Search Results - "WILLIAMS, Jon"

Loteprednol etabonate gel 0.5% vs prednisolone acetate suspension 1% for the treatment of inflammation after cataract surgery in children by Vittitow, Jason L, Williams, Jon I

“…To compare loteprednol etabonate (LE) gel 0.5% with prednisolone acetate suspension (PA) 1% for the treatment of inflammation after cataract surgery in…”
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The central role of arterial retention of cholesterol-rich apolipoprotein-B-containing lipoproteins in the pathogenesis of atherosclerosis: a triumph of simplicity by Borén, Jan, Williams, Kevin Jon

“…Today, it is no longer a hypothesis, but an established fact, that increased plasma concentrations of cholesterol-rich apolipoprotein-B (apoB)-containing…”
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Emerging Chromatography-Free High-Throughput Mass Spectrometry Technologies for Generating Hits and Leads by Pu, Fan, Elsen, Nathaniel L, Williams, Jon D

“…Mass spectrometry (MS) detection can offer unmatched selectivity and sensitivity. The use of MS without chromatography greatly increases the throughput, making…”
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High-Throughput Intact Protein Analysis for Drug Discovery Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry by Pu, Fan, Ugrin, Scott A., Radosevich, Andrew J., Chang-Yen, David, Sawicki, James W., Talaty, Nari N., Elsen, Nathaniel L., Williams, Jon D.

“…Mass spectrometry (MS) is the primary analytical tool used to characterize proteins within the biopharmaceutical industry. Electrospray ionization (ESI)…”
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Applying Machine Learning to Pediatric Critical Care Data by Williams, Jon B, Ghosh, Debjit, Wetzel, Randall C

“…To explore whether machine learning applied to pediatric critical care data could discover medically pertinent information, we analyzed clinically collected…”
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Tobacco Smoke Induces the Generation of Procoagulant Microvesicles From Human Monocytes/Macrophages by Li, Mingzhen, Yu, Demin, Jon Williams, Kevin, Liu, Ming-Lin

“…OBJECTIVE—To investigate whether exposure of human monocytes/macrophages to tobacco smoke induces their release of membrane microvesicles (MVs) that carry…”
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Transcutaneous Electrical Nerve Stimulation Reduces Movement‐Evoked Pain and Fatigue: A Randomized, Controlled Trial by Dailey, Dana L., Vance, Carol G. T., Rakel, Barbara A., Zimmerman, M. Bridget, Embree, Jennie, Merriwether, Ericka N., Geasland, Katharine M., Chimenti, Ruth, Williams, Jon M., Golchha, Meenakshi, Crofford, Leslie J., Sluka, Kathleen A.

“…Objective Fibromyalgia (FM) is characterized by pain and fatigue, particularly during physical activity. Transcutaneous electrical nerve stimulation (TENS)…”
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Comprehensive Middle-Down Mass Spectrometry Characterization of an Antibody–Drug Conjugate by Combined Ion Activation Methods by Watts, Eleanor, Williams, Jon D, Miesbauer, Laura J, Bruncko, Milan, Brodbelt, Jennifer S

“…Antibody–drug conjugates (ADCs) are an increasingly prevalent drug class utilized as chemotherapeutic agents. The complexity of ADCs, including their large…”
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Native Reversed-Phase Liquid Chromatography: A Technique for LCMS of Intact Antibody–Drug Conjugates by Chen, Tse-Hong, Yang, Yun, Zhang, Zhaorui, Fu, Cexiong, Zhang, Qunying, Williams, Jon D, Wirth, Mary J

“…The synthesis of antibody–drug conjugates (ADCs) using the interchain cysteines of the antibody inherently gives a mixture of proteins with varying…”
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Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group by Lobera, Mercedes, Madauss, Kevin P, Pohlhaus, Denise T, Wright, Quentin G, Trocha, Mark, Schmidt, Darby R, Baloglu, Erkan, Trump, Ryan P, Head, Martha S, Hofmann, Glenn A, Murray-Thompson, Monique, Schwartz, Benjamin, Chakravorty, Subhas, Wu, Zining, Mander, Palwinder K, Kruidenier, Laurens, Reid, Robert A, Burkhart, William, Turunen, Brandon J, Rong, James X, Wagner, Craig, Moyer, Mary B, Wells, Carrow, Hong, Xuan, Moore, John T, Williams, Jon D, Soler, Dulce, Ghosh, Shomir, Nolan, Michael A

“…Class IIa histone deacetylases (HDACs) are generally viewed as noncatalytic readers of acetylated lysines within proteins. Specific inhibitors of class IIa…”
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2‑Aryl-5-carboxytetrazole as a New Photoaffinity Label for Drug Target Identification by Herner, András, Marjanovic, Jasmina, Lewandowski, Tracey M, Marin, Violeta, Patterson, Melanie, Miesbauer, Laura, Ready, Damien, Williams, Jon, Vasudevan, Anil, Lin, Qing

“…Photoaffinity labels are powerful tools for dissecting ligand–protein interactions, and they have a broad utility in medicinal chemistry and drug discovery…”
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High-Throughput Label-Free Biochemical Assays Using Infrared Matrix-Assisted Desorption Electrospray Ionization Mass Spectrometry by Pu, Fan, Radosevich, Andrew J, Sawicki, James W, Chang-Yen, David, Talaty, Nari N, Gopalakrishnan, Sujatha M, Williams, Jon D, Elsen, Nathaniel L

“…Mass spectrometry (MS) can provide high sensitivity and specificity for biochemical assays without the requirement of labels, eliminating the risk of assay…”
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Submicron loteprednol etabonate ophthalmic gel 0.38% for the treatment of inflammation and pain after cataract surgery by Fong, Raymond, Silverstein, Bruce E., Peace, James H., Williams, Jon I., Vittitow, Jason L.

“…To assess the safety and efficacy of a 0.38% submicron formulation of loteprednol etabonate (LE) gel for the treatment of postoperative inflammation and pain…”
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Measurement accuracy of heart rate and respiratory rate during graded exercise and sustained exercise in the heat using the Zephyr BioHarness by Kim, J-H, Roberge, R, Powell, J B, Shafer, A B, Jon Williams, W

“…The Zephyr BioHarness was tested to determine the accuracy of heart rate (HR) and respiratory rate (RR) measurements during 2 exercise protocols in conjunction…”
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Effect of cooling on static postural balance while wearing firefighter's protective clothing in a hot environment by Aljaroudi, Ali M., Bhattacharya, Amit, Strauch, Amanda, Quinn, Tyler D., Jon Williams, W.

“…Objectives. Postural imbalance can result from hyperthermia-mediated muscular fatigue and is a major factor contributing to injuries from falling. The…”
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Physiological Impact of the N95 Filtering Facepiece Respirator on Healthcare Workers by ROBERGE, Raymond J, COCA, Aitor, JON WILLIAMS, W, POWELL, Jeffrey B, PALMIERO, Andrew J

“…To assess the physiological impact of the N95 filtering facepiece respirator (FFR) on healthcare workers. Ten healthcare workers each conducted multiple 1-hour…”
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Neuroblastoma cell lines contain pluripotent tumor initiating cells that are susceptible to a targeted oncolytic virus by Mahller, Yonatan Y, Williams, Jon P, Baird, William H, Mitton, Bryan, Grossheim, Jonathan, Saeki, Yoshinaga, Cancelas, Jose A, Ratner, Nancy, Cripe, Timothy P

“…Although disease remission can frequently be achieved for patients with neuroblastoma, relapse is common. The cancer stem cell theory suggests that rare…”
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Optimized C‑Trap Timing of an Orbitrap 240 Mass Spectrometer for High-Throughput Screening and Native MS by IR-MALDESI by Knizner, Kevan T, Bagley, Michael C, Garrard, Kenneth P, Hauschild, Jan-Peter, Pu, Fan, Elsen, Nathaniel L, Williams, Jon D, Muddiman, David C

“…Infrared matrix-assisted laser desorption ionization (IR-MALDESI) is a hybrid mass spectrometry ionization source that combines the benefits of electrospray…”
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Guidance on Setup, Calibration, and Validation of Hydrodynamic, Wave, and Sediment Models for Shelf Seas and Estuaries by Williams, Jon J., Esteves, Luciana S.

“…The paper is motivated by a present lack of clear model performance guidelines for shelf sea and estuarine modellers seeking to demonstrate to clients and end…”
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High-Throughput Deconvolution of Intact Protein Mass Spectra for the Screening of Covalent Inhibitors by Pu, Fan, Knizner, Kevan T., Robey, Matthew T., Radosevich, Andrew J., Ugrin, Scott A., Elsen, Nathaniel L., Durbin, Kenneth R., Williams, Jon D.

“…Deconvolution from intact protein mass-to-charge spectra to mass spectra is essential to generate interpretable data for mass spectrometry (MS) platforms…”
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