Search Results - "WILLIAMS, DARREN R"

Investigation of niclosamide as a repurposing agent for skeletal muscle atrophy by Kim, Hyun-Jun, Lee, Ji-Hyung, Kim, Seon-Wook, Lee, Sang-Hoon, Jung, Da-Woon, Williams, Darren R

“…Skeletal muscle atrophy is a feature of aging (termed sarcopenia) and various diseases, such as cancer and kidney failure. Effective drug treatment options for…”
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ENOblock, a unique small molecule inhibitor of the non-glycolytic functions of enolase, alleviates the symptoms of type 2 diabetes by Cho, Haaglim, Um, JungIn, Lee, Ji-Hyung, Kim, Woong-Hee, Kang, Wan Seok, Kim, So Hun, Ha, Hyung-Ho, Kim, Yong-Chul, Ahn, Young-Keun, Jung, Da-Woon, Williams, Darren R.

“…Type 2 diabetes mellitus (T2DM) significantly impacts on human health and patient numbers are predicted to rise. Discovering novel drugs and targets for…”
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Visualizing sweetness: increasingly diverse applications for fluorescent-tagged glucose bioprobes and their recent structural modifications by Kim, Woong Hee, Lee, Jinho, Jung, Da-Woon, Williams, Darren R

“…Glucose homeostasis is a fundamental aspect of life and its dysregulation is associated with important diseases, such as cancer and diabetes. Traditionally,…”
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Inhibiting 5‐lipoxygenase prevents skeletal muscle atrophy by targeting organogenesis signalling and insulin‐like growth factor‐1 by Kim, Hyun‐Jun, Kim, Seon‐Wook, Lee, Sang‐Hoon, Jung, Da‐Woon, Williams, Darren R.

“…Background Skeletal muscle atrophy can occur in response to numerous factors, such as ageing and certain medications, and produces a major socio‐economic…”
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Natural product derivative BIO promotes recovery after myocardial infarction via unique modulation of the cardiac microenvironment by Kim, Yong Sook, Jeong, Hye-yun, Kim, Ah Ra, Kim, Woong-Hee, Cho, Haaglim, Um, JungIn, Seo, Youngha, Kang, Wan Seok, Jin, Suk-Won, Kim, Min Chul, Kim, Yong-Chul, Jung, Da-Woon, Williams, Darren R., Ahn, Youngkeun

“…The cardiac microenvironment includes cardiomyocytes, fibroblasts and macrophages, which regulate remodeling after myocardial infarction (MI). Targeting this…”
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Chemical genetics and its application to moonlighting in glycolytic enzymes by Jung, Da-Woon, Kim, Woong-Hee, Williams, Darren R

“…Glycolysis is an ancient biochemical pathway that breaks down glucose into pyruvate to produce ATP. The structural and catalytic properties of glycolytic…”
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Biotransformed Metabolites of the Hop Prenylflavanone Isoxanthohumol by Kim, Hyun Jung, Yim, Soon-Ho, Han, Fubo, Kang, Bok Yun, Choi, Hyun Jin, Jung, Da-Woon, Williams, Darren R, Gustafson, Kirk R, Kennelly, Edward J, Lee, Ik-Soo

“…A metabolic conversion study on microbes is known as one of the most useful tools to predict the xenobiotic metabolism of organic compounds in mammalian…”
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Apoptosis-Inducing Small Molecule That Binds to Heat Shock Protein 70 by Williams, Darren R, Ko, Sung-Kyun, Park, Sungjin, Lee, Myung-Ryul, Shin, Injae

“…A cell‐based screening approach in which annexin V was used as a staining agent identified apoptozole (Az; see scheme) as an imidazole‐based molecule which…”
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ENOblock inhibits the pathology of diet-induced obesity by Cho, Haaglim, Lee, Ji-Hyung, Um, JungIn, Kim, Sunwook, Kim, Yukyung, Kim, Woong-Hee, Kim, Yong Sook, Pagire, Haushabhau S., Ahn, Jin Hee, Ahn, Youngkeun, Chang, Young-Tae, Jung, Da-Woon, Williams, Darren R.

“…Obesity is a medical condition that impacts on all levels of society and causes numerous comorbidities, such as diabetes, cardiovascular disease, and cancer…”
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Lithium Chloride Protects against Sepsis-Induced Skeletal Muscle Atrophy and Cancer Cachexia by Lee, Ji-Hyung, Kim, Seon-Wook, Kim, Jun-Hyeong, Kim, Hyun-Jun, Um, JungIn, Jung, Da-Woon, Williams, Darren R

“…Inflammation-mediated skeletal muscle wasting occurs in patients with sepsis and cancer cachexia. Both conditions severely affect patient morbidity and…”
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SRSF9 Regulates Cassette Exon Splicing of Caspase-2 by Interacting with Its Downstream Exon by Ha, Jiyeon, Jang, Hana, Choi, Namjeong, Oh, Jagyeong, Min, Chanhyuk, Pradella, Davide, Jung, Da-Woon, Williams, Darren R, Park, Daeho, Ghigna, Claudia, Zheng, Xuexiu, Shen, Haihong

“…Alternative splicing (AS) is an important posttranscriptional regulatory process. Damaged or unnecessary cells need to be removed though apoptosis to maintain…”
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ZebIAT, an image analysis tool for registering zebrafish embryos and quantifying cancer metastasis by Annila, Teppo, Lihavainen, Eero, Marques, Ines J, Williams, Darren R, Yli-Harja, Olli, Ribeiro, Andre

“…Zebrafish embryos have recently been established as a xenotransplantation model of the metastatic behaviour of primary human tumours. Current tools for…”
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Protective effects of magnesium lithospermate B against diabetic atherosclerosis via Nrf2-ARE-NQO1 transcriptional pathway by Hur, Kyu Yeon, Kim, Soo Hyun, Choi, Min-Ah, Williams, Darren R, Lee, Yong-ho, Kang, Sang Won, Yadav, Umesh C.S, Srivastava, Satish K, Jung, Mankil, Cho, Jin Won, Kim, Sang Geon, Kang, Eun Seok, Lee, Eun Jig, Lee, Hyun Chul

“…Abstract Hyperglycemia-induced oxidative stress is known to play an important role in the development of several diabetic complications, including…”
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Anti-oxidant activity reinforced reduced graphene oxide/alginate microgels: Mesenchymal stem cell encapsulation and regeneration of infarcted hearts by Choe, Goeun, Kim, Seon-Wook, Park, Junggeon, Park, Junha, Kim, Semin, Kim, Yong Sook, Ahn, Youngkeun, Jung, Da-Woon, Williams, Darren R., Lee, Jae Young

“…Mesenchymal stem cell (MSC) transplantation is promising for repairing heart tissues post myocardial infarction (MI). In particular, paracrine effects of the…”
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Inhibited inositol monophosphatase and decreased myo‐inositol concentration improve wasting in skeletal muscles by Lee, Ji‐Hyung, Kim, Hyun‐Jun, Kim, Seon‐Wook, Um, JungIn, Jung, Da‐Woon, Williams, Darren R.

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Analyses of Avascular Mutants Reveal Unique Transcriptomic Signature of Non-conventional Endothelial Cells by Pak, Boryeong, Schmitt, Christopher E, Choi, Woosoung, Kim, Jun-Dae, Han, Orjin, Alsiö, Jessica, Jung, Da-Woon, Williams, Darren R, Coppieters, Wouter, Stainier, Didier Y R, Jin, Suk-Won

“…Endothelial cells appear to emerge from diverse progenitors. However, to which extent their developmental origin contributes to define their cellular and…”
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Chemical characterization and biological activity data for a novel indirubin derivative, LDD-1819 by Kim, Woong-Hee, Jeong, Pyeonghwa, Kim, Seon-Wook, Cho, Haaglim, Lee, Jeong-min, Seo, Shinae, Shen, Haihong, Ahn, Youngkeun, Jung, Da-Woon, Kim, Yong-Chul, Williams, Darren R.

“…This article contains chemical characterization and biological activity data for a novel indirubin derivative, termed LDD-1819. The detailed synthesis…”
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Fluorescent high-throughput screening of chemical inducers of neuronal differentiation in skeletal muscle cells by Shin, Injae, Williams, Darren R, Kim, Gun-Hee, Lee, Myung-Ryul

“…This protocol describes detailed procedures for the fluorescent high-throughput screening of small molecules that induce neurogenesis in cultures of skeletal…”
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Phenolic Constituents from the Flowers of Hamamelis japonica Sieb. et Zucc by Soon Ho Yim, Young Ju Lee, Ki Deok Park, Ik Soo Lee, Boo Ahn Shin, Da Woon Jung, Darren R Williams, Hyun Jung Kim

“…Hamamelis japonica (Hamamelidaceae), widely known as Japanese witch hazel, is a deciduous flowering shrub that produces compact clumps of yellow or orange-red…”
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CAF-Derived IL6 and GM-CSF Cooperate to Induce M2-like TAMs-Response by Cho, Haaglim, Kim, Jun-Hyeong, Jun, Chang-Duk, Jung, Da-Woon, Williams, Darren R

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