Search Results - "WILSON, Michael D"

Epigenetics of Atherosclerosis: Emerging Mechanisms and Methods by Khyzha, Nadiya, Alizada, Azad, Wilson, Michael D, Fish, Jason E

“…Atherosclerosis is a vascular pathology characterized by inflammation and plaque build-up within arterial vessel walls. Vessel occlusion, often occurring after…”
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Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations by MacParland, Sonya A., Liu, Jeff C., Ma, Xue-Zhong, Innes, Brendan T., Bartczak, Agata M., Gage, Blair K., Manuel, Justin, Khuu, Nicholas, Echeverri, Juan, Linares, Ivan, Gupta, Rahul, Cheng, Michael L., Liu, Lewis Y., Camat, Damra, Chung, Sai W., Seliga, Rebecca K., Shao, Zigong, Lee, Elizabeth, Ogawa, Shinichiro, Ogawa, Mina, Wilson, Michael D., Fish, Jason E., Selzner, Markus, Ghanekar, Anand, Grant, David, Greig, Paul, Sapisochin, Gonzalo, Selzner, Nazia, Winegarden, Neil, Adeyi, Oyedele, Keller, Gordon, Bader, Gary D., McGilvray, Ian D.

“…The liver is the largest solid organ in the body and is critical for metabolic and immune functions. However, little is known about the cells that make up the…”
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Waves of Retrotransposon Expansion Remodel Genome Organization and CTCF Binding in Multiple Mammalian Lineages by Schmidt, Dominic, Schwalie, Petra C., Wilson, Michael D., Ballester, Benoit, Gonçalves, Ângela, Kutter, Claudia, Brown, Gordon D., Marshall, Aileen, Flicek, Paul, Odom, Duncan T.

“…CTCF-binding locations represent regulatory sequences that are highly constrained over the course of evolution. To gain insight into how these DNA elements are…”
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Rapid turnover of long noncoding RNAs and the evolution of gene expression by Kutter, Claudia, Watt, Stephen, Stefflova, Klara, Wilson, Michael D, Goncalves, Angela, Ponting, Chris P, Odom, Duncan T, Marques, Ana C

“…A large proportion of functional sequence within mammalian genomes falls outside protein-coding exons and can be transcribed into long RNAs. However, the roles…”
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Cooperativity and Rapid Evolution of Cobound Transcription Factors in Closely Related Mammals by Stefflova, Klara, Thybert, David, Wilson, Michael D., Streeter, Ian, Aleksic, Jelena, Karagianni, Panagiota, Brazma, Alvis, Adams, David J., Talianidis, Iannis, Marioni, John C., Flicek, Paul, Odom, Duncan T.

“…To mechanistically characterize the microevolutionary processes active in altering transcription factor (TF) binding among closely related mammals, we compared…”
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Therapeutic Anti-Depressant Potential of Microbial GABA Produced by Lactobacillus rhamnosus Strains for GABAergic Signaling Restoration and Inhibition of Addiction-Induced HPA Axis Hyperactivity by Tette, Fernanda-Marie, Kwofie, Samuel K., Wilson, Michael D.

“…The role of the microbiota–gut–brain (MGB) axis in mood regulation and depression treatment has gained attention in recent years, as evidenced by the growing…”
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The Evolutionary Landscape of Alternative Splicing in Vertebrate Species by Barbosa-Morais, Nuno L., Irimia, Manuel, Pan, Qun, Xiong, Hui Y., Gueroussov, Serge, Lee, Leo J., Slobodeniuc, Valentina, Kutter, Claudia, Watt, Stephen, Çolak, Recep, Kim, TaeHyung, Misquitta-Ali, Christine M., Wilson, Michael D., Kim, Philip M., Odom, Duncan T., Frey, Brendan J., Blencowe, Benjamin J.

“…How species with similar repertoires of protein-coding genes differ so markedly at the phenotypic level is poorly understood. By comparing organ transcriptomes…”
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Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains by Lambert, Jean-Philippe, Picaud, Sarah, Fujisawa, Takao, Hou, Huayun, Savitsky, Pavel, Uusküla-Reimand, Liis, Gupta, Gagan D., Abdouni, Hala, Lin, Zhen-Yuan, Tucholska, Monika, Knight, James D.R., Gonzalez-Badillo, Beatriz, St-Denis, Nicole, Newman, Joseph A., Stucki, Manuel, Pelletier, Laurence, Bandeira, Nuno, Wilson, Michael D., Filippakopoulos, Panagis, Gingras, Anne-Claude

“…Targeting bromodomains (BRDs) of the bromo-and-extra-terminal (BET) family offers opportunities for therapeutic intervention in cancer and other diseases…”
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ChIP-seq: Using high-throughput sequencing to discover protein–DNA interactions by Schmidt, Dominic, Wilson, Michael D., Spyrou, Christiana, Brown, Gordon D., Hadfield, James, Odom, Duncan T.

“…Chromatin immunoprecipitation (ChIP) allows specific protein–DNA interactions to be isolated. Combining ChIP with high-throughput sequencing reveals the DNA…”
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Five-Vertebrate ChIP-seq Reveals the Evolutionary Dynamics of Transcription Factor Binding by Schmidt, Dominic, Wilson, Michael D, Ballester, Benoit, Schwalie, Petra C, Brown, Gordon D, Marshall, Aileen, Kutter, Claudia, Watt, Stephen, Martinez-Jimenez, Celia P, Mackay, Sarah, Talianidis, Iannis, Flicek, Paul, Odom, Duncan T

“…Transcription factors (TFs) direct gene expression by binding to DNA regulatory regions. To explore the evolution of gene regulation, we used chromatin…”
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Independence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromatic Layer Formation by Chandra, Tamir, Kirschner, Kristina, Thuret, Jean-Yves, Pope, Benjamin D., Ryba, Tyrone, Newman, Scott, Ahmed, Kashif, Samarajiwa, Shamith A., Salama, Rafik, Carroll, Thomas, Stark, Rory, Janky, Rekin's, Narita, Masako, Xue, Lixiang, Chicas, Agustin, Nũnez, Sabrina, Janknecht, Ralf, Hayashi-Takanaka, Yoko, Wilson, Michael D., Marshall, Aileen, Odom, Duncan T., Babu, M. Madan, Bazett-Jones, David P., Tavaré, Simon, Edwards, Paul A.W., Lowe, Scott W., Kimura, Hiroshi, Gilbert, David M., Narita, Masashi

“…The expansion of repressive epigenetic marks has been implicated in heterochromatin formation during embryonic development, but the general applicability of…”
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Heart enhancers with deeply conserved regulatory activity are established early in zebrafish development by Yuan, Xuefei, Song, Mengyi, Devine, Patrick, Bruneau, Benoit G., Scott, Ian C., Wilson, Michael D.

“…During the phylotypic period, embryos from different genera show similar gene expression patterns, implying common regulatory mechanisms. Here we set out to…”
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Spell Checking Nature: Versatility of CRISPR/Cas9 for Developing Treatments for Inherited Disorders by Wojtal, Daria, Kemaladewi, Dwi U., Malam, Zeenat, Abdullah, Sarah, Wong, Tatianna W.Y., Hyatt, Elzbieta, Baghestani, Zahra, Pereira, Sergio, Stavropoulos, James, Mouly, Vincent, Mamchaoui, Kamel, Muntoni, Francesco, Voit, Thomas, Gonorazky, Hernan D., Dowling, James J., Wilson, Michael D., Mendoza-Londono, Roberto, Ivakine, Evgueni A., Cohn, Ronald D.

“…Clustered regularly interspaced short palindromic repeat (CRISPR) has arisen as a frontrunner for efficient genome engineering. However, the potentially broad…”
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Break Check: Transcription-Driven Topoisomerase II Collisions near Chromatin Loop Anchors Are Hotspots for DNA Damage and Translocations by Uusküla-Reimand, Liis, Wilson, Michael D.

“…In this issue of Molecular Cell, Gothe et al. and Canela, Maman et al. demonstrate that type II topoisomerase (TOP2B/TOP2A)-mediated DNA breaks, and the…”
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Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals by Yung, Theodora, Poon, Frankie, Liang, Minggao, Coquenlorge, Sabrina, McGaugh, Emily C., Hui, Chi-chung, Wilson, Michael D., Nostro, M. Cristina, Kim, Tae-Hee

“…Human embryonic stem cell-derived beta cells offer a promising cell-based therapy for diabetes. However, efficient stem cell to beta cell differentiation has…”
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Cheminformatics-Based Identification of Potential Novel Anti-SARS-CoV-2 Natural Compounds of African Origin by Kwofie, Samuel K, Broni, Emmanuel, Asiedu, Seth O, Kwarko, Gabriel B, Dankwa, Bismark, Enninful, Kweku S, Tiburu, Elvis K, Wilson, Michael D

“…The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome virus 2 (SARS-CoV-2) has impacted negatively on public health…”
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The effect of single dose albendazole (400 mg) treatment on the human gut microbiome of hookworm-infected Ghanaian individuals by Appiah-Twum, Francis, Akorli, Jewelna, Okyere, Lydia, Sagoe, Kate, Osabutey, Dickson, Cappello, Michael, Wilson, Michael D.

“…Microbes play a key role in human gut homeostasis, metabolic, immunologic and physiopathology of the body. A longitudinal study conducted during 2018–2021 in…”
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Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks by Zhu, Helen, Uusküla-Reimand, Liis, Isaev, Keren, Wadi, Lina, Alizada, Azad, Shuai, Shimin, Huang, Vincent, Aduluso-Nwaobasi, Dike, Paczkowska, Marta, Abd-Rabbo, Diala, Ocsenas, Oliver, Liang, Minggao, Thompson, J. Drew, Li, Yao, Ruan, Luyao, Krassowski, Michal, Dzneladze, Irakli, Simpson, Jared T., Lupien, Mathieu, Stein, Lincoln D., Boutros, Paul C., Wilson, Michael D., Reimand, Jüri

“…A comprehensive catalog of cancer driver mutations is essential for understanding tumorigenesis and developing therapies. Exome-sequencing studies have mapped…”
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Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules by Faure, Andre J, Schmidt, Dominic, Watt, Stephen, Schwalie, Petra C, Wilson, Michael D, Xu, Huiling, Ramsay, Robert G, Odom, Duncan T, Flicek, Paul

“…The cohesin protein complex contributes to transcriptional regulation in a CTCF-independent manner by colocalizing with master regulators at tissue-specific…”
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Cheminformatics-Based Study Identifies Potential Ebola VP40 Inhibitors by Broni, Emmanuel, Ashley, Carolyn, Adams, Joseph, Manu, Hammond, Aikins, Ebenezer, Okom, Mary, Miller, 3rd, Whelton A, Wilson, Michael D, Kwofie, Samuel K

“…The Ebola virus (EBOV) is still highly infectious and causes severe hemorrhagic fevers in primates. However, there are no regulatorily approved drugs against…”
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