Search Results - "WILLIAMS, J. Andrew"

The evolving role of PD-L1 testing in patients with metastatic urothelial carcinoma by Powles, Thomas, Walker, Jill, Andrew Williams, J., Bellmunt, Joaquim

“…•PD-L1 has emerged as an important cancer biomarker and target for immunotherapy in UC.•PD-L1 is frequently expressed on tumor cells and tumor-infiltrating…”
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PD-L1 Immunohistochemistry Assays for Lung Cancer: Results from Phase 1 of the Blueprint PD-L1 IHC Assay Comparison Project by Hirsch, Fred R, McElhinny, Abigail, Stanforth, Dave, Ranger-Moore, James, Jansson, Malinka, Kulangara, Karina, Richardson, William, Towne, Penny, Hanks, Debra, Vennapusa, Bharathi, Mistry, Amita, Kalamegham, Rasika, Averbuch, Steve, Novotny, James, Rubin, Eric, Emancipator, Kenneth, McCaffery, Ian, Williams, J Andrew, Walker, Jill, Longshore, John, Tsao, Ming Sound, Kerr, Keith M

“…The Blueprint Programmed Death Ligand 1 (PD-L1) Immunohistochemistry (IHC) Assay Comparison Project is an industrial-academic collaborative partnership to…”
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GUT-inspired SUSY and the muon g − 2 anomaly: prospects for LHC 14 TeV by Kowalska, Kamila, Roszkowski, Leszek, Sessolo, Enrico Maria, Williams, Andrew J.

“…A bstract We consider the possibility that the muon g − 2 anomaly, δ ( g − 2) μ , finds its origins in low energy supersymmetry (SUSY). In the general MSSM the…”
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Development of a PD-L1 Complementary Diagnostic Immunohistochemistry Assay (SP142) for Atezolizumab by Vennapusa, Bharathi, Baker, Brian, Kowanetz, Marcin, Boone, Jennifer, Menzl, Ina, Bruey, Jean-Marie, Fine, Gregg, Mariathasan, Sanjeev, McCaffery, Ian, Mocci, Simonetta, Rost, Sandra, Smith, Dustin, Dennis, Eslie, Tang, Szu-Yu, Damadzadeh, Bita, Walker, Espen, Hegde, Priti S, Williams, J Andrew, Koeppen, Hartmut, Boyd, Zachary

“…Cancer immunotherapies, such as atezolizumab, are proving to be a valuable therapeutic strategy across indications, including non-small cell lung cancer…”
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A 16-gene assay to predict recurrence after surgery in localised renal cell carcinoma: development and validation studies by Rini, Brian, Prof, Goddard, Audrey, PhD, Knezevic, Dejan, PhD, Maddala, Tara, PhD, Zhou, Ming, MD, Aydin, Hakan, MD, Campbell, Steven, MD, Elson, Paul, PhD, Koscielny, Serge, PhD, Lopatin, Margarita, MS, Svedman, Christer, MD, Martini, Jean-Francois, PhD, Williams, J Andrew, PhD, Verkarre, Virginie, MD, Radulescu, Camelia, MD, Neuzillet, Yann, MD, Hemmerlé, Isabelle, BS, Timsit, Marc Olivier, MD, Tsiatis, Athanasios C, MD, Bonham, Michael, MD, Lebret, Thierry, Prof, Mejean, Arnaud, Prof, Escudier, Bernard, MD

“…Summary Background The likelihood of tumour recurrence after nephrectomy in localised clear cell renal cell carcinoma is well characterised by clinical and…”
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Optimal PD-L1-high cutoff for association with overall survival in patients with urothelial cancer treated with durvalumab monotherapy by Zajac, Magdalena, Ye, Jiabu, Mukhopadhyay, Pralay, Jin, Xiaoping, Ben, Yong, Antal, Joyce, Gupta, Ashok K, Rebelatto, Marlon C, Williams, J Andrew, Walker, Jill

“…Studies have indicated that programmed death ligand 1 (PD-L1) expression may have utility as a predictive biomarker in patients with advanced/metastatic…”
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Independent Effects of Systemic and Peritoneal Inflammation on Peritoneal Dialysis Survival by LAMBIE, Mark, CHESS, James, DORVAL, Marc, SUMMERS, Angela, WILLIAMS, John D, BANKART, John, DAVIES, Simon J, TOPLEY, Nicholas, DONOVAN, Kieron L, YONG LIM KIM, JUN YOUNG DO, HI BAHL LEE, HYUNJIN NOH, WILLIAMS, Paul F, WILLIAMS, Andrew J, DAVISON, Sara

“…Systemic inflammation, as evidenced by elevated inflammatory cytokines, is a feature of advanced renal failure and predicts worse survival. Dialysate IL-6…”
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Fluorouracil, Leucovorin, and Irinotecan Plus Either Sunitinib or Placebo in Metastatic Colorectal Cancer: A Randomized, Phase III Trial by Carrato, Alfredo, Swieboda-Sadlej, Anna, Staszewska-Skurczynska, Marzanna, Lim, Robert, Roman, Laslo, Shparyk, Yaroslav, Bondarenko, Igor, Jonker, Derek J, Sun, Yan, De la Cruz, Jhony A, Williams, J Andrew, Korytowsky, Beata, Christensen, James G, Lin, Xun, Tursi, Jennifer M, Lechuga, Maria J, Van Cutsem, Eric

“…This double-blind, phase III study aimed to demonstrate that sunitinib plus FOLFIRI (fluorouracil, leucovorin, and irinotecan) was superior to placebo plus…”
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The tales of two cities: use of evidence for introducing 20 miles per hour speed limits in Edinburgh and Belfast (United Kingdom) by Milton, Karen, Baker, Graham, Cleland, Claire L, Cope, Andy, Hunter, Ruth F, Jepson, Ruth, Kee, Frank, Kelly, Paul, Williams, Andrew J, Kelly, Michael P

“…In 2016, large-scale 20 miles per hour speed limits were introduced in the United Kingdom cities of Edinburgh and Belfast. This paper investigates the role…”
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Meta-analysis of contribution of genetic polymorphisms in drug-metabolizing enzymes or transporters to axitinib pharmacokinetics by Brennan, Meghan, Williams, J. Andrew, Chen, Ying, Tortorici, Michael, Pithavala, Yazdi, Liu, Yingxue Cathy

“…Purpose Axitinib, an orally administered inhibitor of vascular endothelial growth factor 1, 2 and 3, is primarily metabolized by cytochrome P450 (CYP) 3A4/5…”
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IN VITRO CHARACTERIZATION OF LAMOTRIGINE N2-GLUCURONIDATION AND THE LAMOTRIGINE-VALPROIC ACID INTERACTION by ROWLAND, Andrew, ELLIOT, David J, WILLIAMS, J. Andrew, MACKENZIE, Peter I, DICKINSON, Ronald G, MINERS, John O

“…Studies were performed to investigate the UDP-glucuronosyltransferase enzyme(s) responsible for the human liver microsomal N 2-glucuronidation of the…”
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Comparative Metabolic Capabilities of CYP3A4, CYP3A5, and CYP3A7 by WILLIAMS, J. Andrew, RING, Barbara J, CANTRELL, Varon E, JONES, David R, ECKSTEIN, James, RUTERBORIES, Kenneth, HAMMAN, Mitchell A, HALL, Stephen D, WRIGHTON, Steven A

“…The human cytochromes P450 (P450) CYP3A contribute to the biotransformation of 50% of oxidatively metabolized drugs. The predominant hepatic form is CYP3A4,…”
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SILYBIN INACTIVATES CYTOCHROMES P450 3A4 AND 2C9 AND INHIBITS MAJOR HEPATIC GLUCURONOSYLTRANSFERASES by SRIDAR, Chitra, GOOSEN, Theunis C, KENT, Ute M, WILLIAMS, J. Andrew, HOLLENBERG, Paul F

“…Silybin, a major constituent of the milk thistle, is used to treat several liver disorders. Silybin inactivated purified, recombinant cytochromes P450 (P450)…”
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Quantitative prediction of in vivo inhibitory interactions involving glucuronidated drugs from in vitro data: the effect of fluconazole on zidovudine glucuronidation by Uchaipichat, Verawan, Winner, Leanne K., Mackenzie, Peter I., Elliot, David J., Williams, J Andrew, Miners, John O.

“…Aims Using the fluconazole–zidovudine (AZT) interaction as a model, to determine whether inhibition of UDP–glucuronosyltransferase (UGT) catalysed drug…”
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A case for the use of receiver operating characteristic analysis of potential clinical efficacy biomarkers in advanced renal cell carcinoma by English, Patricia A, Williams, J Andrew, Martini, Jean-François, Motzer, Robert J, Valota, Olga, Buller, Richard E

“…Assess patient-level utility of suggested pretreatment biomarkers of sunitinib in advanced renal cell carcinoma. Kaplan-Meier analysis of data from a…”
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Why Has the Franco-American Security Relationship Been so Semi—Hostile for so Long? by Williams, Andrew J

“…Many people assume that Franco-American relations since 1776 have been far more harmonious than those of the United States’ relationship with Great Britain…”
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In vitro and pharmacophore insights into CYP3A enzymes by Ekins, Sean, Stresser, David M., Andrew Williams, J.

“…The cytochrome P450 3A (CYP3A) enzymes have a major role in the metabolism of drugs in humans. Their wide substrate specificity and induction by a vast array…”
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Molecular Diversity of Rumen Methanogens from Sheep in Western Australia by WRIGHT, André-Denis G, WILLIAMS, Andrew J, WINDER, Barbara, CHRISTOPHERSEN, Claus T, RODGERS, T. Sharon L, SMITH, Kellie D

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol, and zidovudine glucuronidation by udp-glucuronosyltransferase 2B7 (UGT2B7) provides evidence for multiple substrate binding and effector sites by Uchaipichat, Verawan, Galetin, Aleksandra, Houston, J Brian, Mackenzie, Peter I, Williams, J Andrew, Miners, John O

“…Interactions between the UGT2B7-catalyzed glucuronidation of zidovudine (AZT), 4-methylumbelliferone (4MU), and 1-naphthol (1NP) were analyzed using multisite…”
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Novel polymorphic human UDP-glucuronosyltransferase 2A3: cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction by Court, Michael H, Hazarika, Suwagmani, Krishnaswamy, Soundararajan, Finel, Moshe, Williams, J Andrew

“…UDP-glucuronosyltransferases (UGTs) are critical to the detoxification of numerous drugs, environmental pollutants, and endogenous molecules. However, as yet…”
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