Search Results - "WOLF, Matthew J"
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16S rRNA Gene PCR/Sequencing of Heart Valves for Diagnosis of Infective Endocarditis in Routine Clinical Practice
Published in Journal of clinical microbiology (23-08-2023)“…Sequencing is increasingly used for infective endocarditis (IE) diagnosis. Here, the performance of 16S rRNA gene PCR/sequencing of heart valves utilized in…”
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Cell cycle specific, differentially tagged ribosomal proteins to measure phase specific transcriptomes from asynchronously cycling cells
Published in Scientific reports (18-01-2024)“…Asynchronously cycling cells pose a challenge to the accurate characterization of phase-specific gene expression. Current strategies, including RNAseq, survey…”
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Clinical Use of a 16S Ribosomal RNA Gene-Based Sanger and/or Next Generation Sequencing Assay to Test Preoperative Synovial Fluid for Periprosthetic Joint Infection Diagnosis
Published in mBio (20-12-2022)“…Preoperative pathogen identification in patients with periprosthetic joint infection (PJI) is typically limited to synovial fluid culture. Whether…”
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Self-Consistent-Charge Density-Functional Tight-Binding (SCC-DFTB) Parameters for Ceria in 0D to 3D
Published in Journal of physical chemistry. C (02-03-2017)“…Reducible oxides such as CeO2 are challenging to describe with standard density-functional theory (DFT) due to the mixed valence states of the cations; they…”
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Charge transport modelling of perovskite solar cells accounting for non-Boltzmann statistics in organic and highly-doped transport layers
Published in JPhys Energy (01-04-2023)“…We present a drift–diffusion model of a perovskite solar cell (PSC) in which carrier transport in the charge transport layers (TLs) is not based on the…”
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The Microenvironment of the Pathogenesis of Cardiac Hypertrophy
Published in Cells (Basel, Switzerland) (01-07-2023)“…Pathological cardiac hypertrophy is a key risk factor for the development of heart failure and predisposes individuals to cardiac arrhythmia and sudden death…”
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Heart Failure in the Era of Precision Medicine: A Scientific Statement From the American Heart Association
Published in Circulation. Genomic and precision medicine (01-10-2019)“…One of 5 people will develop heart failure over his or her lifetime. Early diagnosis and better understanding of the pathophysiology of this disease are…”
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Cardiac hypertrophy induced by active Raf depends on Yorkie-mediated transcription
Published in Science signaling (03-02-2015)“…Organ hypertrophy can result from enlargement of individual cells or from cell proliferation or both. Activating mutations in the serine-threonine kinase Raf…”
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Disruption of sarcoendoplasmic reticulum calcium ATPase function in Drosophila leads to cardiac dysfunction
Published in PloS one (03-10-2013)“…Abnormal sarcoendoplasmic reticulum Calcium ATPase (SERCA) function has been associated with poor cardiac function in humans. While modifiers of SERCA function…”
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Drosophila as a model for the identification of genes causing adult human heart disease
Published in Proceedings of the National Academy of Sciences - PNAS (31-01-2006)“…Drosophila melanogaster genetics provides the advantage of molecularly defined P-element insertions and deletions that span the entire genome. Although…”
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In Vivo Methods to Monitor Cardiomyocyte Proliferation
Published in Journal of cardiovascular development and disease (03-03-2022)“…Adult mammalian cardiomyocytes demonstrate scarce cycling and even lower proliferation rates in response to injury. Signals that enhance cardiomyocyte…”
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Suppression of store-operated calcium entry causes dilated cardiomyopathy of the Drosophila heart
Published in Biology open (11-03-2020)“…Store-operated Ca entry (SOCE) is an essential Ca signaling mechanism present in most animal cells. SOCE refers to Ca influx that is activated by depletion of…”
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Raf-mediated cardiac hypertrophy in adult Drosophila
Published in Disease models & mechanisms (01-07-2013)“…In response to stress and extracellular signals, the heart undergoes a process called cardiac hypertrophy during which cardiomyocytes increase in size. If…”
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Multi-omic analysis reveals VEGFR2, PI3K, and JNK mediate the small molecule induction of human iPSC-derived cardiomyocyte proliferation
Published in iScience (16-08-2024)“…Mammalian hearts lose their regenerative potential shortly after birth. Stimulating the proliferation of preexisting cardiomyocytes is a potential therapeutic…”
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STM Images of Anionic Defects at CeO2(111)—A Theoretical Perspective
Published in Frontiers in chemistry (06-06-2019)“…We present a theoretically oriented analysis of the appearance and properties of plausible candidates for the anionic defects observed in scanning tunneling…”
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Multiscale Modeling of Agglomerated Ceria Nanoparticles: Interface Stability and Oxygen Vacancy Formation
Published in Frontiers in chemistry (22-05-2019)“…The interface formation and its effect on redox processes in agglomerated ceria nanoparticles (NPs) have been investigated using a multiscale simulation…”
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Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues
Published in Communications biology (21-06-2023)“…Noonan syndrome (NS), the most common among RASopathies, is caused by germline variants in genes encoding components of the RAS-MAPK pathway. Distinct…”
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Diagnostic Yield of 16S Ribosomal Ribonucleic Acid Gene-Based Targeted Metagenomic Sequencing for Evaluation of Pleural Space Infection: A Prospective Study
Published in Mayo Clinic proceedings. Innovations, quality & outcomes (01-10-2023)“…To better understand the microbial profile of complicated parapneumonic effusions and empyema, and to evaluate whether antimicrobial selection would differ if…”
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Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila
Published in PLoS genetics (27-05-2010)“…Drosophila is a well recognized model of several human diseases, and recent investigations have demonstrated that Drosophila can be used as a model of human…”
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“HETE”ing up mitochondria in human heart failure
Published in The Journal of biological chemistry (05-01-2018)“…A decade of research has established the phospholipase iPLA2γ as being involved in cardiomyocyte dysfunction and necrosis leading to heart failure, but the…”
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