Search Results - "WONG, Ching Hang"

The Blood‐Testis Barrier: Its Biology, Regulation, and Physiological Role in Spermatogenesis by Wong, Ching‐Hang, Cheng, C. Yan

“…The blood‐testis barrier (BTB) in mammals, such as rats, is composed of the tight junction (TJ), the basal ectoplasmic specialization (basal ES), the basal…”
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A male contraceptive targeting germ cell adhesion by Mruk, Dolores D, Cheng, C Yan, Wong, Ching-Hang, Silvestrini, Bruno

“…Throughout spermatogenesis, developing germ cells remain attached to Sertoli cells via testis-specific anchoring junctions. If adhesion between these cell…”
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Regulation of blood-testis barrier dynamics: an in vivo study by Wong, Ching-Hang, Mruk, Dolores D, Lui, Wing-Yee, Cheng, C Yan

“…An in vivo model was used to investigate the regulation of tight junction (TJ) dynamics in the testis when adult rats were treated with CdCl(2). It was shown…”
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Sertoli-Germ Cell Anchoring Junction Dynamics in the Testis Are Regulated by an Interplay of Lipid and Protein Kinases by Siu, Michelle K.Y., Wong, Ching-hang, Lee, Will M., Cheng, C. Yan

“…When Sertoli and germ cells were co-cultured in vitro in serum-free chemically defined medium, functional anchoring junctions such as cell-cell intermediate…”
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TGF-β3 Regulates the Blood-Testis Barrier Dynamics via the p38 Mitogen Activated Protein (MAP) Kinase Pathway: An in Vivo Study by Lui, Wing-Yee, Wong, Ching-Hang, Mruk, Dolores D, Cheng, C. Yan

“…Recent studies using Sertoli cells cultured in vitro to permit tight junction (TJ) assembly have shown that TJ dynamics are regulated, at least in part, by…”
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The Transmembrane src Substrate Trask Is an Epithelial Protein that Signals during Anchorage Deprivation by Spassov, Danislav S, Baehner, Frederick L, Wong, Ching Hang, McDonough, Stephen, Moasser, Mark M

“…The roles of epithelial cells encompass both cellular- and tissue-level functions that involve numerous cell–cell and cell–matrix interactions, which…”
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Blood-Testis Barrier Dynamics Are Regulated by α2-Macroglobulin via the c-Jun N-Terminal Protein Kinase Pathway by Wong, Ching-hang, Mruk, Dolores D, Siu, Michelle K. Y, Cheng, C. Yan

“…The blood-testis barrier (BTB), in contrast to the blood-brain and blood-retina barriers, is composed of coexisting tight junctions, gap junctions, and basal…”
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Regulation of Ectoplasmic Specialization Dynamics in the Seminiferous Epithelium by Focal Adhesion-Associated Proteins in Testosterone-Suppressed Rat Testes by Wong, Ching-Hang, Xia, Weiliang, Lee, Nikki P. Y, Mruk, Dolores D, Lee, Will M, Cheng, C. Yan

“…Apical ectoplasmic specialization (ES) is a unique testis-specific cell-cell actin-based adherens junction type restricted to the…”
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Regulation of Sertoli-Germ Cell Adherens Junction Dynamics via Changes in Protein-Protein Interactions of the N-Cadherin-β-Catenin Protein Complex which Are Possibly Mediated by c-Src and Myotubularin-Related Protein 2: An in Vivo Study Using an Androgen Suppression Model by Zhang, Jiayi, Wong, Ching-hang, Xia, Weiliang, Mruk, Dolores D, Lee, Nikki P. Y, Lee, Will M, Cheng, C. Yan

“…Using a well characterized model of cell-cell actin-based adherens junction (AJ) disruption by suppressing the intratesticular testosterone level in adult rats…”
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Improved tumor vascular function following high-dose epidermal growth factor receptor tyrosine kinase inhibitor therapy by Moasser, Mark M., Wilmes, Lisa J., Wong, Ching Hang, Aliu, Sheye, Li, Ka-Loh, Wang, Donghui, Hom, Yun Kit, Hann, Byron, Hylton, Nola M.

“…Purpose To determine if inhibitors of the human growth factor receptor (HER) family can be used to enhance tumor vascular permeability and perfusion and…”
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Mitogen-activated protein kinases, adherens junction dynamics, and spermatogenesis: A review of recent data by Wong, Ching-Hang, Yan Cheng, C.

“…Mitogen-activated protein kinases (MAPKs) are important regulators of many cellular processes. In mammalian testes, these kinases are involved in controlling…”
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Trask Loss Enhances Tumorigenic Growth by Liberating Integrin Signaling and Growth Factor Receptor Cross-Talk in Unanchored Cells by SPASSOV, Danislav S, WONG, Ching Hang, WONG, Sunny Y, REITER, Jeremy F, MOASSER, Mark M

“…The cell surface glycoprotein Trask/CDCP1 is phosphorylated during anchorage loss in epithelial cells in which it inhibits integrin clustering, outside-in…”
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Phosphorylation of Trask by Src Kinases Inhibits Integrin Clustering and Functions in Exclusion with Focal Adhesion Signaling by Spassov, Danislav S., Wong, Ching Hang, Sergina, Natalia, Ahuja, Deepika, Fried, Michael, Sheppard, Dean, Moasser, Mark M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Phosphorylation of the src Epithelial Substrate Trask Is Tightly Regulated in Normal Epithelia but Widespread in Many Human Epithelial Cancers by CHING HANG WONG, BAEHNER, Frederick L, SPASSOV, Danislav S, AHUJA, Deepika, DONGHUI WANG, HANN, Byron, BLAIR, Jimmy, SHOKAT, Kevan, WELM, Alana L, MOASSER, Mark M

“…Purpose: The frequently elevated activities of the c-src and c-yes products in human epithelial tumors suggest that these activated tyrosine kinases have…”
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The structural features of Trask that mediate its anti-adhesive functions by Spassov, Danislav S, Ahuja, Deepika, Wong, Ching Hang, Moasser, Mark M

“…Trask/CDCP1 is a transmembrane protein with a large extracellular and small intracellular domains. The intracellular domain (ICD) undergoes tyrosine…”
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AF-2364 [1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide] is a potential male contraceptive: a review of recent data by Cheng, C. Yan, Mruk, Dolores, Silvestrini, Bruno, Bonanomi, Michele, Wong, Ching-Hang, Siu, Michelle K.Y., Lee, Nikki P.Y., Lui, Wing-Yee, Mo, Meng-Yun

“…Earlier studies have shown that 1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide (AF-2364) is a potential male contraceptive when administered orally to…”
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Targeted and reversible disruption of the blood-testis barrier by an FSH mutant-occludin peptide conjugate by Wong, Ching-Hang, Mruk, Dolores D, Lee, Will M, Cheng, C. Yan

“…The blood-testis barrier (BTB) is one of the tightest blood-tissue barriers in mammals. As such, it poses a challenge to deliver any drugs to the seminiferous…”
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Regulation of sertoli-germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/β-catenin (CATNB) signaling pathway : An in vitro and in vivo study by LEE, Nikki P. Y, MRUK, Dolores D, WONG, Ching-Hang, YAN CHENG, C

“…During spermatogenesis, extensive restructuring of cell junctions takes place in the seminiferous epithelium to facilitate germ cell movement. However, the…”
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Dynamin II interacts with the cadherin- and occludin-based protein complexes at the blood–testis barrier in adult rat testes by Lie, Pearl P Y, Xia, Weiliang, Wang, Claire Q F, Mruk, Dolores D, Yan, Helen H N, Wong, Ching-hang, Lee, Will M, Cheng, C Yan

“…In adult rat testes, blood–testis barrier (BTB) restructuring facilitates the migration of preleptotene spermatocytes from the basal to the adluminal…”
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The β1-integrin-p-FAK-p130Cas-DOCK180-RhoA-vinculin is a novel regulatory protein complex at the apical ectoplasmic specialization in adult rat testes by Siu, Michelle K.Y., Wong, Ching Hang, Xia, Weiliang, Mruk, Dolores D., Lee, Will M., Cheng, C. Yan

“…During spermatogenesis, step 1 spermatids (round spermatids) derive from spermatocytes following meiosis I and II at stage XIV of the epithelial cycle begin a…”
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