Search Results - "WILSON, Richard J. A"

Asthmatic allergen inhalation sensitises carotid bodies to lysophosphatidic acid by Jendzjowsky, Nicholas G, Roy, Arijit, Wilson, Richard J A

“…The carotid bodies are multimodal sensors that regulate various autonomic reflexes. Recent evidence demonstrates their role in immune reflex regulation. Our…”
Get full text

ROHHAD and Prader-Willi syndrome (PWS): clinical and genetic comparison by Barclay, Sarah F, Rand, Casey M, Nguyen, Lisa, Wilson, Richard J A, Wevrick, Rachel, Gibson, William T, Bech-Hansen, N Torben, Weese-Mayer, Debra E

“…Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) is a very rare and potentially fatal pediatric…”
Get full text

Anandamide modulates carotid sinus nerve afferent activity via TRPV1 receptors increasing responses to heat by ROY, Arijit, MANDADI, Sravan, FIAMMA, Marie-Noelle, RODIKOVA, Ekaterina, FERGUSON, Erin V, WHELAN, Patrick J, WILSON, Richard J. A

“…Abnormal respiratory chemosensitivity is implicated in recurrent apnea syndromes, with the peripheral chemoreceptors, the carotid bodies, playing a…”
Get full text

Intestinal fungi are causally implicated in microbiome assembly and immune development in mice by van Tilburg Bernardes, Erik, Pettersen, Veronika Kuchařová, Gutierrez, Mackenzie W., Laforest-Lapointe, Isabelle, Jendzjowsky, Nicholas G., Cavin, Jean-Baptiste, Vicentini, Fernando A., Keenan, Catherine M., Ramay, Hena R., Samara, Jumana, MacNaughton, Wallace K., Wilson, Richard J. A., Kelly, Margaret M., McCoy, Kathy D., Sharkey, Keith A., Arrieta, Marie-Claire

“…The gut microbiome consists of a multi-kingdom microbial community. Whilst the role of bacteria as causal contributors governing host physiological development…”
Get full text

Stress peptide PACAP engages multiple signaling pathways within the carotid body to initiate excitatory responses in respiratory and sympathetic chemosensory afferents by Roy, Arijit, Derakhshan, Fatemeh, Wilson, Richard J A

“…Consistent with a critical role in respiratory and autonomic stress responses, the carotid bodies are strongly excited by pituitary adenylate…”
Get more information

Tissue-specific mitochondrial HIGD1C promotes oxygen sensitivity in carotid body chemoreceptors by Timón-Gómez, Alba, Scharr, Alexandra L, Wong, Nicholas Y, Ni, Erwin, Roy, Arijit, Liu, Min, Chau, Julisia, Lampert, Jack L, Hireed, Homza, Kim, Noah S, Jan, Masood, Gupta, Alexander R, Day, Ryan W, Gardner, James M, Wilson, Richard J A, Barrientos, Antoni, Chang, Andy J

“…Mammalian carotid body arterial chemoreceptors function as an early warning system for hypoxia, triggering acute life-saving arousal and cardiorespiratory…”
Get full text

A negative interaction between brainstem and peripheral respiratory chemoreceptors modulates peripheral chemoreflex magnitude by Day, Trevor A., Wilson, Richard J. A.

“…Interaction between central (brainstem) and peripheral (carotid body) respiratory chemosensitivity is vital to protect blood gases against potentially…”
Get full text

Severity of central sleep apnea does not affect sleeping oxygen saturation during ascent to high altitude by Bird, Jordan D, Kalker, Anne, Rimke, Alexander N, Chan, Jason S, Chan, Garrick, Saran, Gurkarn, Jendzjowsky, Nicholas G, Wilson, Richard J A, Brutsaert, Thomas D, Sherpa, Mingma T, Day, Trevor A

“…Central sleep apnea (CSA) is characterized by periodic breathing (PB) during sleep, defined as intermittent periods of apnea/hypopnea and hyperventilation,…”
Get full text

Beyond arterial blood gas sensing: the carotid body's TRP to broad physiological function by Zubieta‐DeUrioste, Natalia, Wilson, Richard J.A.

Get full text

Brainstem PCO2 modulates phrenic responses to specific carotid body hypoxia in an in situ dual perfused rat preparation by Day, Trevor A., Wilson, Richard J. A.

“…Inputs from central (brainstem) and peripheral (carotid body) respiratory chemoreceptors are coordinated to protect blood gases against potentially deleterious…”
Get full text

Functional optical coherence tomography at altitude: retinal microvascular perfusion and retinal thickness at 3,800 meters by Baker, Jacquie, Safarzadeh, Mohammad A, Incognito, Anthony V, Jendzjowsky, Nicholas G, Foster, Glen E, Bird, Jordan D, Raj, Satish R, Day, Trevor A, Rickards, Caroline A, Zubieta-DeUrioste, Natalia, Alim, Usman, Wilson, Richard J A

“…Cerebral hypoxia is a serious consequence of several cardiorespiratory illnesses. Measuring the retinal microvasculature at high altitude provides a surrogate…”
Get full text

The coronary vascular response to the metaboreflex at low altitude and during acute and prolonged high altitude in males by White, Austin J, Boulet, Lindsey M, Shafer, Brooke M, Vermeulen, Tyler D, Atwater, Taylor L, Stembridge, Mike, Ainslie, Philip N, Wilson, Richard J A, Day, Trevor A, Foster, Glen E

“…Myocardial oxygen delivery is primarily regulated through changes in vascular tone to match increased metabolic demands. In males, activation of the muscle…”
Get full text

Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors by Jendzjowsky, Nicholas G., Roy, Arijit, Barioni, Nicole O., Kelly, Margaret M., Green, Francis H. Y., Wyatt, Christopher N., Pye, Richard L., Tenorio-Lopes, Luana, Wilson, Richard J. A.

“…Asthma accounts for 380,000 deaths a year. Carotid body denervation has been shown to have a profound effect on airway hyper-responsiveness in animal models…”
Get full text

Time-dependent modulation of carotid body afferent activity during and after intermittent hypoxia by Cummings, Kevin J, Wilson, Richard J A

“…The ventilatory response to several minutes of hypoxia consists of various time-dependent phenomena, some of which occur during hypoxia (e.g., short-term…”
Get more information

PKCε stimulation of TRPV1 orchestrates carotid body responses to asthmakines by Jendzjowsky, Nicholas G., Roy, Arijit, Iftinca, Mircea, Barioni, Nicole O., Kelly, Margaret M., Herrington, Brittney A., Visser, Frank, Altier, Christophe, Wilson, Richard J.A.

“…Key points We have previously shown that carotid body stimulation by lysophosphatidic acid elicits a reflex stimulation of vagal efferent activity sufficient…”
Get full text

Duration at high altitude influences the onset of arrhythmogenesis during apnea by Berthelsen, Lindsey F., van Diepen, Sean, Steele, Andrew R., Vanden Berg, Emily R., Bird, Jordan, Thrall, Scott, Skalk, Alexandra, Byman, Britta, Pentz, Brandon, Wilson, Richard J. A., Jendzjowsky, Nicholas G., Day, Trevor A., Steinback, Craig D.

“…Purpose Autonomic control of the heart is balanced by sympathetic and parasympathetic inputs. Excitation of both sympathetic and parasympathetic systems occurs…”
Get full text

Functional-Optical Coherence Tomography: A Non-invasive Approach to Assess the Sympathetic Nervous System and Intrinsic Vascular Regulation by Jendzjowsky, Nicholas G., Steinback, Craig D., Herman, Robert J., Tsai, Willis H., Costello, Fiona E., Wilson, Richard J. A.

“…Sympathetic nervous system dysregulation and vascular impairment in neuronal tissue beds are hallmarks of prominent cardiorespiratory diseases. However, an…”
Get full text

Editorial: Hypoxia and Cardiorespiratory Control by Okada, Yasumasa, Paton, Julian F R, López-Barneo, José, Wilson, Richard J A, Marina, Nephtali, Pokorski, Mieczyslaw

Get full text

Interleukin-4 Programmed Macrophages Suppress Colitis and Do Not Enhance Infectious-Colitis, Inflammation-Associated Colon Cancer or Airway Hypersensitivity by Callejas, Blanca E, Blyth, Graham A D, Jendzjowsky, Nicholas, Wang, Arthur, Babbar, Anshu, Koro, Konstantin, Wilson, Richard J A, Kelly, Margaret M, Cobo, Eduardo R, McKay, Derek M

“…The murine interleukin-4 treated macrophage (MIL4) exerts anti-inflammatory and pro-healing effects and has been shown to reduce the severity of…”
Get full text

Rapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD): exome sequencing of trios, monozygotic twins and tumours by Barclay, Sarah F, Rand, Casey M, Borch, Lauren A, Nguyen, Lisa, Gray, Paul A, Gibson, William T, Wilson, Richard J A, Gordon, Paul M K, Aung, Zaw, Berry-Kravis, Elizabeth M, Ize-Ludlow, Diego, Weese-Mayer, Debra E, Bech-Hansen, N Torben

“…Rapid-onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD) is thought to be a genetic disease caused by de novo…”
Get full text