Search Results - "WONG, Pamela"

Mechanisms of Drug Release in Nanotherapeutic Delivery Systems by Wong, Pamela T, Choi, Seok Ki

“…Wong and Choi examine mechanisms of drug release in nanotherapeutic delivery systems. They describe nanotherapeutics, nanocarriers, and biomarkers, along with…”
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Mechanisms and implications of dual-acting methotrexate in folate-targeted nanotherapeutic delivery by Wong, Pamela T, Choi, Seok Ki

“…The rational design of a nanoplatform in drug delivery plays a crucial role in determining its targeting specificity and efficacy in vivo. A conventional…”
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HORIZON: An Open-Label Extension Trial of Ranibizumab for Choroidal Neovascularization Secondary to Age-Related Macular Degeneration by Singer, Michael A., MD, Awh, Carl C., MD, Sadda, SriniVas, MD, Freeman, William R., MD, Antoszyk, Andrew N., MD, Wong, Pamela, MPH, Tuomi, Lisa, PharmD

“…Objective To evaluate the long-term safety and efficacy of multiple intravitreal ranibizumab injections (Lucentis, Genentech, Inc., South San Francisco, CA)…”
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The unfulfilled potential of mucosal immunization by Baker, James R., Farazuddin, Mohammad, Wong, Pamela T., O’Konek, Jessica J.

“…Recent events involving the global coronavirus pandemic have focused attention on vaccination strategies. Although tremendous advances have been made in…”
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The evolution of mitochondrial genomes in modern frogs (Neobatrachia): nonadaptive evolution of mitochondrial genome reorganization by Xia, Yun, Zheng, Yuchi, Miura, Ikuo, Wong, Pamela B Y, Murphy, Robert W, Zeng, Xiaomao

“…Although mitochondrial (mt) gene order is highly conserved among vertebrates, widespread gene rearrangements occur in anurans, especially in neobatrachians…”
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A comparative study of two chemical models for creating subsurface caries lesions on aprismatic and prismatic enamel by Wong, Pamela Y. W., Lim, Suh Ling, Loi, Samuel T. Y., Mei, May Lei, Li, Kai Chun, Aziz, Shafiq, Ekambaram, Manikandan

“…Purpose: To investigate the mineral density and lesion depth of artificial caries lesions on aprismatic enamel and prismatic enamel created by lactic acid and…”
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High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy by Gubin, Matthew M., Esaulova, Ekaterina, Ward, Jeffrey P., Malkova, Olga N., Runci, Daniele, Wong, Pamela, Noguchi, Takuro, Arthur, Cora D., Meng, Wei, Alspach, Elise, Medrano, Ruan F.V., Fronick, Catrina, Fehlings, Michael, Newell, Evan W., Fulton, Robert S., Sheehan, Kathleen C.F., Oh, Stephen T., Schreiber, Robert D., Artyomov, Maxim N.

“…Although current immune-checkpoint therapy (ICT) mainly targets lymphoid cells, it is associated with a broader remodeling of the tumor micro-environment…”
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Induction of protective immune responses at respiratory mucosal sites by Park, Seok-Chan, Wiest, Matthew J, Yan, Vivian, Wong, Pamela T, Schotsaert, Michael

“…Many pathogens enter the host through mucosal sites. Thus, interfering with pathogen entry through local neutralization at mucosal sites therefore is an…”
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Light-controlled active release of photocaged ciprofloxacin for lipopolysaccharide-targeted drug delivery using dendrimer conjugates by Wong, Pamela T, Tang, Shengzhuang, Mukherjee, Jhindan, Tang, Kenny, Gam, Kristina, Isham, Danielle, Murat, Claire, Sun, Rachel, Baker, James R, Choi, Seok Ki

“…We report an active delivery mechanism targeted specifically to Gram(-) bacteria based on the photochemical release of photocaged ciprofloxacin carried by a…”
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Control of an Unusual Photo-Claisen Rearrangement in Coumarin Caged Tamoxifen through an Extended Spacer by Wong, Pamela T, Roberts, Edward W, Tang, Shengzhuang, Mukherjee, Jhindan, Cannon, Jayme, Nip, Alyssa J, Corbin, Kaitlin, Krummel, Matthew F, Choi, Seok Ki

“…The use of coumarin caged molecules has been well documented in numerous photocaging applications including for the spatiotemporal control of Cre-estrogen…”
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A Combination Adjuvant for the Induction of Potent Antiviral Immune Responses for a Recombinant SARS-CoV-2 Protein Vaccine by Jangra, Sonia, Landers, Jeffrey J, Rathnasinghe, Raveen, O'Konek, Jessica J, Janczak, Katarzyna W, Cascalho, Marilia, Kennedy, Andrew A, Tai, Andrew W, Baker, Jr, James R, Schotsaert, Michael, Wong, Pamela T

“…Several SARS-CoV-2 vaccines have received EUAs, but many issues remain unresolved, including duration of conferred immunity and breadth of cross-protection…”
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Photocontrolled Release of Doxorubicin Conjugated through a Thioacetal Photocage in Folate-Targeted Nanodelivery Systems by Wong, Pamela T, Tang, Shengzhuang, Cannon, Jayme, Chen, Dexin, Sun, Rachel, Lee, Jennifer, Phan, James, Tao, Ke, Sun, Kang, Chen, Biqiong, Baker, James R, Choi, Seok Ki

“…Despite their proven ability for precise and targeted release, nanoplatform systems for photocontrolled delivery often face formidable synthetic challenges, in…”
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Inuit Methods of Identifying Polar Bear Characteristics: Potential for Inuit Inclusion in Polar Bear Surveys by Wong, Pamela B.Y., Murphy, Robert W.

“…As a result of their close proximity to and frequent interactions with polar bears, Inuit hunters are aware of changes in polar bear population ecology and…”
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Formulation, high throughput in vitro screening and in vivo functional characterization of nanoemulsion-based intranasal vaccine adjuvants by Wong, Pamela T, Leroueil, Pascale R, Smith, Douglas M, Ciotti, Susan, Bielinska, Anna U, Janczak, Katarzyna W, Mullen, Catherine H, Groom, 2nd, Jeffrey V, Taylor, Erin M, Passmore, Crystal, Makidon, Paul E, O'Konek, Jessica J, Myc, Andrzej, Hamouda, Tarek, Baker, Jr, James R

“…Vaccine adjuvants have been reported to induce both mucosal and systemic immunity when applied to mucosal surfaces and this dual response appears important for…”
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Modular Integration of Upconverting Nanocrystal-Dendrimer Composites for Folate Receptor-Specific NIR Imaging and Light-Triggered Drug Release by Wong, Pamela T., Chen, Dexin, Tang, Shengzhuang, Yanik, Sean, Payne, Michael, Mukherjee, Jhindan, Coulter, Alexa, Tang, Kenny, Tao, Ke, Sun, Kang, Baker Jr, James R., Choi, Seok Ki

“…Upconversion nanocrystals (UCNs) display near‐infrared (NIR)‐responsive photoluminescent properties for NIR imaging and drug delivery. The development of…”
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Shielded α‑Nucleophile Nanoreactor for Topical Decontamination of Reactive Organophosphate by Wong, Pamela T, Tang, Shengzhuang, Cannon, Jayme, Yang, Kelly, Harrison, Racquel, Ruge, Matthew, O’Konek, Jessica J, Choi, Seok Ki

“…Here, we describe a nanoscale reactor strategy with a topical application in the therapeutic decontamination of reactive organophosphates (OPs) as chemical…”
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Biphasic Effects of Insulin on Islet Amyloid Polypeptide Membrane Disruption by Brender, Jeffrey R., Lee, Edgar L., Hartman, Kevin, Wong, Pamela T., Ramamoorthy, Ayyalusamy, Steel, Duncan G., Gafni, Ari

“…Type II diabetes, in its late stages, is often associated with the formation of extracellular islet amyloid deposits composed of islet amyloid polypeptide…”
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Formulation and Characterization of Nanoemulsion Intranasal Adjuvants: Effects of Surfactant Composition on Mucoadhesion and Immunogenicity by Wong, Pamela T, Wang, Su He, Ciotti, Susan, Makidon, Paul E, Smith, Douglas M, Fan, Yongyi, Schuler, Charles F, Baker, James R

“…The development of effective intranasal vaccines is of great interest due to their potential to induce both mucosal and systemic immunity. Here we produced…”
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Silver Nanoparticles Enhance Antimicrobial Efficacy of Antibiotics and Restore That Efficacy against the Melioidosis Pathogen by Malawong, Sathit, Thammawithan, Saengrawee, Sirithongsuk, Pawinee, Daduang, Sakda, Klaynongsruang, Sompong, Wong, Pamela T., Patramanon, Rina

“…Melioidosis is an infectious disease caused by Gram-negative bacillus bacteria Burkholderia pseudomallei. Due to the emerging resistance of B. pseudomallei to…”
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Hydrophilic scaffolds of oxime as the potent catalytic inactivator of reactive organophosphate by Tang, Shengzhuang, Wong, Pamela T., Cannon, Jayme, Yang, Kelly, Bowden, Sierra, Bhattacharjee, Somnath, O'Konek, Jessica J., Choi, Seok Ki

“…Despite its efficacy as a skin decontaminant of reactive organophosphates (OP), Dekon 139—a potassium salt of 2,3-butanedione monooxime (DAM)—is associated…”
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