Search Results - "WOOD, Nicholas"

Charlotte’s accessible web: how West Australian children and adolescents can access e‐cigarettes online by Wood, Nicholas

“…The advent of electronic cigarettes (e-cigarettes) has amassed a new generation of child and adolescent nicotine users globally.1 By design, the burgeoning…”
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Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences by Manzoni, Claudia, Kia, Demis A, Vandrovcova, Jana, Hardy, John, Wood, Nicholas W, Lewis, Patrick A, Ferrari, Raffaele

“…Abstract Advances in the technologies and informatics used to generate and process large biological data sets (omics data) are promoting a critical shift in…”
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Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein by Cremades, Nunilo, Cohen, Samuel I.A., Deas, Emma, Abramov, Andrey Y., Chen, Allen Y., Orte, Angel, Sandal, Massimo, Clarke, Richard W., Dunne, Paul, Aprile, Francesco A., Bertoncini, Carlos W., Wood, Nicholas W., Knowles, Tuomas P.J., Dobson, Christopher M., Klenerman, David

“…Here, we use single-molecule techniques to study the aggregation of α-synuclein, the protein whose misfolding and deposition is associated with Parkinson's…”
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LRRK2 activation controls the repair of damaged endomembranes in macrophages by Herbst, Susanne, Campbell, Philip, Harvey, John, Bernard, Elliott M, Papayannopoulos, Venizelos, Wood, Nicholas W, Morris, Huw R, Gutierrez, Maximiliano G

“…Cells respond to endolysosome damage by either repairing the damage or targeting damaged endolysosomes for degradation via lysophagy. However, the signals…”
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MELD 3.0: The Model for End-Stage Liver Disease Updated for the Modern Era by Kim, W. Ray, Mannalithara, Ajitha, Heimbach, Julie K., Kamath, Patrick S., Asrani, Sumeet K., Biggins, Scott W., Wood, Nicholas L., Gentry, Sommer E., Kwong, Allison J.

“…The Model for End-Stage Liver Disease (MELD) has been established as a reliable indicator of short-term survival in patients with end-stage liver disease. The…”
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Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study by Noyce, Alastair J, Kia, Demis A, Hemani, Gibran, Nicolas, Aude, Price, T Ryan, De Pablo-Fernandez, Eduardo, Haycock, Philip C, Lewis, Patrick A, Foltynie, Thomas, Davey Smith, George, Schrag, Anette, Lees, Andrew J, Hardy, John, Singleton, Andrew, Nalls, Mike A, Pearce, Neil, Lawlor, Debbie A, Wood, Nicholas W

“…Both positive and negative associations between higher body mass index (BMI) and Parkinson disease (PD) have been reported in observational studies, but it has…”
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RSV Epidemiology in Australia Before and During COVID-19 by Saravanos, Gemma L, Hu, Nan, Homaira, Nusrat, Muscatello, David J, Jaffe, Adam, Bartlett, Adam W, Wood, Nicholas J, Rawlinson, William, Kesson, Alison, Lingam, Raghu, Britton, Philip N

“…COVID-19 public health measures altered respiratory syncytial virus (RSV) epidemiology. We examined age-stratified trends in RSV-related disease in Australian…”
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Mutations in ANO3 Cause Dominant Craniocervical Dystonia: Ion Channel Implicated in Pathogenesis by Charlesworth, Gavin, Plagnol, Vincent, Holmström, Kira M., Bras, Jose, Sheerin, Una-Marie, Preza, Elisavet, Rubio-Agusti, Ignacio, Ryten, Mina, Schneider, Susanne A., Stamelou, Maria, Trabzuni, Daniah, Abramov, Andrey Y., Bhatia, Kailash P., Wood, Nicholas W.

“…In this study, we combined linkage analysis with whole-exome sequencing of two individuals to identify candidate causal variants in a moderately-sized UK…”
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Correcting the sex disparity in MELD‐Na by Wood, Nicholas L., VanDerwerken, Douglas, Segev, Dorry L., Gentry, Sommer E.

“…MELD‐Na appears to disadvantage women awaiting liver transplant by underestimating their mortality rate. Fixing this problem involves: (1) estimating the…”
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A robust model for read count data in exome sequencing experiments and implications for copy number variant calling by PLAGNOL, Vincent, CURTIS, James, KUMARARATNE, Dinakantha, DOFFINGER, Rainer, NEJENTSEV, Sergey, EPSTEIN, Michael, MOK, Kin Y, STEBBINGS, Emma, GRIGORIADOU, Sofia, WOOD, Nicholas W, HAMBLETON, Sophie, BURNS, Siobhan O, THRASHER, Adrian J

“…Exome sequencing has proven to be an effective tool to discover the genetic basis of Mendelian disorders. It is well established that copy number variants…”
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OPTN/SRTR 2021 Annual Data Report: Intestine by Horslen, Simon P., Wood, Nicholas L., Cafarella, Matthew, Schnellinger, Erin M.

“…There has been just over 30 years of experience in clinical intestine transplant. A rise in demand until 2007 with improving transplant outcomes preceded a…”
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Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation by Chen, Serene W., Drakulic, Srdja, Deas, Emma, Ouberai, Myriam, Aprile, Francesco A., Arranz, Rocío, Ness, Samuel, Roodveldt, Cintia, Guilliams, Tim, De-Genst, Erwin J., Klenerman, David, Wood, Nicholas W., Knowles, Tuomas P.J., Alfonso, Carlos, Rivas, Germán, Abramov, Andrey Y., Valpuesta, José María, Dobson, Christopher M., Cremades, Nunilo

“…Significance Certain oligomeric species generated during the self-assembly of specific proteins into ordered fibrillar aggregates are likely to be key players…”
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Uptake of influenza vaccine by pregnant women: a cross‐sectional survey by Wiley, Kerrie E, Massey, Peter D, Cooper, Spring C, Wood, Nicholas J, Ho, Jane, Quinn, Helen E, Leask, Julie

“…Objectives: To determine influenza vaccination coverage among pregnant women in New South Wales, and factors associated with vaccine uptake during pregnancy…”
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Mitophagy and Parkinson's disease: The PINK1–parkin link by Deas, Emma, Wood, Nicholas W., Plun-Favreau, Hélène

“…The study of rare, inherited mutations underlying familial forms of Parkinson's disease has provided insight into the molecular mechanisms of disease…”
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Multisystem inflammatory syndrome in children and adults (MIS-C/A): Case definition & guidelines for data collection, analysis, and presentation of immunization safety data by Vogel, Tiphanie P., Top, Karina A., Karatzios, Christos, Hilmers, David C., Tapia, Lorena I., Moceri, Pamela, Giovannini-Chami, Lisa, Wood, Nicholas, Chandler, Rebecca E., Klein, Nicola P., Schlaudecker, Elizabeth P., Poli, M. Cecilia, Muscal, Eyal, Munoz, Flor M.

“…This is a Brighton Collaboration Case Definition of the term “Multisystem Inflammatory Syndrome in Children and Adults (MIS-C/A)” to be utilized in the…”
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Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains by Gegg, Matthew E., Burke, Derek, Heales, Simon J. R., Cooper, J. Mark, Hardy, John, Wood, Nicholas W., Schapira, Anthony H. V.

“…Objective: Mutations in the glucocerebrosidase gene (GBA) represent a significant risk factor for developing Parkinson disease (PD). We investigated the…”
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Mutations in HPCA Cause Autosomal-Recessive Primary Isolated Dystonia by Charlesworth, Gavin, Angelova, Plamena R., Bartolomé-Robledo, Fernando, Ryten, Mina, Trabzuni, Daniah, Stamelou, Maria, Abramov, Andrey Y., Bhatia, Kailash P., Wood, Nicholas W.

“…Reports of primary isolated dystonia inherited in an autosomal-recessive (AR) manner, often lumped together as “DYT2 dystonia,” have appeared in the scientific…”
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Principles for simulating the organ allocation system by Wood, Nicholas L, Weaver, Tim, Kwong, Allison J, Gentry, Sommer E

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Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading by Iljina, Marija, Garcia, Gonzalo A., Horrocks, Mathew H., Tosatto, Laura, Choi, Minee L., Ganzinger, Kristina A., Abramov, Andrey Y., Gandhi, Sonia, Wood, Nicholas W., Cremades, Nunilo, Dobson, Christopher M., Knowles, Tuomas P. J., Klenerman, David

“…The protein alpha-synuclein (αS) self-assembles into small oligomeric species and subsequently into amyloid fibrils that accumulate and proliferate during the…”
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The genetics of dystonia: new twists in an old tale by CHARLESWORTH, Gavin, BHATIA, Kailash P, WOOD, Nicholas W

“…Dystonia is a common movement disorder seen by neurologists in clinic. Genetic forms of the disease are important to recognize clinically and also provide…”
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