Search Results - "WORGALL, Stefan"

Sphingosine 1‐Phosphate Receptor 1 Signaling Maintains Endothelial Cell Barrier Function and Protects Against Immune Complex–Induced Vascular Injury by Burg, Nathalie, Swendeman, Steven, Worgall, Stefan, Hla, Timothy, Salmon, Jane E.

“…Objective Immune complex (IC) deposition activates polymorphonuclear neutrophils (PMNs), increases vascular permeability, and leads to organ damage in systemic…”
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Perinatal origins of chronic lung disease: mechanisms–prevention–therapy—sphingolipid metabolism and the genetic and perinatal origins of childhood asthma by Wasserman, Emily, Worgall, Stefan

“…Childhood asthma derives from complex host-environment interactions occurring in the perinatal and infant period, a critical time for lung development…”
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Endothelial-Derived Angiocrine Signals Induce and Sustain Regenerative Lung Alveolarization by Ding, Bi-Sen, Nolan, Daniel J., Guo, Peipei, Babazadeh, Alexander O., Cao, Zhongwei, Rosenwaks, Zev, Crystal, Ronald G., Simons, Michael, Sato, Thomas N., Worgall, Stefan, Shido, Koji, Rabbany, Sina Y., Rafii, Shahin

“…To identify pathways involved in adult lung regeneration, we employ a unilateral pneumonectomy (PNX) model that promotes regenerative alveolarization in the…”
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Post-exposure immunization by capsid-modified AdC7 vector expressing Pseudomonas aeruginosa OprF clears P. aeruginosa respiratory infection by Gomi, Rika, Sharma, Anurag, Wu, Wenzhu, Sung, Biin, Worgall, Stefan

“…•A vaccine against established P. aeruginosa respiratory infections would be helpful.•Capsid-modified AdC7 vectors are potent inducers of respiratory mucosal…”
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Recent developments for Pseudomonas vaccines by Sharma, Anurag, Krause, Anja, Worgall, Stefan

“…Infections with Pseudomonas aeruginosa are a major health problem for immune-compromised patients and individuals with cystic fibrosis. A vaccine against P…”
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Dietary long-chain omega 3 fatty acids modify sphingolipid metabolism to facilitate airway hyperreactivity by Heras, Andrea, Gomi, Rika, Young, Madeline, Chang, Chuchun L., Wasserman, Emily, Sharma, Anurag, Wu, Wenzhu, Gu, Jinghua, Balaji, Uthra, White, Rachel, Permaul, Perdita, Janahi, Ibrahim, Worgall, Tilla S., Worgall, Stefan

“…Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are essential nutrients that can affect inflammatory responses. While n-3 PUFAs are generally considered…”
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Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity by Worgall, Tilla S, Veerappan, Arul, Sung, Biin, Kim, Benjamin I, Weiner, Evan, Bholah, Reshma, Silver, Randi B, Jiang, Xian-Cheng, Worgall, Stefan

“…Asthma is a clinically heterogeneous genetic disease, and its pathogenesis is incompletely understood. Genome-wide association studies link ORM (yeast)-Like…”
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Treatment of late infantile neuronal ceroid lipofuscinosis by CNS administration of a serotype 2 adeno-associated virus expressing CLN2 cDNA by Worgall, Stefan, Sondhi, Dolan, Hackett, Neil R, Kosofsky, Barry, Kekatpure, Minal V, Neyzi, Nurunisa, Dyke, Jonathan P, Ballon, Douglas, Heier, Linda, Greenwald, Bruce M, Christos, Paul, Mazumdar, Madhu, Souweidane, Mark M, Kaplitt, Michael G, Crystal, Ronald G

“…Late infantile neuronal ceroid lipofuscinosis (LINCL) is an autosomal recessive, neurodegenerative lysosomal storage disease affecting the CNS and is fatal by…”
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332 Association of sphingolipid de novo synthesis with airway response to magnesium by Heras, Andrea, Worgall, Stefan, Perez-Zoghbi, Jose

“…OBJECTIVES/GOALS: MgSO4 is a frequently used to treat asthma exacerbations. Its role in the management of pediatric asthma remains controversial. Our objective…”
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Adenovirus-based vaccine with epitopes incorporated in novel fiber sites to induce protective immunity against Pseudomonas aeruginosa by Sharma, Anurag, Krause, Anja, Xu, Yaqin, Sung, Biin, Wu, Wendy, Worgall, Stefan

“…Adenovirus (Ad) vector-based vaccines displaying pathogen-derived epitopes on Ad capsid proteins can elicit anti-pathogen immunity. This approach seems to be…”
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The mast cell exosome-fibroblast connection: A novel pro-fibrotic pathway by Savage, Alexandria, Risquez, Cristobal, Gomi, Kazunori, Schreiner, Ryan, Borczuk, Alain C, Worgall, Stefan, Silver, Randi B

“…In addition to the traditional activation of resident receptors by release of local mediators, new evidence favors the existence of exosomes in cell-to-cell…”
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Neonatal Genetic Delivery of Anti-Respiratory Syncytial Virus (RSV) Antibody by Non-Human Primate-Based Adenoviral Vector to Provide Protection against RSV by Gomi, Rika, Sharma, Anurag, Wu, Wenzhu, Worgall, Stefan

“…Respiratory syncytial virus (RSV) is one of the leading causes of lower respiratory tract infection in infants. Immunoprophylaxis with the anti-RSV monoclonal…”
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Proinflammatory phenotype and increased caveolin-1 in alveolar macrophages with silenced CFTR mRNA by Xu, Yaqin, Krause, Anja, Hamai, Hiroko, Harvey, Ben-Gary, Worgall, Tilla S, Worgall, Stefan

“…The inflammatory milieu in the respiratory tract in cystic fibrosis (CF) has been linked to the defective expression of the cystic transmembrane regulator…”
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3439 Role of the Airway Microbiome in Viral Bronchiolitis Associated Respiratory Failure by Wasserman, Emily, Worgall, Stefan, Sharma, Anurag

“…OBJECTIVES/SPECIFIC AIMS: This study aims to determine if a bronchiolitis specific microbiome exists and how it evolves through disease course. Objective 1…”
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Environmental exposures: another effect on sphingolipids in asthma? by Worgall, Stefan

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Long-term Pulmonary Outcomes in Pediatric Survivors of High-risk Neuroblastoma by Stone, Anne, Novetsky Friedman, Danielle, Worgall, Stefan, Kushner, Brian H, Wolden, Suzanne, Modak, Shakeel, LaQuaglia, Michael P, Wu, Xian, Cheung, Nai-Kong, Sklar, Charles A

“…Children with high-risk neuroblastoma are exposed to multimodality therapies early in life and survivors confront late therapy-related toxicities. This study…”
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Sphingolipids in Childhood Asthma and Obesity (SOAP Study): A Protocol of a Cross-Sectional Study by Antonisamy, Belavendra, Shailesh, Harshita, Hani, Yahya, Ahmed, Lina Hayati M, Noor, Safa, Ahmed, Salma Yahya, Alfaki, Mohamed, Muhayimana, Abidan, Jacob, Shana Sunny, Balayya, Saroja Kotegar, Soloviov, Oleksandr, Liu, Li, Mathew, Lisa Sara, Wang, Kun, Tomei, Sara, Al Massih, Alia, Mathew, Rebecca, Karim, Mohammed Yousuf, Ramanjaneya, Manjunath, Worgall, Stefan, Janahi, Ibrahim A

“…Asthma and obesity are two of the most common chronic conditions in children and adolescents. There is increasing evidence that sphingolipid metabolism is…”
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Annexin A2 Modulates Bleomycin-Induced Interstitial Pulmonary Edema by Luo, Min, PhD, Chen, Huigen, MS, West, Frances, MD, Almeida, Dena, BS, Worgall, Stefan, MD, Hajjar, Katherine, MD

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Transcriptome Analysis of the Response of Pseudomonas aeruginosa to Hydrogen Peroxide by PALMA, Marco, DELUCA, Darrow, WORGALL, Stefan, QUADRI, Luis E. N

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Protective Immunity to Pseudomonas aeruginosa Induced with a Capsid-Modified Adenovirus Expressing P. aeruginosa OprF by WORGALL, Stefan, KRAUSE, Anja, JIANPING QIU, JU JOH, HACKETT, Neil R, CRYSTAL, Ronald G

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