Search Results - "WILLEMEN, D"

Identification of FAM173B as a protein methyltransferase promoting chronic pain by Willemen, Hanneke L D M, Kavelaars, Annemieke, Prado, Judith, Maas, Mirjam, Versteeg, Sabine, Nellissen, Lara J J, Tromp, Jeshua, Gonzalez Cano, Rafael, Zhou, Wenjun, Jakobsson, Magnus E, Małecki, Jędrzej, Posthuma, George, Habib, Abdella M, Heijnen, Cobi J, Falnes, Pål Ø, Eijkelkamp, Niels

“…Chronic pain is a debilitating problem, and insights in the neurobiology of chronic pain are needed for the development of novel pain therapies. A genome-wide…”
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Divergent roles of immune cells and their mediators in pain by Raoof, Ramin, Willemen, Hanneke L D M, Eijkelkamp, Niels

“…Abstract Chronic pain is a major debilitating condition that is difficult to treat. Although chronic pain may appear to be a disorder of the nervous system,…”
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GRK2: A Novel Cell-Specific Regulator of Severity and Duration of Inflammatory Pain by Eijkelkamp, Niels, Heijnen, Cobi J, Willemen, Hanneke L. D. M, Deumens, Ronald, Joosten, Elbert A. J, Kleibeuker, Wendy, den Hartog, Ilona J. M, van Velthoven, Cindy T. J, Nijboer, Cora, Nassar, Mohammed A, Dorn, Gerald W., II, Wood, John N, Kavelaars, Annemieke

“…Chronic pain associated with inflammation is a common clinical problem, and the underlying mechanisms have only begun to be unraveled. GRK2 regulates cellular…”
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The effect of modified quarter laser-assisted zona thinning on the implantation rate per embryo in frozen/vitrified-thawed/warmed embryo transfer cycles: a prospective randomized controlled trial by Debrock, S., Peeraer, K., Spiessens, C., Willemen, D., De Loecker, P., D'Hooghe, T.M.

“…BACKGROUND Freezing/vitrifying and thawing/warming of embryos may impair the successful hatching process of the embryo out of its zona pellucida (ZP) and its…”
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Mitochondria and sensory processing in inflammatory and neuropathic pain by Silva Santos Ribeiro, P, Willemen, Hanneke L D M, Eijkelkamp, Niels

“…Rheumatic diseases, such as osteoarthritis and rheumatoid arthritis, affect over 750 million people worldwide and contribute to approximately 40% of chronic…”
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Mesenchymal Stem Cell Transplantation Attenuates Brain Injury After Neonatal Stroke by VELTHOVEN, Cindy T. J. Van, SHELDON, R. Ann, KAVELAARS, Annemieke, DERUGIN, Nikita, VEXLER, Zinaida S, WILLEMEN, Hanneke L. D. M, MAAS, Mirjam, HEIJNEN, Cobi J, FERRIERO, Donna M

“…Brain injury caused by stroke is a frequent cause of perinatal morbidity and mortality with limited therapeutic options. Mesenchymal stem cells (MSC) have been…”
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Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region by Peters, Marjolein J, Broer, Linda, Willemen, Hanneke L D M, Eiriksdottir, Gudny, Hocking, Lynne J, Holliday, Kate L, Horan, Michael A, Meulenbelt, Ingrid, Neogi, Tuhina, Popham, Maria, Schmidt, Carsten O, Soni, Anushka, Valdes, Ana M, Amin, Najaf, Dennison, Elaine M, Eijkelkamp, Niels, Harris, Tamara B, Hart, Deborah J, Hofman, Albert, Huygen, Frank J P M, Jameson, Karen A, Jones, Gareth T, Launer, Lenore J, Kerkhof, Hanneke J M, de Kruijf, Marjolein, McBeth, John, Kloppenburg, Margreet, Ollier, William E, Oostra, Ben, Payton, Antony, Rivadeneira, Fernando, Smith, Blair H, Smith, Albert V, Stolk, Lisette, Teumer, Alexander, Thomson, Wendy, Uitterlinden, André G, Wang, Ke, van Wingerden, Sophie H, Arden, Nigel K, Cooper, Cyrus, Felson, David, Gudnason, Vilmundur, Macfarlane, Gary J, Pendleton, Neil, Slagboom, P Eline, Spector, Tim D, Völzke, Henry, Kavelaars, Annemieke, van Duijn, Cornelia M, Williams, Frances M K, van Meurs, Joyce B J

“…Chronic widespread pain (CWP) is a common disorder affecting ∼10% of the general population and has an estimated heritability of 48-52%. In the first…”
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Pre-Existing High Glucocorticoid Receptor Number Predicting Development of Posttraumatic Stress Symptoms After Military Deployment by van Zuiden, Mirjam, Geuze, Elbert, Willemen, Hanneke L.D.M., Vermetten, Eric, Maas, Mirjam, Heijnen, Cobi J., Kavelaars, Annemieke

“…Objective:The development of posttraumatic stress disorder (PTSD) is influenced by preexisting vulnerability factors. The authors aimed at identifying a…”
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GRK2 levels in myeloid cells modulate adipose-liver crosstalk in high fat diet-induced obesity by Vila-Bedmar, Rocío, Cruces-Sande, Marta, Arcones, Alba C., Willemen, Hanneke L. D. M., Prieto, Patricia, Moreno-Indias, Isabel, Díaz-Rodríguez, Daniel, Francisco, Sara, Jaén, Rafael I., Gutiérrez-Repiso, Carolina, Heijnen, Cobi J., Boscá, Lisardo, Fresno, Manuel, Kavelaars, Annemieke, Mayor, Federico, Murga, Cristina

“…Macrophages are key effector cells in obesity-associated inflammation. G protein-coupled receptor kinase 2 (GRK2) is highly expressed in different immune cell…”
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Effect of modified quarter laser-assisted zona thinning (mQLAZT) on pregnancy and implantations rates in cryopreserved embryos: a prospective randomized controlled trial by Debrock, S, Spiessens, C, Willemen, D, Peeraer, K, D'Hooghe, T.M

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A computerized scoring system: a benefit in the evaluation of embryo quality? by Paternot, G, Devroe, J, Willemen, D, Debrock, S, D'Hooghe, T, Spiessens, C

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G protein-coupled receptor kinase 6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting phosphatidylinositol 3-kinase and inhibiting p38 signaling by Eijkelkamp, Niels, Heijnen, Cobi J, Carbajal, Anibal Garza, Willemen, Hanneke L D M, Wang, Huijing, Minett, Michael S, Wood, John N, Schedlowski, Manfred, Dantzer, Robert, Kelley, Keith W, Kavelaars, Annemieke

“…The molecular mechanisms determining magnitude and duration of inflammatory pain are still unclear. We assessed the contribution of G protein-coupled receptor…”
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A novel p38 MAPK docking-groove-targeted compound is a potent inhibitor of inflammatory hyperalgesia by Willemen, Hanneke L D M, Campos, Pedro M, Lucas, Elisa, Morreale, Antonio, Gil-Redondo, Rubén, Agut, Juan, González, Florenci V, Ramos, Paula, Heijnen, Cobi, Mayor, Jr, Federico, Kavelaars, Annemieke, Murga, Cristina

“…The MAPK (mitogen-activated protein kinase) p38 is an important mediator of inflammation and of inflammatory and neuropathic pain. We have described recently…”
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Fallen fragment sign by Van Doninck, J, Vanhoenacker, F M, Petré, C, Willemen, D

“…A 16-year-old boy presented at the emergency room after he fell on his left shoulder while playing American football. Plain radiographs showed a pathological…”
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Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain by van der Vlist, Michiel, Raoof, Ramin, Willemen, Hanneke L.D.M., Prado, Judith, Versteeg, Sabine, Martin Gil, Christian, Vos, Martijn, Lokhorst, Roeland E., Pasterkamp, R. Jeroen, Kojima, Toshiyuki, Karasuyama, Hajime, Khoury-Hanold, William, Meyaard, Linde, Eijkelkamp, Niels

“…The current paradigm is that inflammatory pain passively resolves following the cessation of inflammation. Yet, in a substantial proportion of patients with…”
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The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes by Davydova, Erna, Shimazu, Tadahiro, Schuhmacher, Maren Kirstin, Jakobsson, Magnus E., Willemen, Hanneke L. D. M., Liu, Tongri, Moen, Anders, Ho, Angela Y. Y., Małecki, Jędrzej, Schroer, Lisa, Pinto, Rita, Suzuki, Takehiro, Grønsberg, Ida A., Sohtome, Yoshihiro, Akakabe, Mai, Weirich, Sara, Kikuchi, Masaki, Olsen, Jesper V., Dohmae, Naoshi, Umehara, Takashi, Sodeoka, Mikiko, Siino, Valentina, McDonough, Michael A., Eijkelkamp, Niels, Schofield, Christopher J., Jeltsch, Albert, Shinkai, Yoichi, Falnes, Pål Ø.

“…Post-translational methylation plays a crucial role in regulating and optimizing protein function. Protein histidine methylation, occurring as the two isomers…”
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Myostatin and CXCL11 promote nervous tissue macrophages to maintain osteoarthritis pain by Martin Gil, Christian, Raoof, Ramin, Versteeg, Sabine, Willemen, Hanneke L.D.M., Lafeber, Floris P.J.G., Mastbergen, Simon C., Eijkelkamp, Niels

“…•Dorsal Root Ganglia (DRG) macrophages maintain, but do not initiate osteoarthritis (OA) pain.•CXCL1, partially expressed in satellite glial cells, drives…”
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Glucocorticoid Receptor Pathway Components Predict Posttraumatic Stress Disorder Symptom Development: A Prospective Study by van Zuiden, Mirjam, Geuze, Elbert, Willemen, Hanneke L.D.M, Vermetten, Eric, Maas, Mirjam, Amarouchi, Karima, Kavelaars, Annemieke, Heijnen, Cobi J

“…Background Biological correlates of posttraumatic stress disorder (PTSD) have mostly been studied using cross-sectional or posttrauma prospective designs…”
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Monocytes/Macrophages control resolution of transient inflammatory pain by Willemen, Hanneke L D M, Eijkelkamp, Niels, Garza Carbajal, Anibal, Wang, Huijing, Mack, Matthias, Zijlstra, Jitske, Heijnen, Cobi J, Kavelaars, Annemieke

“…Insights into mechanisms governing resolution of inflammatory pain are of great importance for many chronic pain-associated diseases. Here we investigate the…”
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Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2 by Vila-Bedmar, Rocio, Cruces-Sande, Marta, Lucas, Elisa, Willemen, Hanneke L D M, Heijnen, Cobi J, Kavelaars, Annemieke, Mayor, Jr, Federico, Murga, Cristina

“…Insulin resistance is a common feature of obesity and predisposes individuals to various prevalent pathological conditions. G protein (heterotrimeric guanine…”
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