Search Results - "WORRALL, J. J"

Climate change and forest diseases by Sturrock, R. N., Frankel, S. J., Brown, A. V., Hennon, P. E., Kliejunas, J. T., Lewis, K. J., Worrall, J. J., Woods, A. J.

“…As climate changes, the effects of forest diseases on forest ecosystems will change. We review knowledge of relationships between climate variables and several…”
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Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site by Lee, Jaeyong, Worrall, Liam J., Vuckovic, Marija, Rosell, Federico I., Gentile, Francesco, Ton, Anh-Tien, Caveney, Nathanael A., Ban, Fuqiang, Cherkasov, Artem, Paetzel, Mark, Strynadka, Natalie C. J.

“…Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the pathogen that causes the disease COVID-19, produces replicase polyproteins 1a and 1ab that…”
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Near-atomic-resolution cryo-EM analysis of the Salmonella T3S injectisome basal body by Worrall, L. J., Hong, C., Vuckovic, M., Deng, W., Bergeron, J. R. C., Majewski, D. D, Huang, R. K., Spreter, T., Finlay, B. B., Yu, Z., Strynadka, N. C. J.

“…The authors report the structure of the assembled membrane spanning ring forming proteins of the Salmonella Typhimurium injectisome basal body, including the…”
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X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation by Lee, Jaeyong, Kenward, Calem, Worrall, Liam J., Vuckovic, Marija, Gentile, Francesco, Ton, Anh-Tien, Ng, Myles, Cherkasov, Artem, Strynadka, Natalie C. J., Paetzel, Mark

“…Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the pathogen that causes COVID-19, produces polyproteins 1a and 1ab that contain, respectively,…”
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Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin by Hu, J., Worrall, L. J., Hong, C., Vuckovic, M., Atkinson, C. E., Caveney, N., Yu, Z., Strynadka, N. C. J.

“…The bacterial type III secretion system, or injectisome, is a syringe shaped nanomachine essential for the virulence of many disease causing Gram-negative…”
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An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity by Weisser, Nina E., Sanches, Mario, Escobar-Cabrera, Eric, O’Toole, Jason, Whalen, Elizabeth, Chan, Peter W. Y., Wickman, Grant, Abraham, Libin, Choi, Kate, Harbourne, Bryant, Samiotakis, Antonios, Rojas, Andrea Hernández, Volkers, Gesa, Wong, Jodi, Atkinson, Claire E., Baardsnes, Jason, Worrall, Liam J., Browman, Duncan, Smith, Emma E., Baichoo, Priya, Cheng, Chi Wing, Guedia, Joy, Kang, Sohyeong, Mukhopadhyay, Abhishek, Newhook, Lisa, Ohrn, Anders, Raghunatha, Prajwal, Zago-Schmitt, Matteo, Schrag, Joseph D., Smith, Joel, Zwierzchowski, Patricia, Scurll, Joshua M., Fung, Vincent, Black, Sonia, Strynadka, Natalie C. J., Gold, Michael R., Presta, Leonard G., Ng, Gordon, Dixit, Surjit

“…Human epidermal growth factor receptor 2 (HER2) is a receptor tyrosine kinase that plays an oncogenic role in breast, gastric and other solid tumors. However,…”
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Crystal structure of an intramembranal phosphatase central to bacterial cell-wall peptidoglycan biosynthesis and lipid recycling by Workman, Sean D., Worrall, Liam J., Strynadka, Natalie C. J.

“…Undecaprenyl pyrophosphate phosphatase (UppP) is an integral membrane protein that recycles the lipid carrier essential to the ongoing biosynthesis of the…”
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Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry by Majewski, Dorothy D., Worrall, Liam J., Hong, Chuan, Atkinson, Claire E., Vuckovic, Marija, Watanabe, Nobuhiko, Yu, Zhiheng, Strynadka, Natalie C. J.

“…Many Gram-negative bacteria, including causative agents of dysentery, plague, and typhoid fever, rely on a type III secretion system – a multi-membrane…”
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Towards capture of dynamic assembly and action of the T3SS at near atomic resolution by Hu, Jinhong, Worrall, Liam J, Strynadka, Natalie CJ

“…•Cryo-EM and cryo-ET are facilitating major advances in our structural understanding of the T3SS.•Cryo-EM analyses at near-atomic resolutions have revealed the…”
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Overlap of International League of Associations for Rheumatology and Preliminary Pediatric Rheumatology International Trials Organization Classification Criteria for Nonsystemic Juvenile Idiopathic Arthritis in an Established UK Multicentre Inception Cohort by Shoop‐Worrall, Stephanie J. W., Macintyre, Vanessa G., Ciurtin, Coziana, Cleary, Gavin, McErlane, Flora, Wedderburn, Lucy R., Chieng, Alice, Ciurtin, Coziana, Baildam, Eileen, McErlane, Flora, Cleary, Gavin, Foster, Helen, Davidson, Joyce, Wedderburn, Lucy R., Ioannou, Yiannis, Hyrich, Kimme L.

“…Objective The goal was to assess the degree of overlap between existing International League of Associations for Rheumatology (ILAR) and preliminary Paediatric…”
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Rapid mortality of Populus tremuloides in southwestern Colorado, USA by Worrall, James J., Egeland, Leanne, Eager, Thomas, Mask, Roy A., Johnson, Erik W., Kemp, Philip A., Shepperd, Wayne D.

“…Concentrated patches of recent trembling aspen ( Populus tremuloides) mortality covered 56,091 ha of Colorado forests in 2006. Mortality has progressed…”
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Quantum-resistance in blockchain networks by Allende, Marcos, León, Diego López, Cerón, Sergio, Pareja, Adrián, Pacheco, Erick, Leal, Antonio, Da Silva, Marcelo, Pardo, Alejandro, Jones, Duncan, Worrall, David J., Merriman, Ben, Gilmore, Jonathan, Kitchener, Nick, Venegas-Andraca, Salvador E.

“…The advent of quantum computing threatens blockchain protocols and networks because they utilize non-quantum resistant cryptographic algorithms. When quantum…”
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Roles and responsibilities in newborn care in four African sites by Iganus, R., Hill, Z., Manzi, F., Bee, M., Amare, Y., Shamba, D., Odebiyi, A., Adejuyigbe, E., Omotara, B., Skordis‐Worrall, J.

“…Objectives To explore roles and responsibilities in newborn care in the intra‐ and postpartum period in Nigeria, Tanzania and Ethiopia. Methods Qualitative…”
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Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase by Farha, Maya A., Czarny, Tomasz L., Myers, Cullen L., Worrall, Liam J., French, Shawn, Conrady, Deborah G., Wang, Yang, Oldfield, Eric, Strynadka, Natalie C. J., Brown, Eric D.

“…Drug combinations are valuable tools for studying biological systems. Although much attention has been given to synergistic interactions in revealing…”
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Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli by Caveney, Nathanael A., Caballero, Guillermo, Voedts, Henri, Niciforovic, Ana, Worrall, Liam J., Vuckovic, Marija, Fonvielle, Matthieu, Hugonnet, Jean-Emmanuel, Arthur, Michel, Strynadka, Natalie C. J.

“…The bacterial cell wall plays a crucial role in viability and is an important drug target. In Escherichia coli , the peptidoglycan crosslinking reaction to…”
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Cryo-EM characterization of the anydromuropeptide permease AmpG central to bacterial fitness and β-lactam antibiotic resistance by Sverak, Helena E., Yaeger, Luke N., Worrall, Liam J., Vacariu, Condurache M., Glenwright, Amy J., Vuckovic, Marija, Al Azawi, Zayni-Dean, Lamers, Ryan P., Marko, Victoria A., Skorupski, Clarissa, Soni, Arvind S., Tanner, Martin E., Burrows, Lori L., Strynadka, Natalie CJ

“…Bacteria invest significant resources into the continuous creation and tailoring of their essential protective peptidoglycan (PG) cell wall. Several soluble PG…”
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Long-Term Outcomes Following Achievement of Clinically Inactive Disease in Juvenile Idiopathic Arthritis: The Importance of Definition by Shoop-Worrall, Stephanie J W, Verstappen, Suzanne M M, McDonagh, Janet E, Baildam, Eileen, Chieng, Alice, Davidson, Joyce, Foster, Helen, Ioannou, Yiannis, McErlane, Flora, Wedderburn, Lucy R, Thomson, W, Hyrich, Kimme L

“…Potential targets for treat-to-target strategies in juvenile idiopathic arthritis are minimal disease activity (MDA) and clinically inactive disease (CID). We…”
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A refined model of the prototypical Salmonella SPI-1 T3SS basal body reveals the molecular basis for its assembly by Bergeron, Julien R C, Worrall, Liam J, Sgourakis, Nikolaos G, DiMaio, Frank, Pfuetzner, Richard A, Felise, Heather B, Vuckovic, Marija, Yu, Angel C, Miller, Samuel I, Baker, David, Strynadka, Natalie C J

“…The T3SS injectisome is a syringe-shaped macromolecular assembly found in pathogenic Gram-negative bacteria that allows for the direct delivery of virulence…”
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Structure and Mechanism of Staphylococcus aureus TarS, the Wall Teichoic Acid β-glycosyltransferase Involved in Methicillin Resistance by Sobhanifar, Solmaz, Worrall, Liam J, King, Dustin T, Wasney, Gregory A, Baumann, Lars, Gale, Robert T, Nosella, Michael, Brown, Eric D, Withers, Stephen G, Strynadka, Natalie C J

“…In recent years, there has been a growing interest in teichoic acids as targets for antibiotic drug design against major clinical pathogens such as…”
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Strategic Application of Topoclimatic Niche Models in Managing Forest Change by James J. Worrall, Gerald E. Rehfeldt

“…Forest management traditionally has been based on the expectation of a steady climate. In the face of a changing climate, management requires projections of…”
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