Search Results - "WORKMAN, Creg J"

Regulatory T Cells: Barriers of Immune Infiltration Into the Tumor Microenvironment by Scott, Ellen N, Gocher, Angela M, Workman, Creg J, Vignali, Dario A A

“…Regulatory T cells (T ) are key immunosuppressive cells that promote tumor growth by hindering the effector immune response. T utilize multiple suppressive…”
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The costimulatory activity of Tim-3 requires Akt and MAPK signaling and its recruitment to the immune synapse by Kataoka, Shunsuke, Manandhar, Priyanka, Lee, Judong, Workman, Creg J, Banerjee, Hridesh, Szymczak-Workman, Andrea L, Kvorjak, Michael, Lohmueller, Jason, Kane, Lawrence P

“…Expression of the transmembrane protein Tim-3 is increased on dysregulated T cells undergoing chronic activation, including during chronic infection and in…”
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Neuropilin-1: a checkpoint target with unique implications for cancer immunology and immunotherapy by Chuckran, Christopher A, Liu, Chang, Bruno, Tullia C, Workman, Creg J, Vignali, Dario AA

“…Checkpoint blockade immunotherapy established a new paradigm in cancer treatment: for certain patients curative treatment requires immune reinvigoration…”
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Lymphocyte Activation Gene-3 (LAG-3) negatively regulates environmentally-induced autoimmunity by Jha, Vibha, Workman, Creg J, McGaha, Tracy L, Li, Liping, Vas, Jaya, Vignali, Dario A A, Monestier, Marc

“…Environmental factors including drugs, mineral oils and heavy metals such as lead, gold and mercury are triggers of autoimmune diseases in animal models or…”
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LAG-3 Regulates Plasmacytoid Dendritic Cell Homeostasis by Workman, Creg J, Wang, Yao, El Kasmi, Karim C, Pardoll, Drew M, Murray, Peter J, Drake, Charles G, Vignali, Dario A. A

“…Lymphocyte activation gene 3 (LAG-3) is a CD4-related, activation-induced cell surface molecule expressed by various lymphoid cell types and binds to MHC class…”
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Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector by Vignali, Dario A A, Szymczak, Andrea L, Workman, Creg J, Wang, Yao, Vignali, Kate M, Dilioglou, Smaroula, Vanin, Elio F

“…Attempts to generate reliable and versatile vectors for gene therapy and biomedical research that express multiple genes have met with limited success. Here we…”
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Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding by Andrews, Lawrence P, Somasundaram, Ashwin, Moskovitz, Jessica M, Szymczak-Workman, Andrea L, Liu, Chang, Cillo, Anthony R, Lin, Huang, Normolle, Daniel P, Moynihan, Kelly D, Taniuchi, Ichiro, Irvine, Darrell J, Kirkwood, John M, Lipson, Evan J, Ferris, Robert L, Bruno, Tullia C, Workman, Creg J, Vignali, Dario A A

“…Mechanisms of resistance to cancer immunotherapy remain poorly understood. Lymphocyte activation gene-3 (LAG3) signaling is regulated by a disintegrin and…”
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Interferon-γ: teammate or opponent in the tumour microenvironment? by Gocher, Angela M., Workman, Creg J., Vignali, Dario A. A.

“…Cancer immunotherapy offers substantive benefit to patients with various tumour types, in some cases leading to complete tumour clearance. However, many…”
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The CD4‐related molecule, LAG‐3 (CD223), regulates the expansion of activated T cells by Workman, Creg J., Vignali, Dario A. A.

“…The lymphocyte activation gene‐3 (LAG‐3, CD223) is a CD4‐related, activation‐induced cell surface molecule that binds to MHC class II with high affinity. The…”
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Treg-Cell-Derived IL-35-Coated Extracellular Vesicles Promote Infectious Tolerance by Sullivan, Jeremy A., Tomita, Yusuke, Jankowska-Gan, Ewa, Lema, Diego A., Arvedson, Matt P., Nair, Ashita, Bracamonte-Baran, William, Zhou, Ying, Meyer, Kristy K., Zhong, Weixiong, Sawant, Deepali V., Szymczak-Workman, Andrea L., Zhang, Qianxia, Workman, Creg J., Hong, Seungpyo, Vignali, Dario A.A., Burlingham, William J.

“…Interleukin-35 (IL-35) is an immunosuppressive cytokine composed of Epstein-Barr-virus-induced protein 3 (Ebi3) and IL-12α chain (p35) subunits, yet the forms…”
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Cutting Edge: Molecular Analysis of the Negative Regulatory Function of Lymphocyte Activation Gene-3 by Workman, Creg J, Dugger, Kari J, Vignali, Dario A. A

“…Lymphocyte activation gene (LAG)-3 (CD223) is a CD4-related activation-induced cell surface molecule that binds to MHC class II molecules with high affinity…”
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LAG-3 as the third checkpoint inhibitor by Aggarwal, Vaishali, Workman, Creg J., Vignali, Dario A. A.

“…Lymphocyte activation gene 3 (LAG-3) is an inhibitory receptor that is highly expressed by exhausted T cells. LAG-3 is a promising immunotherapeutic target,…”
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Phenotypic analysis of the murine CD4‐related glycoprotein, CD223 (LAG‐3) by Workman, Creg J., Rice, Dennis S., Dugger, Kari J., Kurschner, Cornelia, Vignali, Dario A. A.

“…CD223 (LAG‐3) is an activation‐induced cell surface molecule, structurally similar to the T cell coreceptor CD4, that binds MHC class II molecules with high…”
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Lymphocyte‐Activation Gene 3 Facilitates Pathological Tau Neuron‐to‐Neuron Transmission by Chen, Chan, Kumbhar, Ramhari, Wang, Hu, Yang, Xiuli, Gadhave, Kundlik, Rastegar, Cyrus, Kimura, Yasuyoshi, Behensky, Adam, Kotha, Sumasri, Kuo, Grace, Katakam, Sruthi, Jeong, Deok, Wang, Liang, Wang, Anthony, Chen, Rong, Zhang, Shu, Jin, Lingtao, Workman, Creg J., Vignali, Dario A. A., Pletinkova, Olga, Jia, Hongpeng, Peng, Weiyi, Nauen, David W., Wong, Philip C., Redding‐Ochoa, Javier, Troncoso, Juan C., Ying, Mingyao, Dawson, Valina L., Dawson, Ted M., Mao, Xiaobo

“…The spread of prion‐like protein aggregates is a common driver of pathogenesis in various neurodegenerative diseases, including Alzheimer's disease (AD) and…”
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On the Pathogenicity of Autoantigen-Specific T-Cell Receptors by Burton, Amanda R, Vincent, Erica, Arnold, Paula Y, Lennon, Greig P, Smeltzer, Matthew, Li, Chin-Shang, Haskins, Kathryn, Hutton, John, Tisch, Roland M, Sercarz, Eli E, Santamaria, Pere, Workman, Creg J, Vignali, Dario A A

“…On the Pathogenicity of Autoantigen-Specific T-Cell Receptors Amanda R. Burton 1 , Erica Vincent 1 , Paula Y. Arnold 1 , Greig P. Lennon 1 , Matthew Smeltzer 2…”
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Lymphocyte-activation gene 3 (LAG3): The next immune checkpoint receptor by Ruffo, Elisa, Wu, Richard C., Bruno, Tullia C., Workman, Creg J., Vignali, Dario A.A.

“…Immune checkpoint therapy has revolutionized cancer treatment by blocking inhibitory pathways in T cells that limits the an effective anti-tumor immune…”
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Targeting regulatory T cells in tumors by Liu, Chang, Workman, Creg J., Vignali, Dario A. A.

“…Regulatory T (Treg) cells play a crucial role in maintaining peripheral tolerance and preventing autoimmunity. However, they also represent a major barrier to…”
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Adaptive plasticity of IL-10 + and IL-35 + T reg cells cooperatively promotes tumor T cell exhaustion by Sawant, Deepali V, Yano, Hiroshi, Chikina, Maria, Zhang, Qianxia, Liao, Mengting, Liu, Chang, Callahan, Derrick J, Sun, Zhe, Sun, Tao, Tabib, Tracy, Pennathur, Arjun, Corry, David B, Luketich, James D, Lafyatis, Robert, Chen, Wei, Poholek, Amanda C, Bruno, Tullia C, Workman, Creg J, Vignali, Dario A A

“…Regulatory T cells (T cells) maintain host self-tolerance but are a major barrier to effective cancer immunotherapy. T cells subvert beneficial anti-tumor…”
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Molecular Pathways and Mechanisms of LAG3 in Cancer Therapy by Andrews, Lawrence P, Cillo, Anthony R, Karapetyan, Lilit, Kirkwood, John M, Workman, Creg J, Vignali, Dario A A

“…Immunotherapy targeting coinhibitory receptors has been highly successful in treating a wide variety of malignancies; however, only a subset of patients…”
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Intratumoral regulatory T cells: markers, subsets and their impact on anti‐tumor immunity by Yano, Hiroshi, Andrews, Lawrence P., Workman, Creg J., Vignali, Dario A. A.

“…Summary Regulatory T (Treg) cells play a crucial role in maintaining self‐tolerance and resolution of immune responses by employing multifaceted…”
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