Search Results - "WIRZ, B"

Inflammatory responses predict long-term mortality risk in community-acquired pneumonia by GUERTLER, C, WIRZ, B, CHRIST-CRAIN, M, ZIMMERLI, W, MUELLER, B, SCHUETZ, P

“…Long-term outcomes in patients surviving community-acquired pneumonia (CAP) are still incompletely understood. This study investigates the association of…”
Get full text

Detection of hog cholera virus and differentiation from other pestiviruses by polymerase chain reaction by Wirz, B. (Institut fur Viruskrankheiten und Immunprophylaxe, Mittelhausern, Switzerland), Tratschin, J.D, Muller, H.K, Mitchell, D.B

“…Reverse transcription coupled with the polymerase chain reaction (RT-PCR) was used for the detection and differentiation of pestiviruses. For this purpose, one…”
Get full text

4,5-bis(4-fluoroanilino)phthalimide: A selective inhibitor of the epidermal growth factor receptor signal transduction pathway with potent in vivo antitumor activity by BUCHDUNGER, E, METT, H, LYDON, N. B, TRINKS, U, REGENASS, U, MÜLLER, M, MEYER, T, BEILSTEIN, P, WIRZ, B, SCHNEIDER, P, TRAXLER, P

“…Deregulated signal transduction via the epidermal growth factor (EGF) receptor family of tyrosine protein kinase growth factor receptors is associated with…”
Get full text

Asymmetric oxidoreductions catalyzed by alcohol dehydrogenase in organic solvents by Grunwald, Jacob, Wirz, Beat, Scollar, Mark P, Klibanov, Alexander M

Get full text

Novel versatile approach to an enantiopure 19- nor, des-C,D vitamin D 3 derivative by Hilpert, Hans, Wirz, Beat

“…A short and efficient de novo route to the des-C,D vitamin D 3 derivative 3 (Ro 65-2299), a potential antipsoriatic, has been developed. This route features an…”
Get full text

The Synthetic Development of the Anti-Influenza Neuraminidase Inhibitor Oseltamivir Phosphate (Tamiflu®): A Challenge for Synthesis Process Research by Stefan Abrecht, Peter Harrington, Hans Iding, Martin Karpf, René Trussardi, Beat Wirz, Ulrich Zutter

“…The evolution of the synthesis of oseltamivir phosphate (Tamiflu®), used for the oral treatment and prevention of influenza virus infections (viral flu) is…”
Get full text

Chemo-enzymatic preparation of chiral 3-aminopyrrolidine derivatives by Iding, Hans, Wirz, Beat, Rogers-Evans, Mark

“…A new simple method for the enantioselective enzymatic hydrolysis of N-protected D-asparagine esters suitable for the use on the preparative scale is…”
Get full text

Separation of pyrrolidine allylation products by diastereoselective enzymatic ester hydrolysis by Aggarwal, Varinder K., Astle, Christopher J., Iding, Hans, Wirz, Beat, Rogers-Evans, Mark

“…[Display omitted] A multi-parallel enzyme screen has been used to identify potential catalysts for the selective hydrolysis of diastereomeric esters and then…”
Get full text

Measurement of clomipramine, N-desmethyl-clomipramine, imipramine, and dehydroimipramine in biological fluids by selective ion monitoring, and pharmacokinetics of clomipramine by Dubois, J P, Küng, W, Theobald, W, Wirz, B

“…To quantitatively determine tricyclic antidepressant agents, we used a combined gas chromatograph/mass spectrometer system, and deuterium-labeled internal…”
Get more information

Chemoenzymatic preparation of non-racemic N-Boc-piperidine-3,5-dicarboxylic acid 3-methyl esters and their 5-hydroxymethyl derivatives by Iding, Hans, Wirz, Beat, Rodrı́guez Sarmiento, Rosa-Marı́a

“…For the synthesis of ( R, R)- and ( S, S)- N-Boc-5-hydroxymethyl-piperidine-3-carboxylic acid methyl ester as important basic units for potential inhibitors of…”
Get full text

Chemoenzymatic preparation of non-racemic N-Boc-pyrrolidine-3,4-dicarboxylic acid 3-ethyl esters and their 4-hydroxymethyl derivatives by Rodrı́guez Sarmiento, Rosa Marı́a, Wirz, Beat, Iding, Hans

“…For the synthesis of metalloproteinase inhibitors the ( R, R)- and ( S, S)-monoethyl esters of N-Boc-pyrrolidine-3,4-dicarboxylic acid were prepared as key…”
Get full text

Multiselective enzymatic reactions for the synthesis of protected homochiral cis- and trans-1,3,5-cyclohexanetriols by Wirz, Beat, Iding, Hans, Hilpert, Hans

“…For the synthesis of the potentially antipsoriatic vitamin D derivative 3 (Ro 65-2299) an efficient and multiselective enzymatic step had been developed in…”
Get full text

Enzymatic preparation of homochiral 2-isobutyl succinic acid derivatives by Wirz, Beat, Soukup, Milan

“…An efficient enzymatic procedure for the enantio- and regioselective monohydrolysis of diethyl 2-isobutyl succinate [bd3] using subtilisin Carlsberg has been…”
Get full text

Facile chemoenzymatic preparation of enantiomerically pure 2-methylglycerol derivatives as versatile trifunctional C4-synthons by WIRZ, B, BARNER, R, HÜBSCHER, J

Get full text

A Continuous Lipase-Catalyzed Acylation Process for the Large-Scale Production of Vitamin A Precursors by Bernard Orsat, Beat Wirz, Stefan Bischof

“…A continuous enzyme-catalyzed acylation process for the selective preparation of monoacylated Vitamin A precursors starting from a 1,6-diol on a large scale is…”
Get full text

Synthesis and Metabolism of Drugs by Means of Enzyme-Catalysed Reactions by Hans Georg W. Leuenberger, Peter K. Matzinger, Beat Wirz

“…The usefulness of enzyme catalysed-reactions is exemplified by recent results from research at Roche.Sequences of enzyme reactions, well organised in metabolic…”
Get full text

Large scale preparation of chiral building blocks for the P3 site of renin inhibitors by Doswald, S, Estermann, H, Kupfer, E, Stadler, H, Walther, W, Weisbrod, T, Wirz, B, Wostl, W

“…Racemic ethyl 2-benzyl-3-(tert-butylsulfonyl)propionate (1) and racemic ethyl 2-benzyl-3-[[1-methyl-1-((morpholin-4-yl)carbonyl)ethyl]sulfonyl] propionate (3)…”
Get more information

A generic log-service supporting fast recovery in distributed fault-tolerant systems by Wirz, B., Nett, E.

“…Logs are an important facility for fault-tolerant distributed systems since they allow to reliably store information that is needed to provide a global…”
Get full text

Asymmetric microbial reduction of ethyl and isopropyl α,1,3-trioxo-2-isoindolinebutyrate by MATZINGER, P. K, WIRZ, B, LEUENBERGER, H. G. W

“…Microorganisms are capable of the asymmetric reduction of various types of ketones. From a limited screening with 103 selected microbial strains two have been…”
Get full text

Structure and function of L-lactate dehydrogenases from thermophilic and mesophilic bacteria. III) The primary structure of thermophilic lactate dehydrogenase from Bacillus stearothermophilus. Hydroxylamine-, o-iodosobenzoic acid- and tryptic-fragments. The complete amino-acid sequence by Wirz, B, Suter, F, Zuber, H

“…Based on the partial sequence of the cyanogen bromide fragments [Tratschin, J.D., Wirz, B., Frank, G. and Zuber, H. (1983) Hoppe-Seyler's Z. Physiol. Chem…”
Get more information