Search Results - "WILLIAMS, John T"

Separate GABA Afferents to Dopamine Neurons Mediate Acute Action of Opioids, Development of Tolerance, and Expression of Withdrawal by Matsui, Aya, Jarvie, Brooke C., Robinson, Brooks G., Hentges, Shane T., Williams, John T.

“…GABA release from interneurons in VTA, projections from the nucleus accumbens (NAc), and rostromedial tegmental nucleus (RMTg) was selectively activated in rat…”
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Opioid-sensitive GABA inputs from rostromedial tegmental nucleus synapse onto midbrain dopamine neurons by Matsui, Aya, Williams, John T

“…Opioids increase dopamine release in the brain through inhibition of GABA-A IPSCs onto dopamine cells. Immunolabeling indicates that GABA neurons in the…”
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The Evolving Understanding of Dopamine Neurons in the Substantia Nigra and Ventral Tegmental Area by Gantz, Stephanie C, Ford, Christopher P, Morikawa, Hitoshi, Williams, John T

“…In recent years, the population of neurons in the ventral tegmental area (VTA) and substantia nigra (SN) has been examined at multiple levels. The results…”
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Cholinergic Interneurons Underlie Spontaneous Dopamine Release in Nucleus Accumbens by Yorgason, Jordan T, Zeppenfeld, Douglas M, Williams, John T

“…The release of dopamine from terminals in the NAc is regulated by a number of factors, including voltage-gated ion channels, D2-autoreceptors, and nAChRs…”
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Cellular Tolerance Induced by Chronic Opioids in the Central Nervous System by Adhikary, Sweta, Williams, John T

“…Opioids are powerful analgesics that elicit acute antinociceptive effects through their action the mu opioid receptor (MOR). However opioids are ineffective…”
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Spontaneous Inhibitory Synaptic Currents Mediated by a G Protein-Coupled Receptor by Gantz, Stephanie C., Bunzow, James R., Williams, John T.

“…G protein-coupled receptors (GPCRs) affect many physiological processes by modulating both intrinsic membrane conductances and synaptic transmission. This…”
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Modulating Neuromodulation by Receptor Membrane Traffic in the Endocytic Pathway by von Zastrow, Mark, Williams, John T.

“…Cellular responsiveness to many neuromodulators is controlled by endocytosis of the transmembrane receptors that transduce their effects. Endocytic membrane…”
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Presynaptic gain control by endogenous cotransmission of dopamine and GABA in the olfactory bulb by Vaaga, Christopher E, Yorgason, Jordan T, Williams, John T, Westbrook, Gary L

“…In the olfactory bulb, lateral inhibition mediated by local juxtaglomerular interneurons has been proposed as a gain control mechanism, important for…”
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Cellular tolerance at the µ-opioid receptor is phosphorylation dependent by Arttamangkul, Seksiri, Heinz, Daniel A, Bunzow, James R, Song, Xianqiang, Williams, John T

“…Phosphorylation of the μ-opioid receptor (MOR) is known as a key step in desensitization and internalization but the role in the development of long-term…”
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Desensitized D2 autoreceptors are resistant to trafficking by Robinson, Brooks G., Bunzow, James R., Grimm, Jonathan B., Lavis, Luke D., Dudman, Joshua T., Brown, Jennifer, Neve, Kim A., Williams, John T.

“…Dendritic release of dopamine activates dopamine D2 autoreceptors, which are inhibitory G protein-coupled receptors (GPCRs), to decrease the excitability of…”
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Calcium Release from Stores Inhibits GIRK by Kramer, Paul F., Williams, John T.

“…Synaptic transmission is mediated by ionotropic and metabotropic receptors that together regulate the rate and pattern of action potential firing. Metabotropic…”
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A Gain‐of‐Function Variant in Dopamine D2 Receptor and Progressive Chorea and Dystonia Phenotype by Weijden, Marlous C.M., Rodriguez‐Contreras, Dayana, Delnooz, Cathérine C.S., Robinson, Brooks G., Condon, Alec F., Kielhold, Michelle L., Stormezand, Gilles N., Ma, Kai Yu, Dufke, Claudia, Williams, John T., Neve, Kim A., Tijssen, Marina A.J., Verbeek, Dineke S.

“…ABSTRACT Background We describe a 4‐generation Dutch pedigree with a unique dominantly inherited clinical phenotype of a combined progressive chorea and…”
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Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry by Arttamangkul, Seksiri, Plazek, Andrew, Platt, Emily J, Jin, Haihong, Murray, Thomas F, Birdsong, William T, Rice, Kenner C, Farrens, David L, Williams, John T

“…Identifying neurons that have functional opioid receptors is fundamental for the understanding of the cellular, synaptic and systems actions of opioids…”
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RIM is essential for stimulated but not spontaneous somatodendritic dopamine release in the midbrain by Robinson, Brooks G, Cai, Xintong, Wang, Jiexin, Bunzow, James R, Williams, John T, Kaeser, Pascal S

“…Action potentials trigger neurotransmitter release at active zones, specialized release sites in axons. Many neurons also secrete neurotransmitters or…”
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Synaptotagmin-1 is a Ca2+ sensor for somatodendritic dopamine release by Lebowitz, Joseph J., Banerjee, Aditi, Qiao, Claire, Bunzow, James R., Williams, John T., Kaeser, Pascal S.

“…Modes of somatodendritic transmission range from rapid synaptic signaling to protracted regulation over distance. Somatodendritic dopamine secretion in the…”
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Control of extracellular dopamine at dendrite and axon terminals by Ford, Christopher P, Gantz, Stephanie C, Phillips, Paul E M, Williams, John T

“…Midbrain dopamine neurons release dopamine from both axons and dendrites. The mechanism underlying release at these different sites has been proposed to…”
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Properties and Opioid Inhibition of Mesolimbic Dopamine Neurons Vary according to Target Location by Ford, Christopher P, Mark, Gregory P, Williams, John T

“…The mesolimbic dopamine system, which mediates the rewarding properties of nearly all drugs of abuse, originates in the ventral tegmental area (VTA) and sends…”
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Depression of Serotonin Synaptic Transmission by the Dopamine Precursor L-DOPA by Gantz, Stephanie C., Levitt, Erica S., Llamosas, Nerea, Neve, Kim A., Williams, John T.

“…Imbalance between the dopamine and serotonin (5-HT) neurotransmitter systems has been implicated in the comorbidity of Parkinson’s disease (PD) and psychiatric…”
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Two-color, one-photon uncaging of glutamate and GABA by Passlick, Stefan, Kramer, Paul F, Richers, Matthew T, Williams, John T, Ellis-Davies, Graham C R

“…Neuronal cells receive a variety of excitatory and inhibitory signals which they process to generate an output signal. In order to study the interaction…”
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Vesicular Dopamine Release Elicits an Inhibitory Postsynaptic Current in Midbrain Dopamine Neurons by Beckstead, Michael J, Grandy, David K, Wickman, Kevin, Williams, John T

“…Synchronous activation of dopamine neurons, for instance upon presentation of an unexpected rewarding stimulus, results in the release of dopamine from both…”
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