Search Results - "WITTWER, Matthias"

Fundamental aspects of DMPK optimization of targeted protein degraders by Cantrill, Carina, Chaturvedi, Prasoon, Rynn, Caroline, Petrig Schaffland, Jeannine, Walter, Isabelle, Wittwer, Matthias B.

“…•Degraders are an emerging modality which fall into the ‘beyond rule of 5’ space.•Poor permeability and solubility are critical features limiting oral…”
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Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance by Zamek‐Gliszczynski, Maciej J., Taub, Mitchell E., Chothe, Paresh P., Chu, Xiaoyan, Giacomini, Kathleen M., Kim, Richard B., Ray, Adrian S., Stocker, Sophie L., Unadkat, Jashvant D., Wittwer, Matthias B., Xia, Cindy, Yee, Sook‐Wah, Zhang, Lei, Zhang, Yan

“…This white paper provides updated International Transporter Consortium (ITC) recommendations on transporters that are important in drug development following…”
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Considerations and recommendations for assessment of plasma protein binding and drug-drug interactions for siRNA therapeutics by Humphreys, Sara C, Davis, John A, Iqbal, Sajida, Kamel, Amin, Kulmatycki, Kenneth, Lao, Yanbin, Liu, Xiumin, Rodgers, John, Snoeys, Jan, Vigil, Adam, Weng, Yan, Wiethoff, Christopher M, Wittwer, Matthias B

“…At the time of writing, although siRNA therapeutics are approved for human use, no official regulatory guidance specific to this modality is available. In the…”
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Renal Transporters in Drug Development by MORRISSEY, Kari M, STOCKER, Sophie L, WITTWER, Matthias B, LU XU, GIACOMINI, Kathleen M

“…The kidney plays a vital role in the body's defense against potentially toxic xenobiotics and metabolic waste products through elimination pathways. In…”
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Transporters in Drug Development: International Transporter Consortium Update on Emerging Transporters of Clinical Importance by Zamek‐Gliszczynski, Maciej J., Sangha, Vishal, Shen, Hong, Feng, Bo, Wittwer, Matthias B., Varma, Manthena V. S., Liang, Xiaomin, Sugiyama, Yuichi, Zhang, Lei, Bendayan, Reina

“…During its fourth transporter workshop in 2021, the International Transporter Consortium (ITC) provided updates on emerging clinically relevant transporters…”
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Discovery of Potent, Selective Multidrug and Toxin Extrusion Transporter 1 (MATE1, SLC47A1) Inhibitors Through Prescription Drug Profiling and Computational Modeling by Wittwer, Matthias B, Zur, Arik A, Khuri, Natalia, Kido, Yasuto, Kosaka, Alan, Zhang, Xuexiang, Morrissey, Kari M, Sali, Andrej, Huang, Yong, Giacomini, Kathleen M

“…The human multidrug and toxin extrusion (MATE) transporter 1 contributes to the tissue distribution and excretion of many drugs. Inhibition of MATE1 may result…”
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The genome of Naegleria lovaniensis, the basis for a comparative approach to unravel pathogenicity factors of the human pathogenic amoeba N. fowleri by Liechti, Nicole, Schürch, Nadia, Bruggmann, Rémy, Wittwer, Matthias

“…Members of the genus Naegleria are free-living eukaryotes with the capability to transform from the amoeboid form into resting cysts or moving flagellates in…”
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Targeted protein degraders: a call for collective action to advance safety assessment by Jones, Lyn H., Mitchell, Constance A., Loberg, Lise, Pavkovic, Mira, Rao, Mohan, Roberts, Ruth, Stamp, Katie, Volak, Laurie, Wittwer, Matthias B., Pettit, Syril

“…Targeted protein degraders (TPDs) are emerging classes of therapeutics that have the potential to address difficult drug targets in new ways. In 2021, experts…”
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Involvement of CB1 and CB2 receptors in neuroprotective effects of cannabinoids in experimental TDP-43 related frontotemporal dementia using male mice by Gonzalo-Consuegra, Claudia, Santos-García, Irene, García-Toscano, Laura, Martín-Baquero, Raquel, Rodríguez-Cueto, Carmen, Wittwer, Matthias B., Dzygiel, Pawel, Grether, Uwe, de Lago, Eva, Fernández-Ruiz, Javier

“…The elevation of endocannabinoid levels through inhibiting their degradation afforded neuroprotection in CaMKIIα-TDP-43 mice, a conditional transgenic model of…”
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Identification of ( R )-[ 18 F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development by He, Yingfang, Krämer, Stefanie D, Grether, Uwe, Wittwer, Matthias B, Collin, Ludovic, Kuhn, Bernd, Topp, Andreas, Heer, Dominik, O'Hara, Fionn, Honer, Michael, Pavlovic, Anto, Richter, Hans, Ritter, Martin, Rombach, Didier, Keller, Claudia, Gobbi, Luca, Mu, Linjing

“…This study aimed to evaluate ( )-[ F]YH134 as a novel PET tracer for imaging monoacylglycerol lipase (MAGL). Considering the ubiquitous expression of MAGL…”
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Identification of cryptic Anopheles mosquito species by molecular protein profiling by Müller, Pie, Pflüger, Valentin, Wittwer, Matthias, Ziegler, Dominik, Chandre, Fabrice, Simard, Frédéric, Lengeler, Christian

“…Vector control is the mainstay of malaria control programmes. Successful vector control profoundly relies on accurate information on the target mosquito…”
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The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin by Hibma, Jennifer E., Zur, Arik A., Castro, Richard A., Wittwer, Matthias B., Keizer, Ron J., Yee, Sook Wah, Goswami, Srijib, Stocker, Sophie L., Zhang, Xuexiang, Huang, Yong, Brett, Claire M., Savic, Radojka M., Giacomini, Kathleen M.

“…Introduction Pharmacokinetic outcomes of transporter-mediated drug–drug interactions (TMDDIs) are increasingly being evaluated clinically. The goal of our…”
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ITC Commentary on Metformin Clinical Drug–Drug Interaction Study Design That Enables an Efficacy‐ and Safety‐Based Dose Adjustment Decision by Zamek‐Gliszczynski, Maciej J., Chu, Xiaoyan, Cook, Jack A., Custodio, Joseph M., Galetin, Aleksandra, Giacomini, Kathleen M., Lee, Caroline A., Paine, Mary F., Ray, Adrian S., Ware, Joseph A., Wittwer, Matthias B., Zhang, Lei

“…Metformin drug-drug interaction (DDI) studies are conducted during development of drugs that inhibit organic cation transporters and/or multidrug and toxin…”
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Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice by Mock, Elliot D., Mustafa, Mohammed, Gunduz-Cinar, Ozge, Cinar, Resat, Petrie, Gavin N., Kantae, Vasudev, Di, Xinyu, Ogasawara, Daisuke, Varga, Zoltan V., Paloczi, Janos, Miliano, Cristina, Donvito, Giulia, van Esbroeck, Annelot C. M., van der Gracht, Anouk M. F., Kotsogianni, Ioli, Park, Joshua K., Martella, Andrea, van der Wel, Tom, Soethoudt, Marjolein, Jiang, Ming, Wendel, Tiemen J., Janssen, Antonius P. A., Bakker, Alexander T., Donovan, Colleen M., Castillo, Laura I., Florea, Bogdan I., Wat, Jesse, van den Hurk, Helma, Wittwer, Matthias, Grether, Uwe, Holmes, Andrew, van Boeckel, Constant A. A., Hankemeier, Thomas, Cravatt, Benjamin F., Buczynski, Matthew W., Hill, Matthew N., Pacher, Pal, Lichtman, Aron H., van der Stelt, Mario

“…N -acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical…”
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A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature by Kemble, Alicia M, Hornsperger, Benoit, Ruf, Iris, Richter, Hans, Benz, Jörg, Kuhn, Bernd, Heer, Dominik, Wittwer, Matthias, Engelhardt, Britta, Grether, Uwe, Collin, Ludovic

“…Chronic inflammation and blood–brain barrier dysfunction are key pathological hallmarks of neurological disorders such as multiple sclerosis, Alzheimer’s…”
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Involvement of CB 1 and CB 2 receptors in neuroprotective effects of cannabinoids in experimental TDP-43 related frontotemporal dementia using male mice by Gonzalo-Consuegra, Claudia, Santos-García, Irene, García-Toscano, Laura, Martín-Baquero, Raquel, Rodríguez-Cueto, Carmen, Wittwer, Matthias B, Dzygiel, Pawel, Grether, Uwe, de Lago, Eva, Fernández-Ruiz, Javier

“…The elevation of endocannabinoid levels through inhibiting their degradation afforded neuroprotection in CaMKIIα-TDP-43 mice, a conditional transgenic model of…”
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Associations of the intestinal microbiome with the complement system in neovascular age-related macular degeneration by Zysset-Burri, Denise C., Keller, Irene, Berger, Lieselotte E., Largiadèr, Carlo R., Wittwer, Matthias, Wolf, Sebastian, Zinkernagel, Martin S.

“…Age-related macular degeneration (AMD) is a leading cause of severe vision loss in the aged population. The etiology of AMD is multifactorial including…”
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Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain by He, Yingfang, Grether, Uwe, Taddio, Marco F., Meier, Carla, Keller, Claudia, Edelmann, Martin R., Honer, Michael, Huber, Sylwia, Wittwer, Matthias B., Heer, Dominik, Richter, Hans, Collin, Ludovic, Hug, Melanie N., Hilbert, Manuel, Postmus, Annemarieke G.J., Stevens, Anna Floor, van der Stelt, Mario, Krämer, Stefanie D., Schibli, Roger, Mu, Linjing, Gobbi, Luca C.

“…Monoacylglycerol lipase (MAGL) is a gatekeeper in regulating endocannabinoid signaling and has gained substantial attention as a therapeutic target for…”
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Discovery, synthesis and evaluation of novel reversible monoacylglycerol lipase radioligands bearing a morpholine-3-one scaffold by He, Yingfang, Gobbi, Luca C., Herde, Adrienne Müller, Rombach, Didier, Ritter, Martin, Kuhn, Bernd, Wittwer, Matthias B., Heer, Dominik, Hornsperger, Benoit, Bell, Charles, O'Hara, Fionn, Benz, Jörg, Honer, Michael, Keller, Claudia, Collin, Ludovic, Richter, Hans, Schibli, Roger, Grether, Uwe, Mu, Linjing

“…Monoacylglycerol lipase (MAGL) is a serine hydrolase that plays an important role in the endocannabinoid degradation in the brain. It has recently emerged as a…”
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Functional characterization of Francisella tularensis subspecies holarctica genotypes during tick cell and macrophage infections using a proteogenomic approach by Schütz, Sara Doina, Brackmann, Maximilian, Liechti, Nicole, Moser, Michel, Wittwer, Matthias, Bruggmann, Rémy

“…Tularemia is a vector-borne disease caused by the Gram-negative bacterium . Known hosts and vectors in Europe are hare and ticks. is transmitted from ticks and…”
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