Search Results - "WILLIAMS, R. Scott"

Molecular mechanisms of topoisomerase 2 DNA–protein crosslink resolution by Riccio, Amanda A., Schellenberg, Matthew J., Williams, R. Scott

“…The compaction of DNA and the continuous action of DNA transactions, including transcription and DNA replication, create complex DNA topologies that require…”
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Introduction to the multi-author-review: emerging advances in the structural chemistry of DNA strand break repair by Williams, R. Scott

“…DNA strand breaks present a complex challenge for our cells, and the integrity of the DNA damage response machinery is critical for preventing cancer,…”
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CtIP/Ctp1/Sae2, molecular form fit for function by Andres, Sara N., Williams, R. Scott

“…Vertebrate CtIP, and its fission yeast (Ctp1), budding yeast (Sae2) and plant (Com1) orthologs have emerged as key regulatory molecules in cellular responses…”
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Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease by Sharifi, Reza, Morra, Rosa, Denise Appel, C, Tallis, Michael, Chioza, Barry, Jankevicius, Gytis, Simpson, Michael A, Matic, Ivan, Ozkan, Ege, Golia, Barbara, Schellenberg, Matthew J, Weston, Ria, Williams, Jason G, Rossi, Marianna N, Galehdari, Hamid, Krahn, Juno, Wan, Alexander, Trembath, Richard C, Crosby, Andrew H, Ahel, Dragana, Hay, Ron, Ladurner, Andreas G, Timinszky, Gyula, Williams, R Scott, Ahel, Ivan

“…Adenosine diphosphate (ADP)‐ribosylation is a post‐translational protein modification implicated in the regulation of a range of cellular processes. A family…”
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High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication by Williams, Jessica S., Tumbale, Percy P., Arana, Mercedes E., Rana, Julian A., Williams, R. Scott, Kunkel, Thomas A.

“…DNA ligase 1 (LIG1, Cdc9 in yeast) finalizes eukaryotic nuclear DNA replication by sealing Okazaki fragments using DNA end-joining reactions that strongly…”
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ZATT (ZNF451)–mediated resolution of topoisomerase 2 DNA-protein cross-links by Schellenberg, Matthew J., Lieberman, Jenna Ariel, Herrero-Ruiz, Andrés, Butler, Logan R., Williams, Jason G., Muñoz-Cabello, Ana M., Mueller, Geoffrey A., London, Robert E., Cortés-Ledesma, Felipe, Williams, R. Scott

“…Topoisomerase 2 (TOP2) DNA transactions proceed via formation of the TOP2 cleavage complex (TOP2cc), a covalent enzyme-DNA reaction intermediate that is…”
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The three-component helicase/primase complex of herpes simplex virus-1 by Bermek, Oya, Williams, R Scott

“…Herpes simplex virus type 1 (HSV-1) is one of the nine herpesviruses that infect humans. HSV-1 encodes seven proteins to replicate its genome in the hijacked…”
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APE2 Zf-GRF facilitates 3′-5′ resection of DNA damage following oxidative stress by Wallace, Bret D., Berman, Zachary, Mueller, Geoffrey A., Lin, Yunfeng, Chang, Timothy, Andres, Sara N., Wojtaszek, Jessica L., DeRose, Eugene F., Appel, C. Denise, London, Robert E., Yan, Shan, Williams, R. Scott

“…The Xenopus laevis APE2 (apurinic/apyrimidinic endonuclease 2) nuclease participates in 3′-5′ nucleolytic resection of oxidative DNA damage and activation of…”
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High fidelity DNA ligation prevents single base insertions in the yeast genome by Williams, Jessica S., Lujan, Scott. A., Arana, Mercedes E., Burkholder, Adam B., Tumbale, Percy P., Williams, R. Scott, Kunkel, Thomas A.

“…Finalization of eukaryotic nuclear DNA replication relies on DNA ligase 1 (LIG1) to seal DNA nicks generated during Okazaki Fragment Maturation (OFM). Using a…”
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Structure-specific roles for PolG2–DNA complexes in maintenance and replication of mitochondrial DNA by Wojtaszek, Jessica L, Hoff, Kirsten E, Longley, Matthew J, Kaur, Parminder, Andres, Sara N, Wang, Hong, Williams, R Scott, Copeland, William C

“…Abstract The homodimeric PolG2 accessory subunit of the mitochondrial DNA polymerase gamma (Pol γ) enhances DNA binding and processive DNA synthesis by the…”
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Regulatory control of DNA end resection by Sae2 phosphorylation by Cannavo, Elda, Johnson, Dominic, Andres, Sara N., Kissling, Vera M., Reinert, Julia K., Garcia, Valerie, Erie, Dorothy A., Hess, Daniel, Thomä, Nicolas H., Enchev, Radoslav I., Peter, Matthias, Williams, R. Scott, Neale, Matt J., Cejka, Petr

“…DNA end resection plays a critical function in DNA double-strand break repair pathway choice. Resected DNA ends are refractory to end-joining mechanisms and…”
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Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2·DNA and Top2·RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2) by Gao, Rui, Schellenberg, Matthew J., Huang, Shar-yin N., Abdelmalak, Monica, Marchand, Christophe, Nitiss, Karin C., Nitiss, John L., Williams, R. Scott, Pommier, Yves

“…Eukaryotic type II topoisomerases (Top2α and Top2β) are homodimeric enzymes; they are essential for altering DNA topology by the formation of normally…”
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Ctp1 protein–DNA filaments promote DNA bridging and DNA double-strand break repair by Andres, Sara N., Li, Zimeng M., Erie, Dorothy A., Williams, R. Scott

“…The Ctp1 protein in Schizosaccharomyces pombe is essential for DNA double-strand break (DSB) repair by homologous recombination. Fission yeast Ctp1 and its…”
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Two-tiered enforcement of high-fidelity DNA ligation by Tumbale, Percy P., Jurkiw, Thomas J., Schellenberg, Matthew J., Riccio, Amanda A., O’Brien, Patrick J, Williams, R. Scott

“…DNA ligases catalyze the joining of DNA strands to complete DNA replication, recombination and repair transactions. To protect the integrity of the genome, DNA…”
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Selectable high‐yield recombinant protein production in human cells using a GFP/YFP nanobody affinity support by Schellenberg, Matthew J., Petrovich, Robert M., Malone, Christine C., Williams, R. Scott

“…Recombinant protein expression systems that produce high yields of pure proteins and multi‐protein complexes are essential to meet the needs of biologists,…”
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An autoinhibitory role for the GRF zinc finger domain of DNA glycosylase NEIL3 by Rodriguez, Alyssa A., Wojtaszek, Jessica L., Greer, Briana H., Haldar, Tuhin, Gates, Kent S., Williams, R.Scott, Eichman, Brandt F.

“…The NEIL3 DNA glycosylase maintains genome integrity during replication by excising oxidized bases from single-stranded DNA (ssDNA) and unhooking interstrand…”
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Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis by Kaminski, Andrea M., Tumbale, Percy P., Schellenberg, Matthew J., Williams, R. Scott, Williams, Jason G., Kunkel, Thomas A., Pedersen, Lars C., Bebenek, Katarzyna

“…DNA ligase IV (LigIV) performs the final DNA nick-sealing step of classical nonhomologous end-joining, which is critical for immunoglobulin gene maturation and…”
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Recognition and repair of chemically heterogeneous structures at DNA ends by Andres, Sara N., Schellenberg, Matthew J., Wallace, Bret D., Tumbale, Percy, Williams, R. Scott

“…Exposure to environmental toxicants and stressors, radiation, pharmaceutical drugs, inflammation, cellular respiration, and routine DNA metabolism all lead to…”
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Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair by Williams, R. Scott, Dodson, Gerald E., Limbo, Oliver, Yamada, Yoshiki, Williams, Jessica S., Guenther, Grant, Classen, Scott, Glover, J.N. Mark, Iwasaki, Hiroshi, Russell, Paul, Tainer, John A.

“…The Nijmegen breakage syndrome 1 (Nbs1) subunit of the Mre11-Rad50-Nbs1 (MRN) complex protects genome integrity by coordinating double-strand break (DSB)…”
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ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair by Williams, R Scott, Russell, Paul, Tainer, John A, Williams, Gareth J, Williams, Jessica S, Moncalian, Gabriel, Arvai, Andrew S, Limbo, Oliver, Guenther, Grant, SilDas, Soumita, Hammel, Michal

“…Rad50 is an ABC-type ATPase that forms a complex with the nuclease Mre11 and plays an essential role in the signaling and repair of DNA damage. Now crystal…”
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