Search Results - "WILTON, Daniel"

Neuron-Glia Signaling in Synapse Elimination by Wilton, Daniel K, Dissing-Olesen, Lasse, Stevens, Beth

“…Maturation of neuronal circuits requires selective elimination of synaptic connections. Although neuron-intrinsic mechanisms are important in this process, it…”
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The contribution of glial cells to Huntington's disease pathogenesis by Wilton, Daniel K., Stevens, Beth

“…Glial cells play critical roles in the normal development and function of neural circuits, but in many neurodegenerative diseases, they become dysregulated and…”
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c-Jun Reprograms Schwann Cells of Injured Nerves to Generate a Repair Cell Essential for Regeneration by Arthur-Farraj, Peter J., Latouche, Morwena, Wilton, Daniel K., Quintes, Susanne, Chabrol, Elodie, Banerjee, Ambily, Woodhoo, Ashwin, Jenkins, Billy, Rahman, Mary, Turmaine, Mark, Wicher, Grzegorz K., Mitter, Richard, Greensmith, Linda, Behrens, Axel, Raivich, Gennadij, Mirsky, Rhona, Jessen, Kristján R.

“…The radical response of peripheral nerves to injury (Wallerian degeneration) is the cornerstone of nerve repair. We show that activation of the transcription…”
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CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development by Lehrman, Emily K., Wilton, Daniel K., Litvina, Elizabeth Y., Welsh, Christina A., Chang, Stephen T., Frouin, Arnaud, Walker, Alec J., Heller, Molly D., Umemori, Hisashi, Chen, Chinfei, Stevens, Beth

“…Microglia regulate synaptic circuit remodeling and phagocytose synaptic material in the healthy brain; however, the mechanisms directing microglia to engulf…”
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Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts by Loh, Ken H., Stawski, Philipp S., Draycott, Austin S., Udeshi, Namrata D., Lehrman, Emily K., Wilton, Daniel K., Svinkina, Tanya, Deerinck, Thomas J., Ellisman, Mark H., Stevens, Beth, Carr, Steven A., Ting, Alice Y.

“…Cellular compartments that cannot be biochemically isolated are challenging to characterize. Here we demonstrate the proteomic characterization of the synaptic…”
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Neurotoxic reactive astrocytes are induced by activated microglia by Liddelow, Shane A., Guttenplan, Kevin A., Clarke, Laura E., Bennett, Frederick C., Bohlen, Christopher J., Schirmer, Lucas, Bennett, Mariko L., Münch, Alexandra E., Chung, Won-Suk, Peterson, Todd C., Wilton, Daniel K., Frouin, Arnaud, Napier, Brooke A., Panicker, Nikhil, Kumar, Manoj, Buckwalter, Marion S., Rowitch, David H., Dawson, Valina L., Dawson, Ted M., Stevens, Beth, Barres, Ben A.

“…Reactive astrocytes are strongly induced by central nervous system (CNS) injury and disease, but their role is poorly understood. Here we show that a subtype…”
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A complement–microglial axis drives synapse loss during virus-induced memory impairment by Vasek, Michael J., Garber, Charise, Dorsey, Denise, Durrant, Douglas M., Bollman, Bryan, Soung, Allison, Yu, Jinsheng, Perez-Torres, Carlos, Frouin, Arnaud, Wilton, Daniel K., Funk, Kristen, DeMasters, Bette K., Jiang, Xiaoping, Bowen, James R., Mennerick, Steven, Robinson, John K., Garbow, Joel R., Tyler, Kenneth L., Suthar, Mehul S., Schmidt, Robert E., Stevens, Beth, Klein, Robyn S.

“…People infected with West Nile virus often experience cognitive side effects including memory loss through unknown mechanisms; mice and humans infected with…”
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FEAST: A flow cytometry-based toolkit for interrogating microglial engulfment of synaptic and myelin proteins by Dissing-Olesen, Lasse, Walker, Alec J., Feng, Qian, Barr, Helena J., Walker, Alicia C., Xie, Lili, Wilton, Daniel K., Das, Indrani, Benowitz, Larry I., Stevens, Beth

“…Although engulfment is a hallmark of microglia function, fully validated platforms that facilitate high-throughput quantification of this process are lacking…”
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Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington’s disease by Wilton, Daniel K., Mastro, Kevin, Heller, Molly D., Gergits, Frederick W., Willing, Carly Rose, Fahey, Jaclyn B., Frouin, Arnaud, Daggett, Anthony, Gu, Xiaofeng, Kim, Yejin A., Faull, Richard L. M., Jayadev, Suman, Yednock, Ted, Yang, X. William, Stevens, Beth

“…Huntington’s disease (HD) is a devastating monogenic neurodegenerative disease characterized by early, selective pathology in the basal ganglia despite the…”
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Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice by Lim, Ryan G, Salazar, Lisa L, Wilton, Daniel K, King, Alvin R, Stocksdale, Jennifer T, Sharifabad, Delaram, Lau, Alice L, Stevens, Beth, Reidling, Jack C, Winokur, Sara T, Casale, Malcolm S, Thompson, Leslie M, Pardo, Mónica, Díaz-Barriga, A Gerardo García, Straccia, Marco, Sanders, Phil, Alberch, Jordi, Canals, Josep M, Kaye, Julia A, Dunlap, Mariah, Jo, Lisa, May, Hanna, Mount, Elliot, Anderson-Bergman, Cliff, Haston, Kelly, Finkbeiner, Steven, Kedaigle, Amanda J, Gipson, Theresa A, Yildirim, Ferah, Ng, Christopher W, Milani, Pamela, Housman, David E, Fraenkel, Ernest, Allen, Nicholas D, Kemp, Paul J, Atwal, Ranjit Singh, Biagioli, Marta, Gusella, James F, MacDonald, Marcy E, Akimov, Sergey S, Arbez, Nicolas, Stewart, Jacqueline, Ross, Christopher A, Mattis, Virginia B, Tom, Colton M, Ornelas, Loren, Sahabian, Anais, Lenaeus, Lindsay, Mandefro, Berhan, Sareen, Dhruv, Svendsen, Clive N

“…The Huntington's disease (HD) induced pluripotent stem cell (iPSC) consortium describe the combined use of differentiated patient-derived iPSCs and systems…”
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Microglial-derived C1q integrates into neuronal ribonucleoprotein complexes and impacts protein homeostasis in the aging brain by Scott-Hewitt, Nicole, Mahoney, Matthew, Huang, Youtong, Korte, Nils, Yvanka de Soysa, T, Wilton, Daniel K, Knorr, Emily, Mastro, Kevin, Chang, Allison, Zhang, Allison, Melville, David, Schenone, Monica, Hartigan, Christina, Stevens, Beth

“…Neuroimmune interactions mediate intercellular communication and underlie critical brain functions. Microglia, CNS-resident macrophages, modulate the brain…”
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Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity by Parkinson, David B, Feltri, M Laura, Jessen, Kristján R, D'Antonio, Maurizio, Wilton, Daniel K, Mirsky, Rhona, Meijer, Dies, Woodhoo, Ashwin, Radtke, Freddy, Shen, Jie, Droggiti, Anna, Simons, Paul, Alonso, Maria B Duran, Guillemot, Francois, Wrabetz, Lawrence, Turmaine, Mark, Al-Shawi, Raya

“…Although the role of Notch signaling in CNS glial development is well established, its participation in peripheral glial development is still unclear. This…”
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Astrocytes refine cortical connectivity at dendritic spines by Risher, W Christopher, Patel, Sagar, Kim, Il Hwan, Uezu, Akiyoshi, Bhagat, Srishti, Wilton, Daniel K, Pilaz, Louis-Jan, Singh Alvarado, Jonnathan, Calhan, Osman Y, Silver, Debra L, Stevens, Beth, Calakos, Nicole, Soderling, Scott H, Eroglu, Cagla

“…During cortical synaptic development, thalamic axons must establish synaptic connections despite the presence of the more abundant intracortical projections…”
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Author Correction: Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington’s disease by Wilton, Daniel K., Mastro, Kevin, Heller, Molly D., Gergits, Frederick W., Willing, Carly Rose, Fahey, Jaclyn B., Frouin, Arnaud, Daggett, Anthony, Gu, Xiaofeng, Kim, Yejin A., Faull, Richard L. M., Jayadev, Suman, Yednock, Ted, Yang, X. William, Stevens, Beth

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Structured Illumination Microscopy for the Investigation of Synaptic Structure and Function by Hong, Soyon, Wilton, Daniel K, Stevens, Beth, Richardson, Douglas S

“…The neuronal synapse is a primary building block of the nervous system to which alterations in structure or function can result in numerous pathologies…”
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c-Jun activation in Schwann cells protects against loss of sensory axons in inherited neuropathy by HANTKE, Janina, CARTY, Lucy, WAGSTAFF, Laura J, TURMAINE, Mark, WILTON, Daniel K, QUINTES, Susanne, KOLTZENBURG, Martin, BAAS, Frank, MIRSKY, Rhona, JESSEN, Kristján R

“…Charcot-Marie-Tooth disease type 1A is the most frequent inherited peripheral neuropathy. It is generally due to heterozygous inheritance of a partial…”
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CSMD1 regulates brain complement activity and circuit development by Baum, Matthew L., Wilton, Daniel K., Fox, Rachel G., Carey, Alanna, Hsu, Yu-Han H., Hu, Ruilong, Jäntti, Henna J., Fahey, Jaclyn B., Muthukumar, Allie K., Salla, Nikkita, Crotty, William, Scott-Hewitt, Nicole, Bien, Elizabeth, Sabatini, David A., Lanser, Toby B., Frouin, Arnaud, Gergits, Frederick, Håvik, Bjarte, Gialeli, Chrysostomi, Nacu, Eugene, Lage, Kasper, Blom, Anna M., Eggan, Kevin, McCarroll, Steven A., Johnson, Matthew B., Stevens, Beth

“…Our findings support a model in which CSMD1 opposes actions of the complement cascade in neural tissues (top left). We investigated two models in which…”
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A Fast-Binding, Functionally Reversible, COX‑2 Radiotracer for CNS PET Imaging by Placzek, Michael S., Wilton, Daniel K., Weïwer, Michel, Manter, Mariah A., Reid, Sarah E., Meyer, Christopher J., Campbell, Arthur J., Bajrami, Besnik, Bigot, Antoine, Bricault, Sarah, Fayet, Agathe, Frouin, Arnaud, Gergits, Frederick, Gupta, Mehak, Jiang, Wei, Melanson, Michelle, Romano, Chiara D., Riley, Misha M., Wang, Jessica M., Wey, Hsiao-Ying, Wagner, Florence F., Stevens, Beth, Hooker, Jacob M.

“…Cyclooxygenase-2 (COX-2) is an enzyme that plays a pivotal role in peripheral inflammation and pain via the prostaglandin pathway. In the central nervous…”
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Innate immune mechanisms mediate loss of corticostriatal synapses in Huntington’s disease

“…By analyzing human samples and multiple mouse models of Huntington’s disease, we found that complement proteins and microglia mediate early and selective loss…”
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A complementmicroglial axis drives synapse loss during virus-induced memory impairment by Vasek, Michael J, Garber, Charise, Dorsey, Denise, Durrant, Douglas M, Bollman, Bryan, Soung, Allison, Yu, Jinsheng, Perez-Torres, Carlos, Frouin, Arnaud, Wilton, Daniel K, Funk, Kristen, DeMasters, Bette K, Jiang, Xiaoping, Bowen, James R, Mennerick, Steven, Robinson, John K, Garbow, Joel R, Tyler, Kenneth L, Suthar, Mehul S, Schmidt, Robert E, Stevens, Beth, Klein, Robyn S

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