Search Results - "WOLKOFF, A. W"

Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver by Brazhnik, K, Sun, S, Alani, O, Kinkhabwala, M, Wolkoff, A W, Maslov, A Y, Dong, X, Vijg, J

“…Accumulating somatic mutations have been implicated in age-related cellular degeneration and death. Because of their random nature and low abundance, somatic…”
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A pre-neoplastic epigenetic field defect in HCV-infected liver at transcription factor binding sites and polycomb targets by Wijetunga, N A, Pascual, M, Tozour, J, Delahaye, F, Alani, M, Adeyeye, M, Wolkoff, A W, Verma, A, Greally, J M

“…The predisposition of patients with Hepatitis C virus (HCV) infection to hepatocellular carcinoma (HCC) involves components of viral infection, inflammation…”
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Expression Cloning of a Rat Liver Na+-Independent Organic Anion Transporter by Jacquemin, Emmanuel, Hagenbuch, Bruno, Stieger, Bruno, Wolkoff, Allan W., Meier, Peter J.

“…Using expression cloning in Xenopus laevis oocytes, we have isolated a cDNA encoding a rat liver organic anion-transporting polypeptide (oatp). The cloned oatp…”
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Immunologic distribution of an organic anion transport protein in rat liver and kidney by Bergwerk, A J, Shi, X, Ford, A C, Kanai, N, Jacquemin, E, Burk, R D, Bai, S, Novikoff, P M, Stieger, B, Meier, P J, Schuster, V L, Wolkoff, A W

“…A Na(+)-independent organic anion transport protein was recently cloned from rat liver using a Xenopus laevis oocyte expression system [E. Jacquemin, B…”
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Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver by Kullak-Ublick, G A, Hagenbuch, B, Stieger, B, Schteingart, C D, Hofmann, A F, Wolkoff, A W, Meier, P J

“…Based on a recently cloned rat liver organic anion transporter, we attempted to clone the corresponding human liver organic anion transporting polypeptide. A…”
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Identification and Characterization of a Prostaglandin Transporter by Kanai, Naoaki, Lu, Run, Satriano, Joseph A., Bao, Yi, Wolkoff, Allan W., Schuster, Victor L.

“…Carrier-mediated prostaglandin transport has been postulated to occur in many tissues. On the basis of sequence homology, the protein of unknown function…”
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Effect of fasting on the uptake of bilirubin and sulfobromophthalein by the isolated perfused rat liver by Gartner, U, Goeser, T, Wolkoff, AW

“…BACKGROUND & AIMS: Occurrence of hyperbilirubinemia after fasting has been recognized for many years. The pathogenesis of this syndrome is unclear. Although…”
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Regulation of renal oatp mRNA expression by testosterone by Lu, R, Kanai, N, Bao, Y, Wolkoff, A W, Schuster, V L

“…A recently cloned cDNA encodes the so-called "organic anion-transporting polypeptide" (i.e., oatp), which is expressed in rat liver and in the kidney S3…”
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Transient expression of oatp organic anion transporter in mammalian cells: identification of candidate substrates by Kanai, N, Lu, R, Bao, Y, Wolkoff, A W, Schuster, V L

“…The cDNA for the rat liver organic anion-transporting polypeptide "oatp" has been shown to encode transport of bromosulfophthalein (BSP) and bile salts in…”
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Estradiol 17 beta-D-glucuronide is a high-affinity substrate for oatp organic anion transporter by Kanai, N, Lu, R, Bao, Y, Wolkoff, A W, Vore, M, Schuster, V L

“…Although substantial evidence indicates that estradiol-17 beta (E2) is conjugated to the glucuronide in the kidney and then excreted by a direct tubular…”
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Functional characterization of the basolateral rat liver organic anion transporting polypeptide by Kullak-Ublick, G A, Hagenbuch, B, Stieger, B, Wolkoff, A W, Meier, P J

“…To characterize the transport functions of a recently cloned basolateral organic anion transporting polypeptide of rat hepatocytes we performed further kinetic…”
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The modified dipeptide, enalapril, an angiotensin‐converting enzyme inhibitor, is transported by the rat liver organic anion transport protein by Pang, K. Sandy, Wang, Pi Jun, Chung, Alfred Y., Wolkoff, Allan W.

“…Oatp1, the organic anion transport polypeptide, is an integral membrane protein cloned from rat liver that mediates the uptake of various organic anions such…”
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Characterization and functional studies on rat liver fat-storing cell line and freshly isolated hepatocyte coculture system by Rojkind, M, Novikoff, PM, Greenwel, P, Rubin, J, Rojas-Valencia, L, de Carvalho, AC, Stockert, R, Spray, D, Hertzberg, EL, Wolkoff, AW

“…We developed and characterized a coculture system composed of a fat-storing cell clone (CFSC-2G) and freshly isolated hepatocytes that can reproduce in vitro…”
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Macrophages Specifically Regulate the Concentration of Their Own Growth Factor in the Circulation by Bartocci, A., Mastrogiannis, D. S., Migliorati, G., Stockert, R. J., Wolkoff, A. W., Stanley, E. R.

“…The physiological mechanism of clearance of the mononuclear phagocyte growth factor, colony-stimulating factor 1 (CSF-1), from the circulation of normal mice…”
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A Role for Microtubules in Sorting Endocytic Vesicles in Rat Hepatocytes by Goltz, Jason S., Wolkoff, Allan W., Novikoff, Phyllis M., Stockert, Richard J., Satir, Peter

“…The vectorial nature of hepatocyte receptor-mediated endocytosis (RME) and its susceptibility to cytoskeletal disruptors has suggested that a polarized network…”
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Uptake of Enalapril and Expression of Organic Anion Transporting Polypeptide 1 in Zonal, Isolated Rat Hepatocytes by Abu-Zahra, T N, Wolkoff, A W, Kim, R B, Pang, K S

“…Sinusoidal entry is the first obligatory process preceding intracellular drug removal in liver. Transport of the angiotensin converting enzyme inhibitor…”
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Expression of the hepatocellular chloride-dependent sulfobromophthalein uptake system in Xenopus laevis oocytes by JACQUEMIN, E, HAGENBUCH, B, STIEGER, B, WOLKOFF, A. W, MEIER, P. J

“…The expression of the basolateral chloride-activated organic anion uptake system of rat hepatocytes has been studied in Xenopus laevis oocytes. Injection of…”
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Three-dimensional organization of rat hepatocyte cytoskeleton: relation to the asialoglycoprotein endocytosis pathway by Novikoff, P M, Cammer, M, Tao, L, Oda, H, Stockert, R J, Wolkoff, A W, Satir, P

“…Analysis by confocal microscopy has revealed features of the microtubule network of rat hepatocytes in culture, establishing the three-dimensional disposition…”
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Influence of Cl- on organic anion transport in short-term cultured rat hepatocytes and isolated perfused rat liver by WOLKOFF, A. W, SAMUELSON, A. C, JOHANSEN, K. L, NAKATA, R, WITHERS, D. M, SOSIAK, A

“…Transport of 35S-labeled sulfobromophthalein [35S]BSP was studied in short-term cultured rat hepatocytes incubated in bovine serum albumin. At 37 degrees C,…”
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Intracellular Segregation of Asialoglycoproteins and Their Receptor: A Prelysosomal Event Subsequent to Dissociation of the Ligand-Receptor Complex by Wolkoff, Allan W., Klausner, Richard D., Ashwell, Gilbert, Harford, Joe

“…Rat hepatocytes in monolayer culture rapidly internalized asialoglycoproteins and the receptors to which they are bound. Subsequent to endocytosis, the…”
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