Search Results - "WILLS, Mark"

Ribosome Profiling Reveals Pervasive Translation Outside of Annotated Protein-Coding Genes by Ingolia, Nicholas T., Brar, Gloria A., Stern-Ginossar, Noam, Harris, Michael S., Talhouarne, Gaëlle J.S., Jackson, Sarah E., Wills, Mark R., Weissman, Jonathan S.

“…Ribosome profiling suggests that ribosomes occupy many regions of the transcriptome thought to be noncoding, including 5′ UTRs and long noncoding RNAs…”
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Reduced Incidence of Long Coronavirus Disease Referrals to the Cambridge University Teaching Hospital Long Coronavirus Disease Clinic by Krishna, Benjamin A, Metaxaki, Marina, Wills, Mark R, Sithole, Nyaradzai

“…Long coronavirus disease (COVID [LC]) constitutes a potential health emergency as millions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…”
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Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease by Bergamaschi, Laura, Mescia, Federica, Turner, Lorinda, Hanson, Aimee L., Kotagiri, Prasanti, Dunmore, Benjamin J., Ruffieux, Hélène, De Sa, Aloka, Huhn, Oisín, Morgan, Michael D., Gerber, Pehuén Pereyra, Wills, Mark R., Baker, Stephen, Calero-Nieto, Fernando J., Doffinger, Rainer, Dougan, Gordon, Elmer, Anne, Goodfellow, Ian G., Gupta, Ravindra K., Hosmillo, Myra, Hunter, Kelvin, Kingston, Nathalie, Lehner, Paul J., Matheson, Nicholas J., Nicholson, Jeremy K., Petrunkina, Anna M., Richardson, Sylvia, Saunders, Caroline, Thaventhiran, James E.D., Toonen, Erik J.M., Weekes, Michael P., Göttgens, Berthold, Toshner, Mark, Hess, Christoph, Bradley, John R., Lyons, Paul A., Smith, Kenneth G.C.

“…The kinetics of the immune changes in COVID-19 across severity groups have not been rigorously assessed. Using immunophenotyping, RNA sequencing, and serum…”
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The CD4+ T Cell Response to Human Cytomegalovirus in Healthy and Immunocompromised People by Lim, Eleanor Y, Jackson, Sarah E, Wills, Mark R

“…While CD8+ T cells specific for human cytomegalovirus (HCMV) have been extensively studied in both healthy HCMV seropositive carriers and patients undergoing…”
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Human cytomegalovirus immunity and immune evasion by Jackson, Sarah E., Mason, Gavin M., Wills, Mark R.

“…▶ Cytomegalovirus virus elicits a very broad spectrum of immune responses. ▶ Innate mechanisms, including, inflammatory cytokines from virus-cell binding and…”
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The Expression of Human Cytomegalovirus MicroRNA MiR-UL148D during Latent Infection in Primary Myeloid Cells Inhibits Activin A-triggered Secretion of IL-6 by Lau, Betty, Poole, Emma, Krishna, Benjamin, Montanuy, Immaculada, Wills, Mark R., Murphy, Eain, Sinclair, John

“…The successful establishment and maintenance of human cytomegalovirus (HCMV) latency is dependent on the expression of a subset of viral genes. Whilst the…”
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HCMV Antivirals and Strategies to Target the Latent Reservoir by Perera, Marianne R, Wills, Mark R, Sinclair, John H

“…Human cytomegalovirus (HCMV) is a ubiquitous human herpesvirus. In healthy people, primary infection is generally asymptomatic, and the virus can go on to…”
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Human Cytomegalovirus (HCMV)-Specific CD4 + T Cells Are Polyfunctional and Can Respond to HCMV-Infected Dendritic Cells In Vitro by Jackson, Sarah E, Sedikides, George X, Mason, Gavin M, Okecha, Georgina, Wills, Mark R

“…Human cytomegalovirus (HCMV) infection and periodic reactivation are generally well controlled by the HCMV-specific T cell response in healthy people. While…”
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Generation, maintenance and tissue distribution of T cell responses to human cytomegalovirus in lytic and latent infection by Jackson, Sarah E., Sedikides, George X., Okecha, Georgina, Wills, Mark R.

“…Understanding how the T cell memory response directed towards human cytomegalovirus (HCMV) develops and changes over time while the virus persists is…”
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Latency-Associated Expression of Human Cytomegalovirus US28 Attenuates Cell Signaling Pathways To Maintain Latent Infection by Krishna, Benjamin A, Poole, Emma L, Jackson, Sarah E, Smit, Martine J, Wills, Mark R, Sinclair, John H

“…Reactivation of human cytomegalovirus (HCMV) latent infection from early myeloid lineage cells constitutes a threat to immunocompromised or immune-suppressed…”
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Human cytomegalovirus latency-associated proteins elicit immune-suppressive IL-10 producing CD4⁺ T cells by Mason, Gavin M, Jackson, Sarah, Okecha, Georgina, Poole, Emma, Sissons, J G Patrick, Sinclair, John, Wills, Mark R

“…Human cytomegalovirus (HCMV) is a widely prevalent human herpesvirus, which, after primary infection, persists in the host for life. In healthy individuals,…”
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The immunology of human cytomegalovirus latency： could latent infection be cleared by novel immunotherapeutic strategies by Wills, Mark R, Poole, Emma, Lau, Betty, Krishna, Ben, Sinclair, John H

“…While the host immune response following primary human cytomegalovirus （HCMV） infection is generally effective at stopping virus replication and dissemination,…”
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Utilizing TAPBPR to promote exogenous peptide loading onto cell surface MHC I molecules by Ilca, F. Tudor, Neerincx, Andreas, Wills, Mark R., de la Roche, Maike, Boyle, Louise H.

“…The repertoire of peptides displayed at the cell surface by MHC I molecules is shaped by two intracellular peptide editors, tapasin and TAPBPR. While cell-free…”
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Human cytomegalovirus major immediate early transcripts arise predominantly from the canonical major immediate early promoter in reactivating progenitor-derived dendritic cells by Mason, Rebecca, Groves, Ian J, Wills, Mark R, Sinclair, John H, Reeves, Matthew B

“…Human cytomegalovirus latency and reactivation is a major source of morbidity in immune-suppressed patient populations. Lifelong latent infections are…”
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Bromodomain proteins regulate human cytomegalovirus latency and reactivation allowing epigenetic therapeutic intervention by Groves, Ian J., Jackson, Sarah E., Poole, Emma L., Nachshon, Aharon, Rozman, Batsheva, Schwartz, Michal, Prinjha, Rab K., Tough, David F., Sinclair, John H., Wills, Mark R.

“…Reactivation of human cytomegalovirus (HCMV) from latency is a major health consideration for recipients of stem-cell and solid organ transplantations. With…”
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A highly reproducible quantitative viral outgrowth assay for the measurement of the replication-competent latent HIV-1 reservoir by Fun, Axel, Mok, Hoi Ping, Wills, Mark R., Lever, Andrew M.

“…Cure of Human Immunodeficiency Virus (HIV) infection remains elusive due to the persistence of HIV in a latent reservoir. Strategies to eradicate latent…”
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Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner by Shan, Liling, Li, Shuang, Meeldijk, Jan, Blijenberg, Bernadet, Hendriks, Astrid, van Boxtel, Karlijn J W M, van den Berg, Sara P H, Groves, Ian J, Potts, Martin, Svrlanska, Adriana, Stamminger, Thomas, Wills, Mark R, Bovenschen, Niels

“…Human cytomegalovirus (HCMV) is the most frequent viral cause of congenital defects and can trigger devastating disease in immune-suppressed patients…”
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Bromodomain Inhibitors as Therapeutics for Herpesvirus-Related Disease: All BETs Are Off? by Groves, Ian J, Sinclair, John H, Wills, Mark R

“…Although the ubiquitous human herpesviruses (HHVs) are rarely associated with serious disease of the healthy host, primary infection and reactivation in…”
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Nanopore sequencing and full genome de novo assembly of human cytomegalovirus TB40/E reveals clonal diversity and structural variations by Karamitros, Timokratis, van Wilgenburg, Bonnie, Wills, Mark, Klenerman, Paul, Magiorkinis, Gkikas

“…Human cytomegalovirus (HCMV) has a double-stranded DNA genome of approximately 235 Kbp that is structurally complex including extended GC-rich repeated…”
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NKG2D Ligand MICA Is Retained in the cis-Golgi Apparatus by Human Cytomegalovirus Protein UL142 by ASHIRU, Omodele, BENNETT, Neil J, BOYLE, Louise H, THOMAS, Mair, TROWSDALE, John, WILLS, Mark R

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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