Calretinin Staining Facilitates Differentiation of Olfactory Neuroblastoma From Other Small Round Blue Cell Tumors in the Sinonasal Tract

Olfactory neuroblastoma (ONB) is an uncommon malignant tumor of the sinonasal tract and has a wide histologic differential diagnosis that includes other small round blue cell tumors (SRBCTs). Even with the use of immunohistochemistry (IHC), the correct diagnosis may be difficult, especially in small...

Full description

Saved in:

Bibliographic Details
Published in:	The American journal of surgical pathology Vol. 35; no. 12; pp. 1786 - 1793
Main Authors:	WOOFF, Jill C, WEINREB, Ilan, PEREZ-ORDONEZ, Bayardo, FERGALL MAGEE, James, BULLOCK, Martin J
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD Lippincott Williams & Wilkins 01-12-2011
Subjects:	Adult Aged Biological and medical sciences Biomarkers, Tumor - analysis Calbindin 2 Diagnosis, Differential Esthesioneuroblastoma, Olfactory - diagnosis Esthesioneuroblastoma, Olfactory - metabolism Esthesioneuroblastoma, Olfactory - pathology Female Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Membrane Proteins - biosynthesis Middle Aged Nasal Cavity - pathology Neurology Nose Neoplasms - diagnosis Nose Neoplasms - metabolism Nose Neoplasms - pathology Otorhinolaryngology. Stomatology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques S100 Calcium Binding Protein G - biosynthesis Tumors Tumors of the nervous system. Phacomatoses Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology Young Adult Immunohistochemistry Nose disease Calcium Olfactory neuroblastoma Staining Neuroblastoma Binding protein Nose esthesioneuroblastoma ENT disease Nervous system diseases Calretinin Blue Malignant tumor Cell differentiation p63 Anatomic pathology Small round cell tumor Olfactory pathway small round blue cell tumors Olfactory nerve sinonasal Autonomic neuropathy Differentiation Cancer
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Olfactory neuroblastoma (ONB) is an uncommon malignant tumor of the sinonasal tract and has a wide histologic differential diagnosis that includes other small round blue cell tumors (SRBCTs). Even with the use of immunohistochemistry (IHC), the correct diagnosis may be difficult, especially in small biopsies. The purpose of this study is to determine the usefulness of calretinin and p63 as an aid to distinguish ONB from other sinonasal SRBCTs. IHC staining for calretinin and p63 was performed on 21 specimens diagnosed as ONB and on 42 other sinonasal SRBCTs. Specimens were retrieved from the files of the QEII HSC, Halifax and UHN, Toronto. All but 1 ONB (20 of 21) showed calretinin staining, with 15 of 21 showing staining in >75% of the tumor area and 18 of 21 showing moderate-to-strong staining intensity. Only pituitary adenomas (3 of 3) and a single case of small cell carcinoma, neuroendocrine type (1 of 2), showed a similar staining pattern. None of the ONBs showed staining for p63. P63 was positive in all cases of nonkeratinizing squamous cell carcinoma (2 of 2) and in single cases of mantle cell lymphoma (1 of 1) and poorly differentiated neuroendocrine carcinoma (1 of 1); however, it inconsistently stained diffuse large B-cell lymphoma (4 of 5), extranodal NK/T-cell lymphoma, nasal type (1 of 4), sinonasal undifferentiated carcinoma (1 of 6), and Ewing sarcoma/primitive neuroectodermal tumor (2 of 6). Calretinin appears to be a useful marker to distinguish ONBs from other SRBCTs of the sinonasal tract, particularly when staining is moderate/strong and extensive. The calretinin-positive, p63-negative phenotype is fairly specific for ONB. The addition of these 2 IHC stains may aid in the diagnosis of sinonasal SRBCTs that are poorly differentiated, have inconclusive conventional IHC, or are found in small biopsies.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0147-5185 1532-0979
DOI:	10.1097/pas.0b013e3182363b78