Selective serotonin reuptake inhibitors and rhabdomyolysis after eccentric exercise

The purpose of this report was to review three cases of clinically significant rhabdomyolysis that developed in research subjects after completing an eccentric exercise protocol. All three cases occurred in subjects who reported use of selective serotonin reuptake inhibitors (SSRI). Sixty-three subj...

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Bibliographic Details
Published in:	Medicine and science in sports and exercise Vol. 38; no. 9; pp. 1539 - 1542
Main Authors:	LABOTZ, Michele, WOLFF, Toby K, NAKASONE, Kenneth T, KIMURA, Iris F, HETZLER, Ronald K, NICHOLS, Andrew W
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD Lippincott Williams & Wilkins 01-09-2006
Subjects:	Adult Biological and medical sciences Creatine Kinase - blood Elbow - injuries Female Fundamental and applied biological sciences. Psychology Humans Physical Exertion - physiology Rhabdomyolysis - blood Rhabdomyolysis - etiology Rhabdomyolysis - therapy Serotonin Uptake Inhibitors - adverse effects Severity of Illness Index Space life sciences Transcutaneous Electric Nerve Stimulation - methods Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports Weight Lifting - physiology Physical exercise Human MEDICATION ANTIDEPRESSANT Serotonin Electrical stimulus MICROCURRENT ELECTRICAL NEUROMUSCULAR STIMULATION MUSCLE INJURY Eccentric Rhabdomyolysis Reuptake inhibitor Striated muscle Striated muscle disease Sport ADVERSE EVENT Neurotransmitter Antidepressant agent Lesion
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Summary:	The purpose of this report was to review three cases of clinically significant rhabdomyolysis that developed in research subjects after completing an eccentric exercise protocol. All three cases occurred in subjects who reported use of selective serotonin reuptake inhibitors (SSRI). Sixty-three subjects enrolled in the study. Subjects performed 15 sets of 15 repetitions of maximal eccentric contractions of the elbow flexors. Subjects were then monitored on a daily basis for development of delayed onset muscle soreness (DOMS). Subjects received either microcurrent electrical neuromuscular stimulation (MENS) or sham treatment. Three subjects developed clinically significant rhabdomyolysis after performing this exercise protocol. Affected subjects were the only subjects who reported use of SSRI during the study period. This report raises suspicion of SSRI use as a predisposing factor to muscle injury after eccentric exercise.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Case Study-2 ObjectType-Feature-4 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0195-9131 1530-0315
DOI:	10.1249/01.mss.0000227643.06478.c6