Search Results - "WOLSCHENDORF, Frank"

Mycobacteria, metals, and the macrophage by Neyrolles, Olivier, Wolschendorf, Frank, Mitra, Avishek, Niederweis, Michael

“…Summary Mycobacterium tuberculosis is a facultative intracellular pathogen that thrives inside host macrophages. A key trait of M. tuberculosis is to exploit…”
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Copper resistance is essential for virulence of Mycobacterium tuberculosis by Wolschendorf, Frank, Ackart, David, Shrestha, Tej B, Hascall-Dove, Laurel, Nolan, Scott, Lamichhane, Gyanu, Wang, Ying, Bossmann, Stefan H, Basaraba, Randall J, Niederweis, Michael

“…Copper (Cu) is essential for many biological processes, but is toxic when present in excessive amounts. In this study, we provide evidence that Cu plays a…”
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A copper-dependent compound restores ampicillin sensitivity in multidrug-resistant Staphylococcus aureus by Crawford, Cameron L., Dalecki, Alex G., Perez, Mildred D., Schaaf, Kaitlyn, Wolschendorf, Frank, Kutsch, Olaf

“…Multi-drug resistant Staphylococcus aureus , including methicillin-resistant S. aureus (MRSA), has become a worldwide, major health care problem. While…”
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An AP-1 Binding Site in the Enhancer/Core Element of the HIV-1 Promoter Controls the Ability of HIV-1 To Establish Latent Infection by Duverger, Alexandra, Wolschendorf, Frank, Zhang, Mingce, Wagner, Fredric, Hatcher, Brandon, Jones, Jennifer, Cron, Randall Q, van der Sluis, Renee M, Jeeninga, Rienk E, Berkhout, Ben, Kutsch, Olaf

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Porins Increase Copper Susceptibility of Mycobacterium tuberculosis by Speer, Alexander, Rowland, Jennifer L, Haeili, Mehri, Niederweis, Michael, Wolschendorf, Frank

“…Copper resistance mechanisms are crucial for many pathogenic bacteria, including Mycobacterium tuberculosis, during infection because the innate immune system…”
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Reduced bacterial contamination rates detected on silicone tourniquets compared to conventional tourniquets in clinical routine by Grohmann, Marcus, Schomakers, Lena, Wolschendorf, Frank, Grosch, Janina, Lindner, Susan, Witte, Anna Kristina

“…Tourniquets used for peripheral venous vascular access such as blood sampling are regularly contaminated in clinical routine. Although most contaminations are…”
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Mycobacterium tuberculosis exploits the PPM1A signaling pathway to block host macrophage apoptosis by Schaaf, Kaitlyn, Smith, Samuel R., Duverger, Alexandra, Wagner, Frederic, Wolschendorf, Frank, Westfall, Andrew O., Kutsch, Olaf, Sun, Jim

“…The ability to suppress host macrophage apoptosis is essential for M. tuberculosis ( Mtb ) to replicate intracellularly while protecting it from antibiotic…”
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Copper-Boosting Compounds: a Novel Concept for Antimycobacterial Drug Discovery by SPEER, Alexander, SHRESTHA, Tej B, BOSSMANN, Stefan H, BASARABA, Randall J, HARBER, Gregory J, MICHALEK, Suzanne M, NIEDERWEIS, Michael, KUTSCH, Olaf, WOLSCHENDORF, Frank

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Differential Susceptibility of Mycoplasma and Ureaplasma Species to Compound-Enhanced Copper Toxicity by Totten, Arthur H, Crawford, Cameron L, Dalecki, Alex G, Xiao, Li, Wolschendorf, Frank, Atkinson, Thomas P

“…Mycoplasmas represent important etiologic agents of many human diseases. Due to increasing antimicrobial resistance and slow rate of novel discovery,…”
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Kinase Control of Latent HIV-1 Infection: PIM-1 Kinase as a Major Contributor to HIV-1 Reactivation by Duverger, Alexandra, Wolschendorf, Frank, Anderson, Joshua C, Wagner, Frederic, Bosque, Alberto, Shishido, Takao, Jones, Jennifer, Planelles, Vicente, Willey, Christopher, Cron, Randall Q, Kutsch, Olaf

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Kinase Control Prevents HIV-1 Reactivation in Spite of High Levels of Induced NF-κB Activity by WOLSCHENDORF, Frank, BOSQUE, Alberto, SHISHIDO, Takao, DUVERGER, Alexandra, JONES, Jennifer, PLANELLES, Vicente, KUTSCH, Olaf

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Selected Drugs with Reported Secondary Cell-Differentiating Capacity Prime Latent HIV-1 Infection for Reactivation by SHISHIDO, Takao, WOLSCHENDORF, Frank, DUVERGER, Alexandra, WAGNER, Frederic, KAPPES, John, JONES, Jennifer, KUTSCH, Olaf

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Rv1698 of Mycobacterium tuberculosis Represents a New Class of Channel-forming Outer Membrane Proteins by Siroy, Axel, Mailaender, Claudia, Harder, Daniel, Koerber, Stephanie, Wolschendorf, Frank, Danilchanka, Olga, Wang, Ying, Heinz, Christian, Niederweis, Michael

“…Mycobacteria contain an outer membrane composed of mycolic acids and a large variety of other lipids. Its protective function is an essential virulence factor…”
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Identification of Two Mycobacterium smegmatis Lipoproteins Exported by a SecA2-Dependent Pathway by GIBBONS, Henry S, WOLSCHENDORF, Frank, ABSHIRE, Michelle, NIEDERWEIS, Michael, BRAUNSTEIN, Miriam

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Porins Are Required for Uptake of Phosphates by Mycobacterium smegmatis by WOLSCHENDORF, Frank, MAHFOUD, Maysa, NIEDERWEIS, Michael

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Pyrazolyl Thioureas and Carbothioamides with an NNSN Motif against MSSA and MRSA by Delpe-Acharige, Anjana, Zhang, Man, Eschliman, Kayla, Dalecki, Alex, Covarrubias-Zambrano, Obdulia, Minjarez-Almeida, Azriel, Shrestha, Tejaswi, Lewis, Tanji, Al-Ibrahim, Fatimah, Leonard, Sophia, Roberts, Riana, Tebeje, Anteneh, Malalasekera, Aruni P, Wang, Hongwang, Kalubowilage, Madumali, Wolschendorf, Frank, Kutsch, Olaf, Bossmann, Stefan H

“…A novel series of copper-activatable drugs intended for use against methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus…”
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Facts and fiction: cellular models for high throughput screening for HIV-1 reactivating drugs by Planelles, Vicente, Wolschendorf, Frank, Kutsch, Olaf

“…A curative therapy for HIV-1 infection will have to include measures to eliminate the reservoir of latently HIV- 1 infected cells that allow the virus to…”
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Hit-and-Run Stimulation: a Novel Concept To Reactivate Latent HIV-1 Infection without Cytokine Gene Induction by Wolschendorf, Frank, Duverger, Alexandra, Jones, Jennifer, Wagner, Frederic H, Huff, Jason, Benjamin, William H, Saag, Michael S, Niederweis, Michael, Kutsch, Olaf

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The role of porins in copper acquisition by mycobacteria by Haeili, Mehri, Speer, Alexander, Rowland, Jennifer L, Niederweis, Michael, Wolschendorf, Frank

“…Abstract Aims and objectives Copper poisoning in macrophages plays an important role in immunity against invading pathogens. Many bacteria, including…”
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Copper and Antibiotics: Discovery, Modes of Action, and Opportunities for Medicinal Applications by Dalecki, Alex G, Crawford, Cameron L, Wolschendorf, Frank

“…Copper is a ubiquitous element in the environment as well as living organisms, with its redox capabilities and complexation potential making it indispensable…”
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