Search Results - "WILLIAMS, Alan J"

Unbiased Mapping of Transcription Factor Binding Sites along Human Chromosomes 21 and 22 Points to Widespread Regulation of Noncoding RNAs by Cawley, Simon, Bekiranov, Stefan, Ng, Huck H, Kapranov, Philipp, Sekinger, Edward A, Kampa, Dione, Piccolboni, Antonio, Sementchenko, Victor, Cheng, Jill, Williams, Alan J, Wheeler, Raymond, Wong, Brant, Drenkow, Jorg, Yamanaka, Mark, Patel, Sandeep, Brubaker, Shane, Tammana, Hari, Helt, Gregg, Struhl, Kevin, Gingeras, Thomas R

“…Using high-density oligonucleotide arrays representing essentially all nonrepetitive sequences on human chromosomes 21 and 22, we map the binding sites in vivo…”
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Functional characterization of the cardiac ryanodine receptor pore-forming region by Euden, Joanne, Mason, Sammy A, Williams, Alan J

“…Ryanodine receptors are homotetrameric intracellular calcium release channels. The efficiency of these channels is underpinned by exceptional rates of cation…”
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A mechanistic description of gating of the human cardiac ryanodine receptor in a regulated minimal environment by Mukherjee, Saptarshi, Thomas, N Lowri, Williams, Alan J

“…Cardiac muscle contraction, triggered by the action potential, is mediated by the release of Ca(2+) from the sarcoplasmic reticulum through ryanodine receptor…”
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CLIC2-RyR1 Interaction and Structural Characterization by Cryo-electron Microscopy by Meng, Xing, Wang, Guoliang, Viero, Cedric, Wang, Qiongling, Mi, Wei, Su, Xiao-Dong, Wagenknecht, Terence, Williams, Alan J., Liu, Zheng, Yin, Chang-Cheng

“…Chloride intracellular channel 2 (CLIC2), a newly discovered small protein distantly related to the glutathione transferase (GST) structural family, is highly…”
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Massive Accumulation of Myofibroblasts in the Critical Isthmus Is Associated With Ventricular Tachycardia Inducibility in Post-Infarct Swine Heart by Dhanjal, Tarvinder S., PhD, Lellouche, Nicolas, MD, von Ruhland, Christopher J., PhD, Abehsira, Guillaume, MD, Edwards, David H., PhD, Dubois-Randé, Jean-Luc, MD, PhD, Moschonas, Konstantinos, MB BCh, Teiger, Emmanuel, MD, Williams, Alan J., PhD, George, Christopher H., PhD

“…Abstract Objectives In this study the authors determined the extent of cellular infiltration and dispersion, and regional vascularization in…”
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Ryanodine receptor mutations in arrhythmia: The continuing mystery of channel dysfunction by Thomas, N. Lowri, Maxwell, Chloé, Mukherjee, Saptarshi, Williams, Alan J.

“…Mutations in RyR2 are causative of an inherited disorder which often results in sudden cardiac death. Dysfunctional channel behaviour has been the subject of…”
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Regulated Phosphorylation of 40s Ribosomal Protein S6 in Root Tips of Maize by Williams, Alan J., Joanna Werner-Fraczek, Ing-Feng Chang, Bailey-Serres, Julia

“…Ribosomal protein S6 (RPS6) is located in the mRNA binding site of the 40S subunit of cytosolic ribosomes. Two maize (Zea mays) rps6 genes were identified that…”
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Pharmacological regulators of intracellular calcium release channels by West, Duncan J, Williams, Alan J

“…Intracellular Ca(2+) release channels, such as inositol 1,4,5-trisphosphate receptors (IP(3)Rs) and ryanodine receptors (RyRs), facilitate the release of…”
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Structural insights into Ca(2+)-activated long-range allosteric channel gating of RyR1 by Wei, Risheng, Wang, Xue, Zhang, Yan, Mukherjee, Saptarshi, Zhang, Lei, Chen, Qiang, Huang, Xinrui, Jing, Shan, Liu, Congcong, Li, Shuang, Wang, Guangyu, Xu, Yaofang, Zhu, Sujie, Williams, Alan J, Sun, Fei, Yin, Chang-Cheng

“…Ryanodine receptors (RyRs) are a class of giant ion channels with molecular mass over 2.2 mega-Daltons. These channels mediate calcium signaling in a variety…”
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The mechanism of flecainide action in CPVT does not involve a direct effect on RyR2 by Bannister, Mark L, Thomas, N Lowri, Sikkel, Markus B, Mukherjee, Saptarshi, Maxwell, Chloe, MacLeod, Kenneth T, George, Christopher H, Williams, Alan J

“…Flecainide, a class 1c antiarrhythmic, has emerged as an effective therapy in preventing arrhythmias in patients with catecholaminergic polymorphic ventricular…”
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A Model of the Putative Pore Region of the Cardiac Ryanodine Receptor Channel by Welch, William, Rheault, Shana, West, Duncan J., Williams, Alan J.

“…Using the bacterial K + channel KcsA as a template, we constructed models of the pore region of the cardiac ryanodine receptor channel (RyR2) monomer and…”
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Structural insights into Ca2+-activated long-range allosteric channel gating of RyR1 by Wei, Risheng, Wang, Xue, Zhang, Yan, Mukherjee, Saptarshi, Zhang, Lei, Chen, Qiang, Huang, Xinrui, Jing, Shan, Liu, Congcong, Li, Shuang, Wang, Guangyu, Xu, Yaofang, Zhu, Sujie, Williams, Alan J, Sun, Fei, Yin, Chang-Cheng

“…Ryanodine receptors (RyRs) are a class of giant ion channels with molecular mass over 2.2 mega-Daltons. These channels mediate calcium signaling in a variety…”
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Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains by George, Christopher H, Jundi, Hala, Thomas, N Lowri, Scoote, Mark, Walters, Nicola, Williams, Alan J, Lai, F Anthony

“…Ryanodine receptors (RyR) function as Ca(2+) channels that regulate Ca(2+) release from intracellular stores to control a diverse array of cellular processes…”
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Stable expression and functional characterisation of the diamondback moth ryanodine receptor G4946E variant conferring resistance to diamide insecticides by Troczka, Bartlomiej J., Williams, Alan J., Williamson, Martin S., Field, Linda M., Lüemmen, Peter, Davies, T.G. Emyr

“…Diamides, such as flubendiamide and chlorantraniliprole, belong to a new chemical class of insecticides that act as conformation-sensitive activators of insect…”
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Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain by Handhle, Ahmed, Ormonde, Chloe E, Thomas, N Lowri, Bralesford, Catherine, Williams, Alan J, Lai, F Anthony, Zissimopoulos, Spyros

“…Cardiac muscle contraction requires sarcoplasmic reticulum (SR) Ca release mediated by the quaternary complex comprising the ryanodine receptor 2 (RyR2),…”
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Disparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart by Zissimopoulos, Spyros, Seifan, Sara, Maxwell, Chloe, Williams, Alan J, Lai, F Anthony

“…The FK506-binding proteins (FKBP12 and FKBP12.6; also known as FKBP1A and FKBP1B, respectively) are accessory subunits of the ryanodine receptor (RyR) Ca(2+)…”
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Flecainide reduces Ca(2+) spark and wave frequency via inhibition of the sarcolemmal sodium current by Sikkel, Markus B, Collins, Thomas P, Rowlands, Christina, Shah, Mit, O'Gara, Peter, Williams, Alan J, Harding, Sian E, Lyon, Alexander R, MacLeod, Kenneth T

“…Ca(2+) waves are thought to be important in the aetiology of ventricular tachyarrhythmias. There have been conflicting results regarding whether flecainide…”
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Unambiguous observation of blocked states reveals altered, blocker-induced, cardiac ryanodine receptor gating by Mukherjee, Saptarshi, Thomas, N. Lowri, Williams, Alan J.

“…The flow of ions through membrane channels is precisely regulated by gates. The architecture and function of these elements have been studied extensively,…”
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Electrostatic Mechanisms Underlie Neomycin Block of the Cardiac Ryanodine Receptor Channel (RyR2) by Mead, Fiona C., Williams, Alan J.

“…Neomycin is a large, positively charged, aminoglycoside antibiotic that has previously been shown to induce a voltage-dependent substate block in the cardiac…”
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Insights into the gating mechanism of the ryanodine-modified human cardiac Ca2+-release channel (ryanodine receptor 2) by Mukherjee, Saptarshi, Thomas, N Lowri, Williams, Alan J

“…Ryanodine receptors (RyRs) are intracellular membrane channels playing key roles in many Ca(2+) signaling pathways and, as such, are emerging novel therapeutic…”
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