Search Results - "WOODRUFF, M"

Is the complement activation product C3a a proinflammatory molecule? Re-evaluating the evidence and the myth by Coulthard, Liam G, Woodruff, Trent M

“…The complement activation product C3a is often described as a proinflammatory mediator, alongside its downstream cousin, C5a. However, emerging studies show…”
Get full text

Electrospraying of polymers with therapeutic molecules: State of the art by Bock, N., Dargaville, T.R., Woodruff, M.A.

“…The encapsulation and release of bioactive molecules from polymeric vehicles represents the holy grail of drug and growth factor delivery therapies, whereby…”
Get full text

Complement dysregulation in the central nervous system during development and disease by Lee, John D., Coulthard, Liam G., Woodruff, Trent M.

“…•Complement proteins play essential roles in brain development.•Complement signalling can both protect against and aggravate neurological disease.•Complement…”
Get full text

The Complement Receptor C5aR2: A Powerful Modulator of Innate and Adaptive Immunity by Li, Xaria X, Lee, John D, Kemper, Claudia, Woodruff, Trent M

“…Complement activation generates the core effector protein C5a, a potent immune molecule that is linked to multiple inflammatory diseases. Two C5a receptors,…”
Get full text

New tricks for an ancient system: Physiological and pathological roles of complement in the CNS by Tenner, Andrea J., Stevens, Beth, Woodruff, Trent M.

“…•Complement has critical functional roles in embryonic brain development.•C1, C4, C2, C3 and CR3 are critical in synaptic refinement during brain…”
Get full text

C5aR2 Activation Broadly Modulates the Signaling and Function of Primary Human Macrophages by Li, Xaria X, Clark, Richard J, Woodruff, Trent M

“…The complement activation fragment C5a is a potent proinflammatory mediator that is increasingly recognized as an immune modulator. C5a acts through two C5a…”
Get full text

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins by Deora, Vandana, Lee, John D., Albornoz, Eduardo A., McAlary, Luke, Jagaraj, Cyril J., Robertson, Avril A. B., Atkin, Julie D., Cooper, Matthew A., Schroder, Kate, Yerbury, Justin J., Gordon, Richard, Woodruff, Trent M.

“…Microglial NLRP3 inflammasome activation is emerging as a key contributor to neuroinflammation during neurodegeneration. Pathogenic protein aggregates such as…”
Get full text

Developmental activities of the complement pathway in migrating neurons by Gorelik, Anna, Sapir, Tamar, Haffner-Krausz, Rebecca, Olender, Tsviya, Woodruff, Trent M., Reiner, Orly

“…In recent years the notion that malfunctioning of the immune system may result in developmental brain diseases has emerged. However, the role of immune…”
Get full text

Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment by Beck, Kevin D., Nguyen, Hal X., Galvan, Manuel D., Salazar, Desirée L., Woodruff, Trent M., Anderson, Aileen J.

“…Traumatic injury to the central nervous system results in the disruption of the blood brain/spinal barrier, followed by the invasion of cells and other…”
Get full text

Pathophysiology, treatment, and animal and cellular models of human ischemic stroke by Woodruff, Trent M, Thundyil, John, Tang, Sung-Chun, Sobey, Christopher G, Taylor, Stephen M, Arumugam, Thiruma V

“…Stroke is the world's second leading cause of mortality, with a high incidence of severe morbidity in surviving victims. There are currently relatively few…”
Get full text

The Peripheral Immune System and Amyotrophic Lateral Sclerosis by McCombe, Pamela A, Lee, John D, Woodruff, Trent M, Henderson, Robert D

“…Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease that is defined by loss of upper and lower motor neurons, associated with…”
Get full text

A validated quantitative method for the assessment of neuroprotective barrier impairment in neurodegenerative disease models by Kumar, Vinod, Lee, John D., Coulson, Elizabeth J., Woodruff, Trent M.

“…The blood–brain barrier (BBB) and blood–spinal cord barrier (BSCB) are highly specialized structures that limit molecule entry from the blood and maintain…”
Get full text

C5L2: a controversial receptor of complement anaphylatoxin, C5a by Li, Rui, Coulthard, Liam G., Wu, M. C. L., Taylor, Stephen M., Woodruff, Trent M.

“…C5a is the paramount proinflammatory mediator of the complement cascade, and has been previously thought to act only through a single, G‐protein‐coupled, C5a…”
Get full text

Valproic acid attenuates cellular senescence in diabetic kidney disease through the inhibition of complement C5a receptors by Coughlan, Melinda T., Ziemann, Mark, Laskowski, Adrienne, Woodruff, Trent M., Tan, Sih Min

“…Despite increasing knowledge about the factors involved in the progression of diabetic complications, diabetic kidney disease (DKD) continues to be a major…”
Get full text

Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration by Gordon, Richard, Neal, Matthew L., Luo, Jie, Langley, Monica R., Harischandra, Dilshan S., Panicker, Nikhil, Charli, Adhithiya, Jin, Huajun, Anantharam, Vellareddy, Woodruff, Trent M., Zhou, Qun-Yong, Kanthasamy, Anumantha G., Kanthasamy, Arthi

“…Prokineticin-2 (PK2), a recently discovered secreted protein, regulates important physiological functions including olfactory biogenesis and circadian rhythms…”
Get full text

Revisiting the role of the innate immune complement system in ALS by Parker, Sandra E., Hanton, Angela M., Stefanou, Stephen N., Noakes, Peter G., Woodruff, Trent M., Lee, John D.

“…Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing motor neuron disease without effective treatment. Although the precise mechanisms…”
Get full text

Biomimetic tubular nanofiber mesh and platelet rich plasma-mediated delivery of BMP-7 for large bone defect regeneration by Berner, A, Boerckel, J. D, Saifzadeh, S, Steck, R, Ren, J, Vaquette, C, Zhang, J. Qiyi, Nerlich, M, Guldberg, R. E, Hutmacher, D. W, Woodruff, M. A

“…There is a growing need for successful bone tissue engineering strategies and advanced biomaterials that mimic the structure and function of native tissues…”
Get full text

The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury by Brennan, Faith H, Gordon, Richard, Lao, Hong W, Biggins, Patrick J, Taylor, Stephen M, Franklin, Robin J M, Woodruff, Trent M, Ruitenberg, Marc J

“…This study investigated the role of the complement activation fragment C5a in secondary pathology following contusive spinal cord injury (SCI). C5ar(-/-) mice,…”
Get full text

C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis by Dick, Jonathan, Gan, Poh-Yi, Ford, Sharon L, Odobasic, Dragana, Alikhan, Maliha A, Loosen, Sven H, Hall, Pam, Westhorpe, Clare L, Li, Anqi, Ooi, Joshua D, Woodruff, Trent M, Mackay, Charles R, Kitching, A Richard, Hickey, Michael J, Holdsworth, Stephen R

“…The prospects for complement-targeted therapy in ANCA-associated vasculitis have been enhanced by a recent clinical trial in which C5a receptor 1 (C5aR1)…”
Get more information

Absence of the C5a Receptor C5aR2 Worsens Ischemic Tissue Injury by Increasing C5aR1-Mediated Neutrophil Infiltration by Wu, Mike C L, Lee, John D, Ruitenberg, Marc J, Woodruff, Trent M

“…Neutrophil infiltration to ischemic tissues following reperfusion worsens injury. A key driver of neutrophil recruitment and activation is the complement…”
Get full text