Search Results - "WILMOTT, James"

Primary and Acquired Resistance to Immune Checkpoint Inhibitors in Metastatic Melanoma by Gide, Tuba N, Wilmott, James S, Scolyer, Richard A, Long, Georgina V

“…Immune checkpoint inhibitors have revolutionized the treatment of patients with advanced-stage metastatic melanoma, as well as patients with many other solid…”
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Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy by Gide, Tuba N., Quek, Camelia, Menzies, Alexander M., Tasker, Annie T., Shang, Ping, Holst, Jeff, Madore, Jason, Lim, Su Yin, Velickovic, Rebecca, Wongchenko, Matthew, Yan, Yibing, Lo, Serigne, Carlino, Matteo S., Guminski, Alexander, Saw, Robyn P.M., Pang, Angel, McGuire, Helen M., Palendira, Umaimainthan, Thompson, John F., Rizos, Helen, Silva, Ines Pires da, Batten, Marcel, Scolyer, Richard A., Long, Georgina V., Wilmott, James S.

“…Cancer immunotherapies provide survival benefits in responding patients, but many patients fail to respond. Identifying the biology of treatment response and…”
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Macrophage-Derived CXCL9 and CXCL10 Are Required for Antitumor Immune Responses Following Immune Checkpoint Blockade by House, Imran G, Savas, Peter, Lai, Junyun, Chen, Amanda X Y, Oliver, Amanda J, Teo, Zhi L, Todd, Kirsten L, Henderson, Melissa A, Giuffrida, Lauren, Petley, Emma V, Sek, Kevin, Mardiana, Sherly, Gide, Tuba N, Quek, Camelia, Scolyer, Richard A, Long, Georgina V, Wilmott, James S, Loi, Sherene, Darcy, Phillip K, Beavis, Paul A

“…Response rates to immune checkpoint blockade (ICB; anti-PD-1/anti-CTLA-4) correlate with the extent of tumor immune infiltrate, but the mechanisms underlying…”
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Combination nivolumab and ipilimumab or nivolumab alone in melanoma brain metastases: a multicentre randomised phase 2 study by Long, Georgina V, Atkinson, Victoria, Lo, Serigne, Sandhu, Shahneen, Guminski, Alexander D, Brown, Michael P, Wilmott, James S, Edwards, Jarem, Gonzalez, Maria, Scolyer, Richard A, Menzies, Alexander M, McArthur, Grant A

“…Nivolumab monotherapy and combination nivolumab plus ipilimumab increase proportions of patients achieving a response and survival versus ipilimumab in…”
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Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition by Lee, Jenny H., Shklovskaya, Elena, Lim, Su Yin, Carlino, Matteo S., Menzies, Alexander M., Stewart, Ashleigh, Pedersen, Bernadette, Irvine, Malama, Alavi, Sara, Yang, Jean Y. H., Strbenac, Dario, Saw, Robyn P. M., Thompson, John F., Wilmott, James S., Scolyer, Richard A., Long, Georgina V., Kefford, Richard F., Rizos, Helen

“…Transcriptomic signatures designed to predict melanoma patient responses to PD-1 blockade have been reported but rarely validated. We now show that…”
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Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin by Park, Simone L., Buzzai, Anthony, Rautela, Jai, Hor, Jyh Liang, Hochheiser, Katharina, Effern, Maike, McBain, Nathan, Wagner, Teagan, Edwards, Jarem, McConville, Robyn, Wilmott, James S., Scolyer, Richard A., Tüting, Thomas, Palendira, Umaimainthan, Gyorki, David, Mueller, Scott N., Huntington, Nicholas D., Bedoui, Sammy, Hölzel, Michael, Mackay, Laura K., Waithman, Jason, Gebhardt, Thomas

“…The immune system can suppress tumour development both by eliminating malignant cells and by preventing the outgrowth and spread of cancer cells that resist…”
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Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets by Newell, Felicity, Kong, Yan, Wilmott, James S., Johansson, Peter A., Ferguson, Peter M., Cui, Chuanliang, Li, Zhongwu, Kazakoff, Stephen H., Burke, Hazel, Dodds, Tristan J., Patch, Ann-Marie, Nones, Katia, Tembe, Varsha, Shang, Ping, van der Weyden, Louise, Wong, Kim, Holmes, Oliver, Lo, Serigne, Leonard, Conrad, Wood, Scott, Xu, Qinying, Rawson, Robert V., Mukhopadhyay, Pamela, Dummer, Reinhard, Levesque, Mitchell P., Jönsson, Göran, Wang, Xuan, Yeh, Iwei, Wu, Hong, Joseph, Nancy, Bastian, Boris C., Long, Georgina V., Spillane, Andrew J., Shannon, Kerwin F., Thompson, John F., Saw, Robyn P. M., Adams, David J., Si, Lu, Pearson, John V., Hayward, Nicholas K., Waddell, Nicola, Mann, Graham J., Guo, Jun, Scolyer, Richard A.

“…Knowledge of key drivers and therapeutic targets in mucosal melanoma is limited due to the paucity of comprehensive mutation data on this rare tumor type. To…”
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Dynamic Changes in PD-L1 Expression and Immune Infiltrates Early During Treatment Predict Response to PD-1 Blockade in Melanoma by Vilain, Ricardo E, Menzies, Alexander M, Wilmott, James S, Kakavand, Hojabr, Madore, Jason, Guminski, Alexander, Liniker, Elizabeth, Kong, Benjamin Y, Cooper, Adam J, Howle, Julie R, Saw, Robyn P M, Jakrot, Valerie, Lo, Serigne, Thompson, John F, Carlino, Matteo S, Kefford, Richard F, Long, Georgina V, Scolyer, Richard A

“…Disruption of PD-L1/cytotoxic T-cell PD-1 signaling by immune checkpoint inhibitors improves survival in cancer patients. This study sought to identify changes…”
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PD-L1 expression in melanoma shows marked heterogeneity within and between patients: implications for anti-PD-1/PD-L1 clinical trials by Madore, Jason, Vilain, Ricardo E., Menzies, Alexander M., Kakavand, Hojabr, Wilmott, James S., Hyman, Jessica, Yearley, Jennifer H., Kefford, Richard F., Thompson, John F., Long, Georgina V., Hersey, Peter, Scolyer, Richard A.

“…Summary This study evaluated the expression of PD‐L1 in immunotherapy‐naïve metastatic melanoma patients to determine longitudinal intrapatient concordance and…”
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CD103 + Tumor-Resident CD8 + T Cells Are Associated with Improved Survival in Immunotherapy-Naïve Melanoma Patients and Expand Significantly During Anti-PD-1 Treatment by Edwards, Jarem, Wilmott, James S, Madore, Jason, Gide, Tuba Nur, Quek, Camelia, Tasker, Annie, Ferguson, Angela, Chen, Jinbiao, Hewavisenti, Rehana, Hersey, Peter, Gebhardt, Thomas, Weninger, Wolfgang, Britton, Warwick J, Saw, Robyn P M, Thompson, John F, Menzies, Alexander M, Long, Georgina V, Scolyer, Richard A, Palendira, Umaimainthan

“…Therapeutic blockade of immune checkpoints has revolutionized cancer treatment. Durable responses, however, occur in less than half of those treated, and…”
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Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity by Newell, Felicity, Wilmott, James S., Johansson, Peter A., Nones, Katia, Addala, Venkateswar, Mukhopadhyay, Pamela, Broit, Natasa, Amato, Carol M., Van Gulick, Robert, Kazakoff, Stephen H., Patch, Ann-Marie, Koufariotis, Lambros T., Lakis, Vanessa, Leonard, Conrad, Wood, Scott, Holmes, Oliver, Xu, Qinying, Lewis, Karl, Medina, Theresa, Gonzalez, Rene, Saw, Robyn P. M., Spillane, Andrew J., Stretch, Jonathan R., Rawson, Robert V., Ferguson, Peter M., Dodds, Tristan J., Thompson, John F., Long, Georgina V., Levesque, Mitchell P., Robinson, William A., Pearson, John V., Mann, Graham J., Scolyer, Richard A., Waddell, Nicola, Hayward, Nicholas K.

“…To increase understanding of the genomic landscape of acral melanoma, a rare form of melanoma occurring on palms, soles or nail beds, whole genome sequencing…”
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Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours by Johansson, Peter A., Brooks, Kelly, Newell, Felicity, Palmer, Jane M., Wilmott, James S., Pritchard, Antonia L., Broit, Natasa, Wood, Scott, Carlino, Matteo S., Leonard, Conrad, Koufariotis, Lambros T., Nathan, Vaishnavi, Beasley, Aaron B., Howlie, Madeleine, Dawson, Rebecca, Rizos, Helen, Schmidt, Chris W., Long, Georgina V., Hamilton, Hayley, Kiilgaard, Jens F., Isaacs, Timothy, Gray, Elin S., Rolfe, Olivia J., Park, John J., Stark, Andrew, Mann, Graham J., Scolyer, Richard A., Pearson, John V., van Baren, Nicolas, Waddell, Nicola, Wadt, Karin W., McGrath, Lindsay A., Warrier, Sunil K., Glasson, William, Hayward, Nicholas K.

“…Uveal melanoma (UM) is the most common intraocular tumour in adults and despite surgical or radiation treatment of primary tumours, ~50% of patients progress…”
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Negative immune checkpoint regulation by VISTA: a mechanism of acquired resistance to anti-PD-1 therapy in metastatic melanoma patients by Kakavand, Hojabr, Jackett, Louise A, Menzies, Alexander M, Gide, Tuba N, Carlino, Matteo S, Saw, Robyn P M, Thompson, John F, Wilmott, James S, Long, Georgina V, Scolyer, Richard A

“…Understanding the mechanisms of acquired resistance to anti-PD-1 will allow development of better treatment strategies for cancer patients. This study…”
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Whole-genome landscapes of major melanoma subtypes by Hayward, Nicholas K., Wilmott, James S., Waddell, Nicola, Johansson, Peter A., Field, Matthew A., Nones, Katia, Patch, Ann-Marie, Kakavand, Hojabr, Alexandrov, Ludmil B., Burke, Hazel, Jakrot, Valerie, Kazakoff, Stephen, Holmes, Oliver, Leonard, Conrad, Sabarinathan, Radhakrishnan, Mularoni, Loris, Wood, Scott, Xu, Qinying, Waddell, Nick, Tembe, Varsha, Pupo, Gulietta M., De Paoli-Iseppi, Ricardo, Vilain, Ricardo E., Shang, Ping, Lau, Loretta M. S., Dagg, Rebecca A., Schramm, Sarah-Jane, Pritchard, Antonia, Dutton-Regester, Ken, Newell, Felicity, Fitzgerald, Anna, Shang, Catherine A., Grimmond, Sean M., Pickett, Hilda A., Yang, Jean Y., Stretch, Jonathan R., Behren, Andreas, Kefford, Richard F., Hersey, Peter, Long, Georgina V., Cebon, Jonathan, Shackleton, Mark, Spillane, Andrew J., Saw, Robyn P. M., López-Bigas, Núria, Pearson, John V., Thompson, John F., Scolyer, Richard A., Mann, Graham J.

“…Melanoma of the skin is a common cancer only in Europeans, whereas it arises in internal body surfaces (mucosal sites) and on the hands and feet (acral sites)…”
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Immunohistochemistry is highly sensitive and specific for the detection of V600E BRAF mutation in melanoma by Long, Georgina V, Wilmott, James S, Capper, David, Preusser, Matthias, Zhang, Yuxiao E, Thompson, John F, Kefford, Richard F, von Deimling, Andreas, Scolyer, Richard A

“…This study investigated the sensitivity and specificity of immunohistochemical (IHC) analysis using an anti-BRAF antibody to detect the presence of the BRAF…”
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Temporal and spatial modulation of the tumor and systemic immune response in the murine Gl261 glioma model by McKelvey, Kelly J, Hudson, Amanda L, Prasanna Kumar, Ramyashree, Wilmott, James S, Attrill, Grace H, Long, Georgina V, Scolyer, Richard A, Clarke, Stephen J, Wheeler, Helen R, Diakos, Connie I, Howell, Viive M

“…Glioblastoma, the most aggressive form of glioma, has a 5-year survival rate of <5%. While radiation and immunotherapies are routinely studied in the murine…”
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UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas by Wong, Stephen Q, Waldeck, Kelly, Vergara, Ismael A, Schröder, Jan, Madore, Jason, Wilmott, James S, Colebatch, Andrew J, De Paoli-Iseppi, Ricardo, Li, Jason, Lupat, Richard, Semple, Timothy, Arnau, Gisela Mir, Fellowes, Andrew, Leonard, J Helen, Hruby, George, Mann, Graham J, Thompson, John F, Cullinane, Carleen, Johnston, Meredith, Shackleton, Mark, Sandhu, Shahneen, Bowtell, David D L, Johnstone, Ricky W, Fox, Stephen B, McArthur, Grant A, Papenfuss, Anthony T, Scolyer, Richard A, Gill, Anthony J, Hicks, Rodney J, Tothill, Richard W

“…Merkel cell carcinoma (MCC) is an uncommon, but highly malignant, cutaneous tumor. Merkel cell polyoma virus (MCV) has been implicated in a majority of MCC…”
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Selective BRAF Inhibitors Induce Marked T-cell Infiltration into Human Metastatic Melanoma by WILMOTT, James S, LONG, Georgina V, HOWLE, Julie R, HAYDU, Lauren E, SHARMA, Raghwa N, THOMPSON, John F, KEFFORD, Richard F, HERSEY, Peter, SCOLYER, Richard A

“…To evaluate the effects of treatment with the potent mutant BRAF inhibitors GSK2118436 or vemurafenib (PLX4720) on immune responses to metastatic melanoma in…”
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Diet-driven microbial ecology underpins associations between cancer immunotherapy outcomes and the gut microbiome by Simpson, Rebecca C., Shanahan, Erin R., Batten, Marcel, Reijers, Irene L. M., Read, Mark, Silva, Ines P., Versluis, Judith M., Ribeiro, Rosilene, Angelatos, Alexandra S., Tan, Jian, Adhikari, Chandra, Menzies, Alexander M., Saw, Robyn P. M., Gonzalez, Maria, Shannon, Kerwin F., Spillane, Andrew J., Velickovic, Rebecca, Lazar, Alexander J., Damania, Ashish V., Mishra, Aditya K., Chelvanambi, Manoj, Banerjee, Anik, Ajami, Nadim J., Wargo, Jennifer A., Macia, Laurence, Holmes, Andrew J., Wilmott, James S., Blank, Christian U., Scolyer, Richard A., Long, Georgina V.

“…The gut microbiota shapes the response to immune checkpoint inhibitors (ICIs) in cancer, however dietary and geographic influences have not been well-studied…”
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Tissue-based Profiling Techniques to Achieve Precision Medicine in Cancer: Opportunities and Challenges in Melanoma by Gide, Tuba N, Mao, Yizhe, Scolyer, Richard A, Long, Georgina V, Wilmott, James S

“…Immunotherapies targeting the programmed cell death 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) checkpoint receptors have revolutionised the…”
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