Search Results - "WINTER, Steven M"

The role of absorption, distribution, metabolism, excretion and toxicity in drug discovery by Lin, Jing, Sahakian, Diana C, de Morais, Sonia M F, Xu, Jinghai J, Polzer, Robert J, Winter, Steven M

“…Major reasons preventing many early candidates reaching market are the inappropriate ADME (absorption, distribution, metabolism and excretion) properties and…”
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Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor by JANI, Jitesh P, FINN, Richard S, MORRIS, Joel, MOYER, James D, PUSTILNIK, Leslie R, RAFIDI, Kristina, RALSTON, Sherry, ROSSI, Ann Marie K, STEYN, Stefanus J, WAGNER, Larry, WINTER, Steven M, BHATTACHARYA, Samit K, CAMPBELL, Mary, COLEMAN, Kevin G, CONNELL, Richard D, CURRIER, Nicolas, EMERSON, Erling O, FLOYD, Eugenia, HARRIMAN, Shawn, KATH, John C

“…Amplification and overexpression of erbB2 (Her-2/neu) proto-oncogene has been linked to human malignancies including tumors of the breast, ovary, and stomach…”
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Synthesis and Oral Efficacy of a 4-(Butylethylamino)pyrrolo[2,3-d]pyrimidine:  A Centrally Active Corticotropin-Releasing Factor1 Receptor Antagonist by Chen, Yuhpyng L, Mansbach, Robert S, Winter, Steven M, Brooks, Elizabeth, Collins, Judith, Corman, Michael L, Dunaiskis, Audrey R, Faraci, W. Stephen, Gallaschun, Randall J, Schmidt, Anne, Schulz, David W

“…The syntheses of a centrally active nonpeptide CRF1 receptor antagonist 2,…”
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Tissue distribution and elimination of indium in male Fischer 344 rats following oral and intratracheal administration of indium phosphide by Zheng, W, Winter, S M, Kattnig, M J, Carter, D E, Sipes, I G

“…The use of indium phosphide (InP) in the semiconductor industry has raised concerns about potential occupational exposure. The tissue distribution and…”
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Synthesis and Oral Efficacy of a 4-(Butylethylamino)pyrrolo[2,3- d ]pyrimidine:  A Centrally Active Corticotropin-Releasing Factor 1 Receptor Antagonist by Chen, Yuhpyng L., Mansbach, Robert S., Winter, Steven M., Brooks, Elizabeth, Collins, Judith, Corman, Michael L., Dunaiskis, Audrey R., Faraci, W. Stephen, Gallaschun, Randall J., Schmidt, Anne, Schulz, David W.

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Stereoselective aliphatic hydroxylation of 6-n-propylchromone-2-carboxylic acid by female Dutch rabbits by Winter, S M, Caldwell, J

“…6-n-Alkylchromone-2-carboxylic acids are metabolized solely by aliphatic oxidation. In the rabbit, the 6-n-propyl congener (PCCA) undergoes omega-1…”
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