Search Results - "WOLFFE, Alan P."

Methylation-Induced Repression— Belts, Braces, and Chromatin by Bird, Adrian P, Wolffe, Alan P

“…DNA methylation is essential for development in the mouse and plays an important role in inactivation of the X-chromosome and genomic imprinting. It may also…”
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Epigenetics: Regulation Through Repression by Wolffe, Alan P., Matzke, Marjori A.

“…Epigenetics is the study of heritable changes in gene expression that occur without a change in DNA sequence. Epigenetic phenomena have major economic and…”
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Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription by Wolffe, Alan P, Jones, Peter L, Jan Veenstra, Gert C, Wade, Paul A, Vermaak, Danielle, Kass, Stefan U, Landsberger, Nicoletta, Strouboulis, John

“…CpG methylation in vertebrates correlates with alterations in chromatin structure and gene silencing. Differences in DNA-methylation status are associated with…”
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Selective Association of the Methyl-CpG Binding Protein MBD2 with the Silent p14/p16 Locus in Human Neoplasia by Magdinier, Frédérique, Wolffe, Alan P.

“…DNA methylation of tumor suppressor genes is a common feature of human cancer. The cyclin-dependent kinase inhibitor gene p16/Ink4A is hypermethylated in a…”
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Gene regulation by Y-box proteins: coupling control of transcription and translation by Matsumoto, Ken, Wolffe, Alan P

“…Y-box proteins are multifunctional regulators of gene expression. In somatic cells, they have the capacity to exert positive and negative effects on both…”
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Precipitous Release of Methyl-CpG Binding Protein 2 and Histone Deacetylase 1 from the Methylated Human Multidrug Resistance Gene (MDR1) on Activation by El-Osta, Assam, Kantharidis, Phillip, Zalcberg, John R., Wolffe, Alan P.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Acetylation of general transcription factors by histone acetyltransferases by Imhof, Axel, Yang, Xiang-Jiao, Ogryzko, Vasily V, Nakatani, Yoshihiro, Wolffe, Alan P, Ge, Hui

“…The acetylation of histones increases the accessibility of nucleosomal DNA to transcription factors [1,2], relieving transcriptional repression [3] and…”
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Histone Deacetylase: A Regulator of Transcription by Wolffe, Alan P.

“…Histones are DNA binding proteins that bind without regard to the sequence of the DNA and help determine the three-dimensional organization of the chromatin…”
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Active Remodeling of Somatic Nuclei in Egg Cytoplasm by the Nucleosomal ATPase ISWI by Kikyo, Nobuaki, Wade, Paul A., Guschin, Dmitry, Ge, Hui, Wolffe, Alan P.

“…Cloning by the transplantation of somatic nuclei into unfertilized eggs requires a dramatic remodeling of chromosomal architecture. Many proteins are…”
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DNA methylation directs a time-dependent repression of transcription initiation by Kass, Stefan U, Landsberger, Nicoletta, Wolffe, Alan P

“…Background: The regulation of DNA methylation is required for differential expression of imprinted genes during vertebrate development. Earlier studies that…”
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Structural and functional properties of the evolutionarily ancient Y-box family of nucleic acid binding proteins by Wolffe, A P

“…The Y-box proteins are the most evolutionarily conserved nucleic acid binding proteins yet defined in bacteria, plants and animals. The central nucleic acid…”
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Structure and Function of the Core Histone N-Termini:  More Than Meets the Eye by Hansen, Jeffrey C, Tse, Christin, Wolffe, Alan P

“…For two decades, the core histone N-termini generally have been thought of as unstructured domains whose function is to bind to DNA and screen negative charge…”
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Nuclear history of a pre-mRNA determines the translational activity of cytoplasmic mRNA by Matsumoto, Ken, Wassarman, Karen Montzka, Wolffe, Alan P.

“…The pathways of synthesis and maturation of pre‐messenger RNA in the nucleus have a direct effect on the translational efficiency of mRNA in the cytoplasm. The…”
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DNA Demethylation by Wolffe, Alan P., Jones, Peter L., Wade, Paul A.

“…Although strategies for demethylating DNA have been proposed, none have yet been proven to operate under relevant physiological circumstances in vivo. Recent…”
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Chromatin: Histone acetyltransferases in control by Wade, Paul A, Wolffe, Alan P

“…Several transcriptional regulators have been found to act as enzymes that acetylate histones. The targeted post-translational modification of histones within…”
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DNA methylation in health and disease by Robertson, Keith D, Wolffe, Alan P

“…DNA methylation has recently moved to centre stage in the aetiology of human neurodevelopmental syndromes such as the fragile X, ICF and Rett syndromes. These…”
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An Asymmetric Model for the Nucleosome: A Binding Site for Linker Histones Inside the DNA Gyres by Pruss, Dmitry, Bartholomew, Blaine, Persinger, Jim, Hayes, Jeffrey, Arents, Gina, Moudrianakis, Evangelos N., Wolffe, Alan P.

“…Histone-DNA contacts within a nucleosome influence the function of trans-acting factors and the molecular machines required to activate the transcription…”
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Nuclear Hormone Receptor Coregulators In Action: Diversity For Shared Tasks by Robyr, Daniel, Wolffe, Alan P, Wahli, Walter

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Nucleosomal anatomy--where are the histones? by Pruss, D, Hayes, J J, Wolffe, A P

“…The recent surge of discoveries concerning the structural organization of nucleosomes, together with genetic evidence of highly specialized roles for the…”
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Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation by Aubry, Florence, Wade, Paul A, Gegonne, Anne, Wolffe, Alan P, Ballestar, Esteban, Jones, Peter L

“…Methylation of DNA at the dinucleotide CpG is essential for mammalian development and is correlated with stable transcriptional silencing. This transcriptional…”
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