Search Results - "WILLIAMS, Geraint T"

Review of the pathological results of 2660 appendicectomy specimens by Marudanayagam, Ravi, Williams, Geraint T, Rees, Brian I

“…Appendicitis is the most commonly performed emergency abdominal surgery. The appendix can also be the site of a variety of neoplasms and unusual inflammatory…”
Get full text

The future of the TNM staging system in colorectal cancer: time for a debate? by Quirke, Philip, Prof, Williams, Geraint T, Prof, Ectors, Nadine, Prof, Ensari, Arzu, Prof, Piard, Françoise, Prof, Nagtegaal, Iris, PhD

“…Summary TNM staging has made a major contribution to the clinical management of patients with cancer over the past 50 years, but are we sure it delivers what…”
Get full text

PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine by Davies, Emma J, Marsh Durban, Victoria, Meniel, Valerie, Williams, Geraint T, Clarke, Alan R

“…Mutation or loss of the genes PTEN and KRAS have been implicated in human colorectal cancer (CRC), and have been shown to co‐occur despite both playing a role…”
Get full text

Adenoma development in familial adenomatous polyposis and MUTYH-associated polyposis: somatic landscape and driver genes by Rashid, Mamunur, Fischer, Andrej, Wilson, Cathy H, Tiffen, Jessamy, Rust, Alistair G, Stevens, Philip, Idziaszczyk, Shelley, Maynard, Julie, Williams, Geraint T, Mustonen, Ville, Sampson, Julian R, Adams, David J

“…Familial adenomatous polyposis (FAP) and MUTYH‐associated polyposis (MAP) are inherited disorders associated with multiple colorectal adenomas that lead to a…”
Get full text

Brg1 loss attenuates aberrant wnt-signalling and prevents wnt-dependent tumourigenesis in the murine small intestine by Holik, Aliaksei Z, Young, Madeleine, Krzystyniak, Joanna, Williams, Geraint T, Metzger, Daniel, Shorning, Boris Y, Clarke, Alan R

“…Tumourigenesis within the intestine is potently driven by deregulation of the Wnt pathway, a process epigenetically regulated by the chromatin remodelling…”
Get full text

PTEN loss and KRAS activation cooperate in murine biliary tract malignancies by Marsh, Victoria, Davies, Emma J, Williams, Geraint T, Clarke, Alan R

“…Carcinomas of the biliary tract are aggressive malignancies in humans. Loss of the tumour suppressor PTEN has previously been associated with…”
Get full text

Interobserver agreement in the reporting of colorectal polyp pathology among bowel cancer screening pathologists in Wales by Turner, Jeff K, Williams, Geraint T, Morgan, Meleri, Wright, Melissa, Dolwani, Sunil

“…Aims To assess the interobserver agreement in the reporting of colorectal polyps among histopathologists participating in the Welsh Bowel Cancer Screening…”
Get full text

Conditional Disruption of Axin1 Leads to Development of Liver Tumors in Mice by Feng, Gui Jie, Cotta, Welwyn, Wei, Xiao Qing, Poetz, Oliver, Evans, Rebecca, Jardé, Thierry, Reed, Karen, Meniel, Valerie, Williams, Geraint T, Clarke, Alan R, Dale, Trevor C

“…Background & Aims Mutations in components of the Wnt signaling pathway, including β-catenin and AXIN1, are found in more than 50% of human hepatocellular…”
Get full text

CD4+CD25+FOXP3+ regulatory T cells suppress anti-tumor immune responses in patients with colorectal cancer by Clarke, Sarah L, Betts, Gareth J, Plant, Andrea, Wright, Kate L, El-Shanawany, Tariq M, Harrop, Richard, Torkington, Jared, Rees, Brian I, Williams, Geraint T, Gallimore, Awen M, Godkin, Andrew J

“…A wealth of evidence obtained using mouse models indicates that CD4(+)CD25(+)FOXP3(+) regulatory T cells (Treg) maintain peripheral tolerance to self-antigens…”
Get full text

Cited1 deficiency suppresses intestinal tumorigenesis by Méniel, Valérie, Song, Fei, Phesse, Toby, Young, Madeleine, Poetz, Oliver, Parry, Lee, Jenkins, John R, Williams, Geraint T, Dunwoodie, Sally L, Watson, Alastair, Clarke, Alan R

“…Conditional deletion of Apc in the murine intestine alters crypt-villus architecture and function. This process is accompanied by multiple changes in gene…”
Get full text

The natural course of peritoneal membrane biology during peritoneal dialysis by Williams, John D., Craig, Kathrine J., Ruhland, Chris von, Topley, Nicholas, Williams, Geraint T., for the Biopsy Registry Study Group

Get full text

Peritoneal dialysis: Changes to the structure of the peritoneal membrane and potential for biocompatible solutions by Williams, John D., Craig, Kathrine J., Topley, Nicholas, Williams, Geraint T.

“…Peritoneal dialysis: Changes to the structure of the peritoneal membrane and potential for biocompatible solutions. Peritoneal dialysis (PD) is now established…”
Get full text

Photosensitivity and acute liver injury in myeloproliferative disorder secondary to late-onset protoporphyria caused by deletion of a ferrochelatase gene in hematopoietic cells by Goodwin, Richard G., Kell, W. Jonathan, Laidler, Peter, Long, C. Colin, Whatley, Sharon D., McKinley, Mark, Badminton, Michael N., Burnett, Alan K., Williams, Geraint T., Elder, George H.

“…Late-onset erythropoietic protoporphyria (EPP) is a rare complication of myelodysplastic syndrome (MDS) but has not been described in association with a…”
Get full text

Megacystis-microcolon-intestinal hypoperistalsis syndrome and the absence of the α3 nicotinic acetylcholine receptor subunit by Richardson, Charles E., Morgan, John M., Jasani, Bharat, Green, John T., Rhodes, John, Williams, Geraint T., Lindstrom, Jon, Wonnacott, Sue, Thomas, Gareth A.O., Smith, Virpi

“…Background & Aims: The megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS) is a rare disease of childhood that presents early with intestinal…”
Get full text

A randomized trial of nicotine enemas for active ulcerative colitis by Ingram, John R, Thomas, Gareth A O, Rhodes, John, Green, John T, Hawkes, Neil D, Swift, Jill L, Srivastava, Emmanuel D, Evans, Brian K, Williams, Geraint T, Newcombe, Robert G, Courtney, Edward, Pillai, Suresh

“…Ulcerative colitis (UC) is largely a disease of nonsmokers in which transdermal nicotine improves the symptoms but often causes adverse events (AEs). Nicotine…”
Get more information

Extensive Telomere Erosion in the Initiation of Colorectal Adenomas and Its Association With Chromosomal Instability by ROGER, Laureline, JONES, Rhiannon E, HEPPEL, Nicole H, WILLIAMS, Geraint T, SAMPSON, Julian R, BAIRD, Duncan M

“…Telomere shortening, dysfunction, and fusion may facilitate the acquisition of large-scale genomic rearrangements, driving clonal evolution and tumor…”
Get full text

PIGA Mutations and Glycosylphosphatidylinositol Anchor Dysregulation in Polyposis-Associated Duodenal Tumorigenesis by Meuser, Elena, Chang, Kyle, Walters, Angharad, Hurley, Joanna J, West, Hannah D, Perry, Iain, Mort, Matthew, Reyes-Uribe, Laura, Truscott, Rebekah, Jones, Nicholas, Lawrence, Rachel, Jenkins, Gareth, Giles, Peter, Dolwani, Sunil, Al-Sarireh, Bilal, Hawkes, Neil, Short, Emma, Williams, Geraint T, Taggart, Melissa W, Luetchford, Kim, Lynch, Patrick M, Terlouw, Diantha, Nielsen, Maartje, Walton, Sarah-Jane, Latchford, Andrew, Clark, Susan K, Sampson, Julian R, Vilar, Eduardo, Thomas, Laura E

“…The pathogenesis of duodenal tumors in the inherited tumor syndromes familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP) is poorly…”
Get more information

High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression by Bento, Diana Costa, Jones, Emma, Junaid, Syed, Tull, Justyna, Williams, Geraint T, Godkin, Andrew, Ager, Ann, Gallimore, Awen

“…Prolonged patient survival after surgical resection, is associated with a higher cytotoxic and memory T cell density within colorectal cancers (CRC). High…”
Get full text

Transdermal Nicotine for Active Ulcerative Colitis by Pullan, Rupert D, Rhodes, John, Ganesh, Subramanian, Mani, Venk, Morris, John S, Williams, Geraint T, Newcombe, Robert G, Russell, Michael, Feyerabend, Colin, Thomas, Gareth, Sawe, Urbain

“…Most patients with ulcerative colitis are nonsmokers, and patients with a history of smoking usually acquire their disease within a few years after they have…”
Get full text

Morphologic predictors of lymph node status in rectal cancer with use of high-spatial-resolution MR imaging with histopathologic comparison by Brown, Gina, Richards, Catherine J, Bourne, Michael W, Newcombe, Robert G, Radcliffe, Andrew G, Dallimore, Nicholas S, Williams, Geraint T

“…To evaluate signal intensity and border characteristics of lymph nodes at high-spatial-resolution magnetic resonance (MR) imaging in patients with rectal…”
Get more information