Direct Action of Insulin on Plasma Membrane ATPase Activity in Human Lymphocytes

Direct Action of Insulin on Plasma Membrane ATPase Activity in Human Lymphocytes

LITTLE is known about the effects of insulin on lymphocytes. Helmreich and Eisen1 concluded that it has insignificant effects, but others2-5 have made a case for a role in inflammatory and immunological responses. We6,7 have demonstrated that noradrenaline enhances the uptake of both glucose and pot...

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Bibliographic Details
Published in:Nature. New biology (London) Vol. 235; no. 58; pp. 174 - 177
Main Authors: HADDEN, JOHN W, HADDEN, ELBA M, WILSON, EDWIN E, GOOD, ROBERT A, COFFEY, RONALD G
Format: Journal Article
Language:English
Published: England 09-02-1972
Subjects:
Adenosine Diphosphate - biosynthesis
Adenosine Triphosphatases - blood
Adenosine Triphosphate - metabolism
Biological Transport - drug effects
Cell Membrane - enzymology
Cell Membrane - metabolism
Cells, Cultured
Humans
Insulin - pharmacology
Lymphocytes - cytology
Lymphocytes - enzymology
Lymphocytes - metabolism
Phosphates - biosynthesis
Potassium - metabolism
Radioisotopes
Rubidium
Sodium - metabolism
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Summary:LITTLE is known about the effects of insulin on lymphocytes. Helmreich and Eisen1 concluded that it has insignificant effects, but others2-5 have made a case for a role in inflammatory and immunological responses. We6,7 have demonstrated that noradrenaline enhances the uptake of both glucose and potassium by lymphocytes, as does insulin in several tissues. We have associated this action of noradrenaline with a direct effect on membrane adenosine triphosphatase (ATPase) activity7. The observation8 that insulin bound to 'Sepharose' polymers enhances glucose transport while in contact only with the plasma membrane indicated that insulin might have a direct action similar to that of noradrenaline on membrane ATPase. The observations reported here show that insulin stimulates ATPase activity and glucose uptake in the lymphocyte and suggest a relationship between membrane ATPase activity and glucose transport.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0090-0028
2058-1092
DOI:10.1038/newbio235174a0