Search Results - "WILLIS, Monte S"

Proteotoxicity and Cardiac Dysfunction — Alzheimer's Disease of the Heart? by Willis, Monte S, Patterson, Cam

“…Defective disposal of misfolded proteins is involved in the pathogenesis of neurodegenerative diseases, cystic fibrosis, and heart failure. Experimental…”
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The role of heat shock proteins and co-chaperones in heart failure by Ranek, Mark J., Stachowski, Marisa J., Kirk, Jonathan A., Willis, Monte S.

“…The ongoing contractile and metabolic demands of the heart require a tight control over protein quality control, including the maintenance of protein folding,…”
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Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover by Martin, Thomas G., Myers, Valerie D., Dubey, Praveen, Dubey, Shubham, Perez, Edith, Moravec, Christine S., Willis, Monte S., Feldman, Arthur M., Kirk, Jonathan A.

“…The association between reduced myofilament force-generating capacity (F max ) and heart failure (HF) is clear, however the underlying molecular mechanisms are…”
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MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice by Callis, Thomas E, Pandya, Kumar, Seok, Hee Young, Tang, Ru-Hang, Tatsuguchi, Mariko, Huang, Zhan-Peng, Chen, Jian-Fu, Deng, Zhongliang, Gunn, Bronwyn, Shumate, Janelle, Willis, Monte S, Selzman, Craig H, Wang, Da-Zhi

“…MicroRNAs (miRNAs) are a class of small noncoding RNAs that have gained status as important regulators of gene expression. Here, we investigated the function…”
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Cardiomyocyte glucocorticoid and mineralocorticoid receptors directly and antagonistically regulate heart disease in mice by Oakley, Robert H, Cruz-Topete, Diana, He, Bo, Foley, Julie F, Myers, Page H, Xu, Xiaojiang, Gomez-Sanchez, Celso E, Chambon, Pierre, Willis, Monte S, Cidlowski, John A

“…Stress is increasingly associated with heart dysfunction and is linked to higher mortality rates in patients with cardiometabolic disease. Glucocorticoids are…”
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The story so far: post-translational regulation of peroxisome proliferator-activated receptors by ubiquitination and SUMOylation by Wadosky, Kristine M, Willis, Monte S

“…Many studies have implicated the peroxisome proliferator-activated receptor (PPAR) family of nuclear receptor transcription factors in regulating cardiac…”
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Doxorubicin Exposure Causes Subacute Cardiac Atrophy Dependent on the Striated Muscle-Specific Ubiquitin Ligase MuRF1 by Willis, Monte S, Parry, Traci L, Brown, David I, Mota, Roberto I, Huang, Wei, Beak, Ju Youn, Sola, Michael, Zhou, Cynthia, Hicks, Sean T, Caughey, Melissa C, D'Agostino, Jr, Ralph B, Jordan, Jennifer, Hundley, W Gregory, Jensen, Brian C

“…Background Anthracycline chemotherapeutics, such as doxorubicin, are used widely in the treatment of numerous malignancies. The primary dose-limiting adverse…”
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Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heart by Anderson, Ethan J, Katunga, Lalage A, Willis, Monte S

“…Summary 1. The heart is a highly oxidative organ in which cardiomyocyte turnover is virtually absent, making it particularly vulnerable to accumulation of…”
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Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins by Li, Hui-Hua, Willis, Monte S, Lockyer, Pamela, Miller, Nathaniel, McDonough, Holly, Glass, David J, Patterson, Cam

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The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability by Rodrigues, Anna C. Z., Messi, Maria L., Wang, Zhong‐Min, Abba, Martin C., Pereyra, Andrea, Birbrair, Alexander, Zhang, Tan, O’Meara, Meaghan, Kwan, Ping, Lopez, Elsa I. S., Willis, Monte S., Mintz, Akiva, Files, D. Clark, Furdui, Cristina, Oppenheim, Ronald W., Delbono, Osvaldo

“…Aim Symptoms of autonomic failure are frequently the presentation of advanced age and neurodegenerative diseases that impair adaptation to common physiologic…”
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Tearin' Up My Heart: Proteolysis in the Cardiac Sarcomere by Portbury, Andrea L., Willis, Monte S., Patterson, Cam

“…Proteolysis within the cardiac sarcomere is a constantly evolving area of research. Three major pathways of proteolysis have been identified as being active…”
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Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy by Adamo, Candace M., Dai, Dao-Fu, Percival, Justin M., Minami, Elina, Willis, Monte S., Patrucco, Enrico, Froehner, Stanley C., Beavo, Joseph A.

“…Duchenne muscular dystrophy (DMD) is a progressive and fatal genetic disorder of muscle degeneration. Patients with DMD lack expression of the protein…”
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Essential role of stress hormone signaling in cardiomyocytes for the prevention of heart disease by Oakley, Robert H., Ren, Rongqin, Cruz-Topete, Diana, Bird, Gary S., Myers, Page H., Boyle, Michael C., Schneider, Michael D., Willis, Monte S., Cidlowski, John A.

“…Heart failure is a leading cause of death in humans, and stress is increasingly associated with adverse cardiac outcomes. Glucocorticoids are primary stress…”
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Depletion of PHD3 protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis by Xie, Liang, Pi, Xinchun, Wang, Zhongjing, He, Jun, Willis, Monte S, Patterson, Cam

“…Abstract PHD3, a member of a family of Prolyl-4 Hydroxylase Domain (PHD) proteins, has long been considered a pro-apoptotic protein. Although the pro-apoptotic…”
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Back to your heart: Ubiquitin proteasome system-regulated signal transduction by Portbury, Andrea L, Ronnebaum, Sarah M, Zungu, Makhosazane, Patterson, Cam, Willis, Monte S

“…Abstract Awareness of the regulation of cell signaling by post-translational ubiquitination has emerged over the past 2 decades. Like phosphorylation,…”
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CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury by Ranek, Mark J., Oeing, Christian, Sanchez-Hodge, Rebekah, Kokkonen-Simon, Kristen M., Dillard, Danielle, Aslam, M. Imran, Rainer, Peter P., Mishra, Sumita, Dunkerly-Eyring, Brittany, Holewinski, Ronald J., Virus, Cornelia, Zhang, Huaqun, Mannion, Matthew M., Agrawal, Vineet, Hahn, Virginia, Lee, Dong I., Sasaki, Masayuki, Van Eyk, Jennifer E., Willis, Monte S., Page, Richard C., Schisler, Jonathan C., Kass, David A.

“…Proteotoxicity from insufficient clearance of misfolded/damaged proteins underlies many diseases. Carboxyl terminus of Hsc70-interacting protein (CHIP) is an…”
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Mouse Cardiac Acyl Coenzyme A Synthetase 1 Deficiency Impairs Fatty Acid Oxidation and Induces Cardiac Hypertrophy by Ellis, Jessica M., Mentock, Shannon M., DePetrillo, Michael A., Koves, Timothy R., Sen, Shiraj, Watkins, Steven M., Muoio, Deborah M., Cline, Gary W., Taegtmeyer, Heinrich, Shulman, Gerald I., Willis, Monte S., Coleman, Rosalind A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Myosin Light Chain Phosphorylation Is Critical for Adaptation to Cardiac Stress by WARREN, Sonisha A, BRIGGS, Laura E, SPINALE, Francis G, MAUPIN-FURLOWE, Julie, MCMULLEN, Julie R, MOSS, Richard L, KASAHARA, Hideko, HUADONG ZENG, CHUANG, Joyce, CHANG, Eileen I, TERADA, Ryota, LI, Moyi, SWANSON, Maurice S, LECKER, Stewart H, WILLIS, Monte S

“…Cardiac hypertrophy is a common response to circulatory or neurohumoral stressors as a mechanism to augment contractility. When the heart is under sustained…”
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Cancer cachexia update in head and neck cancer: Definitions and diagnostic features by Couch, Marion E., Dittus, Kim, Toth, Michael J., Willis, Monte S., Guttridge, Denis C., George, Jonathan R., Barnes, Christie A., Gourin, Christine G., Der-Torossian, Hirak

“…ABSTRACT Cachexia is a profoundly debilitating wasting syndrome that affects patients with head and neck cancer and often contributes to their demise. A…”
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Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling by Quintana, Megan T, Parry, Traci L, He, Jun, Yates, Cecelia C, Sidorova, Tatiana N, Murray, Katherine T, Bain, James R, Newgard, Christopher B, Muehlbauer, Michael J, Eaton, Samuel C, Hishiya, Akinori, Takayama, Shin, Willis, Monte S

“…The Bcl2-associated anthanogene (BAG) 3 protein is a member of the BAG family of cochaperones, which supports multiple critical cellular processes, including…”
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