Search Results - "WILLEY, CHRISTOPHER D"

HPAanalyze: an R package that facilitates the retrieval and analysis of the Human Protein Atlas data by Tran, Anh Nhat, Dussaq, Alex M, Kennell, Jr, Timothy, Willey, Christopher D, Hjelmeland, Anita B

“…The Human Protein Atlas (HPA) aims to map human proteins via multiple technologies including imaging, proteomics and transcriptomics. Access of the HPA data is…”
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Understanding Drug Sensitivity and Tackling Resistance in Cancer by Tyner, Jeffrey W, Haderk, Franziska, Kumaraswamy, Anbarasu, Baughn, Linda B, Van Ness, Brian, Liu, Song, Marathe, Himangi, Alumkal, Joshi J, Bivona, Trever G, Chan, Keith Syson, Druker, Brian J, Hutson, Alan D, Nelson, Peter S, Sawyers, Charles L, Willey, Christopher D

“…Decades of research into the molecular mechanisms of cancer and the development of novel therapeutics have yielded a number of remarkable successes. However,…”
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Exploring the Roles of lncRNAs in GBM Pathophysiology and Their Therapeutic Potential by Stackhouse, Christian T, Gillespie, G Yancey, Willey, Christopher D

“…Glioblastoma (GBM) remains the most devastating primary central nervous system malignancy with a median survival of around 15 months. The past decades of…”
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Pathologic Predictors of Local Recurrence in Atypical Meningiomas Following Gross Total Resection by Barrett, Olivia Claire, Hackney, James R., McDonald, Andrew M., Willey, Christopher D., Bredel, Markus, Fiveash, John B.

“…To assess the local recurrence rate of gross totally resected atypical meningiomas and evaluate for pathologic predictors of recurrence. All patients meeting…”
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Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell death by Britain, Colleen M, Holdbrooks, Andrew T, Anderson, Joshua C, Willey, Christopher D, Bellis, Susan L

“…The ST6Gal-I sialyltransferase is upregulated in numerous cancers, and high expression of this enzyme correlates with poor patient prognosis in various…”
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Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling by Shen, Hongxing, Huang, Fengyuan, Zhang, Xiangmin, Ojo, Oluwagbemiga A., Li, Yuebin, Trummell, Hoa Quang, Anderson, Joshua C., Fiveash, John, Bredel, Markus, Yang, Eddy S., Willey, Christopher D., Chong, Zechen, Bonner, James A., Shi, Lewis Zhichang

“…Therapeutic resistance to immune checkpoint blockers (ICBs) in melanoma patients is a pressing issue, of which tumor loss of IFN-γ signaling genes is a major…”
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Inhibition of DNA-PK may improve response to neoadjuvant chemoradiotherapy in rectal cancer by Smithson, Mary, Irwin, Regina K., Williams, Gregory, McLeod, M. Chandler, Choi, E. Karen, Ganguly, Anutosh, Pepple, Ashley, Cho, Clifford S., Willey, Christopher D., Leopold, Judith, Hardiman, Karin M.

“…Treatment of locally advanced rectal cancer includes chemoradiation and surgery, but patient response to treatment is variable. Patients who have a complete…”
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A cell-penetrating MARCKS mimetic selectively triggers cytolytic death in glioblastoma by Eustace, Nicholas J., Anderson, Joshua C., Warram, Jason M., Widden, Hayley N., Pedersen, Rune T., Alrefai, Hasan, Patel, Zeel, Hicks, Patricia H., Placzek, William J., Gillespie, G. Yancey, Hjelmeland, Anita B., Willey, Christopher D.

“…Glioblastoma (GBM) is an aggressive malignancy with limited effectiveness of standard of care therapies including surgery, radiation, and temozolomide…”
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Novel EGFR ectodomain mutations associated with ligand-independent activation and cetuximab resistance in head and neck cancer by Nair, Sindhu, Trummell, Hoa Q, Rajbhandari, Rajani, Thudi, Nanda K, Nozell, Susan E, Warram, Jason M, Willey, Christopher D, Yang, Eddy S, Placzek, William J, Bonner, James A, Bredel, Markus

“…Epidermal growth factor receptor (EGFR) is a pro-tumorigenic receptor tyrosine kinase that facilitates growth for cancer cells that overexpress the receptor…”
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High Throughput Kinomic Profiling of Human Clear Cell Renal Cell Carcinoma Identifies Kinase Activity Dependent Molecular Subtypes by Anderson, Joshua C, Willey, Christopher D, Mehta, Amitkumar, Welaya, Karim, Chen, Dongquan, Duarte, Christine W, Ghatalia, Pooja, Arafat, Waleed, Madan, Ankit, Sudarshan, Sunil, Naik, Gurudatta, Grizzle, William E, Choueiri, Toni K, Sonpavde, Guru

“…Despite the widespread use of kinase-targeted agents in clear cell renal cell carcinoma (CC-RCC), comprehensive kinase activity evaluation (kinomic profiling)…”
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Inhibition of Poly(ADP-Ribose) Polymerase Enhances Cell Death and Improves Tumor Growth Delay in Irradiated Lung Cancer Models by Albert, Jeffrey M, Cao, Carolyn, Kim, Kwang Woon, Willey, Christopher D, Geng, Ling, Xiao, Dakai, Wang, Hong, Sandler, Alan, Johnson, David H, Colevas, Alexander D, Low, Jennifer, Rothenberg, Mace L, Lu, Bo

“…Purpose: Poly(ADP-ribose) polymerase-1 (PARP-1) is the founding member of a family of enzymes that catalyze the addition of ADP-ribose units to proteins that…”
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Expression signature of IFN/STAT1 signaling genes predicts poor survival outcome in glioblastoma multiforme in a subtype-specific manner by Duarte, Christine W, Willey, Christopher D, Zhi, Degui, Cui, Xiangqin, Harris, Jacqueline J, Vaughan, Laura Kelly, Mehta, Tapan, McCubrey, Raymond O, Khodarev, Nikolai N, Weichselbaum, Ralph R, Gillespie, G Yancey

“…Previous reports have implicated an induction of genes in IFN/STAT1 (Interferon/STAT1) signaling in radiation resistant and prosurvival tumor phenotypes in a…”
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Kinomics toolbox-A web platform for analysis and viewing of kinomic peptide array data by Dussaq, Alex M, Kennell, Jr, Timothy, Eustace, Nicholas J, Anderson, Joshua C, Almeida, Jonas S, Willey, Christopher D

“…Kinomics is an emerging field of science that involves the study of global kinase activity. As kinases are essential players in virtually all cellular…”
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Leukemia Inhibitory Factor Signaling Enhances Production of Galactose-Deficient IgA1 in IgA Nephropathy by Yamada, Koshi, Huang, Zhi qiang, Raska, Milan, Reily, Colin, Anderson, Joshua C., Suzuki, Hitoshi, Kiryluk, Krzysztof, Gharavi, Ali G., Julian, Bruce A., Willey, Christopher D., Novak, Jan

“…Objectives: IgA nephropathy (IgAN) is thought to involve an autoimmune process wherein galactose-deficient IgA1 (Gd-IgA1), recognized as autoantigen by…”
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PIM kinases mediate resistance to cisplatin chemotherapy in hepatoblastoma by Marayati, Raoud, Stafman, Laura L., Williams, Adele P., Bownes, Laura V., Quinn, Colin H., Aye, Jamie M., Stewart, Jerry E., Yoon, Karina J., Anderson, Joshua C., Willey, Christopher D., Beierle, Elizabeth A.

“…Despite increasing incidence, treatment for hepatoblastoma has not changed significantly over the past 20 years. Chemotherapeutic strategies continue to rely…”
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Fractionated stereotactic radiation therapy for intact brain metastases by Marcrom, Samuel R., MD, McDonald, Andrew M., MD, Thompson, Jonathan W., MD, Popple, Richard A., PhD, Riley, Kristen O., MD, Markert, James M., MD, Willey, Christopher D., MD, PhD, Bredel, Markus, MD, PhD, Fiveash, John B., MD

“…Abstract Purpose Limited data exist on fractionated stereotactic radiation therapy (FSRT) for brain metastases. We sought to evaluate the safety and efficacy…”
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Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth by Zeng, Ling, Boggs, Drexell Hunter, Xing, Chuan, Zhang, Zhuo, Anderson, Joshua C., Wajapeyee, Narendra, Veale, Chris, Bredel, Markus, Shi, Lewis Z., Bonner, James A., Willey, Christopher D., Yang, Eddy S.

“…Novel targeted agents to inhibit DNA repair pathways to sensitize tumors to irradiation (IR) are being investigated as an alternative to chemoradiation for…”
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The Effector Domain of MARCKS Is a Nuclear Localization Signal that Regulates Cellular PIP2 Levels and Nuclear PIP2 Localization by Rohrbach, Timothy D, Shah, Nishi, Jackson, William P, Feeney, Erin V, Scanlon, Samantha, Gish, Robert, Khodadadi, Ryan, Hyde, Stephen O, Hicks, Patricia H, Anderson, Joshua C, Jarboe, John S, Willey, Christopher D

“…Translocation to the nucleus of diacylglycerol kinase (DGK)- ζ is dependent on a sequence homologous to the effector domain of Myristoylated Alanine Rich…”
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Correction: Chen et al. Targeted Extracellular Vesicles Delivered Verrucarin A to Treat Glioblastoma. Biomedicines 2022, 10 , 130 by Chen, Kai, Si, Yingnan, Guan, Jia-Shiung, Zhou, Zhuoxin, Kim, Seulhee, Kim, Taehyun, Shan, Liang, Willey, Christopher D, Zhou, Lufang, Liu, Xiaoguang

“…In the original publication [...]…”
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Fibroblast growth factor receptor facilitates recurrence of minimal residual disease following trastuzumab emtansine therapy by Akhand, Saeed S., Chen, Hao, Purdy, Stephen Connor, Liu, Zian, Anderson, Joshua C., Willey, Christopher D., Wendt, Michael K.

“…Trastuzumab-emtansine (T-DM1) is an antibody-drug conjugate (ADC) that efficiently delivers a highly potent microtubule inhibitor to HER2 overexpressing cells…”
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