Search Results - "WILSON, Kaley D"

Effects of intravenous and subcutaneous administration on the pharmacokinetics, biodistribution, cellular uptake and immunostimulatory activity of CpG ODN encapsulated in liposomal nanoparticles by Wilson, Kaley D., Raney, Sameersingh G., Sekirov, Laura, Chikh, Ghania, deJong, Susan D., Cullis, Pieter R., Tam, Ying K.

“…We have previously demonstrated that the immune response to an unmethylated cytidine–guanosine (CpG)-containing oligonucleotide (ODN) is greatly enhanced when…”
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Synthetic methylated CpG ODNs are potent in vivo adjuvants when delivered in liposomal nanoparticles by Chikh, Ghania, de Jong, Susan D., Sekirov, Laura, Raney, Sameersingh G., Kazem, Mikameh, Wilson, Kaley D., Cullis, Pieter R., Dutz, Jan P., Tam, Ying K.

“…Although it is well documented that the immunological activity of cytosine–guanine (CpG) motifs is abrogated by 5′ methylation of the cytosine residue,…”
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The combination of stabilized plasmid lipid particles and lipid nanoparticle encapsulated CpG containing oligodeoxynucleotides as a systemic genetic vaccine by Wilson, Kaley D., de Jong, Susan D., Kazem, Mikameh, Lall, Ryan, Hope, Michael J., Cullis, Pieter R., Tam, Ying K.

“…Background DNA vaccines offer unique potential for generating protective and therapeutic immunity against infectious and malignant diseases. Unfortunately,…”
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Lipid-based delivery of CpG oligonucleotides enhances immunotherapeutic efficacy by Wilson, Kaley D., de Jong, Susan D., Tam, Ying K.

“…There has been significant interest in the potential of cytosine–guanine (CpG) containing oligodeoxynucleotides (ODN) as an immunotherapy for malignant,…”
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The immunostimulatory activity of unmethylated and methylated CpG oligodeoxynucleotide is dependent on their ability to colocalize with TLR9 in late endosomes by de Jong, Susan D, Basha, Genc, Wilson, Kaley D, Kazem, Mikameh, Cullis, Pieter, Jefferies, Wilf, Tam, Ying

“…TLR9 recognizes CpG motifs present in pathogenic DNA and triggers potent immune responses. It is generally accepted that TLR9 distinguishes pathogenic DNA…”
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The effect of circulation lifetime and drug-to-lipid ratio of intravenously administered lipid nanoparticles on the biodistribution and immunostimulatory activity of encapsulated CpG-ODN by Raney, Sameersingh G., Wilson, Kaley D., Sekirov, Laura, Chikh, Ghania, de Jong, Susan D., Cullis, Pieter R., Tam, Ying K.

“…The encapsulation of conventional drugs in lipid nanoparticles (LNs) has been extensively utilized to enhance therapeutic activity by altering their…”
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Lipid-based delivery of CpG oligonucleotides enhances immunotherapeutic efficacy: CpG Oligonucleotides as Immunotherapeutic Adjuvants: Innovative Applications and Delivery Strategies by WILSON, Kaley D, DE JONG, Susan D, TAM, Ying K

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