Search Results - "WILSON, Heather M"

SOCS Proteins in Macrophage Polarization and Function by Wilson, Heather M

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Myocardial and Systemic Inflammation in Acute Stress-Induced (Takotsubo) Cardiomyopathy by Scally, Caroline, Abbas, Hassan, Ahearn, Trevor, Srinivasan, Janaki, Mezincescu, Alice, Rudd, Amelia, Spath, Nicholas, Yucel-Finn, Alim, Yuecel, Raif, Oldroyd, Keith, Dospinescu, Ciprian, Horgan, Graham, Broadhurst, Paul, Henning, Anke, Newby, David E., Semple, Scott, Wilson, Heather M., Dawson, Dana K.

“…BACKGROUND:Acute stress-induced (takotsubo) cardiomyopathy can result in a heart failure phenotype with a prognosis comparable with that of myocardial…”
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Recent Developments in the Role of Protein Tyrosine Phosphatase 1B (PTP1B) as a Regulator of Immune Cell Signalling in Health and Disease by Read, Neve E, Wilson, Heather M

“…Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor tyrosine phosphatase best known for its role in regulating insulin and leptin signalling. Recently,…”
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Electric fields are novel determinants of human macrophage functions by Hoare, Joseph I., Rajnicek, Ann M., McCaig, Colin D., Barker, Robert N., Wilson, Heather M.

“…Physiological strength EFs modulates macrophage migration, phagocytosis, and cytokine secretion through activation of key signaling pathways. Macrophages are…”
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The burden of metabolic syndrome on osteoarthritic joints by Dickson, Bruce M, Roelofs, Anke J, Rochford, Justin J, Wilson, Heather M, De Bari, Cosimo

“…The prevalence of osteoarthritis (OA) increases with obesity, with up to two thirds of the elderly obese population affected by OA of the knee. The metabolic…”
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Macrophages heterogeneity in atherosclerosis – implications for therapy by Wilson, Heather M.

“…•  Introduction •  Current concepts in monocyte heterogeneity •  Pro‐atherogenic role of plaque macrophages •  Anti‐atherogenic role of plaque macrophages • …”
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Similarities and differences in surface receptor expression by THP-1 monocytes and differentiated macrophages polarized using seven different conditioning regimens by Forrester, Megan A., Wassall, Heather J., Hall, Lindsay S., Cao, Huan, Wilson, Heather M., Barker, Robert N., Vickers, Mark A.

“…•Human cell line THP-1 monocytes expressed 14 of 49 surface markers examined.•THP-1 differentiated macrophages expressed a wider repertoire of receptors…”
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Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function by Whyte, Claire S., Bishop, Eileen T., Rückerl, Dominik, Gaspar‐Pereira, Silvia, Barker, Robert N., Allen, Judith E., Rees, Andrew J., Wilson, Heather M.

“…M2 macrophages activated in vitro and in vivo show polarized up‐regulation of SOCS1 expression that is critical in directing their activation and function…”
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Characterization of the Myocardial Inflammatory Response in Acute Stress-Induced (Takotsubo) Cardiomyopathy by Wilson, Heather M., BSc, PhD, Cheyne, Lesley, BSc, Brown, Paul A.J., MBChB, PhD, Kerr, Keith, MBChB, Hannah, Andrew, MBChB, Srinivasan, Janaki, RDCS, Duniak, Natallia, MBChB, Horgan, Graham, BA, MSc, PhD, Dawson, Dana K., DM, DPhil

“…Visual Abstract…”
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Immune Privilege: The Microbiome and Uveitis by Mölzer, Christine, Heissigerova, Jarmila, Wilson, Heather M, Kuffova, Lucia, Forrester, John V

“…Immune privilege (IP), a term introduced to explain the unpredicted acceptance of allogeneic grafts by the eye and the brain, is considered a unique property…”
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Myeloid PTP1B deficiency protects against atherosclerosis by improving cholesterol homeostasis through an AMPK-dependent mechanism by Oliver, Helk, Ruta, Dekeryte, Thompson, Dawn, Kamli-Salino, Sarah, Philip, Sam, Wilson, Heather M, Mody, Nimesh, Delibegovic, Mirela

“…Atherosclerosis is a chronic inflammatory process induced by the influx and entrapment of excess lipoproteins into the intima media of arteries. Previously,…”
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SOCS3 is a modulator of human macrophage phagocytosis by Gordon, Peter, Okai, Blessing, Hoare, Joseph I., Erwig, Lars P., Wilson, Heather M.

“…SOCS3 in human macrophages modulates signaling pathways organizing the actin cytoskeleton to regulate the efficiency of phagocytosis. Suppressor of cytokine…”
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Monocytes Expose Factor XIII-A and Stabilize Thrombi against Fibrinolytic Degradation by Alshehri, Fahad S M, Whyte, Claire S, Tuncay, Ahmet, Williams, Maria-Louise, Wilson, Heather M, Mutch, Nicola J

“…Factor XIII (FXIII) is a transglutaminase that promotes thrombus stability by cross-linking fibrin. The cellular form, a homodimer of the A subunits, denoted…”
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Low Intensity Shockwave Treatment Modulates Macrophage Functions Beneficial to Healing Chronic Wounds by Holsapple, Jason S., Cooper, Ben, Berry, Susan H., Staniszewska, Aleksandra, Dickson, Bruce M., Taylor, Julie A., Bachoo, Paul, Wilson, Heather M.

“…Extracorporeal Shock Wave Therapy (ESWT) is used clinically in various disorders including chronic wounds for its pro-angiogenic, proliferative, and…”
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The activation status of human macrophages presenting antigen determines the efficiency of Th17 responses by Arnold, Christina E, Gordon, Peter, Barker, Robert N, Wilson, Heather M

“…Abstract Macrophages are antigen presenting cells that can adopt different activation states as directed by microenvironmental stimuli. It is well-recognised…”
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A Role for Folate in Microbiome-Linked Control of Autoimmunity by Mölzer, Christine, Wilson, Heather M., Kuffova, Lucia, Forrester, John V.

“…The microbiome exerts considerable control over immune homeostasis and influences susceptibility to autoimmune and autoinflammatory disease (AD/AID) such as…”
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Myeloid-Cell Protein Tyrosine Phosphatase-1B Deficiency in Mice Protects Against High-Fat Diet and Lipopolysaccharide-Induced Inflammation, Hyperinsulinemia, and Endotoxemia Through an IL-10 STAT3-Dependent Mechanism by GRANT, Louise, SHEARER, Kirsty D, MODY, Nimesh, DELIBEGOVIC, Mirela, CZOPEK, Alicja, LEES, Emma K, OWEN, Carl, AGOUNI, Abdelali, WORKMAN, James, MARTIN-GRANADOS, Cristina, FORRESTER, John V, WILSON, Heather M

“…Protein tyrosine phosphatase-1B (PTP1B) negatively regulates insulin and leptin signaling, rendering it an attractive drug target for treatment of…”
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CFTR Modulators Dampen Aspergillus -Induced Reactive Oxygen Species Production by Cystic Fibrosis Phagocytes by Currie, Alexander J, Main, Ellen T, Wilson, Heather M, Armstrong-James, Darius, Warris, Adilia

“…Excessive inflammation by phagocytes during infection is thought to promote lung function decline in CF patients. CFTR modulators have been shown to reduce…”
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Unique Expression of Suppressor of Cytokine Signaling 3 Is Essential for Classical Macrophage Activation in Rodents In Vitro and In Vivo by Liu, Yu, Stewart, Keith N, Bishop, Eileen, Marek, Carylyn J, Kluth, David C, Rees, Andrew J, Wilson, Heather M

“…On infiltrating inflamed tissue, macrophages respond to the local microenvironment and develop one of two broad phenotypes: classically activated (M1)…”
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The intracellular signaling pathways governing macrophage activation and function in human atherosclerosis by Wilson, Heather M

“…Atherosclerosis is a chronic inflammatory disease characterized by lipid accumulation and plaque formation in arterial vessel walls. Atherosclerotic plaques…”
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