Search Results - "WINK, D. A"

NO Synthase 2 (NOS2) Deletion Promotes Multiple Pathologies in a Mouse Model of Alzheimer's Disease by Colton, C. A., Vitek, M. P., Wink, D. A., Xu, Q., Cantillana, V., Previti, M. L., Van Nostrand, W. E., Weinberg, B., Dawson, H.

“…Alzheimer's disease is characterized by two primary pathological features: amyloid plaques and neurofibrillary tangles. The interconnection between amyloid and…”
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The multifaceted roles of nitric oxide in cancer by WINK, D. A, VODOVOTZ, Y, LAVAL, J, LAVAL, F, DEWHIRST, M. W, MITCHELL, J. B

“…The roles of nitric oxide (NO) in numerous disease states have generated considerable discussion over the past several years. NO has been labeled as the…”
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Modulation of angiogenesis by dithiolethione‐modified NSAIDs and valproic acid by Isenberg, J S, Jia, Y, Field, L, Ridnour, L A, Sparatore, A, Soldato, P, Sowers, A L, Yeh, G C, Moody, T W, Wink, D A, Ramchandran, R, Roberts, D D

“…Background and purpose: Angiogenesis involves multiple signaling pathways that must be considered when developing agents to modulate pathological angiogenesis…”
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Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity by Switzer, C H, Ridnour, L A, Cheng, R Y S, Sparatore, A, Del Soldato, P, Moody, T W, Vitek, M P, Roberts, D D, Wink, D A

“…The chemopreventative effects of dithiolethione compounds are attributed to their activation of antioxidant response elements (AREs) by reacting with the…”
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The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations by Ridnour, Lisa A, Thomas, Douglas D, Mancardi, Daniele, Espey, Michael G, Miranda, Katrina M, Paolocci, Nazareno, Feelisch, Martin, Fukuto, Jon, Wink, David A

“…This review addresses many of the chemical aspects of nitrosative stress mediated by N2O3. From a cellular perspective, N2O3 and the resulting reactive…”
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Nitric Oxide Protects Against Cellular Damage and Cytotoxicity From Reactive Oxygen Species by Wink, David A., Hanbauer, Ingeborg, Krishna, Murali C., DeGraff, William, Gamson, Janet, Mitchell, James B.

“…Nitric oxide, NO, which is generated by various components of the immune system, has been presumed to be cytotoxic. However, NO has been proposed to be…”
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Chemistry of the Diazeniumdiolates. 2. Kinetics and Mechanism of Dissociation to Nitric Oxide in Aqueous Solution by Davies, Keith M, Wink, David A, Saavedra, Joseph E, Keefer, Larry K

“…Diazeniumdiolate ions of structure R2N[N(O)NO]- (1) are of pharmacological interest because they spontaneously generate the natural bioregulatory species,…”
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Review article: chronic inflammation and reactive oxygen and nitrogen metabolism – implications in DNA damage and mutagenesis by Grisham, M. B., Jourd'Heuil, D., Wink, D. A.

“…Summary It is well known that chronic inflammation of the digestive tract is associated with an increased risk of malignant transformation. Because phagocytic…”
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Targeting SET I PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy by Switzer, C H, Cheng, R Y S, Vitek, T M, Christensen, D J, Wink, D A, Vitek, M P

“…The SET oncoprotein participates in cancer progression by affecting multiple cellular processes, inhibiting the tumor suppressor protein phosphatase 2A (PP2A),…”
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Targeting SET/I2PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy by Switzer, C H, Cheng, R Y S, Vitek, T M, Christensen, D J, Wink, D A, Vitek, M P

“…The SET oncoprotein participates in cancer progression by affecting multiple cellular processes, inhibiting the tumor suppressor protein phosphatase 2A (PP2A),…”
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Regulation and control of nitric oxide (NO) in macrophages: Protecting the “professional killer cell” from its own cytotoxic arsenal via MRP1 and GSTP1 by Kovacevic, Z., Sahni, S., Lok, H., Davies, M.J., Wink, D.A., Richardson, D.R.

“…We recently demonstrated that a novel storage and transport mechanism for nitric oxide (NO) mediated by glutathione-S-transferase P1 (GSTP1) and multidrug…”
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Nitroxyl anion regulation of the NMDA receptor by Colton, C. A., Gbadegesin, M., Wink, D. A., Miranda, K. M., Espey, M. G., Vicini, S.

“…Nitric oxide (NO) is an important regulator of NMDA channel function in the CNS. Recent findings suggest that nitroxyl anion (NO−) may also be generated by…”
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Autoxidation kinetics of aqueous nitric oxide by Ford, Peter C., Wink, David A., Stanbury, David M.

“…Reports on the kinetics of the autoxidation of aqueous nitric oxide are discussed. It is concluded that the correct rate law is -d[NO]/d t = 4 k aq[NO] 2 [O 2]…”
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The Fpg protein, a DNA repair enzyme, is inhibited by the biomediator nitric oxide in vitro and in vivo by Wink, D A, Laval, J

“…Nitric oxide has been shown to be a mediator molecule in the regulation of many physiological functions. However, this small diatomic molecule in the presence…”
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Nitric oxide potentiates hydrogen peroxide-induced killing of Escherichia coli by Pacelli, R, Wink, D A, Cook, J A, Krishna, M C, DeGraff, W, Friedman, N, Tsokos, M, Samuni, A, Mitchell, J B

“…Previously, we reported that nitric oxide (NO) provides significant protection to mammalian cells from the cytotoxic effects of hydrogen peroxide (H2O2)…”
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Nitric oxide inhibits DNA ligase activity: potential mechanisms for NO-mediated DNA damage by Graziewicz, Maria, Wink, David A., Laval, Francoise

“…Nitric oxide-induced modifications of DNA occur either by directly altering DNA chemically through reactive nitrogen oxide species (RNOS) or indirectly by…”
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Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media : determination of the kinetics for oxidation and nitrosation by intermediates generated in the NO/O2 reaction by WINK, D. A, DARBYSHIRE, J. F, NIMS, R. W, SAAVEDRA, J. E, FORD, P. C

“…The reaction kinetics of nitric oxide autoxidation in aerobic solutions were investigated by direct observation of the nitrite ion product and by trapping the…”
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Production of reactive oxygen species after reperfusion in vitro and in vivo: protective effect of nitric oxide by MASON, R. B, PLUTA, R. M, WALBRIDGE, S, WINK, D. A, OLDFIELD, E. H, BOOCK, R. J

“…Thrombolytic treatments for ischemic stroke can restore circulation, but reperfusion injury, mediated by oxygen free radicals, can limit their utility. The…”
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Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects by Maragos, Chris M, Morley, Deborah, Wink, David A, Dunams, Tambra M, Saavedra, Joseph E, Hoffman, Aaron, Bove, Alfred A, Isaac, Lawrence, Hrabie, Joseph A, Keefer, Larry K

“…Selected nucleophile/nitric oxide adducts [compounds which contain the anionic moiety, XN(O-)N = O] were studied for their ability to release nitric oxide…”
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Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide by Wink, David A., Mitchell, James B.

“…There has been confusion as to what role(s) nitric oxide (NO) has in different physiological and pathophysiological mechanisms. Some studies imply that NO has…”
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