Search Results - "WOHLLEBEN, Wolfgang"

Antibiotic drug discovery by Wohlleben, Wolfgang, Mast, Yvonne, Stegmann, Evi, Ziemert, Nadine

“…Summary Due to the threat posed by the increase of highly resistant pathogenic bacteria, there is an urgent need for new antibiotics; all the more so since in…”
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Polyamine and Ethanolamine Metabolism in Bacteria as an Important Component of Nitrogen Assimilation for Survival and Pathogenicity by Krysenko, Sergii, Wohlleben, Wolfgang

“…Nitrogen is an essential element required for bacterial growth. It serves as a building block for the biosynthesis of macromolecules and provides precursors…”
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Role of Carbon, Nitrogen, Phosphate and Sulfur Metabolism in Secondary Metabolism Precursor Supply in Streptomyces spp by Krysenko, Sergii, Wohlleben, Wolfgang

“…The natural soil environment of is characterized by variations in the availability of nitrogen, carbon, phosphate and sulfur, leading to complex primary and…”
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Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution by Rausch, Christian, Hoof, Ilka, Weber, Tilmann, Wohlleben, Wolfgang, Huson, Daniel H

“…Non-ribosomal peptide synthetases (NRPSs) are large multimodular enzymes that synthesize a wide range of biologically active natural peptide compounds, of…”
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Streptomyces coelicolor GlnR regulon: identification of new GlnR targets and evidence for a central role of GlnR in nitrogen metabolism in actinomycetes by Tiffert, Yvonne, Supra, Petra, Wurm, Reinhild, Wohlleben, Wolfgang, Wagner, Rolf, Reuther, Jens

“…Streptomyces coelicolor GlnR is a global regulator that controls genes involved in nitrogen metabolism. By genomic screening 10 new GlnR targets were…”
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Generation of lysolipin derivatives by genetic engineering by Robertsen, Helene, Rohrer, Sabrina, Kulik, Andreas, Wohlleben, Wolfgang, Mast, Yvonne

“…Lysolipin I is a halogenated, polycyclic xanthone natural product belonging to the polyketide class of antibiotics, naturally produced by Streptomyces…”
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A Second Gamma-Glutamylpolyamine Synthetase, GlnA2, Is Involved in Polyamine Catabolism in Streptomyces coelicolor by Krysenko, Sergii, Okoniewski, Nicole, Nentwich, Merle, Matthews, Arne, Bäuerle, Moritz, Zinser, Alina, Busche, Tobias, Kulik, Andreas, Gursch, Stephanie, Kemeny, Annika, Bera, Agnieszka, Wohlleben, Wolfgang

“…is a soil bacterium living in a habitat with very changeable nutrient availability. This organism possesses a complex nitrogen metabolism and is able to…”
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Mining Indonesian Microbial Biodiversity for Novel Natural Compounds by a Combined Genome Mining and Molecular Networking Approach by Handayani, Ira, Saad, Hamada, Ratnakomala, Shanti, Lisdiyanti, Puspita, Kusharyoto, Wien, Krause, Janina, Kulik, Andreas, Wohlleben, Wolfgang, Aziz, Saefuddin, Gross, Harald, Gavriilidou, Athina, Ziemert, Nadine, Mast, Yvonne

“…Indonesia is one of the most biodiverse countries in the world and a promising resource for novel natural compound producers. Actinomycetes produce about two…”
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A Regulator Based “Semi-Targeted” Approach to Activate Silent Biosynthetic Gene Clusters by Mingyar, Erik, Mühling, Lucas, Kulik, Andreas, Winkler, Anika, Wibberg, Daniel, Kalinowski, Jörn, Blin, Kai, Weber, Tilmann, Wohlleben, Wolfgang, Stegmann, Evi

“…By culturing microorganisms under standard laboratory conditions, most biosynthetic gene clusters (BGCs) are not expressed, and thus, the products are not…”
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Acyltransferases as Tools for Polyketide Synthase Engineering by Musiol-Kroll, Ewa Maria, Wohlleben, Wolfgang

“…Polyketides belong to the most valuable natural products, including diverse bioactive compounds, such as antibiotics, anticancer drugs, antifungal agents,…”
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The Endophytic Fungus Cyanodermella asteris Influences Growth of the Nonnatural Host Plant Arabidopsis thaliana by Jahn, Linda, Storm-Johannsen, Lisa, Seidler, Diana, Noack, Jasmin, Gao, Wei, Schafhauser, Thomas, Wohlleben, Wolfgang, van Berkel, Willem J H, Jacques, Philippe, Kar, Tambi, Piechulla, Birgit, Ludwig-Müller, Jutta

“…is a fungal endophyte from , a perennial plant from the northern part of Asia. Here, we demonstrated an interaction of with , Chinese cabbage, rapeseed,…”
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antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters by Weber, Tilmann, Blin, Kai, Duddela, Srikanth, Krug, Daniel, Kim, Hyun Uk, Bruccoleri, Robert, Lee, Sang Yup, Fischbach, Michael A., Müller, Rolf, Wohlleben, Wolfgang, Breitling, Rainer, Takano, Eriko, Medema, Marnix H.

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Engineering of Streptoalloteichus tenebrarius 2444 for Sustainable Production of Tobramycin by Mitousis, Lena, Maier, Hannes, Martinovic, Luka, Kulik, Andreas, Stockert, Sigrid, Wohlleben, Wolfgang, Stiefel, Alfred, Musiol-Kroll, Ewa

“…Tobramycin is a broad-spectrum aminoglycoside antibiotic agent. The compound is obtained from the base-catalyzed hydrolysis of carbamoyltobramycin (CTB), which…”
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Optimization of the precursor supply for an enhanced FK506 production in Streptomyces tsukubaensis by Schulz, Susann, Schall, Christoph, Stehle, Thilo, Breitmeyer, Christian, Krysenko, Sergii, Mitulski, Agnieszka, Wohlleben, Wolfgang

“…Tacrolimus (FK506) is a macrolide widely used as immunosuppressant to prevent transplant rejection. Synthetic production of FK506 is not efficient and costly,…”
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Synthetic Biology of secondary metabolite biosynthesis in actinomycetes: Engineering precursor supply as a way to optimize antibiotic production by Wohlleben, Wolfgang, Mast, Yvonne, Muth, Günther, Röttgen, Marlene, Stegmann, Evi, Weber, Tilmann

“…Actinomycetes are a rich source for the synthesis of medically and technically useful natural products. The genes encoding the enzymes for their biosynthesis…”
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The roles of the nitrate reductase NarGHJI, the nitrite reductase NirBD and the response regulator GlnR in nitrate assimilation of Mycobacterium tuberculosis by Malm, Sven, Tiffert, Yvonne, Micklinghoff, Julia, Schultze, Sonja, Joost, Insa, Weber, Isabel, Horst, Sarah, Ackermann, Birgit, Schmidt, Mascha, Wohlleben, Wolfgang, Ehlers, Stefan, Geffers, Robert, Reuther, Jens, Bange, Franz-Christoph

“…1 Department of Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany 2…”
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Control of Morphological Differentiation of Streptomyces coelicolor A3(2) by Phosphorylation of MreC and PBP2 by Ladwig, Nils, Franz-Wachtel, Mirita, Hezel, Felix, Soufi, Boumediene, Macek, Boris, Wohlleben, Wolfgang, Muth, Günther

“…During morphological differentiation of Streptomyces coelicolor A3(2), the sporogenic aerial hyphae are transformed into a chain of more than fifty spores in a…”
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Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis by Mast, Yvonne, Weber, Tilmann, Gölz, Melanie, Ort-Winklbauer, Regina, Gondran, Anne, Wohlleben, Wolfgang, Schinko, Eva

“…Summary Pristinamycin, produced by Streptomyces pristinaespiralis Pr11, is a streptogramin antibiotic consisting of two chemically unrelated compounds,…”
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Genome Assembly and Genetic Traits of the Pleuromutilin-Producer Clitopilus passeckerianus DSM1602 by Schafhauser, Thomas, Wibberg, Daniel, Binder, Antonia, Rückert, Christian, Busche, Tobias, Wohlleben, Wolfgang, Kalinowski, Jörn

“…The gilled mushroom Clitopilus passeckerianus (Entolomataceae, Agaricales, Basidiomycota) is well known to produce the terpenoid pleuromutilin, which is the…”
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The AT2 Domain of KirCI Loads Malonyl Extender Units to the ACPs of the Kirromycin PKS by Musiol, Ewa Maria, Greule, Anja, Härtner, Thomas, Kulik, Andreas, Wohlleben, Wolfgang, Weber, Tilmann

“…The antibiotic kirromycin is assembled by a hybrid modular polyketide synthases (PKSs)/nonribosomal peptide synthetases (NRPSs). Five of six PKSs of this…”
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