Search Results - "WINSTON, R. M. L"

The 40th anniversary of human IVF: time to celebrate and time to reflect by Winston, R M L

Get full text

High fat diet causes distinct aberrations in the testicular proteome by Jarvis, S., Gethings, L. A., Samanta, L., Pedroni, S. M. A., Withers, D. J., Gray, N., Plumb, R. S., Winston, R. M. L., Williamson, C., Bevan, C. L.

“…Diet has important effects on normal physiology and the potential deleterious effects of high fat diets and obesity on male reproductive health are being…”
Get full text

Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification by Handyside, A. H, Kontogianni, E. H, Hardy, K, Winston, R. M. L

“…Over 200 recessive X chromosome-linked diseases, typically affecting only hemizygous males, have been identified. In many of these, prenatal diagnosis is…”
Get full text

Effects of pyruvate and glucose on the development of human preimplantation embryos in vitro by Conaghan, J, Handyside, A H, Winston, R M, Leese, H J

“…Although human embryos will develop in vitro for six days or more, little is known about the effects of the primary nutrients, pyruvate and glucose, on…”
Get full text

Increased number of cells and metabolic activity in male human preimplantation embryos following in vitro fertilization by Ray, P F, Conaghan, J, Winston, R M, Handyside, A H

“…The number of cells and metabolic activity of male and female human preimplantation embryos were examined to determine whether male embryos are more advanced…”
Get full text

Binucleate blastomeres in preimplantation human embryos in vitro: failure of cytokinesis during early cleavage by Hardy, K, Winston, R M, Handyside, A H

“…The nuclei of disaggregated blastomeres from two hundred preimplantation human embryos were examined between days 2 and 4 after insemination in vitro by vital…”
Get full text

From Cell Death to Embryo Arrest: Mathematical Models of Human Preimplantation Embryo Development by Hardy, K., Spanos, S., Becker, D., Iannelli, P., Winston, R. M. L., Stark, J.

“…Human preimplantation embryos exhibit high levels of apoptotic cells and high rates of developmental arrest during the first week in vitro. The relation…”
Get full text

Caspase activity and expression of cell death genes during development of human preimplantation embryos by Spanos, S, Rice, S, Karagiannis, P, Taylor, D, Becker, DL, Winston, RM, Hardy, K

“…It has been observed that apoptosis occurs in human blastocysts. In other types of cell, the characteristic morphological changes seen in apoptotic cells are…”
Get full text

Activity of enzymes of energy metabolism in single human preimplantation embryos by Martin, K L, Hardy, K, Winston, R M, Leese, H J

“…A method was developed to measure the activities of enzymes in extracts from single human preimplantation embryos. The method permits the analysis of two…”
Get full text

Cellular basis of luteal steroidogenesis in the human ovary by Fisch, B, Margara, R A, Winston, R M, Hillier, S G

“…A primary monolayer cell culture system was developed to investigate human corpus luteum (CL) function in vitro. Steroidogenic cells were isolated by…”
Get more information

First application of preimplantation genetic diagnosis to neurofibromatosis type 2 (NF2) by Abou-Sleiman, P. M., Apessos, A., Harper, J. C., Serhal, P., Winston, R. M. L., Delhanty, J. D. A.

“…Neurofibromatosis type 2 (NF2) is a dominantly inherited cancer predisposition syndrome that is caused bymutations in the NF2 gene. We report here the first…”
Get full text

Energy metabolism of the human Fallopian tube by Brewis, I A, Winston, R M, Leese, H J

“…The consumption of oxygen ( Q O 2 ), the production of lactate and the profile of four key metabolic enzymes were measured in small samples of human oviductal…”
Get full text

Rapid sexing of human embryos by non-radioactive in situ hybridization: potential for preimplantation diagnosis of X-linked disorders by Penketh, R J, Delhanty, J D, van den Berghe, J A, Finklestone, E M, Handyside, A H, Malcolm, S, Winston, R M

“…Sixty spare human embryos at various stages of preimplantation development were prepared for cytogenetic analysis. Fluorescent staining of those with…”
Get more information

Profiles of hypoxanthine guanine phosphoribosyl transferase and adenine phosphoribosyl transferase activities measured in single preimplantation human embryos by high-performance liquid chromatography by Leese, H J, Humpherson, P G, Hardy, K, Hooper, M A, Winston, R M, Handyside, A H

“…The profiles of hypoxanthine guanine phosphoribosyl transferase (HGPRT) and adenine phosphoribosyl transferase (APRT) activities were examined in normally…”
Get full text

In vitro fertilization treatment in genital tuberculosis by SOUSSIS, I, TREW, G, MATALLIOTAKIS, I, MARGARA, R, WINSTON, R. M. L

“…We describe our experience with in vitro fertilization (IVF) treatment in 13 women with histologically proven genital tuberculosis. For IVF treatment the above…”
Get full text

Microsurgical salpingostomy is not an obsolete procedure by Winston, R M, Margara, R A

“…A review of the results of microsurgery for bilateral distal tubal blockage. A retrospective review. Hammersmith Hospital London and local private hospitals…”
Get more information

Serum oestradiol and preovulatory follicular development before in-vitro fertilization by Hillier, S G, Parsons, J H, Margara, R A, Winston, R M, Crofton, M E

“…Twenty-three in-vitro fertilization (IVF) treatment cycles (four unstimulated and 19 clomiphene-stimulated) were assessed retrospectively to discern…”
Get more information

Inhibition of oestradiol production by epidermal growth factor in human granulosa cells of normal and polycystic ovaries by Mason, H D, Margara, R, Winston, R M, Beard, R W, Reed, M J, Franks, S

“…Anovulation in women with polycystic ovary syndrome results from a disorder of FSH-mediated follicular maturation which may involve paracrine modulation of FSH…”
Get more information

Sporadic Perrault syndrome by Nikolaou, D S, Winston, R M

“…The case of a child born deaf who developed primary gonadal dysgenesis at age 14 is reported. She was diagnosed with Perrault syndrome, which is characterized…”
Get full text

Does Government Regulation Inhibit Embryonic Stem Cell Research and Can It Be Effective? by Winston, R.M.L.

“…The UK was one of the first countries to introduce legislation regulating embryo research, and the British Parliament has taken a liberal view of the field…”
Get full text