Search Results - "WONG, Simon G"

Prediction of drug-drug interactions arising from mechanism-based inactivation: key input parameters and impact on risk assessment by Wong, Simon G

“…As the prevalence of polypharmacy increases with our aging population, the propensity for adverse drug-drug interactions arising from the altered metabolism of…”
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An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing by Tonn, George R, Wong, Simon G, Wong, Sylvia C, Johnson, Michael G, Ma, Ji, Cho, Robert, Floren, Leslie C, Kersey, Kathryn, Berry, Karen, Marcus, Andrew P, Wang, Xuemei, Van Lengerich, Bettina, Medina, Julio C, Pearson, Paul G, Wong, Bradley K

“…( R )- N -{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3- d ]-pyrimidin-2-yl]-ethyl}- N -pyridin-3-yl-methyl-2-(4-trifluoromethoxyphenyl)-acetamide (AMG…”
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Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment by Wong, Simon G, Ramsden, Diane, Dallas, Shannon, Fung, Conrad, Einolf, Heidi J, Palamanda, Jairam, Chen, Liangfu, Goosen, Theunis C, Siu, Y Amy, Zhang, George, Tweedie, Donald, Hariparsad, Niresh, Jones, Barry, Yates, Phillip D

“…Translational and ADME Sciences Leadership Group Induction Working Group (IWG) presents an analysis on the time course for cytochrome P450 induction in primary…”
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Development of a mass spectrometry-based tryptophan 2, 3-dioxygenase assay using liver cytosol from multiple species by Wang, Jing, Takahashi, Ryan H., DeMent, Kevin, Gustafson, Amy, Kenny, Jane R., Wong, Simon G., Yan, Zhengyin

“…A novel and rapid method to determine the potency of inhibitors for tryptophan 2, 3-dioxygenase (TDO2) activities in human and preclinical species was…”
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Discovery and in Vivo Evaluation of Macrocyclic Mcl‑1 Inhibitors Featuring an α‑Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere by Rescourio, Gwenaella, Gonzalez, Ana Z, Jabri, Salman, Belmontes, Brian, Moody, Gordon, Whittington, Doug, Huang, Xin, Caenepeel, Sean, Cardozo, Mario, Cheng, Alan C, Chow, David, Dou, Hannah, Jones, Adrie, Kelly, Ron C, Li, Yihong, Lizarzaburu, Mike, Lo, Mei-Chu, Mallari, Rommel, Meleza, Cesar, Rew, Yosup, Simonovich, Scott, Sun, Daqing, Turcotte, Simon, Yan, Xuelei, Wong, Simon G, Yanez, Evelyn, Zancanella, Manuel, Houze, Jonathan, Medina, Julio C, Hughes, Paul E, Brown, Sean P

“…Overexpression of the antiapoptotic protein Mcl-1 provides a survival advantage to some cancer cells, making inhibition of this protein an attractive…”
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Single concentration loss of activity assay provides an improved assessment of drug-drug interaction risk compared to IC50-shift by Wong, Simon G., Lee, Mey, Wong, Bradley K.

“…1. The utility of two abbreviated, higher-throughput assays [IC50-shift and the loss of activity (LOA) assay] to evaluate time-dependent inhibition (TDI) of 24…”
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Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme by Henne, Kirk R, Tran, Thuy B, VandenBrink, Brooke M, Rock, Dan A, Aidasani, Divesh K, Subramanian, Raju, Mason, Andrew K, Stresser, David M, Teffera, Yohannes, Wong, Simon G, Johnson, Michael G, Chen, Xiaoqi, Tonn, George R, Wong, Bradley K

“…CYP3A4-mediated biotransformation of…”
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Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DP by Johnson, Michael G, Liu, Jim Jiwen, Li, An-Rong, van Lengerich, Bettina, Wang, Sophie, Medina, Julio C, Collins, Tassie L, Danao, Jay, Seitz, Lisa, Willee, Angela, D'Souza, Warren, Budelsky, Alison L, Fan, Peter W, Wong, Simon G W

“…Based on their structural similarity to previously described compound AMG 009, indole-phenyl acetic acids were proposed to be potent dual inhibitors of…”
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Bioactivation of a Novel 2-Methylindole-Containing Dual Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type-2 Cells/D-Prostanoid Receptor Antagonist Leads to Mechanism-Based CYP3A Inactivation: Glutathione Adduct Characterization and Prediction of In Vivo Drug-Drug Interaction by WONG, Simon G, FAN, Peter W, SUBRAMANIAN, Raju, TONN, George R, HENNE, Kirk R, JOHNSON, Michael G, TADANO LOHR, Michelle, WONG, Bradley K

“…The 2-methyl substituted indole, 2MI [2-(4-(4-(2,4-dichlorophenylsulfonamido)-2-methyl-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid] is a potent dual…”
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Isolation of regioisomers of N-alkylprotoporphyrin IX from chick embryo liver after treatment with porphyrinogenic xenobiotics by Kobus, S M, Wong, S G, Marks, G S

“…Several porphyrinogenic xenobiotics cause mechanism-based inactivation of cytochrome P450 (P450) isozymes with concomitant formation of a mixture of four…”
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Use of recombinant human ferrochelatase as a sensitive bioassay for N-alkylprotoporphyrin IX formed after interaction of porphyrinogenic xenobiotics with rat liver microsomes by Gamble, J T, Wong, S G, Dailey, H A, Marks, G S

“…Several porphyrinogenic xenobiotics elicit mechanism-based inactivation of cytochrome P450 (CYP) isozymes, leading to the formation of N-alkylprotoporphyrin IX…”
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An Inhibitory Metabolite Leads to Dose-and Time-Dependent Pharmacokinetics of (R)-A/-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing by TONN, George R, WONG, Simon G, XUEMEI WANG, VAN LENGERICH, Bettina, MEDINA, Julio C, PEARSON, Paul G, WONG, Bradley K, WONG, Sylvia C, JOHNSON, Michael G, JI MA, CHO, Robert, FLOREN, Leslie C, KERSEY, Kathryn, BERRY, Karen, MARCUS, Andrew P

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Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD sub(2) receptors CRTH2 and DP by Johnson, Michael G, Liu, Jim, Li, An-Rong, Lengerich, Bettina van, Wang, Sophie, Medina, Julio C, Collins, Tassie L, Danao, Jay, Seitz, Lisa, Willee, Angela, D'Souza, Warren, Budelsky, Alison L, Fan, Peter W, Wong, Simon GW

“…Based on their structural similarity to previously described compound AMG 009, indole-phenyl acetic acids were proposed to be potent dual inhibitors of…”
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The role of mitochondrial injury in bromobenzene and furosemide induced hepatotoxicity by Wong, Simon G.W, Card, Jeffrey W, Racz, William J

“…Bromobenzene (BB) and furosemide (FS) are two hepatotoxicants whose bioactivation to reactive intermediates is crucial to the development of liver injury…”
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Cytochrome CYP Sources of N-Alkylprotoporphyrin IX after Administration of Porphyrinogenic Xenobiotics to Rats by WONG, S. G. W, LIN, E. H, MARKS, G. S

“…Cytochrome P-450 (CYP) 3A2 and CYP2C11 are sources of 70 and 30%, respectively, of N- vinylprotoporphyrin IX ( N -vinylPP) formation after administration of…”
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Neutron Reflection from 2,4-Bis(4-(N-methyl-N-octylamino)phenyl)squaraine at the Air−Water Interface and the Linear and Nonlinear Optical Properties of Its Langmuir−Blodgett and Spun-Coated Films by Ashwell, Geoffrey J, Wong, G. M. Simon, Bucknall, David G, Bahra, Gurmit S, Brown, Christopher R

“…Neutron specular reflection has been used to probe the structure of monolayer films of an anilino squaraine, 2,4-bis(4-(N-methyl-N-octylamino)phenyl)squaraine,…”
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