Search Results - "WONG, Richard J"
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Survival outcomes after treatment of cancer of the oral cavity (1985–2015)
Published in Oral oncology (01-03-2019)“…•2082 patients with OSCC operated at a tertiary cancer care center from 1985 to 2015 were studied.•Age, comorbidity, margin, vascular and perineural invasion,…”
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Tobacco Smoking-Associated Alterations in the Immune Microenvironment of Squamous Cell Carcinomas
Published in JNCI : Journal of the National Cancer Institute (01-12-2018)“…Tobacco smoking creates DNA damage, inducing mutations and potentially altering the tumor immune microenvironment. These types of genetic and immune…”
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Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors
Published in Nature communications (01-02-2021)“…Treatment with immune checkpoint inhibitors (ICI) has demonstrated clinical benefit for a wide range of cancer types. Because only a subset of patients…”
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Natural History and Tumor Volume Kinetics of Papillary Thyroid Cancers During Active Surveillance
Published in JAMA otolaryngology-- head & neck surgery (01-10-2017)“…Active surveillance of low-risk papillary thyroid cancer (PTC) is now an accepted alternative to immediate surgery, but experience with this approach outside…”
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Tracheostomy during SARS‐CoV‐2 pandemic: Recommendations from the New York Head and Neck Society
Published in Head & neck (01-06-2020)“…The rapid spread of SARS‐CoV‐2 in 2019 and 2020 has resulted in a worldwide pandemic characterized by severe pulmonary inflammation, effusions, and rapid…”
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The Immune Microenvironment and Neoantigen Landscape of Aggressive Salivary Gland Carcinomas Differ by Subtype
Published in Clinical cancer research (15-06-2020)“…Salivary gland carcinomas (SGC) are rare, aggressive cancers with high rates of recurrence and distant metastasis. These factors, and a lack of active systemic…”
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AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY DISEASE STATE CLINICAL REVIEW: THE INCREASING INCIDENCE OF THYROID CANCER
Published in Endocrine practice (01-06-2015)“…(1) Describe current epidemiology of thyroid cancer in the United States; (2) evaluate hypothesized causes of the increased incidence of thyroid cancer; and…”
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Malignancy rate in thyroid nodules classified as Bethesda category III (AUS/FLUS)
Published in Thyroid (New York, N.Y.) (01-05-2014)“…The Bethesda System for Reporting Thyroid Cytopathology is the standard for interpreting fine needle aspiration (FNA) specimens. The "atypia of undetermined…”
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Distant metastasis of salivary gland cancer: Incidence, management, and outcomes
Published in Cancer (15-05-2020)“…Background Distant metastases (DMs) are the primary cause of treatment failure in patients with salivary gland carcinoma. There is no consensus on the standard…”
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Osteoradionecrosis of the Jaw Following Proton Radiation Therapy for Patients With Head and Neck Cancer
Published in JAMA otolaryngology-- head & neck surgery (01-02-2023)“…Proton radiation therapy (PRT) has reduced radiation-induced toxic effects, such as mucositis and xerostomia, over conventional photon radiation therapy,…”
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Pretreatment peripheral blood leukocytes are independent predictors of survival in oral cavity cancer
Published in Cancer (01-03-2020)“…Background Inflammation and immune surveillance evasion are cancer hallmarks. Peripheral blood leukocytes (PBLs) represent both. The aim of the current study…”
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GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling
Published in Proceedings of the National Academy of Sciences - PNAS (13-05-2014)“…The ability of cancer cells to invade along nerves is associated with aggressive disease and diminished patient survival rates. Perineural invasion (PNI) may…”
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Endoneurial Macrophages Induce Perineural Invasion of Pancreatic Cancer Cells by Secretion of GDNF and Activation of RET Tyrosine Kinase Receptor
Published in Cancer research (Chicago, Ill.) (15-11-2012)“…Perineural invasion of cancer cells (CPNI) is found in most patients with pancreatic adenocarcinomas (PDA), prostate, or head and neck cancers. These patients…”
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Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Published in Cancer research (Chicago, Ill.) (15-11-2017)“…Perineural invasion (PNI) is an ominous event strongly linked to poor clinical outcome. Cells residing within peripheral nerves collaborate with cancer cells…”
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Tumor Grade Predicts for Calcitonin Doubling Times and Disease-Specific Outcomes After Resection of Medullary Thyroid Carcinoma
Published in Thyroid (New York, N.Y.) (01-10-2022)“…Tumor grade is a new validated prognostic factor for medullary thyroid cancer (MTC). Calcitonin doubling time can predict MTC recurrence. We aimed to describe…”
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Paracrine Regulation of Pancreatic Cancer Cell Invasion by Peripheral Nerves
Published in JNCI : Journal of the National Cancer Institute (20-01-2010)“…Background The ability of cancer to infiltrate along nerves is a common clinical observation in pancreas, head and neck, prostate, breast, and gastrointestinal…”
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External-beam radiotherapy for differentiated thyroid cancer locoregional control: A statement of the American Head and Neck Society
Published in Head & neck (01-04-2016)“…The use of external‐beam radiotherapy (EBRT) in differentiated thyroid cancer (DTC) is debated because of a lack of prospective clinical data, but recent…”
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Cdc42 Mediates Cancer Cell Chemotaxis in Perineural Invasion
Published in Molecular cancer research (01-06-2020)“…Perineural invasion (PNI) is an ominous form of cancer progression along nerves associated with poor clinical outcome. Glial derived neurotrophic factor (GDNF)…”
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Sentinel Lymph Node Biopsy Accurately Stages the Regional Lymph Nodes for T1-T2 Oral Squamous Cell Carcinomas: Results of a Prospective Multi-Institutional Trial
Published in Journal of clinical oncology (10-03-2010)“…The validity of sentinel lymph node biopsy (SLNB) for T1 or T2, clinically N0, oral cancer was tested by correlation of sentinel node pathologic status with…”
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