Search Results - "WILSON, Sylvia M"

Serial Plasma Osteopontin Levels Have Prognostic Value in Metastatic Breast Cancer by BRAMWELL, Vivien H. C, DOIG, Gordon S, TUCK, Alan B, WILSON, Sylvia M, TONKIN, Katia S, TOMIAK, Anna, PERERA, Francisco, VANDENBERG, Theodore A, CHAMBERS, Ann F

“…Purpose: Osteopontin is a malignancy-associated protein measurable in blood and tumor tissue. To evaluate its prognostic value in advanced disease, we…”
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Ineffectiveness of doxorubicin treatment on solitary dormant mammary carcinoma cells or late-developing metastases by NAUMOV, George N, TOWNSON, Jason L, MACDONALD, Ian C, WILSON, Sylvia M, BRAMWELL, Vivien H. C, GROOM, Alan C, CHAMBERS, Ann F

“…Breast cancer is noted for long periods of tumor dormancy and metastases can occur many years after treatment. Adjuvant chemotherapy is used to prevent…”
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Dietary genistein reduces metastasis in a postsurgical orthotopic breast cancer model by VANTYGHEM, Sharon A, WILSON, Sylvia M, POSTENKA, Carl O, AL-KATIB, Waleed, TUCK, Alan B, CHAMBERS, Ann F

“…Metastatic spread, not primary tumor burden, is the leading cause of breast cancer deaths. For patient prognosis to improve, new systemic adjuvant therapies…”
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Selective Prostacyclin Receptor Agonism Augments Glucocorticoid-Induced Gene Expression in Human Bronchial Epithelial Cells by Wilson, Sylvia M, Shen, Pamela, Rider, Christopher F, Traves, Suzanne L, Proud, David, Newton, Robert, Giembycz, Mark A

“…Prostacyclin receptor (IP-receptor) agonists display anti-inflammatory and antiviral activity in cell-based assays and in preclinical models of asthma and…”
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Changes over time of extracellular domain of HER2 (ECD/HER2) serum levels have prognostic value in metastatic breast cancer by Bramwell, Vivien H. C, Doig, Gordon S, Tuck, Alan B, Wilson, Sylvia M, Tonkin, Katia S, Tomiak, Anna, Perera, Francisco, Vandenberg, Theodore A, Chambers, Ann F

“…Background Blood levels of the extracellular domain of HER-2/neu (ECD/HER2) have been suggested to have potential as a tumor marker in breast cancer. Our aim…”
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4,5-Dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxy-benzyl)-phenyl]-amine (RO1138452) is a selective, pseudo-irreversible orthosteric antagonist at the prostacyclin (IP)-receptor expressed by human airway epithelial cells: IP-receptor-mediated inhibition of CXCL9 and CXCL10 release by Ayer, Linda M, Wilson, Sylvia M, Traves, Suzanne L, Proud, David, Giembycz, Mark A

“…The extent to which the prostacyclin (IP) receptor regulates the release of two proinflammatory chemokines from human airway epithelial cells was investigated…”
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Phosphodiesterase 4 inhibitors augment the ability of formoterol to enhance glucocorticoid-dependent gene transcription in human airway epithelial cells: a novel mechanism for the clinical efficacy of roflumilast in severe chronic obstructive pulmonary disease by Moodley, Thunicia, Wilson, Sylvia M, Joshi, Taruna, Rider, Christopher F, Sharma, Pawan, Yan, Dong, Newton, Robert, Giembycz, Mark A

“…Post-hoc analysis of two phase III clinical studies found that the phosphodiesterase 4 (PDE4) inhibitor, roflumilast, reduced exacerbation frequency in…”
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Expression of osteopontin and HGF/Met in adult soft tissue tumors by Bramwell, Vivien H.C., Tuck, Alan B., Wilson, Sylvia M., Stitt, Larry W., Cherian, Anil K., Rorke, Stewart C., Al-Katib, Waleed, Postenko, Carl O., Postenko, Carl O., Chambers, Ann F.

“…There is a need for molecular markers that predict biological behavior of adult soft tissue tumors. Elevated levels of osteopontin (OPN) a…”
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Evidence for a second receptor for prostacyclin on human airway epithelial cells that mediates inhibition of CXCL9 and CXCL10 release by Wilson, Sylvia M, Sheddan, Neil A, Newton, Robert, Giembycz, Mark A

“…Herein we provide evidence for the coexpression of two distinct prostacyclin (PGI(2)) receptors (IP) on BEAS-2B human airway epithelial cells. IP receptor…”
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Persistence of solitary mammary carcinoma cells in a secondary site: A possible contributor to dormancy by NAUMOV, George N, MACDONALD, Ian C, WEINMEISTER, Pascal M, KERKVLIET, Nancy, NADKARNI, Kishore V, WILSON, Sylvia M, MORRIS, Vincent L, GROOM, Alan C, CHAMBERS, Ann F

“…Tumors can recur years after treatment, and breast cancer is especially noted for long periods of dormancy. The status of the cancer during this period is…”
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SnoN Is a Cell Type-specific Mediator of Transforming Growth Factor-β Responses by Sarker, Krishna P., Wilson, Sylvia M., Bonni, Shirin

“…The transforming growth factor-β (TGF-β) family of secreted proteins have pleiotropic functions that are critical to normal development and homeostasis…”
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Osteopontin inhibits inducible nitric oxide synthase activity in rat vascular tissue by Scott, J A, Weir, M L, Wilson, S M, Xuan, J W, Chambers, A F, McCormack, D G

“…We tested the hypothesis that osteopontin (OPN) can inhibit the induction of inducible nitric oxide synthase (iNOS) in vascular tissue. iNOS activity was…”
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New Dual Monoclonal ELISA for Measuring Plasma Osteopontin as a Biomarker Associated with Survival in Prostate Cancer: Clinical Validation and Comparison of Multiple ELISAs by Anborgh, Pieter H, Wilson, Sylvia M, Tuck, Alan B, Winquist, Eric, Schmidt, Nancy, Hart, Russell, Kon, Shigeyuki, Maeda, Masahiro, Uede, Toshimitsu, Stitt, Larry W, Chambers, Ann F

“…A previously developed monoclonal/polyclonal ELISA (Mono/Poly) to detect plasma concentrations of osteopontin (OPN) was shown to provide prognostic information…”
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Plasma osteopontin: associations with survival and metastasis to bone in men with hormone-refractory prostate carcinoma by Hotte, Sebastien J, Winquist, Eric W, Stitt, Larry, Wilson, Sylvia M, Chambers, Ann F

“…Osteopontin (OPN) is a secreted glycoprotein that is detectable in human body fluids. Its increased expression has been found in many malignancies, and a…”
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Osteopontin-induced migration of human mammary epithelial cells involves activation of EGF receptor and multiple signal transduction pathways by TUCK, Alan B, HOTA, Charulata, WILSON, Sylvia M, CHAMBERS, Ann F

“…Osteopontin (OPN) is a secreted, integrin-binding glycophosphoprotein that has been implicated in breast cancer. We previously showed that OPN-induced cell…”
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β3 Integrin expression increases breast carcinoma cell responsiveness to the malignancy-enhancing effects of osteopontin by FURGER, Kara A, ALLAN, Alison L, WILSON, Sylvia M, HOTA, Charulata, VANTYGHEM, Sharon A, POSTENKA, Carl O, AL-KATIB, Waleed, CHAMBERS, Ann F, TUCK, Alan B

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Osteopontin induces increased invasiveness and plasminogen activator expression of human mammary epithelial cells by TUCK, A. B, ARSENAULT, D. M, O'MALLEY, F. P, HOTA, C, LING, M. C, WILSON, S. M, CHAMBERS, A. F

“…Osteopontin (OPN) has been associated with enhanced malignancy in breast cancer, but its functional role in this disease is poorly understood. To study the…”
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Activated ras regulates the proliferation/apoptosis balance and early survival of developing micrometastases by VARGHESE, Hemanth J, DAVIDSON, Melanie T. M, MACDONALD, Ian C, WILSON, Sylvia M, NADKARNI, Kishore V, GROOM, Alan C, CHAMBERS, Ann F

“…Mutant, activated ras oncogenes are found in many human cancers. Experimental studies have shown that Ras enhances metastatic ability in several cell types…”
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Reduced malignancy of ras-transformed NIH 3T3 cells expressing antisense osteopontin RNA by BEHREND, E. I, CRAIG, A. M, WILSON, S. M, DENHARDT, D. T, CHAMBERS, A. F

“…Osteopontin (OPN) is a secreted, calcium-binding phosphoprotein that frequently has been associated with the transformed phenotype. To clarify the function of…”
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Experimental metastasis assays in the chick embryo by Wilson, Sylvia M, Chambers, Ann F

“…Experimental metastasis assays are used to measure the ability of cancer cells to grow in secondary organs following injection of the cells into the…”
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