Search Results - "WILLIAMS, L. David"

Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB Activation via GPR81-Mediated Signaling by Yang, Kun, Xu, Jingjing, Fan, Min, Tu, Fei, Wang, Xiaohui, Ha, Tuanzhu, Williams, David L, Li, Chuanfu

“…Recent evidence from cancer research indicates that lactate exerts a suppressive effect on innate immune responses in cancer. This study investigated the…”
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Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection by Bosteels, Cedric, Neyt, Katrijn, Vanheerswynghels, Manon, van Helden, Mary J., Sichien, Dorine, Debeuf, Nincy, De Prijck, Sofie, Bosteels, Victor, Vandamme, Niels, Martens, Liesbet, Saeys, Yvan, Louagie, Els, Lesage, Manon, Williams, David L., Tang, Shiau-Choot, Mayer, Johannes U., Ronchese, Franca, Scott, Charlotte L., Hammad, Hamida, Guilliams, Martin, Lambrecht, Bart N.

“…The phenotypic and functional dichotomy between IRF8+ type 1 and IRF4+ type 2 conventional dendritic cells (cDC1s and cDC2s, respectively) is well accepted; it…”
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Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity by Arts, Rob J.W., Novakovic, Boris, ter Horst, Rob, Carvalho, Agostinho, Bekkering, Siroon, Lachmandas, Ekta, Rodrigues, Fernando, Silvestre, Ricardo, Cheng, Shih-Chin, Wang, Shuang-Yin, Habibi, Ehsan, Gonçalves, Luís G., Mesquita, Inês, Cunha, Cristina, van Laarhoven, Arjan, van de Veerdonk, Frank L., Williams, David L., van der Meer, Jos W.M., Logie, Colin, O'Neill, Luke A., Dinarello, Charles A., Riksen, Niels P., van Crevel, Reinout, Clish, Clary, Notebaart, Richard A., Joosten, Leo A.B., Stunnenberg, Hendrik G., Xavier, Ramnik J., Netea, Mihai G.

“…Induction of trained immunity (innate immune memory) is mediated by activation of immune and metabolic pathways that result in epigenetic rewiring of cellular…”
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Attenuation of Cardiac Dysfunction in Polymicrobial Sepsis by MicroRNA-146a Is Mediated via Targeting of IRAK1 and TRAF6 Expression by Gao, Ming, Wang, Xiaohui, Zhang, Xia, Ha, Tuanzhu, Ma, He, Liu, Li, Kalbfleisch, John H, Gao, Xiang, Kao, Race L, Williams, David L, Li, Chuanfu

“…Cardiac dysfunction is a major consequence of sepsis/septic shock and contributes to the high mortality of sepsis. Innate and inflammatory responses mediated…”
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Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction by Fan, Min, Yang, Kun, Wang, Xiaohui, Chen, Linjian, Gill, P Spencer, Ha, Tuanzhu, Liu, Li, Lewis, Nicole H, Williams, David L, Li, Chuanfu

“…High levels of lactate are positively associated with the prognosis and mortality in patients with heart attack. Endothelial-to-mesenchymal transition (EndoMT)…”
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The genome of the blood fluke Schistosoma mansoni by Berriman, Matthew, Haas, Brian J., LoVerde, Philip T., Wilson, R. Alan, Dillon, Gary P., Cerqueira, Gustavo C., Mashiyama, Susan T., Al-Lazikani, Bissan, Andrade, Luiza F., Ashton, Peter D., Aslett, Martin A., Bartholomeu, Daniella C., Blandin, Gaelle, Caffrey, Conor R., Coghlan, Avril, Coulson, Richard, Day, Tim A., Delcher, Art, DeMarco, Ricardo, Djikeng, Appolinaire, Eyre, Tina, Gamble, John A., Ghedin, Elodie, Gu, Yong, Hertz-Fowler, Christiane, Hirai, Hirohisha, Hirai, Yuriko, Houston, Robin, Ivens, Alasdair, Johnston, David A., Lacerda, Daniela, Macedo, Camila D., McVeigh, Paul, Ning, Zemin, Oliveira, Guilherme, Overington, John P., Parkhill, Julian, Pertea, Mihaela, Pierce, Raymond J., Protasio, Anna V., Quail, Michael A., Rajandream, Marie-Adèle, Rogers, Jane, Sajid, Mohammed, Salzberg, Steven L., Stanke, Mario, Tivey, Adrian R., White, Owen, Williams, David L., Wortman, Jennifer, Wu, Wenjie, Zamanian, Mostafa, Zerlotini, Adhemar, Fraser-Liggett, Claire M., Barrell, Barclay G., El-Sayed, Najib M.

“…Schistosoma mansoni is responsible for the neglected tropical disease schistosomiasis that affects 210 million people in 76 countries. Here we present analysis…”
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An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity by Borriello, Francesco, Poli, Valentina, Shrock, Ellen, Spreafico, Roberto, Liu, Xin, Pishesha, Novalia, Carpenet, Claire, Chou, Janet, Di Gioia, Marco, McGrath, Marisa E., Dillen, Carly A., Barrett, Nora A., Lacanfora, Lucrezia, Franco, Marcella E., Marongiu, Laura, Iwakura, Yoichiro, Pucci, Ferdinando, Kruppa, Michael D., Ma, Zuchao, Lowman, Douglas W., Ensley, Harry E., Nanishi, Etsuro, Saito, Yoshine, O’Meara, Timothy R., Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Dowling, David J., Frieman, Matthew, Elledge, Stephen J., Levy, Ofer, Irvine, Darrell J., Ploegh, Hidde L., Williams, David L., Zanoni, Ivan

“…Activation of the innate immune system via pattern recognition receptors (PRRs) is key to generate lasting adaptive immunity. PRRs detect unique chemical…”
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Scavenger receptor-A (CD204): a two-edged sword in health and disease by Kelley, Jim L, Ozment, Tammy R, Li, Chuanfu, Schweitzer, John B, Williams, David L

“…Scavenger receptor A (SR-A), also known as the macrophage scavenger receptor and cluster of differentiation 204 (CD204), plays roles in lipid metabolism,…”
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Immunoregulatory Activity of the Natural Product Laminarin Varies Widely as a Result of Its Physical Properties by Smith, Alyson J, Graves, Bridget, Child, Robert, Rice, Peter J, Ma, Zuchao, Lowman, Douglas W, Ensley, Harry E, Ryter, Kendal T, Evans, Jay T, Williams, David L

“…Ligation of Dectin-1 by fungal glucans elicits a Th17 response that is necessary for clearing many fungal pathogens. Laminarin is a (1→3, 1→6)-β-glucan that is…”
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Trained immunity or tolerance: opposing functional programs induced in human monocytes after engagement of various pattern recognition receptors by Ifrim, Daniela C, Quintin, Jessica, Joosten, Leo A B, Jacobs, Cor, Jansen, Trees, Jacobs, Liesbeth, Gow, Neil A R, Williams, David L, van der Meer, Jos W M, Netea, Mihai G

“…Upon priming with Candida albicans or with the fungal cell wall component β-glucan, monocytes respond with an increased cytokine production upon restimulation,…”
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Memory-Like Inflammatory Responses of Microglia to Rising Doses of LPS: Key Role of PI3Kγ by Lajqi, Trim, Lang, Guang-Ping, Haas, Fabienne, Williams, David L, Hudalla, Hannes, Bauer, Michael, Groth, Marco, Wetzker, Reinhard, Bauer, Reinhard

“…Trained immunity and immune tolerance have been identified as long-term response patterns of the innate immune system. The causes of these opposing reactions…”
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Immunobiology and application of toll-like receptor 4 agonists to augment host resistance to infection by Hernandez, Antonio, Patil, Naeem K., Stothers, Cody L., Luan, Liming, McBride, Margaret A., Owen, Allison M., Burelbach, Katherine R., Williams, David L., Sherwood, Edward R., Bohannon, Julia K.

“…[Display omitted] Infectious diseases remain a threat to critically ill patients, particularly with the rise of antibiotic-resistant bacteria. Septic shock…”
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Human Dectin-1 Deficiency and Mucocutaneous Fungal Infections by Ferwerda, Gerben, Ferwerda, Bart, Plantinga, Theo S, Willment, Janet A, van Spriel, Annemiek B, Venselaar, Hanka, Elbers, Clara C, Johnson, Melissa D, Cambi, Alessandra, Huysamen, Cristal, Jacobs, Liesbeth, Jansen, Trees, Verheijen, Karlijn, Masthoff, Laury, Morré, Servaas A, Vriend, Gert, Williams, David L, Perfect, John R, Joosten, Leo A.B, Wijmenga, Cisca, van der Meer, Jos W.M, Adema, Gosse J, Kullberg, Bart Jan, Brown, Gordon D, Netea, Mihai G

“…A family with recurrent mucocutaneous candidiasis was evaluated for a potential genetic cause. An early-stop-codon mutation in the β-glucan receptor dectin-1…”
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Taking Advantage of the Morpheein Behavior of Peroxiredoxin in Bionanotechnology by Ardini, Matteo, Bellelli, Andrea, Williams, David L, Di Leandro, Luana, Giansanti, Francesco, Cimini, Annamaria, Ippoliti, Rodolfo, Angelucci, Francesco

“…Morpheeins are proteins that reversibly assemble into different oligomers, whose architectures are governed by conformational changes of the subunits. This…”
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Cardiovascular Dysfunction in COVID-19: Association Between Endothelial Cell Injury and Lactate by Yang, Kun, Holt, Matthew, Fan, Min, Lam, Victor, Yang, Yong, Ha, Tuanzhu, Williams, David L, Li, Chuanfu, Wang, Xiaohui

“…Coronavirus disease 2019 (COVID-19), an infectious respiratory disease propagated by a new virus known as Severe Acute Respiratory Syndrome Coronavirus-2…”
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Role of the Methoxy Group in Immune Responses to mPEG-Protein Conjugates by Sherman, Merry R, Williams, L. David, Sobczyk, Monika A, Michaels, Shawnya J, Saifer, Mark G. P

“…Anti-PEG antibodies have been reported to mediate the accelerated clearance of PEG-conjugated proteins and liposomes, all of which contain methoxyPEG (mPEG)…”
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β-Glucan Size Controls Dectin-1-Mediated Immune Responses in Human Dendritic Cells by Regulating IL-1β Production by Elder, Matthew J, Webster, Steve J, Chee, Ronnie, Williams, David L, Hill Gaston, J S, Goodall, Jane C

“…Dectin-1/CLEC7A is a pattern recognition receptor that recognizes β-1,3 glucans, and its stimulation initiates signaling events characterized by the production…”
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Efficacy of a crosslinked hyaluronic acid-based hydrogel as a tear film supplement: a masked controlled study by Williams, David L, Mann, Brenda K

“…Keratoconjunctivitis sicca (KCS), or dry eye, is a significant medical problem in both humans and dogs. Treating KCS often requires the daily application of…”
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Novel Structural Features in Candida albicans Hyphal Glucan Provide a Basis for Differential Innate Immune Recognition of Hyphae Versus Yeast by Lowman, Douglas W., Greene, Rachel R., Bearden, Daniel W., Kruppa, Michael D., Pottier, Max, Monteiro, Mario A., Soldatov, Dmitriy V., Ensley, Harry E., Cheng, Shih-Chin, Netea, Mihai G., Williams, David L.

“…The innate immune system differentially recognizes Candida albicans yeast and hyphae. It is not clear how the innate immune system effectively discriminates…”
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Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo by Petukhova, Valentina Z., Aboagye, Sammy Y., Ardini, Matteo, Lullo, Rachel P., Fata, Francesca, Byrne, Margaret E., Gabriele, Federica, Martin, Lucy M., Harding, Luke N. M., Gone, Vamshikrishna, Dangi, Bikash, Lantvit, Daniel D., Nikolic, Dejan, Ippoliti, Rodolfo, Effantin, Grégory, Ling, Wai Li, Johnson, Jeremy J., Thatcher, Gregory R. J., Angelucci, Francesco, Williams, David L., Petukhov, Pavel A.

“…Only praziquantel is available for treating schistosomiasis, a disease affecting more than 200 million people. Praziquantel-resistant worms have been selected…”
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