Search Results - "WILLIAMS, Tim D"

Mixture effects in samples of multiple contaminants – An inter-laboratory study with manifold bioassays by Altenburger, Rolf, Scholze, Martin, Busch, Wibke, Escher, Beate I., Jakobs, Gianina, Krauss, Martin, Krüger, Janet, Neale, Peta A., Ait-Aissa, Selim, Almeida, Ana Catarina, Seiler, Thomas-Benjamin, Brion, François, Hilscherová, Klára, Hollert, Henner, Novák, Jiří, Schlichting, Rita, Serra, Hélène, Shao, Ying, Tindall, Andrew, Tollefsen, Knut Erik, Umbuzeiro, Gisela, Williams, Tim D., Kortenkamp, Andreas

“…Chemicals in the environment occur in mixtures rather than as individual entities. Environmental quality monitoring thus faces the challenge to comprehensively…”
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Identifying Health Impacts of Exposure to Copper Using Transcriptomics and Metabolomics in a Fish Model by Santos, Eduarda M, Ball, Jonathan S, Williams, Tim D, Wu, Huifeng, Ortega, Fernando, van Aerle, Ronny, Katsiadaki, Ioanna, Falciani, Francesco, Viant, Mark R, Chipman, James K, Tyler, Charles R

“…Copper (Cu) is a micronutrient essential for the biochemical functioning of numerous processes in vertebrates but is also often present in the aquatic…”
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Towards a system level understanding of non-model organisms sampled from the environment: a network biology approach by Williams, Tim D, Turan, Nil, Diab, Amer M, Wu, Huifeng, Mackenzie, Carolynn, Bartie, Katie L, Hrydziuszko, Olga, Lyons, Brett P, Stentiford, Grant D, Herbert, John M, Abraham, Joseph K, Katsiadaki, Ioanna, Leaver, Michael J, Taggart, John B, George, Stephen G, Viant, Mark R, Chipman, Kevin J, Falciani, Francesco

“…The acquisition and analysis of datasets including multi-level omics and physiology from non-model species, sampled from field populations, is a formidable…”
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Hepatic transcriptomic and metabolomic responses in the Stickleback ( Gasterosteus aculeatus) exposed to ethinyl-estradiol by Katsiadaki, Ioanna, Williams, Tim D., Ball, Jonathan S., Bean, Tim P., Sanders, Matthew B., Wu, Huifeng, Santos, Eduarda M., Brown, Margaret M., Baker, Paul, Ortega, Fernando, Falciani, Francesco, Craft, John A., Tyler, Charles R., Viant, Mark R., Chipman, James K.

“…An established three-spined stickleback ( Gasterosteus aculeatus) cDNA array was expanded to 14,496 probes with the addition of hepatic clones derived from…”
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Hepatic Transcriptomic and Metabolomic Responses in the Stickleback (Gasterosteus aculeatus) Exposed to Environmentally Relevant Concentrations of Dibenzanthracene by Williams, Tim D, Wu, Huifeng, Santos, Eduarda M, Ball, Jon, Katsiadaki, Ioanna, Brown, Margaret M, Baker, Paul, Ortega, Fernando, Falciani, Francesco, Craft, John A, Tyler, Charles R, Chipman, James K, Viant, Mark R

“…A three-spined stickleback (Gasterosteus aculeatus) cDNA array and one-dimensional 1H nuclear magnetic resonance (NMR) spectroscopy-based metabolomics…”
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Comparative aquatic toxicity of propranolol and its photodegraded mixtures: Algae and rotifer screening by Liu, Qin-Tao, Williams, Tim D., Cumming, Rob I., Holm, Gisela, Hetheridge, Malcolm J., Murray-Smith, Richard

“…Transformation products of pharmaceuticals formed by human metabolism within sewage treatment plant or receiving waters are predicted, in most cases, to be…”
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High-throughput functional annotation and data mining with the Blast2GO suite by Götz, Stefan, García-Gómez, Juan Miguel, Terol, Javier, Williams, Tim D, Nagaraj, Shivashankar H, Nueda, María José, Robles, Montserrat, Talón, Manuel, Dopazo, Joaquín, Conesa, Ana

“…Functional genomics technologies have been widely adopted in the biological research of both model and non-model species. An efficient functional annotation of…”
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Future water quality monitoring--adapting tools to deal with mixtures of pollutants in water resource management by Altenburger, Rolf, Ait-Aissa, Selim, Antczak, Philipp, Backhaus, Thomas, Barceló, Damià, Seiler, Thomas-Benjamin, Brion, Francois, Busch, Wibke, Chipman, Kevin, de Alda, Miren López, de Aragão Umbuzeiro, Gisela, Escher, Beate I, Falciani, Francesco, Faust, Michael, Focks, Andreas, Hilscherova, Klara, Hollender, Juliane, Hollert, Henner, Jäger, Felix, Jahnke, Annika, Kortenkamp, Andreas, Krauss, Martin, Lemkine, Gregory F, Munthe, John, Neumann, Steffen, Schymanski, Emma L, Scrimshaw, Mark, Segner, Helmut, Slobodnik, Jaroslav, Smedes, Foppe, Kughathas, Subramaniam, Teodorovic, Ivana, Tindall, Andrew J, Tollefsen, Knut Erik, Walz, Karl-Heinz, Williams, Tim D, Van den Brink, Paul J, van Gils, Jos, Vrana, Branislav, Zhang, Xiaowei, Brack, Werner

“…Environmental quality monitoring of water resources is challenged with providing the basis for safeguarding the environment against adverse biological effects…”
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Molecular toxicity of cerium oxide nanoparticles to the freshwater alga Chlamydomonas reinhardtii is associated with supra-environmental exposure concentrations by Taylor, Nadine S., Merrifield, Ruth, Williams, Tim D., Chipman, J. Kevin, Lead, Jamie R., Viant, Mark R.

“…Ceria nanoparticles (NPs) are widely used as fuel catalysts and consequently are likely to enter the environment. Their potential impacts on. biota at…”
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cDNA cloning and expression of a cytochrome P450 1A ( CYP1A) gene from the hermaphroditic fish Rivulus marmoratus by Lee, Young-Mi, Williams, Tim D., Jung, Sang-Oun, Lee, Jae-Seong

“…We previously described the genomic structure of the cytochrome P450 1A ( CYP1A) gene from the hermaphroditic fish Rivulus marmoratus [Kim, I.-C., Kim, Y.J.,…”
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The toxicological application of transcriptomics and epigenomics in zebrafish and other teleosts by Williams, Tim D, Mirbahai, Leda, Chipman, J Kevin

“…Zebrafish (Danio rerio) is one of a number of teleost fish species frequently employed in toxicology. Toxico-genomics determines global transcriptomic…”
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Molecular responses of European flounder (Platichthys flesus) chronically exposed to contaminated estuarine sediments by Williams, Tim D., Davies, Ian M., Wu, Huifeng, Diab, Amer M., Webster, Lynda, Viant, Mark R., Chipman, J. Kevin, Leaver, Michael J., George, Stephen G., Moffat, Colin F., Robinson, Craig D.

“…•Flounders were exposed to contaminated sediments in mesocosms for 7months.•Little differential accumulation of contaminants was found by chemical…”
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Integrating Omic Technologies into Aquatic Ecological Risk Assessment and Environmental Monitoring: Hurdles, Achievements, and Future Outlook by Van Aggelen, Graham, Ankley, Gerald T., Baldwin, William S., Bearden, Daniel W., Benson, William H., Chipman, J. Kevin, Collette, Tim W., Craft, John A., Denslow, Nancy D., Embry, Michael R., Falciani, Francesco, George, Stephen G., Helbing, Caren C., Hoekstra, Paul F., Iguchi, Taisen, Kagami, Yoshi, Katsiadaki, Ioanna, Kille, Peter, Liu, Li, Lord, Peter G., McIntyre, Terry, O'Neill, Anne, Osachoff, Heather, Perkins, Ed J., Santos, Eduarda M., Skirrow, Rachel C., Snape, Jason R., Tyler, Charles R., Versteeg, Don, Viant, Mark R., Volz, David C., Williams, Tim D., Yu, Lorraine

“…Background: In this commentary we present the findings from an international consortium on fish toxicogenomics sponsored by the U.K. Natural Environment…”
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Gene expression and epigenetic changes by furan in rat liver by Chen, Tao, Williams, Tim D, Mally, Angela, Hamberger, Carolin, Mirbahai, Leda, Hickling, Kevin, Chipman, J. Kevin

“…Abstract Furan, a widely used industrial compound, has been found in a number of heated food items. Furan is carcinogenic to rats and mice, but the mechanism…”
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Molecular basis of carcinogenicity of tungsten alloy particles by Harris, Robert M., Williams, Tim D., Waring, Rosemary H., Hodges, Nikolas J.

“…The tungsten alloy of 91% tungsten, 6% nickel and 3% cobalt (WNC 91–6–3) induces rhabdomyosarcoma when implanted into a rat thigh muscle. To investigate…”
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Hepatic transcriptional responses to copper in the three-spined stickleback are affected by their pollution exposure history by Uren Webster, Tamsyn M., Williams, Tim D., Katsiadaki, Ioanna, Lange, Anke, Lewis, Ceri, Shears, Janice A., Tyler, Charles R., Santos, Eduarda M.

“…•Historical metal exposure is linked to altered transcriptional responses to copper.•Stickleback from metal-rich areas have higher basal transcription of genes…”
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Disruption of DNA Methylation via S‑Adenosylhomocysteine Is a Key Process in High Incidence Liver Carcinogenesis in Fish by Mirbahai, Leda, Southam, Andrew D, Sommer, Ulf, Williams, Tim D, Bignell, John P, Lyons, Brett P, Viant, Mark R, Chipman, James K

“…Interactions between epigenome and the environment in biology and in disease are of fundamental importance. The incidence of hepatocellular adenomas in…”
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Hepatic gene expression in flounder chronically exposed to multiply polluted estuarine sediment: Absence of classical exposure ‘biomarker’ signals and induction of inflammatory, innate immune and apoptotic pathways by Leaver, Michael J., Diab, Amer, Boukouvala, Evridiki, Williams, Tim D., Chipman, J. Kevin, Moffat, Colin F., Robinson, Craig D., George, Stephen G.

“…The effects of chronic long-term exposure to multiply polluted environments on fish are not well understood, but environmental surveys suggest that such…”
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Gene expression responses of European flounder ( Platichthys flesus) to 17-β estradiol by Williams, Tim D., Diab, Amer M., George, Stephen G., Sabine, Victoria, Chipman, James K.

“…Male European flounder ( Platichthys flesus) were intraperitoneally injected with 10 mg/kg 17-beta estradiol and tissues taken from individuals over a…”
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Global genomic methylation levels in the liver and gonads of the three-spine stickleback (Gasterosteus aculeatus) after exposure to hexabromocyclododecane and 17-β oestradiol by Aniagu, Stanley O., Williams, Tim D., Allen, Yvonne, Katsiadaki, Ioanna, Chipman, J. Kevin

“…Alteration of DNA methylation is a major epigenetic mechanism associated with the effects of nongenotoxic carcinogens. We evaluated the effects of two…”
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