Search Results - "WOOLHISER, M. R"

Assessment of the respiratory sensitization potential of proteins using an enhanced mouse intranasal test (MINT) by Krieger, S.M., Boverhof, D.R., Woolhiser, M.R., Hotchkiss, J.A.

“…•The MINT was evaluated with additional endpoints to improve assay performance.•Assessment of airway hyperresponsiveness did not provide additional value.•BAL…”
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Acute toxicologic and neurotoxic effects of inhaled 1,2-dichloroethane in adult Fischer 344 rats by Hotchkiss, J.A., Andrus, A.K., Johnson, K.A., Krieger, S.M., Woolhiser, M.R., Maurissen, J.P.

“…Acute toxicologic and neurotoxic effects were evaluated in Fischer 344 rats exposed to 0, 50, 200, 600, or 2000 ppm 1,2-dichloroethane (ethylene dichloride;…”
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Cytokine mRNA profiles for isocyanates with known and unknown potential to induce respiratory sensitization by Plitnick, L.M., Loveless, S.E., Ladics, G.S., Holsapple, M.P., Smialowicz, R.J., Woolhiser, M.R., Anderson, P.K., Smith, C., Selgrade, M.J.K.

“…Isocyanates are low-molecular-weight chemicals implicated in allergic asthmatic-type reactions. Identification of chemicals likely to cause asthma is difficult…”
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Immunological responses of mice following administration of natural rubber latex proteins by different routes of exposure by WOOLHISER, M. R, MUNSON, A. E, MEADE, B. J

“…Although the prevalence of IgE-mediated latex allergy has increased over the past decade, the circumstances which culminate in sensitization remain uncertain…”
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Repeated Inhalation Challenge with Diphenylmethane-4,4′-Diisocyanate in Brown Norway Rats Leads to a Time-Related Increase of Neutrophils in Bronchoalveolar Lavage After Topical Induction by Pauluhn, J., Woolhiser, M. R., Bloemen, L.

“…Abstract Diphenylmethane-4,4′-diisocyanate (MDI) is a low-molecular-weight chemical known to cause occupational asthma. The objective of this study was to…”
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Comparison of mouse strains using the local lymph node assay by Woolhiser, Michael R, Munson, Albert E, Meade, B.Jean

“…The local lymph node assay (LLNA), as recommended by the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), only allows for…”
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Inconsistencies between Cytokine Profiles, Antibody Responses, and Respiratory Hyperresponsiveness following Dermal Exposure to Isocyanates by Selgrade, MaryJaneK, Boykin, Elizabeth H., Haykal-Coates, Najwa, Woolhiser, Michael R., Wiescinski, Connie, Andrews, Debora L., Farraj, Aimen K., Doerfler, Donald L., Gavett, Stephen H.

“…Cytokine profiling of local lymph node responses has been proposed as a simple test to identify chemicals, such as low molecular weight diisocyanates, that…”
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Activation of human mast cells by aggregated IgG through FcγRI: additive effects of C3a by Woolhiser, Michael R., Brockow, Knut, Metcalfe, Dean D.

“…Human mast cells (huMC) increase surface expression of FcγRI (CD64) in response to IFNγ. Subsequent receptor aggregation of FcγR1 using CD64-specific F(ab′) 2…”
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Adrenomedullin Is a Cross-Talk Molecule that Regulates Tumor and Mast Cell Function during Human Carcinogenesis by Zudaire, Enrique, Martínez, Alfredo, Garayoa, Mercedes, Pío, Rubén, Kaur, Gurmeet, Woolhiser, Michael R., Metcalfe, Dean D., Hook, William A., Siraganian, Reuben P., Guise, Theresa A., Chirgwin, John M., Cuttitta, Frank

“…We have previously demonstrated that adrenomedullin (AM) plays a critical role as an autocrine/paracrine tumor cell survival factor. We now present evidence…”
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Identifying airway sensitizers: cytokine mRNA profiles induced by various anhydrides by Plitnick, L.M, Loveless, S.E, Ladics, G.S, Holsapple, M.P, Smialowicz, R.J, Woolhiser, M.R, Anderson, P.K, Smith, C, Selgrade, M.J.K

“…Exposure to low molecular weight (LMW) chemicals in the workplace has been linked to a variety of respiratory effects. Within the LMW chemicals, one of the…”
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IgG‐dependent activation of human mast cells following up‐regulation of FcγRI by IFN‐γ by Woolhiser, Michael R., Okayama, Yoshimichi, Gilfillan, Alasdair M., Metcalfe, Dean D.

“…It has been reported that FcγRI is up‐regulated on human mast cells (huMC) by IFN‐γ and aggregation of this receptor using mouse F(ab′)2 specific for…”
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Toxicology and Humoral Immunity Assessment of Octamethylcyclotetrasiloxane (D4) Following a 28-day whole body Vapor Inhalation Exposure in Fischer 344 Rats by Klykken, P. C., Galbraith, T. W., Kolesar, G. B., Jean, P. A., Woolhiser, M. R., Elwell, M. R., Burns-Naas, L. A., Mast, R. W., Mccay, J. A., White Jr, K. L., Munson, A. E.

“…ABSTRACT Octamethylcyclotetrasiloxane, D4, is a low viscosity, silicone fluid consisting of four dimethyl-siloxy units ((CH3)2SiO)4 in a cyclic structure. It…”
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Activation of human mast cells through the high affinity IgG receptor by Tkaczyk, Christine, Okayama, Yoshimichi, Woolhiser, Michael R, Hagaman, David D, Gilfillan, Alasdair M, Metcalfe, Dean D

“…Mast cells are known to participate in the induction of inflammation through interaction of antigen with specific IgE bound to the high affinity receptor for…”
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Role of sensitization routes in the development of type I hypersensitivity to natural rubber latex in mice by Woolhiser, Michael R., Munson, Albert E., Meade, B. Jean

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Respiratory sensitization and allergy: Current research approaches and needs by Boverhof, Darrell R., Billington, Richard, Gollapudi, B. Bhaskar, Hotchkiss, John A., Krieger, Shannon M., Poole, Alan, Wiescinski, Connie M., Woolhiser, Michael R.

“…There are currently no accepted regulatory models for assessing the potential of a substance to cause respiratory sensitization and allergy. In contrast, a…”
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DELAYED ASSESSMENT OF IMMUNOLOGICAL FUNCTION ALLOWING FOR TRANSPORTATION OF LYMPHOID TISSUES TO DISTANT LABORATORY SITES by Woolhiser, Michael, Ann, Mccay

“…The immune system is a frequent target for chemical toxicity. Accordingly, a number of immunotoxicological assays are performed during the research and…”
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ELISA INHIBITION ASSAY FOR THE QUANTITATION OF ANTIGENIC PROTEIN IN NATURAL RUBBER LATEX by Tomazic-Jezic, Vesna J., Woolhiser, Michael R., Beezhold, Donald H.

“…Evaluating allergenicity of natural rubber latex (NRL) products is essential for the successful reduction of the consumer's exposure to potentially allergenic…”
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Immunotoxicogenomics: The Potential of Genomics Technology in the Immunotoxicity Risk Assessment Process by Luebke, Robert W., Holsapple, Michael P., Ladics, Gregory S., Luster, Michael I., Selgrade, MaryJane, Smialowicz, Ralph J., Woolhiser, Michael R., Germolec, Dori R.

“…Evaluation of xenobiotic-induced changes in gene expression as a method to identify and classify potential toxicants is being pursued by industry and…”
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IgG-dependent activation of human mast cells following up-regulation of FcgammaRI by IFN-gamma by Woolhiser, M R, Okayama, Y, Gilfillan, A M, Metcalfe, D D

“…It has been reported that FcgammaRI is up-regulated on human mast cells (huMC) by IFN-gamma and aggregation of this receptor using mouse F(ab')(2) specific for…”
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Assessing the Potential to Induce Respiratory Hypersensitivity by Holsapple, Michael P., Jones, David, Kawabata, Thomas T., Kimber, Ian, Sarlo, Kathy, Selgrade, MaryJane K., Shah, Jui, Woolhiser, Michael R.

“…Acute and repeat dose inhalation studies have been an important part of the safety assessment of drugs, chemicals, and other products throughout the world for…”
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