Search Results - "WILLEM LEEUWIS, Jan"

Loss of Endogenous Bone Morphogenetic Protein-6 Aggravates Renal Fibrosis by Dendooven, Amélie, van Oostrom, Olivia, van der Giezen, Dionne M, Willem Leeuwis, Jan, Snijckers, Cristel, Joles, Jaap A, Robertson, Elizabeth J, Verhaar, Marianne C, Nguyen, Tri Q, Goldschmeding, Roel

“…Bone morphogenetic protein-6 (BMP-6) suppresses inflammatory genes in renal proximal tubular cells and regulates iron metabolism by inducing hepcidin. In…”
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Nebulized Amphotericin B in Mechanically Ventilated COVID-19 Patients to Prevent Invasive Pulmonary Aspergillosis: A Retrospective Cohort Study by Melchers, Max, van Zanten, Arthur R H, Heusinkveld, Moniek, Leeuwis, Jan Willem, Schellaars, Roel, Lammers, Hendrick J W, Kreemer, Freek J, Haas, Pieter-Jan, Verweij, Paul E, van Bree, Sjoerd H W

“…Despite high mortality rates of COVID-19-associated pulmonary aspergillosis (CAPA) in the ICU, antifungal prophylaxis remains a subject of debate. We initiated…”
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Lymphoblastic lymphoma with a triple hit profile: a rare but distinct and relevant entity by Hiemcke-Jiwa, Laura S., MD, Leguit, Roos J., MD, van der Veken, Lars T., PhD, Buijs, Arjan, PhD, Leeuwis, Jan Willem, MD, PhD, de Boer, Mirthe, MD, Jiwa, N. Mehdi, MD, PhD, Bloem, Andries C., PhD, Petersen, Eefke J., MD, PhD, de Weger, Roel A., PhD, Huibers, Manon M.H., PhD

“…Summary Follicular lymphoma with progression to a high grade lymphoma bears a poor prognosis. We describe a case of a 60-year old man who presented in 2012…”
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CCN2 reduction mediates protective effects of BMP7 treatment in obstructive nephropathy by Falke, Lucas L., Leeuwis, Jan Willem, Lyons, Karen M., Mummery, Christine L., Nguyen, Tri Q., Goldschmeding, Roel

“…Treatment with rhBMP7 exerts profound protective effects in a wide variety of experimental models of renal disease. However, little is known about how these…”
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Elevated Urinary Connective Tissue Growth Factor in Diabetic Nephropathy Is Caused by Local Production and Tubular Dysfunction by Joles, Jaap A., Kok, Robbert Jan, Goldschmeding, Roel, Nguyen, Tri Q., Rossing, Peter, Tarnow, Lise, Aten, Jan, van Oeveren, Wim, Bakker, Stephan J. L., Koeners, Maarten P., Leeuwis, Jan Willem, Gerritsen, Karin G. F., Wetzels, Jack F. M.

“…Connective tissue growth factor (CTGF; CCN2) plays a role in the development of diabetic nephropathy (DN). Urinary CTGF (uCTGF) is elevated in DN patients and…”
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Targeting podocyte-associated diseases by Leeuwis, Jan Willem, Nguyen, Tri Q., Dendooven, Amélie, Kok, Robbert J., Goldschmeding, Roel

“…Injury to the podocytes is the initiating cause of many renal diseases, leading to proteinuria with possible progression to end-stage renal disease. Podocytes…”
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Distribution of mucosal PD-1 expressing T cells in patients with colitis of different etiologies by Roosenboom, Britt, Horjus Talabur Horje, Carmen S., Smids, Carolijn, Leeuwis, Jan Willem, van Koolwijk, Elly, Groenen, Marcel J. M., Wahab, Peter J., van Lochem, Ellen G.

“…Immunotherapy, targeting programmed death-1 (PD-1) enhances antitumor T-cell activity in patients with malignancies. Blocking PD-1 or its ligand may lead to…”
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Reclassification of diffuse large B cell lymphoma to large B cell lymphoma with IRF4 rearrangement in an adult population by Hesius, Eva A M, Laar, Lidia, Oosterveld, Margriet, Spriel, Annemiek B, Scheijen, Blanca, Leeuwis, Jan Willem, Marres, Henri A M, Groenen, Patricia J T A, Stevens, Wendy B C, Spek, Ellen, Brule, Adriaan J C, Hoevenaars, Brigiet M, Hebeda, Konnie M, Brand, Michiel

“…Aims Large B cell lymphoma with IRF4 rearrangement (LBCL‐IRF4) is a new entity in the 2017 revised World Health Organisation (WHO) classification that was…”
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Mutational analysis using Sanger and next generation sequencing in sporadic spindle cell hemangiomas: A study of 19 cases by ten Broek, Roel W., Bekers, Elise M., de Leng, Wendy W. J., Strengman, Eric, Tops, Bastiaan B. J., Kutzner, Heinz, Leeuwis, Jan Willem, van Gorp, Joost M., Creytens, David H., Mentzel, Thomas, van Diest, Paul J., Eijkelenboom, Astrid, Flucke, Uta

“…Spindle cell hemangioma (SCH) is a distinct vascular soft‐tissue lesion characterized by cavernous blood vessels and a spindle cell component mainly occurring…”
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Discrepancies in digital hematopathology diagnoses for consultation and expert panel analysis by van den Brand, Michiel, Nooijen, Peet T. G. A., van der Laan, Kimberly D., de Bruin, Peter C., van Leeuwen, A. M. (Gijs), Leeuwis, Jan Willem, Meijer, Jos W., Otte-Höller, Irene, Hebeda, Konnie M.

“…Digital pathology with whole-slide imaging (WSI) has a large potential to make the process of expert consultation and expert panel diagnosis more rapid and…”
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BMP Signaling and Podocyte Markers Are Decreased in Human Diabetic Nephropathy in Association With CTGF Overexpression by Turk, Tamara, Leeuwis, Jan Willem, Gray, Julia, Torti, Suzy V, Lyons, Karen M, Nguyen, Tri Q, Goldschmeding, Roel

“…Diabetic nephropathy is characterized by decreased expression of bone morphogenetic protein-7 (BMP-7) and decreased podocyte number and differentiation…”
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Connective Tissue Growth Factor Is Associated With a Stable Atherosclerotic Plaque Phenotype and Is Involved in Plaque Stabilization After Stroke by LEEUWIS, Jan Willem, NGUYEN, Tri Q, THEUNISSEN, Maarten G. J, PEETERS, Wouter, GOLDSCHMEDING, Roel, PASTERKAMP, Gerard, VINK, Aryan

“…Carotid plaques remodel toward a more stable phenotype after stroke, but not after TIA. Connective tissue growth factor (CTGF) is involved in extracellular…”
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Hemizygous deletion of CTGF/CCN2 does not suffice to prevent fibrosis of the severely injured kidney by Falke, Lucas L., Dendooven, Amélie, Leeuwis, Jan Willem, Nguyen, Tri Q., van Geest, Rob J., van der Giezen, Dionne M., Broekhuizen, Roel, Lyons, Karen, Stoop, Reinout, Kemperman, Hans, Schlingemann, Reinier, Joles, Jaap A., Goldschmeding, Roel

“…Connective Tissue Growth Factor (CTGF/CCN2) is an important mediator of kidney fibrosis. Previous observations indicated that attenuation of CCN2 expression…”
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Connective Tissue Growth Factor Is Involved in Structural Retinal Vascular Changes in Long-Term Experimental Diabetes by Van Geest, Rob J., Leeuwis, Jan Willem, Dendooven, Amélie, Pfister, Frederick, Bosch, Klazien, Hoeben, Kees A., Vogels, Ilse M.C., Van der Giezen, Dionne M., Dietrich, Nadine, Hammes, Hans-Peter, Goldschmeding, Roel, Klaassen, Ingeborg, Van Noorden, Cornelis J.F., Schlingemann, Reinier O.

“…Early retinal vascular changes in the development of diabetic retinopathy (DR) include capillary basal lamina (BL) thickening, pericyte loss and the…”
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The Course of Unilateral Intracranial Arteriopathy in Young Adults With Arterial Ischemic Stroke by BULDER, Marcel M. M, BRAUN, Kees P. J, LEEUWIS, Jan Willem, LO, Rob T. H, VAN NIEUWENHUIZEN, Onno, KAPPELLE, L. Jaap, KLIJN, Catharina J. M

“…Unilateral intracranial focal nonprogressive arteriopathy is often found in children with arterial ischemic stroke. We aimed to investigate the course of…”
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Targeting podocyte-associated diseases: DRUG TARGETING TO THE KIDNEY by LEEUWIS, Jan Willem, NGUYEN, Tri Q, DENDOOVEN, Amélie, KOK, Robbert J, GOLDSCHMEDING, Roel

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Direct visualization of Smad1/5/8-mediated transcriptional activity identifies podocytes and collecting ducts as major targets of BMP signalling in healthy and diseased kidneys by Leeuwis, Jan Willem, Nguyen, Tri Q, Chuva de Sousa Lopes, Susana M, van der Giezen, Dionne M, van der Ven, Kevin, Rouw, Peter JH, Offerhaus, G Johan A, Mummery, Christine L, Goldschmeding, Roel

“…Bone morphogenetic protein 7 (BMP7) is a key determinant of renal response to injury, exhibiting strong protective as well as regenerative potential in a…”
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Ruptured Aneurysm of the Splenic Artery Associated with Fibromuscular Dysplasia by Ünlü, Çağdaş, van den Heuvel, Danyel A.F, Leeuwis, Jan Willem, de Vries, Jean-Paul P.M

“…Rupture of a splenic artery aneurysm is a rare event associated with high mortality rates. Aneurysm of the splenic artery associated with fibromuscular…”
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Direct visualization of Smad 1/5/8―mediated transcriptional activity identifies podocytes and collecting ducts as major targets of BMP signalling in healthy and diseased kidneys by WILLEM LEEUWIS, Jan, NGUYEN, Tri Q, CHUVA DE SOUSA LOPES, Susana M, VAN DER GIEZEN, Dionne M, VAN DER VEN, Kevin, ROUW, Peter Jh, OFFERHAUS, G. Johan A, MUMMERY, Christine L, GOLDSCHMEDING, Roel

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Visceral endoderm induces specification of cardiomyocytes in mice by Nijmeijer, Rian M, Leeuwis, Jan Willem, DeLisio, Anna, Mummery, Christine L, Chuva de Sousa Lopes, Susana M

“…The endoderm plays an inductive role in the formation of cardiomyocytes in many vertebrates. Here, we provide further evidence for this in the mouse and…”
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