 K ATP channels by Nielsen, Flemming E., Jacobsen, Palle, Worsaae, Anne, Arkhammar, Per O.G., Wahl, Philip, Bondo Hansen, John

“…[Display omitted] 2-(4-Methoxyphenoxy)-5-nitro- N-(4-sulfamoylphenyl)benzamide and close analogues inhibit glucose stimulated insulin release through…”
Get full text

6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-Dioxide Derivatives Potently and Selectively Activate ATP Sensitive Potassium Channels of Pancreatic β-Cells by Nielsen, Flemming E, Bodvarsdottir, Thora B, Worsaae, Anne, MacKay, Peter, Stidsen, Carsten E, Boonen, Harrie C. M, Pridal, Lone, Arkhammar, Per O. G, Wahl, Philip, Ynddal, Lars, Junager, Finn, Dragsted, Nils, Tagmose, Tina M, Mogensen, John P, Koch, Anette, Treppendahl, Svend P, Hansen, J. Bondo

“…6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives were synthesized and characterized as activators of adenosine 5‘-triphosphate…”
Get full text

Synthesis and pharmacological evaluation of 4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide and N-(2-cyanomethylsulfonylphenyl)acylamide derivatives as potential activators of ATP sensitive potassium channels by SCHOU, Søren C, HANSEN, Holger C, LEBRUN, Philippe, HANSEN, John Bondo, TAGMOSE, Tina M, BOONEN, Harrie C. M, WORSAAE, Anne, DRABOWSKI, Michael, WAHL, Philip, ARKHAMMAR, Per O. G, BODVARSDOTTIR, Thora, ANTOINE, Marie-Hélène

“…1,2,4-Thiadiazine derivatives, like 3-methyl-7-chlorobenzo-4H-1,2,4-thiadiazine 1,1-dioxide, diazoxide and 7-chloro-3-isopropylamino-4H-benzo-1,2,4-thiadiazine…”
Get full text

2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 K(ATP) channels by Nielsen, Flemming E, Jacobsen, Palle, Worsaae, Anne, Arkhammar, Per O G, Wahl, Philip, Bondo Hansen, John

“…2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide and close analogues inhibit glucose stimulated insulin release through activation of Kir6.2/SUR1…”
Get full text

New 3-Alkylamino-4 H -thieno-1,2,4-thiadiazine 1,1-Dioxide Derivatives Activate ATP-Sensitive Potassium Channels of Pancreatic Beta Cells by Nielsen, Flemming E., Ebdrup, Søren, Jensen, Anette Frost, Ynddal, Lars, Bodvarsdottir, Thora B., Stidsen, Carsten, Worsaae, Anne, Boonen, Harrie C. M., Arkhammar, Per O. G., Fremming, Tinna, Wahl, Philip, Kornø, Hanne T., Hansen, J. Bondo

Get full text

Arylcyanoguanidines as Activators of Kir6.2/SUR1KATP Channels and Inhibitors of Insulin Release by Tagmose, Tina M, Schou, Søren C, Mogensen, John P, Nielsen, Flemming E, Arkhammar, Per O. G, Wahl, Philip, Hansen, Birgit S, Worsaae, Anne, Boonen, Harrie C. M, Antoine, Marie-Hélène, Lebrun, Philippe, Hansen, John Bondo

“…Phenylcyanoguanidines substituted with lipophilic electron-withdrawing functional groups, e.g. N-cyano-N‘-[3,5-bis-(trifluoromethyl)phenyl]-N‘…”
Get full text

2-(4-methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 KATP channels by NIELSEN, Flemming E, JACOBSEN, Palle, WORSAAE, Anne, ARKHAMMAR, Per O. G, WAHL, Philip, HANSEN, John Bondo

Get full text

Neonatal tolerization with glutamic acid decarboxylase but not with bovine serum albumin delays the onset of diabetes in NOD mice by PETERSEN, J. S, KARLSEN, A. E, MARKHOLST, H, WORSAAE, A, DYRBERG, T, MICHELSEN, B

“…To test the role of glutamic acid decarboxylase (GAD65) or bovine serum albumin (BSA) autoimmunity in the pathogenesis of diabetes, GAD65 or BSA was injected…”
Get full text

Synthesis and pharmacological evaluation of 4 H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide and N-(2-cyanomethylsulfonylphenyl)acylamide derivatives as potential activators of ATP sensitive potassium channels by Schou, Søren C., Hansen, Holger C., Tagmose, Tina M., Boonen, Harrie C.M., Worsaae, Anne, Drabowski, Michael, Wahl, Philip, Arkhammar, Per O.G., Bodvarsdottir, Thora, Antoine, Marie-Hélène, Lebrun, Philippe, Hansen, John Bondo

“…[Display omitted] 1,2,4-Thiadiazine derivatives, like 3-methyl-7-chlorobenzo-4 H-1,2,4-thiadiazine 1,1-dioxide, diazoxide and 7-chloro-3-isopropylamino-4…”
Get full text

Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release by Tagmose, Tina M, Schou, Søren C, Mogensen, John P, Nielsen, Flemming E, Arkhammar, Per O G, Wahl, Philip, Hansen, Birgit S, Worsaae, Anne, Boonen, Harrie C M, Antoine, Marie-Hélène, Lebrun, Philippe, Hansen, John Bondo

“…Phenylcyanoguanidines substituted with lipophilic electron-withdrawing functional groups, e.g. N-cyano-N'-[3,5-bis-(trifluoromethyl)phenyl]-N'…”
Get full text

Synthesis and biological activity of 3,3-Diamino-sulfonylacrylonitriles as novel inhibitors of glucose induced insulin secretion from beta cells by Tagmose, Tina M, Zaragoza, Florencio, Boonen, Harrie C.M, Worsaae, Anne, Mogensen, John P, Nielsen, Flemming E, Jensen, Anette Frost, Hansen, John Bondo

“…Pinacidil analogues, for example, N-cyano- N′-(3,5-dichlorophenyl)- N″-(3-methylbutyl)guanidine, 1, have previously been described as potassium channel openers…”
Get full text

6-Chloro-3-alkylamino-4 H -thieno[3,2 -e ]-1,2,4-thiadiazine 1,1-Dioxide Derivatives Potently and Selectively Activate ATP Sensitive Potassium Channels of Pancreatic β-Cells by Nielsen, Flemming E., Bodvarsdottir, Thora B., Worsaae, Anne, MacKay, Peter, Stidsen, Carsten E., Boonen, Harrie C. M., Pridal, Lone, Arkhammar, Per O. G., Wahl, Philip, Ynddal, Lars, Junager, Finn, Dragsted, Nils, Tagmose, Tina M., Mogensen, John P., Koch, Anette, Treppendahl, Svend P., Hansen, J. Bondo

Get full text

Phenylcyanoguanidines as inhibitors of glucose-induced insulin secretion from beta cells by Tagmose, Tina M, Mogensen, John P, Agerholm, Pia C, Arkhammar, Per O.G, Wahl, Philip, Worsaae, Anne, Hansen, J.Bondo

“…3,5-Disubstituted-phenylcyanoguanidines have been identified as activators of SUR1/Kir6.2 potassium channels and as potent inhibitors of insulin release from…”
Get full text

Immunization of Diabetes-prone or Non-diabetes-Prone Mice with GAD65 Does Not Induce Diabetes or Islet Cell Pathology by Plesner, Annette, Worsaae, Anne, Dyrberg, Thomas, Gotfredsen, Carsten, Michelsen, Birgitte K., Petersen, Jacob S.

“…Glutamic acid decarboxylase autoimmunity was investigated by immunizing female BALB/c, C57B1/6, National Marine Research Institute (NMRI) and non-obese…”
Get full text

T cell proliferative responses to glutamic acid decarboxylase-65 in IDDM are negatively associated with HLA DR3/4 by Worsaae, A, Hejnaes, K, Moody, A, Ludvigsson, J, Pociot, F, Lorenzen, T, Dyrberg, T

“…Based on studies in spontaneously non-obese diabetic (NOD) mice, it has been suggested that the Mr 65,000 isoform of glutamic acid decarboxylase (GAD65) is of…”
Get more information