Search Results - "WOLBURG, Hartwig"

Tight junction proteins at the blood–brain barrier: far more than claudin-5 by Berndt, Philipp, Winkler, Lars, Cording, Jimmi, Breitkreuz-Korff, Olga, Rex, André, Dithmer, Sophie, Rausch, Valentina, Blasig, Rosel, Richter, Matthias, Sporbert, Anje, Wolburg, Hartwig, Blasig, Ingolf E., Haseloff, Reiner F.

“…At the blood–brain barrier (BBB), claudin (Cldn)-5 is thought to be the dominant tight junction (TJ) protein, with minor contributions from Cldn3 and -12, and…”
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Transmembrane proteins of the tight junctions at the blood–brain barrier: Structural and functional aspects by Haseloff, Reiner F., Dithmer, Sophie, Winkler, Lars, Wolburg, Hartwig, Blasig, Ingolf E.

“…The blood–brain barrier (BBB) is formed by microvascular endothelial cells sealed by tetraspanning tight junction (TJ) proteins, such as claudins and TAMPs…”
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Brain endothelial cells and the glio-vascular complex by Wolburg, Hartwig, Noell, Susan, Mack, Andreas, Wolburg-Buchholz, Karen, Fallier-Becker, Petra

“…We present and discuss the role of endothelial and astroglial cells in managing the blood-brain barrier (BBB) and aspects of pathological alterations in the…”
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Tight junctions in the blood–brain barrier promote edema formation and infarct size in stroke – Ambivalent effects of sealing proteins by Winkler, Lars, Blasig, Rosel, Breitkreuz-Korff, Olga, Berndt, Philipp, Dithmer, Sophie, Helms, Hans C, Puchkov, Dmytro, Devraj, Kavi, Kaya, Mehmet, Qin, Zhihai, Liebner, Stefan, Wolburg, Hartwig, Andjelkovic, Anuska V, Rex, Andre, Blasig, Ingolf E, Haseloff, Reiner F

“…The outcome of stroke is greatly influenced by the state of the blood–brain barrier (BBB). The BBB endothelium is sealed paracellularly by tight junction (TJ)…”
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Sublamina‐specific organization of the blood brain barrier in the mouse olfactory nerve layer by Beiersdorfer, Antonia, Wolburg, Hartwig, Grawe, Janine, Scheller, Anja, Kirchhoff, Frank, Lohr, Christian

“…Astrocytes constitute the main glial component of the mammalian blood brain barrier (BBB). However, in the olfactory bulb (OB), the olfactory nerve layer (ONL)…”
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Mini‐review: Transendothelial migration of leukocytes: through the front door or around the side of the house? by Engelhardt, Britta, Wolburg, Hartwig

“…Leukocyte adhesion to the endothelial cells lining the vessel wall and the subsequent migration of the leukocytes into the underlying tissue are key elements…”
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Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes by Hinson, Shannon R, Romero, Michael F, Popescu, Bogdan F. Gh, Lucchinetti, Claudia F, Fryer, James P, Wolburg, Hartwig, Fallier-Becker, Petra, Noell, Susan, Lennon, Vanda A

“…The astrocytic aquaporin-4 (AQP4) water channel is the target of pathogenic antibodies in a spectrum of relapsing autoimmune inflammatory central nervous…”
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Astroglial structures in the zebrafish brain by Grupp, Larissa, Wolburg, Hartwig, Mack, Andreas F.

“…To understand components shaping the neuronal environment we studied the astroglial cells in the zebrafish brain using immunocytochemistry for structural and…”
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In tight junctions, claudins regulate the interactions between occludin, tricellulin and marvelD3, which, inversely, modulate claudin oligomerization by Cording, Jimmi, Berg, Johanna, Käding, Nadja, Bellmann, Christian, Tscheik, Christian, Westphal, Julie K, Milatz, Susanne, Günzel, Dorothee, Wolburg, Hartwig, Piontek, Jörg, Huber, Otmar, Blasig, Ingolf Ernst

“…Tight junctions seal the paracellular cleft of epithelia and endothelia, form vital barriers between tissue compartments and consist of…”
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Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1 by Krebiehl, Guido, Ruckerbauer, Sabine, Burbulla, Lena F, Kieper, Nicole, Maurer, Brigitte, Waak, Jens, Wolburg, Hartwig, Gizatullina, Zemfira, Gellerich, Frank N, Woitalla, Dirk, Riess, Olaf, Kahle, Philipp J, Proikas-Cezanne, Tassula, Krüger, Rejko

“…Mitochondrial dysfunction and degradation takes a central role in current paradigms of neurodegeneration in Parkinson's disease (PD). Loss of DJ-1 function is…”
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Viscoelastic Properties of Individual Glial Cells and Neurons in the CNS by Lu, Yun-Bi, Franze, Kristian, Seifert, Gerald, Steinhäuser, Christian, Kirchhoff, Frank, Wolburg, Hartwig, Guck, Jochen, Janmey, Paul, Wei, Er-Qing, Käs, Josef, Reichenbach, Andreas

“…One hundred fifty years ago glial cells were discovered as a second, non-neuronal, cell type in the central nervous system. To ascribe a function to these new,…”
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Formation of tight junction: determinants of homophilic interaction between classic claudins by Piontek, Jörg, Winkler, Lars, Wolburg, Hartwig, Müller, Sebastian L, Zuleger, Nikolaj, Piehl, Christian, Wiesner, Burkhard, Krause, Gerd, Blasig, Ingolf E

“…Claudins are the critical transmembrane proteins in tight junctions. Claudin-5, for instance, prevents paracellular permeation of small molecules. However, the…”
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Aβ42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology by Radde, Rebecca, Bolmont, Tristan, Kaeser, Stephan A, Coomaraswamy, Janaky, Lindau, Dennis, Stoltze, Lars, Calhoun, Michael E, Jäggi, Fabienne, Wolburg, Hartwig, Gengler, Simon, Haass, Christian, Ghetti, Bernardino, Czech, Christian, Hölscher, Christian, Mathews, Paul M, Jucker, Mathias

“…We have generated a novel transgenic mouse model on a C57BL/6J genetic background that coexpresses KM670/671NL mutated amyloid precursor protein and L166P…”
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Mode of action of claudin peptidomimetics in the transient opening of cellular tight junction barriers by Staat, Christian, Coisne, Caroline, Dabrowski, Sebastian, Stamatovic, Svetlana M, Andjelkovic, Anuska V, Wolburg, Hartwig, Engelhardt, Britta, Blasig, Ingolf E

“…Abstract In epithelial/endothelial barriers, claudins form tight junctions, seal the paracellular cleft, and limit the uptake of solutes and drugs. The…”
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Polar and charged extracellular residues conserved among barrier‐forming claudins contribute to tight junction strand formation by Piontek, Anna, Rossa, Jan, Protze, Jonas, Wolburg, Hartwig, Hempel, Caroline, Günzel, Dorothee, Krause, Gerd, Piontek, Jörg

“…Claudins (Cldn) form the backbone of tight junction (TJ) strands and thereby regulate paracellular permeability for solutes and water. Polymeric strands are…”
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Participation of the second extracellular loop of claudin-5 in paracellular tightening against ions, small and large molecules by Piehl, Christian, Piontek, Jörg, Cording, Jimmi, Wolburg, Hartwig, Blasig, Ingolf E

“…Tight junctions control paracellular permeability. Here, we analyzed the impact of residues in the second extracellular loop (ECL2) of mouse claudin-5 on…”
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Loss of Mpdz impairs ependymal cell integrity leading to perinatal‐onset hydrocephalus in mice by Feldner, Anja, Adam, M Gordian, Tetzlaff, Fabian, Moll, Iris, Komljenovic, Dorde, Sahm, Felix, Bäuerle, Tobias, Ishikawa, Hiroshi, Schroten, Horst, Korff, Thomas, Hofmann, Ilse, Wolburg, Hartwig, von Deimling, Andreas, Fischer, Andreas

“…Hydrocephalus is a common congenital anomaly. LCAM1 and MPDZ ( MUPP1 ) are the only known human gene loci associated with non‐syndromic hydrocephalus. To…”
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Development of the Zebrafish Lymphatic System Requires Vegfc Signaling by Küchler, Axel M., Gjini, Evisa, Peterson-Maduro, Josi, Cancilla, Belinda, Wolburg, Hartwig, Schulte-Merker, Stefan

“…Lymphangiogenesis results in the formation of a vascular network distinct from arteries and veins that serves to drain interstitial fluid from surrounding…”
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Aquaporin-4 in Astroglial Cells in the CNS and Supporting Cells of Sensory Organs-A Comparative Perspective by Gleiser, Corinna, Wagner, Andreas, Fallier-Becker, Petra, Wolburg, Hartwig, Hirt, Bernhard, Mack, Andreas F

“…The main water channel of the brain, aquaporin-4 (AQP4), is one of the classical water-specific aquaporins. It is expressed in many epithelial tissues in the…”
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Structure and Functions of Aquaporin-4-Based Orthogonal Arrays of Particles by Wolburg, Hartwig, Wolburg-Buchholz, Karen, Fallier-Becker, Petra, Noell, Susan, Mack, Andreas F.

“…Orthogonal arrays or assemblies of intramembranous particles (OAPs) are structures in the membrane of diverse cells which were initially discovered by means of…”
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