Search Results - "WIRTH, Dagmar"

A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance by Zhao, Gang, Wirth, Dagmar, Schmitz, Ingo, Meyer-Hermann, Michael

“…Physiological insulin secretion exhibits various temporal patterns, the dysregulation of which is involved in diabetes development. We analyzed the impact of…”
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Neoantigen Expression in Steady-State Langerhans Cells Induces CTL Tolerance by Strandt, Helen, Pinheiro, Douglas Florindo, Kaplan, Daniel H, Wirth, Dagmar, Gratz, Iris Karina, Hammerl, Peter, Thalhamer, Josef, Stoecklinger, Angelika

“…The skin hosts a variety of dendritic cells (DCs), which act as professional APC to control cutaneous immunity. Langerhans cells (LCs) are the only DC subset…”
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Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis by Ziegler, Paul K., Bollrath, Julia, Pallangyo, Charles K., Matsutani, Takaji, Canli, Özge, De Oliveira, Tiago, Diamanti, Michaela A., Müller, Nina, Gamrekelashvili, Jaba, Putoczki, Tracy, Horst, David, Mankan, Arun K., Öner, Meryem G., Müller, Susanna, Müller-Höcker, Josef, Kirchner, Thomas, Slotta-Huspenina, Julia, Taketo, M. Mark, Reinheckel, Thomas, Dröse, Stefan, Larner, Andrew C., Wels, Winfried S., Ernst, Matthias, Greten, Tim F., Arkan, Melek C., Korn, Thomas, Wirth, Dagmar, Greten, Florian R.

“…In colorectal cancer patients, a high density of cytotoxic CD8+ T cells in tumors is associated with better prognosis. Using a Stat3 loss-of-function approach…”
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Mouse Models for Human Herpesviruses by Kutle, Ivana, Dittrich, Anne, Wirth, Dagmar

“…More than one hundred herpesviruses have been isolated from different species so far, with nine infecting humans. Infections with herpesviruses are…”
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3D culture conditions support Kaposi’s sarcoma herpesvirus (KSHV) maintenance and viral spread in endothelial cells by Dubich, Tatyana, Dittrich, Anne, Bousset, Kristine, Geffers, Robert, Büsche, Guntram, Köster, Mario, Hauser, Hansjörg, Schulz, Thomas F., Wirth, Dagmar

“…Kaposi’s sarcoma–associated herpesvirus (KSHV) is a human tumorigenic virus and the etiological agent of an endothelial tumor (Kaposi’s sarcoma) and two B cell…”
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Engineering of Chinese hamster ovary cells for co-overexpressing MYC and XBP1s increased cell proliferation and recombinant EPO production by Latorre, Yesenia, Torres, Mauro, Vergara, Mauricio, Berrios, Julio, Sampayo, Maria Molina, Gödecke, Natasha, Wirth, Dagmar, Hauser, Hansjörg, Dickson, Alan J., Altamirano, Claudia

“…Improving the cellular capacity of Chinese hamster ovary (CHO) cells to produce large amounts of therapeutic proteins remains a major challenge for the…”
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Controlled re-activation of epigenetically silenced Tet promoter-driven transgene expression by targeted demethylation by Gödecke, Natascha, Zha, Lisha, Spencer, Shawal, Behme, Sara, Riemer, Pamela, Rehli, Michael, Hauser, Hansjörg, Wirth, Dagmar

“…Faithful expression of transgenes in cell cultures and mice is often challenged by locus dependent epigenetic silencing. We investigated silencing of…”
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Targeting Kaposi's Sarcoma-Associated Herpesvirus ORF21 Tyrosine Kinase and Viral Lytic Reactivation by Tyrosine Kinase Inhibitors Approved for Clinical Use by Beauclair, Guillaume, Naimo, Eleonora, Dubich, Tatyana, Rückert, Jessica, Koch, Sandra, Dhingra, Akshay, Wirth, Dagmar, Schulz, Thomas F

“…Kaposi's sarcoma-associated herpesvirus (KSHV) is the cause of three human malignancies: Kaposi's sarcoma, primary effusion lymphoma, and the plasma cell…”
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Wilms' tumor 1 (WT1) antigen is overexpressed in Kaposi Sarcoma and is regulated by KSHV vFLIP by Morales, Ayana E, Gumenick, Ruby, Genovese, Caitlyn M, Jang, Yun Yeong, Ouedraogo, Ariene, Ibáñez de Garayo, Maite, Pannellini, Tania, Patel, Sanjay, Bott, Matthew E, Alvarez, Julio, Mun, Sung Soo, Totonchy, Jennifer, Gautam, Archana, Delgado de la Mora, Jesus, Chang, Stephanie, Wirth, Dagmar, Horenstein, Marcelo, Dao, Tao, Scheinberg, David A, Rubinstein, Paul G, Semeere, Aggrey, Martin, Jeffrey, Godfrey, Catherine C, Moser, Carlee B, Matining, Roy M, Campbell, Thomas B, Borok, Margaret Z, Krown, Susan E, Cesarman, Ethel

“…In people living with HIV, Kaposi Sarcoma (KS), a vascular neoplasm caused by KS herpesvirus (KSHV/HHV-8), remains one of the most common malignancies…”
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Expansion of functional personalized cells with specific transgene combinations by Lipps, Christoph, Klein, Franziska, Wahlicht, Tom, Seiffert, Virginia, Butueva, Milada, Zauers, Jeannette, Truschel, Theresa, Luckner, Martin, Köster, Mario, MacLeod, Roderick, Pezoldt, Jörn, Hühn, Jochen, Yuan, Qinggong, Müller, Peter Paul, Kempf, Henning, Zweigerdt, Robert, Dittrich-Breiholz, Oliver, Pufe, Thomas, Beckmann, Rainer, Drescher, Wolf, Riancho, Jose, Sañudo, Carolina, Korff, Thomas, Opalka, Bertram, Rebmann, Vera, Göthert, Joachim R., Alves, Paula M., Ott, Michael, Schucht, Roland, Hauser, Hansjörg, Wirth, Dagmar, May, Tobias

“…Fundamental research and drug development for personalized medicine necessitates cell cultures from defined genetic backgrounds. However, providing sufficient…”
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Cell Polarization and Epigenetic Status Shape the Heterogeneous Response to Type III Interferons in Intestinal Epithelial Cells by Bhushal, Sudeep, Wolfsmüller, Markus, Selvakumar, Tharini A, Kemper, Lucas, Wirth, Dagmar, Hornef, Mathias W, Hauser, Hansjörg, Köster, Mario

“…Type I and type III interferons (IFNs) are crucial components of the first-line antiviral host response. While specific receptors for both IFN types exist,…”
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Road to precision: recombinase-based targeting technologies for genome engineering by Wirth, Dagmar, Gama-Norton, Leonor, Riemer, Pamela, Sandhu, Upneet, Schucht, Roland, Hauser, Hansjörg

“…In the past years, recombinase-based approaches for integrating transgenes into defined chromosomal loci of mammalian cells have gained increasing attention…”
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Model-based analysis of influenza A virus replication in genetically engineered cell lines elucidates the impact of host cell factors on key kinetic parameters of virus growth by Laske, Tanja, Bachmann, Mandy, Dostert, Melanie, Karlas, Alexander, Wirth, Dagmar, Frensing, Timo, Meyer, Thomas F, Hauser, Hansjörg, Reichl, Udo

“…The best measure to limit spread of contagious diseases caused by influenza A viruses (IAVs) is annual vaccination. The growing global demand for low-cost…”
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A permanently growing human endothelial cell line supports productive infection with human cytomegalovirus under conditional cell growth arrest by Lieber, Diana, Hochdorfer, Daniel, Stoehr, Dagmar, Schubert, Axel, Lotfi, Ramin, May, Tobias, Wirth, Dagmar, Sinzger, Christian

“…Infection of vascular endothelial cells (ECs) is assumed to contribute to dissemination of human cytomegalovirus (HCMV). Investigation of virus-host…”
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The Immunomodulatory CEA Cell Adhesion Molecule 6 (CEACAM6/CD66c) Is a Protein Receptor for the Influenza a Virus by Rahman, Shah Kamranur, Ansari, Mairaj Ahmed, Gaur, Pratibha, Ahmad, Imtiyaz, Chakravarty, Chandrani, Verma, Dileep Kumar, Sharma, Anshika, Chhibber, Sanjay, Nehal, Naila, Wirth, Dagmar, Lal, Sunil K

“…To establish a productive infection in host cells, viruses often use one or multiple host membrane glycoproteins as their receptors. For Influenza A virus…”
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Effective intrahepatic CD8＋ T-cell immune responses are induced by low but not high numbers of antigen-expressing hepatocytes by Ochel, Aaron, Cebula, Marcin, Riehn, Mathias, Hillebrand, Upneet, Lipps, Christoph, Schirmbeck, Reinhold, Hauser, Hansjörg, Wirth, Dagmar

“…Liver infections with hepatotropic viruses, such as hepatitis B virus and hepatitis C virus are accompanied by viral persistence and immune failure. CD8＋ T…”
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Reversible silencing of cytomegalovirus genomes by type I interferon governs virus latency by Dağ, Franziska, Dölken, Lars, Holzki, Julia, Drabig, Anja, Weingärtner, Adrien, Schwerk, Johannes, Lienenklaus, Stefan, Conte, Ianina, Geffers, Robert, Davenport, Colin, Rand, Ulfert, Köster, Mario, Weiß, Siegfried, Adler, Barbara, Wirth, Dagmar, Messerle, Martin, Hauser, Hansjörg, Cičin-Šain, Luka

“…Herpesviruses establish a lifelong latent infection posing the risk for virus reactivation and disease. In cytomegalovirus infection, expression of the major…”
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Identification of a Predominantly Interferon-λ-Induced Transcriptional Profile in Murine Intestinal Epithelial Cells by Selvakumar, Tharini A, Bhushal, Sudeep, Kalinke, Ulrich, Wirth, Dagmar, Hauser, Hansjörg, Köster, Mario, Hornef, Mathias W

“…Type I (α and β) and type III (λ) interferons (IFNs) induce the expression of a large set of antiviral effector molecules their respective surface membrane…”
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Endothelial derived, secreted long non-coding RNAs Gadlor1 and Gadlor2 aggravate cardiac remodeling by Keles, Merve, Grein, Steve, Froese, Natali, Wirth, Dagmar, Trogisch, Felix A., Wardman, Rhys, Hemanna, Shruthi, Weinzierl, Nina, Koch, Philipp-Sebastian, Uhlig, Stefanie, Lomada, Santosh, Dittrich, Gesine M., Szaroszyk, Malgorzata, Haustein, Ricarda, Hegermann, Jan, Martin-Garrido, Abel, Bauersachs, Johann, Frank, Derk, Frey, Norbert, Bieback, Karen, Cordero, Julio, Dobreva, Gergana, Wieland, Thomas, Heineke, Joerg

“…Pathological cardiac remodeling predisposes individuals to developing heart failure. Here, we investigated two co-regulated long non-coding RNAs (lncRNAs),…”
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The CpG-sites of the CBX3 ubiquitous chromatin opening element are critical structural determinants for the anti-silencing function by Kunkiel, Jessica, Gödecke, Natascha, Ackermann, Mania, Hoffmann, Dirk, Schambach, Axel, Lachmann, Nico, Wirth, Dagmar, Moritz, Thomas

“…Suppression of therapeutic transgene expression from retroviral gene therapy vectors by epigenetic defence mechanisms represents a problem that is particularly…”
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