Search Results - "WINCHESTER, Lee C"

In-vitro and in-vivo assessment of nirmatrelvir penetration into CSF, central nervous system cells, tissues, and peripheral blood mononuclear cells by Avedissian, Sean N., Malik, Johid R., Podany, Anthony T., Neely, Michael, Rhodes, Nathaniel J., Scarsi, Kimberly K., Scheetz, Marc H., Duryee, Michael J., Modebelu, Ukamaka O., Mykris, Timothy M., Winchester, Lee C., Byrareddy, Siddappa N., Fletcher, Courtney V.

“…Three years after SARS-CoV-2 emerged as a global infectious threat, the virus has become endemic. The neurological complications such as depression, anxiety,…”
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CD8+ cells and small viral reservoirs facilitate post-ART control of SIV replication in M3+ Mauritian cynomolgus macaques initiated on ART two weeks post-infection by Harwood, Olivia E, Matschke, Lea M, Moriarty, Ryan V, Balgeman, Alexis J, Weaver, Abigail J, Ellis-Connell, Amy L, Weiler, Andrea M, Winchester, Lee C, Fletcher, Courtney V, Friedrich, Thomas C, Keele, Brandon F, O'Connor, David H, Lang, Jessica D, Reynolds, Matthew R, O'Connor, Shelby L

“…Sustainable HIV remission after antiretroviral therapy (ART) withdrawal, or post-treatment control (PTC), remains a top priority for HIV treatment. We observed…”
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An Efficient Humanized Mouse Model for Oral Anti-Retroviral Administration by Virdi, Amber K, Ho, Sang, Seaton, Melanie S, Olali, Arnold Z, Narasipura, Srinivas D, Barbian, Hannah J, Olivares, Leannie J, Gonzalez, Hemil, Winchester, Lee C, Podany, Anthony T, Ross, Ryan D, Al-Harthi, Lena, Wallace, Jennillee

“…HIV anti-retrovirals (ARVs) have vastly improved the life expectancy of people living with HIV (PLWH). However, toxic effects attributed to long-term ARV use…”
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Cross-validation of a high-performance liquid chromatography nevirapine plasma assay in a resource-limited setting in Zimbabwe by Makita-Chingombe, Faithful, Podany, Anthony T., Mykris, Timothy, Muzambi, Farai, Browne, Richard W., Ocque, Andrew J., DiFrancesco, Robin, Winchester, Lee C., Fletcher, Courtney V., Mudzviti, Tinashe, Maponga, Charles C., Morse, Gene D.

“…An international HIV pharmacology specialty laboratory (PSL) was established at the University of Zimbabwe to increase bioanalytical and investigator…”
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The Lymphoid Tissue Pharmacokinetics of Tenofovir Disoproxil Fumarate and Tenofovir Alafenamide in HIV‐Infected Persons by Fletcher, Courtney V., Podany, Anthony T., Thorkelson, Ann, Winchester, Lee C., Mykris, Timothy, Anderson, Jodi, Jorstad, Siri, Baker, Jason V., Schacker, Timothy W.

“…The secondary lymphoid tissues (LT), lymph nodes (LN) and gut‐associated lymphoid tissue are the primary sites of HIV replication and where the latent pool of…”
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Alterations in P-Glycoprotein Expression and Function Between Macrophage Subsets by Cory, Theodore J., He, Hui, Winchester, Lee C., Kumar, Santosh, Fletcher, Courtney V.

“…Purpose Macrophages are an important cellular reservoir in HIV, and exist in two phenotypically dissimilar subsets, the pro-inflammatory M1 phenotype, and the…”
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Hepatocytic transcriptional signatures predict comparative drug interaction potential of rifamycin antibiotics by Dyavar, Shetty Ravi, Mykris, Timothy M., Winchester, Lee C., Scarsi, Kimberly K., Fletcher, Courtney V., Podany, Anthony T.

“…Current strategies to treat tuberculosis (TB) and co-morbidities involve multidrug combination therapies. Rifamycin antibiotics are a key component of TB…”
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Quantification of nine antiretroviral drugs in cerebrospinal fluid: An approach to overcome sample collection tube adsorption by Mykris, Timothy M., Weinhold, Jonathan, Winchester, Lee C., Scarsi, Kimberly K., Fletcher, Courtney V., Podany, Anthony T., Avedissian, Sean N.

“…•A LC-MS/MS method was developed and validated for nine antiretrovirals.•Ammonium hydroxide was used to remedy adsorption issues caused by polypropylene based…”
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Assessing the lymphoid tissue bioavailability of antiretrovirals in human primary lymphoid endothelial cells and in mice by Dyavar, Shetty Ravi, Gautam, Nagsen, Podany, Anthony T, Winchester, Lee C, Weinhold, Jonathan A, Mykris, Timothy M, Campbell, Kayla M, Alnouti, Yazen, Fletcher, Courtney V

“…Abstract Background The secondary lymphoid tissues (LTs), lymph nodes (LNs) and gut-associated lymphoid tissue (GALT) are considered reservoirs for HIV…”
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Intramuscular and subcutaneous administration of antiretroviral drugs, compared with oral, enhances delivery to lymphoid tissues in BALB/c mice by Dyavar, Shetty Ravi, Kumar, Sushil, Gautam, Nagsen, Podany, Anthony T, Winchester, Lee C, Weinhold, Jonathan A, Mykris, Timothy M, Nallasamy, Palanisamy, Alnouti, Yazen, Fletcher, Courtney V

“…Abstract Background Multiple tissue reservoirs are established soon after HIV infection, and some tissues may also be pharmacological sanctuaries. Parenteral…”
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Adipocytes impair efficacy of antiretroviral therapy by Couturier, Jacob, Winchester, Lee C., Suliburk, James W., Wilkerson, Gregory K., Podany, Anthony T., Agarwal, Neeti, Xuan Chua, Corrine Ying, Nehete, Pramod N., Nehete, Bharti P., Grattoni, Alessandro, Sastry, K. Jagannadha, Fletcher, Courtney V., Lake, Jordan E., Balasubramanyam, Ashok, Lewis, Dorothy E.

“…Adequate distribution of antiretroviral drugs to infected cells in HIV patients is critical for viral suppression. In humans and primates, HIV- and…”
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Comparison of etonogestrel bioanalytical assay results in plasma and serum within and across laboratories by Sunagawa, Shawnalyn W., Winchester, Lee C., Wichman, Christopher S., Avedissian, Sean N., Erikson, David W., Kernan, Molly, Marzinke, Mark A., Mykris, Timothy M., Nandakumar, Renu, Nolin, Thomas D., Podany, Anthony T., West, Raymond E., Chen, Beatrice A., Chappell, Catherine A., Scarsi, Kimberly K.

“…To compare performance characteristics of etonogestrel bioanalytical assays across laboratories. We conducted a blinded, six laboratory study: five academic…”
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Normalization of cell associated antiretroviral drug concentrations with a novel RPP30 droplet digital PCR assay by Dyavar, Shetty Ravi, Ye, Zhen, Byrareddy, Siddappa N., Scarsi, Kimberly K., Winchester, Lee C., Weinhold, Jonathan A., Fletcher, Courtney V., Podany, Anthony T.

“…Quantification of antiretroviral (ARV) drug concentrations in peripheral blood mononuclear cells (PBMCs) and tissue isolated mononuclear cells (TIMCs) from…”
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Development, validation and utilization of a highly sensitive LC-MS/MS method for quantification of levonorgestrel released from a subdermal implant in human plasma by Cirrincione, Lauren R., Penchala, Sujan Dilly, Scarsi, Kimberly K., Podany, Anthony T., Winchester, Lee C., Back, David J., Khoo, Saye H., Fletcher, Courtney V., Siccardi, Marco, Else, Laura J.

“…Levonorgestrel (LNG) is a synthetic progestin that is available in oral contraceptive tablets, a subdermal implant, and an intrauterine system for…”
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Quantification of Cell-Associated Atazanavir, Darunavir, Lopinavir, Ritonavir, and Efavirenz Concentrations in Human Mononuclear Cell Extracts by PODANY, Anthony T, WINCHESTER, Lee C, ROBBINS, Brian L, FLETCHER, Courtney V

“…An ultrasensitive assay utilizing high-pressure liquid chromatography and mass spectrometry detection was developed and validated for the quantification of the…”
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Impact of efavirenz pharmacokinetics and pharmacogenomics on neuropsychological performance in older HIV-infected patients by Sandkovsky, Uriel, Podany, Anthony T, Fletcher, Courtney V, Owen, Andrew, Felton-Coleman, Angela, Winchester, Lee C, Robertson, Kevin, Swindells, Susan

“…Pharmacokinetics (PK) and pharmacodynamics of efavirenz and its 8-hydroxy metabolite (8-OH-efavirenz) have not been robustly evaluated in older HIV-infected…”
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Determination of the rifamycin antibiotics rifabutin, rifampin, rifapentine and their major metabolites in human plasma via simultaneous extraction coupled with LC/MS/MS by Winchester, Lee C., Podany, Anthony T., Baldwin, Joshua S., Robbins, Brian L., Fletcher, Courtney V.

“…•Validated simultaneous LC/MS assay for rifabutin, rifampin and rifapentine.•High clinical utility to support pharmacokinetic and drug–drug interaction…”
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The anti-HIV drug abacavir stimulates β-catenin activity in osteoblast lineage cells by Olali, Arnold Z, Wallace, Jennillee, Gonzalez, Hemil, Carpenter, Kelsey A, Patel, Niyati, Winchester, Lee C, Podany, Anthony T, Venkatesh, Ishwarya, Narasipura, Srinivas D, Al-Harthi, Lena, Ross, Ryan D

“…Bone mineral density (BMD) loss in people living with HIV occurs with the initiation of combined antiretroviral therapy (cART), particularly with tenofovir…”
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A rapid spin through oil results in higher cell-associated concentrations of antiretrovirals compared with conventional cell washing by Cory, Theodore J, Winchester, Lee C, Robbins, Brian L, Fletcher, Courtney V

“…Determination of cell-associated antiretroviral drug concentrations is necessary for research into reservoirs of HIV. Variation exists in cell-associated drug…”
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Enhancing antiretroviral drug penetration into lymph nodes through intramuscular and subcutaneous routes of administration in BALB/c mice by Shetty Ravi Dyavar, Sushil Kumar, Nagsen Gautam, Anthony T. Podany, Lee C. Winchester, Jonathan A. Weinhold, Timothy M. Mykris, Kayla M. Campbell, Palanisamy Nallasamy, Yazen Alnouti, Courtney V. Fletcher

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